CN1449840A - 遥控药物输注和分析物监视的系统和方法 - Google Patents

遥控药物输注和分析物监视的系统和方法 Download PDF

Info

Publication number
CN1449840A
CN1449840A CN03110722A CN03110722A CN1449840A CN 1449840 A CN1449840 A CN 1449840A CN 03110722 A CN03110722 A CN 03110722A CN 03110722 A CN03110722 A CN 03110722A CN 1449840 A CN1449840 A CN 1449840A
Authority
CN
China
Prior art keywords
pump
user
remote control
patient
physiological liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN03110722A
Other languages
English (en)
Inventor
A·D·拜伦
W·J·杜尔班
M·D·瓦德勒
K·M·隆
J·麦克克卢斯基
U·克拉夫特
M·埃布纳
M·施泰尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeScan Inc
Original Assignee
LifeScan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LifeScan Inc filed Critical LifeScan Inc
Publication of CN1449840A publication Critical patent/CN1449840A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/002—Monitoring the patient using a local or closed circuit, e.g. in a room or building
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings
    • A61B2560/0412—Low-profile patch shaped housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1405—Patient controlled analgesia [PCA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Business, Economics & Management (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Business, Economics & Management (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

本发明提供一种通过药物注液泵，例如一个皮下注液泵，遥控病人的药物输送，和通过一个经皮测量装置遥控和监视一个或多个生理液分析物的装置，系统，和方法。本发明的系统包括一个药物注液泵和一个用于遥控注液泵和/或测量装置的手持表链。除了遥控胰岛素泵和测量装置，表链提供了在一段时间内的血液化学特性数据和胰岛素输送数据的联合并保持这个联合数据以便用户或医生立即和以后取回。本发明的方法是，通过计入或补偿用户当前的或实际当前的血液化学特性评估和/或用户预期的和/或实际的碳水化合物摄取量而使用户定制和最佳化胰岛素食团输送规约，即，食团量和输送持续时间。

Description

遥控药物输注和分析物 监视的系统和方法
技术领域
本发明涉及连续输送的药物输注系统和生理液特性监视系统。特别是，本发明涉及这种连续/输送的药物输注系统和生理液特性监视系统的用户一交互性遥控，以及在遥控装置中集成这种生理液特性监视系统。
背景技术
药物输注装置和生理液特性监视装置在医学界是公知的。这种装置的一个公共应用是输送胰岛素和监视糖尿病患者的血液葡萄糖水平。近年有很多进展，和这种装置结合起来而形成一个合用装置，该合用装置根据实时病人血液葡萄糖水平和其它要求控制对病人的胰岛素输送。
一个这样的装置在美国专利U.S.5,665,065号中被公开了，它提供一个自动注液泵，以便连续地，按程序地输送胰岛素到病人的皮下部位。根据一个预定规约，该泵被设计成，经过一个注入管子从贮液器到病人程序可控地输送胰岛素。泵的外壳包括一个集成的血液传感器，用以获得病人的当前的血液葡萄糖水平。除了当前的血液的化学数据而外，该装置用以接收与特定事件的病人活动有关的病人的数据，例如，病人锻炼或进餐时刻表的变化，或预期摄取食物的增减，这些可能影响病人当前血液的化学特性。这种特定事件数据和血液数据被提供给一个安装在泵监视装置中的中心控制器信息处理机，它可以自动修改胰岛素输送规约，对胰岛素的剂量和用泵输送这个剂量的时间选择进行必要的变化。
虽然这种高度自动化的装置具有许多优点，许多病人还是想要直接控制药物的配给。例如，病人可能要求在药剂输送期间停止药物的配给，即使在最初的配给是由病人开始的，而不是根据预定程序算法开始的场合。可能有这样的情况，例如，糖尿病患者预期摄取的碳水化合物发生变化，例如，在进餐中，病人发现自己吃进的碳水化合物的数量大于或小于餐前预期的量。这种情况要求立即修改实际用泵输送的当时的当前胰岛素输送参数。
因此，继续对用泵进行病人控制药物输送的新装置和新方法的研究感兴趣，它对适应每个病人的实时的，即时的需要，适应药物的实时输送的特殊控制提供了更大的灵活性。特别感兴趣的是这样一种病人控制药物输送系统的研制，它提供给病人这样的灵活性和控制能力而增加了方便性和使用容易，加强了便携性和在需要与药物输送系统接口时提高了病人的稳私性。
发明内容
提供一种通过药物注液泵例如是一个皮下注液泵，遥控病人的药物输送，和/或通过一个经皮生理液监视装置遥控生理液，例如是病人的血液或间隙流体的测量的装置，系统和方法。本发明的系统包括一个手持“表链”，它用于遥控注液泵和/或监视装置。注液泵和监视装置可以分开安装或合在一起装入一个单一的外壳中。
注液泵包括一个药物贮液器和一个用于分配贮液器的药物的驱动电机。注液泵可以进一步包括一个电源和一个电池，一个报警器，一个数字显示器，一个具有微处理机以便控制泵的操作和泵通信功能的泵控制器，一个用于双向连通表链和其它装置的通信模块，一个用于短期或长期存储数据的存储器，和控制键，用于记入或选择显示器上显示的菜单的数据或参数。
生理液监视装置包括一个液体采样装置，用于存取和收集人的血液或间隙流体，包括一个特征测量装置，用于监视一个或多个特征，例如，采样液体的分析物。采样和后来的监视生理液可能实现上是连续进行的。生理液监视装置可能进一步包括一个电源和一个电池，一个报警器，一个数字显示装置，一个与表链和其它设备双向通信的通信模块，短期或长期存储数据的存储器，和用户接口控制键，用于使用户记入或选择显示器上显示的菜单的数据或参数。生理液监视装置进一步包括一个控制器，它具有一个微处理机以控制采样操作，包括测量装置，它经通信模块控制信号接收和传输，在监视装置中各组成部分之间处理和传递数据。生理液监视装置的一个特点是，它能被程序化，以便提供生理液的连续的，不断进行的存取，收集和测量，而不需要人的干予。
表链包括遥控泵和/或生理液连续收集的装置和监视装置。可选择地，表链也可以包括一个“不连续的”或短暂的生理液测量仪。表链具有一个试验片条端口以便接收，用仪器短暂测量病人血液采样的血液葡萄糖浓度的试验片条。表链还包括用户遥控注液泵和生理液收集装置的部分，包括一个表链控制器，它具有一个微处理机，用于控制泵和仪器操作功能，和一个通信模块，用于传送泵的操作，一个显示器和控制键，用于泵的数据的记入，选择和传送，和生理液收集装置，存储这些数据的存储器。
本系统优于许多传统的胰岛素输送和监视系统的优点在于，在很小的，独立的表链中，合并了短暂血液化学仪和很分散的，遥控胰岛素泵的零部件和/或连续测量分析物试验器。除了遥控胰岛素泵和连续/测量分析物试验器，表链提供了在一段时间上的血液化学数据和胰岛素输送数据的联合并保持这个联合数据以便用户或医生立即和以后取回。这样，所有关键信息和影响病人治疗的事件的综合分析可以被做出。
本系统的特点带来的优点在于，它使用户在监视和控制血液葡萄糖水平中具有广泛的灵活性。特别是，本系统使用户有能力改变食团和在任何时间上的基本定量输送缺省参数。通过软件算法控制和调整药物食团提供了许多这种灵活性。
为了更好地处理用户直接的和发展中的要求，本发明通过计入或补偿用户当前的或实际上当前的血液化学评估和/或用户的预期的和/或实际的碳水化合物摄取量，而使用户定制一个胰岛素食团输送规约，即，食团的体积和输送持续时间。特别是，本发明提供了三种计算器功能选择，即碳水化合物计算器功能，血液葡萄糖计算器功能和联合计算器功能，它允许用户选择考虑血液化学特性和碳水化合物的任一个或两者，以及其它因素，例如在执行食团输送规约以前用户进行的锻炼。进行这样的计算的某些参数是缺省值，例如，食团与碳水化合物的比，食团与血液葡萄糖的比，和用户的目标血液葡萄糖水平，它们已被予先编制程序到系统控制器中，而其它参数，例如，用户实际血液葡萄糖水平，将要消耗的碳水化合物的数量，和食团剂量校正因素，将由用户实时记入。
本发明的方法包括用表链装置遥控药物胰岛素泵和生理液监视装置，如上所述。这种遥控包括在泵和表链之间和在监视装置和表链之间(和在泵和监视装置之间进行选择)的“符号交换”，其中，数据和指令经过它们各自的通信模块在各个装置之间来回传送。
这些方法可以包括实现各种食团输送算法的一个或多个，这些算法包括，标准食团输送算法，展开食团输送算法和双食团输送算法。上述每一种算法可以用或不用上述计算器功能来实现，以便定制和最佳化在任一给定时间上的每个食团输送规约。
通过阅读下面的本发明的方法和系统的详细说明，本发明的这些和其它目的，优点，和特点对于那些本领域的普通技术人员来说会变得更明显。
附图说明
图1是本发明的一个系统，它具有一个病人佩带的便携药物输送泵和一个血液特性仪，做成遥控装置用于控制所述仪器和泵的功能。
图1A是沿图1中A-A线截取的图1的泵的视图。
图1B是沿图1中B-B线截取的图1的遥控仪装置的视图。
图2是图1系统的方块图。
图3A是本发明标准食团输送算法的流程图。
图3B是本发明展开食团输送算法的流程图。
图3C是本发明双食团输送算法的流程图。
图4A是本发明碳水化合物计算器方式算法的流程图。
图4B是本发明血液葡萄糖计算器方式算法的流程图。
图4C是本发明碳水化合物/血液葡萄糖计算器方式算法的流程图。
图5是本发明的方法的流程图。
图6是本发明的另一个系统，它具有病人佩带的便携连续生理液监视器，和控制该监视器功能的遥控装置，该遥控装置还提供一个用于生理液监视的积分仪。
图7是图6的系统的连续生理液监视器，它包括一个和该监视器一起使用的可自由使用的卡盘(cartridge)。
图8是图7的卡盘的放大透视图。
图9是图6系统的方块图。
图10是本发明另一系统的方块图，它包括一个便携药物输送泵，一个连续生理液监视器，和一个控制输送泵和监视器的功能的遥控器。
具体实施方式
在对本发明进行描述以前，应该理解，本发明不限于所描述的具体实施例，它们是可以变化的。同样也应该理解，这里所用术语只是为了描述具体的实施例而不是限制本发明，本发明的范围仅由所附权利要求来限定。
当提及值的范围时，应该理解，对于下限单位十位以内的每个插入值，如果没有上下文明确规定，就是在这个范围的上限和下限之间，任何其它规定的，或在那个规定范围中的插入值被包括在本发明之中。能够独立地包括在小范围之中的小范围的上限和下限也包括在本发明之中，服从在规定范围之中的任何特殊的除外界限。在规定范围包括一个或两个限界的地方，排除任一或两个所包括界限的范围也包括在本发明之中。
除非有规定，这里使用的技术与科学术语具有熟悉本发明技术的普通人员所一般理解的相同意义。虽然任何类似于或等于这里所描述的方法和资料也能被用于实践或试验本发明，现在描述最佳方法和资料。
必须指出，如这里和权利要求书中所使用的，单数冠词“a”，“an”和“the”包括多种对象，除非上下文明确规定。因此，例如，“a test strip”(一试验片条)包括多个这样的试验片条，“the device”(一设备)包括一个或多个本领域普通技术人员所知道的设备和其等价物，等等。
这里所讨论的那些公开物，只是因为它们是在本申请申请日以前公开的。这些先前的公开物不会影响本发明的授权。此外，所提供的公开日期可能与实际公开日期不同，实际公开日期需要被独立地证实。
现在将详细描述本发明，在进一步描述本发明的时候，主题系统和设备组成部分将首先描述，其次使用的主题设备和系统的各种方法，以及控制生理采样特性的试验和控制药物输送给病人的方法也将被描述。最后简短描述所提供的主题成套部件，这些成套部件包括在实践主题方法中使用的主题设备和系统。
在下面的描述中，本发明将描述葡萄糖浓度测量和胰岛素输送应用；不过，这不限制本发明，本领域普通技术人员将理解，主题设备，系统和方法在测量其它物理和化学特性中是有用的，例如生物物质的凝血时间，胆固醇血的水平等，在输送其它药物中也是有用的，例如疼痛控制药物，抗菌素，在化学疗法和营养疗法中也是有用的。
系统和设备
现在参考图1和2解释本发明的系统，它具有一个注液泵4和一个遥控装置6，一般称为“表链”(fob)。图1A沿线A-A示出了泵4的顶视图。图1B沿线B-B示出了装置6的侧视图。图2是泵4和表链6的方块图和它们各自的组成部分。图6-9是本发明的另一个系统，它具有生理液监视装置300和表链350。图6-8是系统的组成部分的外部视图，图9与图10一道，提供了监视装置300和表链350的方块图。图10是本发明的另一个系统，它包括泵和监视装置。
注液泵
注液泵4具有一个外壳8，它最好是用耐用的塑料材料制成，它有一个部分8a，适用于接收或容纳注射器或贮液器(未示出)，贮液器贮存配给病人的规定的药物，配给病人药物是通过一个留置导管10进行的。外壳8最好足够小型紧凑以便用户舒适地，单独地携带，例如，通过一个腰带夹子等进行携带。一般，外壳8的长度Lp是在约2.5到5英寸的范围内，更典型的是约3英寸到约3.5英寸，高Hp是在约1.5至约3英寸的范围内，更一般的是从约2英寸到约2.5英寸，厚Tp在约0.5到约1.5英寸的范围内，更一般的是从约0.75到约1英寸。虽然泵4实际上是长方形或正方形的，它也可以是任何合适的形状，例如，园形，长椭园形等等。
注液泵4包括许多与现有技术注液泵相同的基本的组成部分和结构，例如在下述美国专利中公开的那些，这些美国专利的专利号是，4,562,751；4,678,903；5,080,653；5,097,122；5,935,099；6,248,093B1和6,406,605B1，这些美国专利被引入作为参考。这些基本部件包括一个药物贮液器50和一个驱动电机52，它使用一个引导螺旋部件，以便电机驱动贮液器活塞(未示出)前进，使药物退出泵的出口而进入注液管10；不过，其它合适的从贮液器50分配药物的机制也可能被使用，例如，电渗流(也称动电流)。因此，电源62和电池64被提供，以便提供必要的电力去操作泵4的各组成部件。
用于泵药的电渗泵的例子公开在美国专利No 6,406,605，3,923,426和PCT公报WO 02/094440中。电渗泵主要包括一个被要被泵的液体弄湿的泵媒介物，和一对电极，电极把电压加在流动方向中的泵媒介物上。通常，泵媒介物是多孔薄膜的形式，当被要被泵的液体弄湿的时候呈现净电表面电荷。电场建立在电极之间，引起泵媒介物的表面附近的液体中的带电物质的移动。这种带电物质的运送沿着将被泵的液体拖拉并在电场方向中产生需要的液体流。每种公开的泵可以用于直接地或间接地泵药物。在直接泵药情况下，药物流过泵媒介物，在间接泵药的情况下，一个第二液体通过泵媒介物被泵出，这个第二液体的移动被用于对要输送的药物加压和驱动。
泵4可以进一步包括声音的，视觉的和/或振动报警器/提醒器66，使用户警觉报警状态，例如，在贮液器中正保留的药物是低量的时候，血液的化学测量是在允许范围以外的情况，低的电池功率，输注管出现堵塞的情况，泵失灵的情况，提醒用户一个事件或执行必要的行动，例如，执行血液化学特性评估，执行药物输送规约，等等，或某些其它用户可确定的警报。和泵4一起使用的合用的警报器/提醒器66可以包括声音装置，例如压电呼叫机，运动装置，例如振动马达；和/或视觉装置，例如，LED，等等。
泵4还包括一个显示器14，例如液晶显示器(LCD)，用于图和字母数字显示。图的显示可以包括一些图符，它代表，例如，食团和基本速度输送状态和调整，关于血液葡萄糖水平的历史数据，存储在存储器中的胰岛素的输送，停止食团指令，等等。选择一个图符将提出相应的用户接口菜单。
泵4还包括一个泵控制器54，它具有一个微处理机，用于控制泵的操作和泵的通信功能。泵控制器54还可能具有一个用于存储泵操作软件程序和其它静数据的存储单元，这些静数据有，例如，预编程序缺省值，它包括但不限于，血液化学特性仪标定信息，用户的偏爱，例如，语言，用户基本定量，碳水化合物和血液葡萄糖食团较正因素，用户目标血液葡萄糖水平，计算器，等等。
存储装置56用于暂时存储动态数据，例如泵输注数据，血液化学特性数据(表链6的仪器/传感器80获得的)和其它用户记入的数据。泵输注数据可以包括的信息，例如药物输送速度(单位/小时)，在贮液器中容有的当时的药物量，食团输送开始/停止时间，食团输送持续时间，等等。血液化学特性数据包括血液葡萄糖浓度(mg/dl)的一些测量和它们各自的日期和时间。用户通过键12记入的其它数据包括但不限于，碳水化合物摄取量(mmol/L)和有关食团输送的参数，例如，食团剂量，食团持续时间，食团开始和停止时间，等等。
泵4还包括控制键12a，12b，和12c，用于使用户记入或选择数据或显示器14上显示菜单的参数。例如，控制键12a可能具有一个凸轮(jogwheel)形状，如图1A所示。特别是，凸轮12a由用户转动以选择所希望的，用泵4输送的药物食团的量。凸轮12a也可被用于通过显示器14上的菜单项目卷动，和通过压下凸轮12a选择这些菜单项目。控制键12b和12c是可压低的按钮，用于启动从表链来和去到表链的数据通信，或其它辅助设备，并用于启动食团输送。泵4可以有任意数目的键，每一个具有合适的形状，例如，凸轮(jogwheel)，可按压按钮，键垫等等，用于控制泵4。
指令和数据是通过单向和双向数据线或总线72和74进入泵控制器54和从泵控制器54出来的。更具体的是，泵控制器54接收来自电源62和电池64的电力，通过控制键12接收来自用户的输入数据和指令，并在单向线路72上传送指令到报警/提醒器66；另一方面，在泵控制器54和泵4的各个部件之间的通信是由双向线路74完成的。泵4和表链6和其它外部设备之间的信息传送将在下面详细描述。
泵遥控/血液化学特性仪(“表链”)
图6是一个短暂血液特性测量传感器和泵4的遥控装置。表链6具有一个外壳20，它最好明和耐用的塑料材料制成，它具有一个小的尺寸，一个工效学的形状，以便在人的衣服里例如口袋，单独携带，或人手持。一般，表链的尺寸不大于泵4的尺寸的1/3。表链外壳20的长度LF在1.5到4英寸的范围内，一般是2到2.5英寸，宽WF在0.75到2英寸的范围内，一般是1到1.5英寸，厚TF在0.25到1英寸的范围内，一般是0.5到0.75。虽然图示中表链实际是一个长椭园形或椭园形，它可以有任何形状，例如是园形等等，最好是一个工效形状。表链6还可以这样构成，例如在它的近端28上提供与附件环22连接，它可以被用于使表链6固定到衣服的一件东西上或钥匙上等等。
在表链’s的远端30上有一个试验片条端口32，用于接收试验片条40，例如一个电化学的，色度的或光度的，在分析物浓度确定中使用的试验片条，例如是，在用户血液抽样中的葡萄糖浓度。安排在表链6中的是仪器80，它用于上述这种确定。试验片条端口32和仪器80也可用于接收标定器80的标定片条等。
适合于和主题发明一起使用的电化学试验片条的例子包括在待审US.申请中所描述的那些，这些待审U.S申请的序号是，09/497,269；09/736,788，和09/746,116，U.S专利6,475,372；6,193,873；5,708,247；5,951,836；6,241,862；6,284,125；和6,444,115，和国际专利申请公报WO/0167099；WO/0173124；WO/0173109；和WO/0206806，它们的公开被这里参考引用。适合于和主题发明一起使用的色度或光度试验片条的例子包括在下述美国专利中描述的那些，这些美国专利是，5,563,042；5,753,452；和5,789,255，这里引入作为参考。适合于和主题系统一起使用的电化学仪的功能性的某些方面被公开在美国专利U.S.6,193,873，以及待审的，共同拥有的美国申请中，其序号是，09/497,304，09/497,269，09/736,788，09/746,116和09/923，093，它们在这里被引入作为参考。适合于和本发明一起使用的色度/光度仪的功能性的某些方面公开在下述美国专利中，U.S专利号是，4,734,360；4,900,666；4,935,346；5,059,394；5,304,468；5,306,623；5,418,142；5,426,032；5,515,170；5,526,120；5,563,042；5,620,863；5,753,429；5,773,452；5,780,304；5,789,255；5,843,691；5,846,486；5,968,836和5,972,294，它们在这里被引入作为参考。
除了包括试验片条仪80，表链6还包括使用户能够遥控注液泵4的部件。这些部件包括一个表链控制器82，它类似于一个泵控制器54，它包括一个微处理机，用于控制泵和传感器/仪器操作功能，并把泵的操作功能和血液化学特性信息从表链6传送给泵4或其它外部设备。表链控制器82可能有一个存储器单元，用于存储泵和传感器操作的软件程序。
表链6还包括一个存储器装置84，用于存储动态数据，例如血液化学特性数据和用户记入的其它数据。存储器84存储有限的数，约10个，例如，最近的血液化学特性测量和这个测量的对应的日期和时间，用户特殊事件的参数，例如，锻炼时间，碳水化合物的摄取，等等。
控制键24可以具有一个凸轮(jog wheel)和/或下压的按钮，形状类似于泵4的控制键12，它使用户记入或选择显示器26上显示的程序菜单数据，该显示器，例如是一个液晶显示器(LCD)，用于显示图和字母数字信息。一般，凸轮(jog wheel)被用于选择或调用数据或选择要实现的食团输送程序或参数。下压按钮通常用于传送数据，例如，葡萄糖结果，食团输送指令，无声警报指令，终止食团输送指令，到泵4或到其它外部设备。由用户经控制键24记入或选择的数据被送到控制器82，以便实现传感器或泵功能，或者把这些数据存储在存储器装置84中。表链6可以具有任意数目的控制键，每个键具有任意合适的形状，例如，凸轮(jog wheel)，下压按钮，键垫，等等。
用户经控制键24记入的数据包括，但不限于，碳水化合物的摄取(克)，所希望的食团输送程序和与食团输送有关的参数，例如，食团剂量，食团持续时间，食团开始和停止时间，药物的类型，药物的数量，目标葡萄糖范围(上限和下限)，锻炼强度，锻炼时间，健康评语，食物类型，食物数量，HbAlc，血压，和在英国专利GB 02129 20.3中公开的其它数据，以及为了确定和调整适当食团体量的用户操作计算器的预备措施。
指令和数据分别经单向和双向数据线路或总线94和96，往返传送到表链控制器82。特别是，表链控制器82接收电源86和电池88的电力和接收用户经控制键24在单向线路94上发送的输入数据和指令；另一方面，在表链控制器82和表链6的各个部件之间的往返通信是通过双向线路96完成的。在表链6和泵4和其它外部设备之间的信息传送将在下面详细描述。
连续生理液监视装置
图6是本发明的另一个系统，它包括连续生理液监视装置300和遥控装置350。遥控装置或表链350可以类似于上述表链6的结构和功能，它可以选择地包括一个用于生理液的不连续的或短暂分析物试验的生理液测量仪。例如，表链350具有一个试验片条端口352，用于接收试验片条40，如上所述。和表链6一样，表链350具有一个低轮廓外壳358，一个显示器354，控制键356，和相同或类似的内部部件(未示出)。
监视装置300也有一个低轮廓外壳360和一个带条362，它可以被佩带在四肢上，例如手臂上，在图6中装置300是戴在病人的上手臂上，但是也可以戴在前臂或手腕上。监视装置300也可以带有显示器364和类似于上述的显示器和控制键的控制键366。如图7所示，外壳360的下面或皮肤一接触侧368带有一个插入槽382，用于接收盘形的，易置的卡盘380，卡盘包括一个液体采样装置302，它可操作地与装在卡盘中的测量传感器或装置304液体连通。测量传感器304可以具有一个电化学的或光度/色度结构，它有能力，类似于WO 02/49507 A1中所公开的那些仪器那样半连续地或连续地测量葡萄糖，该文件在这里全部被引用。在图7的实施例中测量传感器具有电化学的构形，通过一组在卡盘380园周上的电接触垫对384和对应的在插入槽382中的电接触销386，在传感器和监视器300的电子器件之间建立电联系。
图8是卡盘380的放大透视图。卡盘380是由模制基座392制的，它是盘形，直径是20mm到40mm，一般是35mm，厚0.1mm到3mm，一般是2mm。采样装置302是针状410，一个加压环412形成在基座302的底表面390上。针410用于刺入用户的皮肤，以便抽取生物液。针410的内径是在0.1mm到0.5mm的范围内，一般是0.3mm(25号针)。加压环412的作用是对刺入部位周围的皮肤区稳定和加压，以便实际上容易地抽取ISF进入针410。为了完成这些功能，加压环412的直径一般是5mm到30mm，更一般的是12mm。针410被安排在加压环412的槽(未示出)中的近端。针302最好有一个刺入长度尺寸，使得刺入皮肤的深度，病人感觉的疼痛最小。凹槽的深度决定针410的最大刺入深度。象这样，针410可以相对于加压环412被形成和安排，它仅仅刺入而不通过皮肤的真皮层，在这里实际存在着血液自由间隙流体(ISF)，一般是刺入皮肤表面下1.5mm到3.0mm的深度。
最好是，针410和加压环412移动并彼此独立地应用于皮肤。在实际中，一个驱动装置，例如是一个弹簧，被用于推动压力环412抵住皮肤，一个第二驱动装置，例如是一个第二弹簧，用于把针410射入皮肤。虽然这种机械在这里没有专门论述，本领域的普通技术的人是了解这种机械的。
针410安排在与卡盘380中的至少一个或多个传感器或检测器液体相通，以便执行装置300的分析物测量功能。和监视装置300一起使用的合适的卡盘等，被公开在共同拥有的，指定的国际公布的WO 02/49507中，在这里它被全部引用。
图9是图6的系统的功能的原理说明。如图9所示，该系统一般包括监视装置300和遥控表链350。监视器300包括一个易置卡盘380，它与控制器306电连接。卡盘380，如上所述，包括一个采样装置302，与传感器304相连液体通。采样装置302有一个液体取得装置，例如是一个针，它安排在设备外壳外面，用于抽取生理液，例如是来自身体的ISF。在操作中，在皮肤中取得的液体被传送450到采样装置302的液体收集区。该采样液体然后被输送到传感器304中，在这里选择分析物被测量。代表测量值的信号被输入454到控制器306，控制器通过输出信号456(见图10)控制液体抽样测量操作。然后，这些值的表达被显示在显示器364上供使用者观察。然后这个数据通过双向通信信号325被传送到遥控表链350上，在下面将更详细描述。如上所述，表链350还可能具有一个传感器机械，以便测量来自抽样液体458，一般是血液的分析物浓度，抽样液体加到试验片条，插入460到表链350供传感器机械试验。表链350的遥控传感器可被用于校准监视器300的本地传感器。
图10进一步解释监视器300的内部组成部分。如上所述，控制器306具有一个微处理器，用于控制液体抽样测量操作，和装置300的各部分之间的通信，也用于按双向通讯协议325，控制监视器300和表链350之间的通讯。控制器306还可能具有一个存储单元，用于存储传感器操作软件程序和其它静态数据，例如预编程序缺省值，它包括但不限于传感器标定信息，报警，和单位识别/序号。
测量装置300还可能包括声音，视觉和/或振动报警/提醒装置308，用于使用户警觉报警状况，例如，血液葡萄糖水平落在充许值的外面，电池功率降低，液体抽样或传感器失灵，或者用于提醒用户一个事件或执行一个必要的行动，例如替换采样装置。适用的报警/提醒装置308可能包括声音装置，例如一个压电呼叫器；运动装置，例如是一个振动马达；和/或视觉装置，例如一个LED，等等。
测量装置300还包括一个显示器364，例如是液晶显示器(LCD)，用于数据的图象和字母数字显示，例如是抽样液体试验结果，如血液葡萄糖水平，和标定结果。存储器312用于暂时存储动态数据，例如通过传感器装置304获得的血液化学特性数据和用户记入的数据。血液化学特性数据包括各种血液葡萄糖浓度(mg/dL)测量和它们各自的日期和时间。其它可存储在存储器312中的数据的类型包括但不限于下列类型，药物，药物的数量，目标葡萄糖范围(上限和下限)，锻炼强度，锻炼持续时间，健康评语，食物类型，食物数量，HbAlc，血压，等等。此外，电源314和电池316提供必要的电功率以操作测量装置300的各个组成部分。
测量装置300还包括控制键366，使用户记入或选择显示器364显示的菜单的数据或参数，例如，接通和关断设备的信息，暂时中止操作的信息，关断RF发送(在受限制的区域内)，报警确认和复位，与其它设备同步通讯的信息。和泵4和表链6的控制键一样，控制键366可以具有任何数目的控制键，每个键具有任意的合适的形状，例如凸轮下压按钮，键垫等等，用于控制测量装置300。
指令和数据分别通过单向和双向线路或总线320和322，被往、返传送到控制器306。特别是，控制器306接收电源314和电池316的电功率，通过控制键318接收用户的输入数据和指令，在单向线路320上传送指令到报警/提醒装置308；另一方面，在控制器306和测量设备300的各组成部分之间的往返通讯是通过双向线路322完成的。在测量装置300和表链350和其它外部设备之间的信息通讯，在下文中更详细地描述。
如图10所示，本发明的系统可以包括注液泵4和连续生理液监视装置300，其中泵4和设备300之间的双向通讯也被提供。虽然注液泵4和测量装置300是作为分开的部分进行描述，药物输送和生理液抽象和测量元件和功能可以被结合成一个整一的装置，从而共同具有电源，控制器，报警器，显示器，存储器，通讯部分。这样一个整一的单元的优点是，病人只需携带或佩带一件硬件而不是两件。
通信和数据传输
双向通信(图2中参考标号15，图9和10中参考标号325，图10中参考标号340所标示的)和在泵4和表链6之间，在测量装置300和表链350之间的数据传送，可以通过任何合适的装置，例如无线电频率(RF)传输，红外线(IR)传输，等实现。例如，泵4和表链6每一个可以具有一个RF通信模块68和92，它们分别由各自的控制器控制，使得在所提供的两个设备和这些设备之间的双向通信是在其相互最大的范围之内。一般，这个范围是在0到10ft的范围内，更一般的是在0到4ft的范围内，通常不大于25feet。类似地，测量装置300可能具有RF通信模块324，它由控制器306控制，控制器306提供了在测量装置300和表链350之间的双向通信。此外，泵4和测量装置300可以以同样的双向方式或通过一个表链，彼此直接通信。在注液泵和测量装置整体化为一个单一单元的系统中，通信是由共同的控制器或微处理器管理。
模块68、92和324被编程序以便把特定的泵单元和/或测量装置“链接”到一个特定的表链单元，防止在相同频率范围内，在表链和其它注液泵和测量装置之间出现无故通信。在泵—表链或测量装置—表链，或泵/测量装置—表链组合之间建立通讯协议，以便提供与先于两个之间的每个数据传输的一对有关的地址，以防止在一个用户系统和另一个用户系统之间出现无故传输。模块可能进一步链接一个表链到多于一个的泵和/或属于相同用户的测量装置，因为某些用户具有多于一个的泵。同样，模块可以被编程序去链接一个泵和/或测量装置到属于同一用户的多于一个的表链上。
虽然在泵4和表链6之间传输的大多数数据和信息是由用户开始的，但在两个设备之间也存在某些通讯，它们是自动的，不需要用户干予的。例如，模块可以这样形成，使血液化学特性数据和用户偏爱信息，例如语言，食团限制等等，周期性地从表链发送到泵，或从泵发送到表链，或在接通表链的情况下自动发送。同时，模块也可以这样形成，使药物输注信息，例如，历史基本定量和食团输送数据，周期性地从泵发送到表链。
类似地，关于病人的血液葡萄糖水平的信息，如测量装置300所监视的那样，可以自动地连续地或周期性地被传送给表链350。特别在警报装置没有被提供的测量装置300的那些实施例中，表链可以具有警报器，使病人警觉，病人的血液葡萄糖水平落入充许范围之外，这个充许范围可以是用户或医生规定的。系统可以被编程序以便自动调节，处理胰岛素输送规约或通过进入表链350的输入信息提示病人放弃规约。
系统还可以这样形成，使得泵4和测量装置300能够彼此通信。在泵4和测量装置300是分开的组成部分的地方，它们可以通过类似于泵和表链互相通讯的方式的，双向通讯340的装置进行通讯。在整一设备中，药物输送泵和液体抽样和测量装置的功能是由一个公共控制器(未示出)控制的。在任一情况下，系统可以被编程，使得泵4执行的药物协议，根据测量装置300确定的分析物测量水平，通过表链6的往返指令，自动进行调整。这个工作可以被完成而无需病人的任何干予，甚至没有通知病人或病人没有意识到规约的调整。
泵4，表链6或350，和测量装置300分别可选择地包括通信模块和/或输入/输出端口70，90和326，(例如一个RS232(IEEE标准)或通用串行总线(USB))，以便和外部设备，例如个人计算机(PC)，个人数字助理(PDA)等进行通信。在本发明的实施例中，通信模块可以采用无线通讯方法，例如Bluetooth或一个Wi-Fi 802.11方案。例如，存储在泵，表链，或测量装置控制器和存储器装置的任一个或每个中的数据可以被下载到一个外部计算机，供医生详细检查，分析或进一步处理，以便确定，例如，药物方法的有效性，病人的配合或病人葡萄糖水平的趋向。相反，医生可以使用外部计算机下载软件程序和操作参数，例如，病人的基本量和某些定制的目标值，范围，提示和警报，到泵和/或表链控制器。本发明的装置和外部装置之间的通信可以通过遥测器传送提供，例如是，RF，IR，等，或数据端口技术，例如，调制解调器，电缆，等等。
在本发明的实施例中，表链6还结合了存储器84的一部分，使得进一步更新(“程序升顷”)操作系统和/或其它软件单元。最好是，存储器84的一部分，是“闪存”(“flash memory“)型的，它不需要电能，以便可靠地存储它的内容。
表链6还可能包括一个通信狭孔(未示出)，以便接收数据运载单元和与其通信。这个数据运载单元最好是一个“SIM”卡型装置。一个单一应用的数据运载单元是由或在每个易置卡盘上提供的，它包括许多特殊数据的生产(标定数据，识别数字等等)。数据运载单元由遥控器读出，由此接收的数据被用于整理分析从表链6收到的ISF葡萄糖数据。
软件算法
主题系统的每一个组成部分具有软件，它使得各组成部分执行不同的功能和使它们彼此通信。本发明使用的软件的某些特点和算法在下面详细描述。
主题系统优于许多传统的胰岛素输送系统的优点在于，它把血液化学特性仪和胰岛素泵的遥控零部件结合在一个很小的，独立的设备，例如上述的表链之中。除了遥控胰岛素泵和测量装置而外，表链还使在一段时期的血液化学特性数据和胰岛素输送数据结合起来，并保持这个结合数据供用户或医生立即和以后取回。这样，所有关键信息和影响病人治疗的事件的综合分析就可以做出。
这个优点是由主题系统的某些特点提供的，它使得用户在监视和控制血液葡萄糖水平中具有广泛的灵活性。特别是，主题系统使用户有能力在任何时间上改变食团和基本定量输送缺省参数。软件算法提供了更多的这种灵活性，以便控制和调整药物食团。
泵4的控制器54和表链6的控制器82用软件编程序，支持几种食团输送规约的类型：标准型，展开型和双重型。标准或“快速”食团输送规约使用户选择药物剂量以便整个食团立即输注。用户可能要求的刚刚进餐或快餐以前的快速食团输送，它包括简单的碳水化合物，例如水果等等。展开食团输送规约使用户在某个时间范围内的一段选择时间上，选择输注的药物剂量。展开食团输送规约一般在进餐以前实行，它包括复杂碳水化合物的相当大的部分，例如淀粉，等等。双重食团输送规约联合上述两种规约，使用户按单一指令程序连续地实行快速食团和展开食团。双食团输送协议一般先于进食实行，食物包括简单的和复杂的碳水化合物两者。
为了更好地处理用户立即的和发展中的需要，本发明通过计入或补偿用户当前的或实际当前的血液化学特性评估和/或用户的预期的和/或实际的碳水化合物摄入量而使用户定制一个胰岛素食团输送规约。特别是本发明提供了三种计算器功能选择，即碳水化合物计算器功能，血液葡萄糖计算器功能和联合计算器功能，它使用户选择血液化学特性和碳水化合物摄取的任何一个或两个，以及更多的次要因素，例如，先于实行食团输送规约，用户所进行的锻炼。虽然所有三种食团输送算法可提供所有三种计算器功能选择，但是，一般对于展开食团输送(或独立或与快速食团输送结合)计入血液化学特性数据是不合适的，因为血液化学特性在较短的时间期间以后可能变化，即先于展开食团输送的完成。
图3A，3B和3C分别是本发明三种食团输送算法的方块图，图4A，4B和4C分别是本发明的计算器功能选择的方块图。在本发明的进一步的描述中，三种输送算法的每一种首先在没有计算器功能选择的情况下被描述，当其应用于标准和展开输送算法的时候，三种计算器功能的描述跟在其后。虽然这些算法可以通过用户与泵或表链的任何一个接口来实现，下面的描述是用户与表链接口的情况，即最可能的情况。
                    A、食团输送算法
                    1、标准食团输送算法
如图3A的方块图所示，在从表链显示的食团功能菜单(见图5的246步)选择标准胰岛素食团输送程序100的时候，用户被请求调整他或她希望配给的标准食团剂量(SDOS)102。为了防止过剂量，如果进入的单位少于最大数量(SMAXU)104，算法将只实行食团输送，SMAXU将取决于个别用户身体的体重和新陈代谢而变化。对于具有平均体重和新陈代谢的用户，SMAXU约是10个单位。不过，SMAXU对于儿童可能低，对于肥胖者可能高。SMAXU在主题系统的开始程序中可作为缺省值被调整，或在特定标准食团的程序中由用户改变。步骤102和104总括成为126，用于描述图3C的步骤，如下所述。一旦食团的剂量被调整到合适的限度以内，用户就被提示开始定制的食团输送106。在开始这个SDOS输送的时候，全部SDOS被立即输送给用户，步骤108。
                   2、展开食团输送算法
如图3B的方块图所示，在从表链显示的食团功能菜单(见图5步骤246)选择展开食团输送程序110时，用户被请求调整，他或她希望输送的展开胰岛素食团剂量(EDOS)(单位)，步骤112。为了防止过剂量，如果进入的EDOS值小于最大最(EMAXU)114，算法将仅执行食团输送，如上所述，它取决于个别用户的体重和新陈代谢而变化。然后，用户被提示记入所希望的展开食团输送(DTIM)116的持续时间，它的时间期范围是从最小时间(MINT)到最大时间(MAXT)。这样的DTIME的范围是从1分钟到24小时，但是更一般的范围是从30分钟到8小时。如果进来的DTIME的值是在充许范围118的外面，用户就被提醒再记入一个充许值。步骤110，112，114，116和118合并成为128，目的是描述图3C的步骤，如下所述。一旦两个参数被调整在充许的限度内，用户就被提醒开始所定制的展开食团输送120。在开始这个EDOS输送的情况下，在DTIME 122上，EDOS被输送给用户。
                   3、双重食团输送算法
如图3C的方块图所示，在从表链显示的食团功能菜单(见图5的步骤246)中选择双重食团输送程序的时候，和在图3A中标准食团输送算法126中一样，用户被请求调整他或她所希望输送的标准食团剂量(SDOS)(单位)，它具有小于最大量(SMAXU)的值，如上所述。然后，和图3B的128所示的展开食团输送算法中一样，用户被请求再次调整，他或她所希望输送的展开胰岛素食团剂量(EDOS)(单位)，它具有小于最大值(EMAXU)的值。此外，用户被提示记入在充许时间范围内的所希望的展开食团输送(DTIME)128的持续时间，如关于图3B所述。一旦这两个参数被调整到充许范围之内，用户被提示开始SDOS和EDOS130两者的输送。在开始这样的SDOS和EDOS输送的时候，完整的SDOS立即被输送132到用户，在SDOS输送134完成的时候，EDOS输送开始136，并在DTIME138上被连续输送给用户。
                    B、计数器方式
                1、碳水化合物计数器方式
参考图4A，在选择碳水化合物计算器方式(CARB、CALC)140的时候，用户首先被提示记入他或他打算马上消耗的碳水化合物(CARB)的预期或实际的克数。一般表链被编程序以接收不大于约200g的一个预选最大碳水化合物值(MAXG)，即一个具有平均体重和新陈代谢的成年人用户的一般MAXG值，但是可以按用户的体重和新陈代谢的不同而变化。如果记入的CARB值大于MAXG144，用户被提示再记入一个可接受的CARB值。
根据在这点上用户可以改变的，预编程序食团剂量与碳水化合物的比(B/CRATIO)(单位/克)(Units/g)，表链控制器82确定要输送的胰岛素的剂量(XDOS)(单位)146，其中XDOS可能是SDOS或EDOS。B/CRATIO一般是在1单位：30g到1单位：50g的范围之中，但是取决于用户的条件和需要它可以更多或更少。XDOS的值是CARB的值和B/C RAT10的值的乘积(CARB×B/CRATIO)。
在B/C RAT10被设定以后，用户被提示记入碳水化合物校正因素(CARBCF)(单位)148，以便调整XDOS，即减少或增加XDOS，以便精细地调整食团量，例如，当进餐以后不久用户预期锻炼的时候。CARB CF值必须在最小值MIN CF)到最大值(MAX CF)的范围内。对于一般用户，CARB CF值一般在0单位到10个单位的范围内，但是根据用户的需要可以多些或少些。如果所记入的CARB CF值是在允许范围150之外，用户被提示再输入一个充许的CARB CF值。
一旦所有参数被设定在合适的限度内，表链就提示用户启动XDOS输送，并且，反过来，用户起动表链传送一个XDOS输送指令152到泵。泵然后起动XDOS输送到用户154。
                 2、血液葡萄糖计算器方式
参考图4B，在选择血液葡萄糖计算器方式(BG CALC)160的时候，表链提示用户记入他的或她的由表链的仪器80测得的最近的血液葡萄糖浓度水平(ACTUAL BG)(mg/dL)162，或者如果它产生在规定期限以内，最近的血液葡萄糖试验的血液葡萄糖浓度水平可以被自动记入。可选择的是，ACTUALBG可以用生理液测量装置300测量并直接传送到表链6，如果仪器80被单独使用的话，它使得BGCALC在高频率上被利用。ACTUAL BG值必须是从最小值(MIN ABG)到最大值(MAX ABG)的范围之中。对于一般用户，ACTUAL BG的值一般是在0mg/dL到600mg/dL的范围之间，但是可依据用户的需要更多或更少。如果记入值是在这个范围164以外，用户被提示再记入一个可接受的ACTUAL BG值。
然后表链控制器82确定要被输送的胰岛素(SDOS)(单位)(Units)的标准食团剂量166，它的值是食团与血液葡萄糖的比(B/GB RATIO)(Units/point，这里一个点(point)等于1mg/dL)和ACTUALBG的值与用户的目标血液葡萄糖水平(TARGET BG)(mg/dL)之间的差的乘积，用下列等式表示：B/BG RATIO X(ACTUAL BG-TARGET BG)。B/BG RATIO是预编程序值，它的值，在这点上，可以在预定范围内被用户从最小值改变。对于一般用户，B/BG RAT10的变化范围是从1单位：150Pt到1单位：10pt，但是可依据用户的需要或更多或更少。TARGET BG也是一个预编程序值，它的值也可以由用户在预定范围内改变。对于一般用户，TARGET BG可以是60到250mg/dL，但是可以依据用户需要更多或更少。
其次，表链提示用户记入血液葡萄糖校正因素(BG CF)(单位)174以便调节SDOS，即，减少或增加SDOS以便精确调整食团量，例如，当在餐后不久用户期望锻炼的时候。BGCF的值必须在最小值(MIN BGCF)到最大值(MAXBGCF)的范围以内。对于一般用户，GB CF一般是从O单位到10单位，但是可以取决于用户的需要更多或更少。如果记入的BG CF的值是在充许范围176的外边，用户被提示再记入一个可接受的BG CF值。
一旦所有的参数已被设定在合适的限度内，表链提示用户开始SDOS输送，然后，用户起动表链，发送一个SDOS输送指令到泵178。泵然后起动SDOS输送到用户180。
                     3、联合计数器方式
现在参考图4C，在选择联合碳水化合物/血液葡萄糖计数器方式(CBGCALC)190的时候，要求用户记入他或她预期吃进的碳水化合物的量，在图4A的集合步骤192上，表链根据这个CARB值和预编程序的B/C RATIO确定XDOS。然后，在图4B的集合步骤194上，用户记入他或她的ACTUAL BG，并根据ACTUAL BG和用户的B/BG RATIO和TARGET BG的预编程序值表链确定要被输送的SDOS值。在本发明的另一实施例中，用户的ACTUAL BG被自动发送到表链，然后表链根据ACTUAL BG，根据用户的B/BG RATIO和TARGET BG，确定要被输送的SDOS。
然后，如果必要的话，表链提示用户选择一个校正因数(COMBO CF)(U单位)196去调整XDOS，即，减少或增加XDOS，以便精确调节食团量，例如，当在进餐以后不久用户期望锻炼的时候。COMBO CF值必须在从最小值(MIN COMBO CF)到最大值(MAX COMBO CF)198的范围内。对于一般用户，COMBO CF一般从0单位到10单位，但是可以依据用户的需要更多或更少。如果所记入的COMBO CF值是在可接受的范围的外面，用户被提示再记入一个可接受的COMBO CF值。
一旦所有参数已被调整在合适的限度内，表链提示用户开始XDOS输送，依次，用户起动表链发送一个XDOS输送指令到泵200。泵然后开始XDOS输送到用户202。
方法
综上所述，本发明提供了遥控病人药物输注的方法。本发明的某些方法现在参考图5进行描述。在一般由用户的医生执行的，主题系统的泵和表链的开始程序以后，表链将保持在睡眠方式220直到用户起动222。在这个开始阶段，表链，通过信息链路，要求泵给表链提供泵的状态信息，例如，正在进行中的食团的状态，进行中的基本量，保留的胰岛素，等等，算法结构信息，例如，缺省值，它包括但不限于，B/C RATIO，B/BG RATIO，TRAGET BG，食团限度，食团步骤，程序结构，即，所选择的展开或双重食团功能，所选择的碳水化合物或血液葡萄糖计算器方式。在接收这个请求的阶段，泵发送请求状态和结构信息到表链224，它然后被表链接收226。
如果这个信息表示食团输送是在进行之中228，表链将显示“食团在进行中”菜单230，并询问用户他或她是否想要停止食团输送232。如果用户表示他或她希望停止食团输送，表链发送一个STOP BOLUS指令到泵234。在收到这个指令以后，泵停止食团输送并发送修改的泵状态信息到表链236。表链显示这个状态信息给用户238，在短时间以后，返回睡眠状态240。
另一方面，如果用户不想停止进行中的食团242，或者目前没有食团在进行之中244，表链显示泵状态信息和“食团功能”菜单246。然后用户选择所希望的食团程序，例如，标准食团程序，展开食团程序或双重食团程序，表链发送食团输送程序起始指令到泵248。根据这个指令，泵使食团输送计时复位，并发送一个肯定符号到表链250。表链然后询问用户关于具体食团程序数据252，有或没有使用计算器功能，例如，碳水化合物计算器方式，血液葡萄糖计算器方式或联合方式，这一切包括记入或选择所选择的算法所要求的所有必要信息，如图3A-3C和4A-4C中所示。
在完成食团输送规约的程序以后，用户起动表链发送食团值和DELIVER食团指令给泵254。如果食团输送在食团输送计时期满以前开始256，则泵起动食团输送，取消计时器并发送一个肯定符号到表链258。在一段短时间以后，表链返回睡眠状态260。
另一方面，如果计时器在食团输送开始以前期满262，泵起动报警264，或者声音，振动和/或视觉的警报，如上所述，显示给用户，泵有故障。泵同时起动报警，以便使用户注意到预编程序提醒器，例如，进行血液葡萄糖测量的提醒器，等等。在报警提醒以后，用户开始启动睡眠的(如果是睡眠的)表链，然后表链请求泵提供给表链警戒/报警/提醒状态266。泵，依次，发送这些信息给表链268。表链然后显示当前正在进行中的警戒/报警/提醒，根据它们用户起动表链发送CANCEL ALARM指令到泵270，并处理报警的原因，例如清除泵输注管的阻塞，或执行必要的任务，进行血液葡萄糖测量。随后，泵取消了报警和食团输送计时272。在一段短时间以后，表链返回到睡眠状态274。
成套部件
主题发明还提供了一些成套部件，它们用于实践主题方法。主题发明的一个实施例的一些成套部件包括至少一个主题注液泵和至少一个主题表链，如上所述。成套部件可以包括一个或多个泵输注装置和/或一个或多个适于和表链仪器一起使用的试验片条。在主题发明的另一个实施例中，成套部件包括至少一个测量装置和至少一个表链。另一些成套部件包括至少一个注液泵，至少一个测量装置和至少一个表链。成套部件还可能包括记录在CD-ROM等上的软件程序，它的程序可以通过外部设备，例如是一台计算机，由用户或医生下载到泵和/或表链。最后，成套装置还进一步包括使用主题设备的说明。这些说明可以提供在成套部件中的一个或多个包装件，标签插入件或容器上，或提供在CD-ROM等中。
由上述描述和讨论可以明白，上述发明提供了一个对病人执行药物规约的简单，方便和单独的方法。本发明最小化了病人他或她必须携带的装置的数量，以便有效地分配药物和监视它在病人身上的效果。本发明对病人他或她的药物配给具有最大实时控制的灵活性。因此，本发明对本技术领域起了重大促进作用。
本说明书中引用的所有公报和专利这里被引入作为参考，正如个别的公报或专利被专门地，单独地引用一样。任何公报的引入是在申请日期以前的公开，不应理解为承认本发明因在先发明而不享有比上述在前公开之前要早的权利。
虽然为了清楚理解的目的，上述发明用图解和举例的方法作了详细描述，本发明的内容对那些熟悉技术的普通技术人员是显而易见的，某些变化和修改可以做出而不脱离所附权利要求书的精神和范围。

Claims (11)

1、一种系统，包括：
一个可以佩带在病人身体上的药物注液泵；
一个可以佩带在病人身体上的生理液监视装置，它实际地，连续地监视生理液的至少一个特征；
一个遥控装置，用于遥控药物注液泵和生理液监视装置，其中遥控装置包括一个生理液监视装置，用于短暂监视至少一个生理液的特征。
2、权利要求1的系统，包括在遥控装置，药物注液泵和生理液监视装置之间进行通信的装置。
3、权利要求1的系统，其特征在于，所述遥控装置包括：一个通信模块，用于与药物注液泵进行通信和用于与生理液监视装置进行通信；
一个或多个控制键，用于用户与遥控装置进行接口；和
一个控制器，用于控制往返通信模块的数据的传送和接收，并用于处理用户接口数据。
4、权利要求1的系统，其特征在于，所述遥控装置还包括一个端口，用于可操作地接收生理液试验片条。
5、权利要求1的系统，其特征在于，所述药物注液泵还包括：
一个通信模块，用于与遥控装置进行通信；
一个或多个控制键，用于用户与药物注液泵接口；和
一个控制器，用于控制往返遥控装置的数据的传送和接收，并用于处理用户接口数据。
6、权利要求1的系统，其特征在于，所述生理液监视装置包括：
一个生理液采样装置；
一个传感器，用于测量生理液中一个或多个分析物的浓度，其中所述传感器可操作地与上述生理液采样装置液体连通。
7、权利要求6的系统，其特征在于，所述生理液监视装置还包括：
一个通信模块，用于与遥控装置进行通信；
一个或多个控制键，用于用户与药物注液泵接口；和
一个控制器，用于控制往返遥控装置的数据的传送和接收，并用于处理用户接口数据。
8、一种分配药物的系统，包括：
一个可以佩带在病人身体上的药物注液泵；
一个遥控装置用于遥控药物注液泵；和
一个处理器，与上述遥控装置结合在一起；
与上述处理器一起使用的软件通过上述药物注液泵实现药物输送规约，所述药物输送规约包括，第一药物输送规约，用于立即输注所选择的药物剂量，第二药物输送规约，用于输注在所选择的时间段上所选择的药物剂量，和第三药物输送规约，用于在所选择的时间期间内立即输注第一选择药物剂量，随后输注第二选择药物剂量。
9、权利要求8的系统，其特征在于，所述软件包括算法，用于计算病人当前或实际当前的血液葡萄糖水平或病人预期的或实际的碳水化合物摄取，并用于根据所述血液葡萄糖水平或所述碳水化合物摄取量修改所述药物输送规约。
10、一种监视和控制病人的生理液分析物的浓度的方法，包括：
短暂测量病人的生理液抽样的分析物的浓度，其中短暂测量是用遥控装置进行的。
使用经皮装置对病人的生理液进行实际的连续地抽样。
实际地连续地测量抽样生理液中的分析物的浓度；
传送代表分析物浓度的数据到遥控装置；
确定是否分析物浓度落在充许范围的外面；和
根据分析物浓度落在充许范围的外面的确定调整药物输送规程。
11、一种监视和控制病人葡萄糖水平的方法，包括：
短暂测量病人的生理液抽样的葡萄糖浓度；
提供表示病人碳水化合物摄取量的值；
根据所述葡萄糖浓度和所述碳水化合物摄取值计算配给病人的胰岛素的剂量；
发送代表所述剂量的无线电频率信号到病人佩带的胰岛素注液泵，所述注液泵包括一个无线电频率接收机，用于接收所述无线电频率信号；和
通过所述注液泵，分配所述剂量的胰岛素给病人。
CN03110722A 2002-02-26 2003-02-25 遥控药物输注和分析物监视的系统和方法 Pending CN1449840A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36040102P 2002-02-26 2002-02-26
US60/360401 2002-02-26

Publications (1)

Publication Number Publication Date
CN1449840A true CN1449840A (zh) 2003-10-22

Family

ID=23417816

Family Applications (1)

Application Number Title Priority Date Filing Date
CN03110722A Pending CN1449840A (zh) 2002-02-26 2003-02-25 遥控药物输注和分析物监视的系统和方法

Country Status (15)

Country Link
US (1) US20030212379A1 (zh)
EP (1) EP1338295A1 (zh)
JP (1) JP2003290345A (zh)
KR (1) KR20030070857A (zh)
CN (1) CN1449840A (zh)
AU (2) AU2003200685A1 (zh)
CA (1) CA2420136A1 (zh)
IL (1) IL154635A (zh)
MX (1) MXPA03001781A (zh)
NO (1) NO20030850L (zh)
PL (1) PL358897A1 (zh)
RU (1) RU2003105304A (zh)
SG (1) SG155760A1 (zh)
TW (1) TW200307571A (zh)
WO (1) WO2003071930A2 (zh)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101743550A (zh) * 2007-06-27 2010-06-16 霍夫曼-拉罗奇有限公司 具有开放结构的治疗传递系统及其方法
CN101789229A (zh) * 2009-01-23 2010-07-28 李秀 健康信息显示控制的装置、方法及对应设备和试剂载体
CN102048546A (zh) * 2010-12-30 2011-05-11 中国人民解放军第三军医大学第一附属医院 人体血液生物信息实时监测、采集及检测系统
CN101128229B (zh) * 2005-02-28 2011-05-25 诺和诺德公司 用于改变输药速率的装置
CN102138800A (zh) * 2010-12-30 2011-08-03 中国人民解放军第三军医大学第一附属医院 人体血液活塞式便携检测系统
CN102648992A (zh) * 2011-02-24 2012-08-29 上海微创生命科技有限公司 一种胰岛素输注控制方法及应用该方法的输注控制装置
CN103495232A (zh) * 2013-10-16 2014-01-08 李秀 智能药物释放装置
CN105339023A (zh) * 2013-03-15 2016-02-17 普迈针药物公司 用于经皮递送化合物的设备、系统和方法
CN110461391A (zh) * 2017-03-23 2019-11-15 泰尔茂株式会社 便携医疗设备以及便携医疗设备的控制方法
CN111317889A (zh) * 2020-02-14 2020-06-23 微泰医疗器械(杭州)有限公司 一种胰岛素泵输注控制方法
CN114786744A (zh) * 2019-09-25 2022-07-22 杨森制药公司 与外部系统和/或其它装置通信的药物施用装置
CN114828918A (zh) * 2019-10-04 2022-07-29 阿诺·查斯 基于生活方式事件检测的控制器
US12059553B2 (en) 2019-10-04 2024-08-13 Arnold Chase Intelligent drug delivery system

Families Citing this family (666)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
EP1119285A1 (en) 1998-10-08 2001-08-01 Minimed Inc. Telemetered characteristic monitor system
US7621893B2 (en) 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US7766873B2 (en) 1998-10-29 2010-08-03 Medtronic Minimed, Inc. Method and apparatus for detecting occlusions in an ambulatory infusion pump
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
CN100394889C (zh) * 2000-11-30 2008-06-18 爱科来株式会社 具有注释输入功能的测定装置
EP1347705B1 (en) * 2000-12-21 2005-12-07 Insulet Corporation Medical apparatus remote control
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
JP4498636B2 (ja) 2001-04-27 2010-07-07 日本サーモスタット株式会社 サーモスタット装置
MX348295B (es) 2001-05-18 2017-06-05 Deka Products Lp * Equipo de infusión para una bomba de fluido.
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
EP1395185B1 (en) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Electric lancet actuator
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US10173008B2 (en) 2002-01-29 2019-01-08 Baxter International Inc. System and method for communicating with a dialysis machine through a network
US8504179B2 (en) 2002-02-28 2013-08-06 Smiths Medical Asd, Inc. Programmable medical infusion pump
US8250483B2 (en) * 2002-02-28 2012-08-21 Smiths Medical Asd, Inc. Programmable medical infusion pump displaying a banner
US6852104B2 (en) * 2002-02-28 2005-02-08 Smiths Medical Md, Inc. Programmable insulin pump
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
NL1021054C1 (nl) * 2002-07-12 2004-01-13 Best Medical Internat Beheer B Universele meetinrichting voor medische toepassing.
US20040068230A1 (en) * 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US8512276B2 (en) * 2002-07-24 2013-08-20 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
EP2383470A1 (en) 2002-10-09 2011-11-02 Abbott Diabetes Care Inc. Plunger pump actuated by a shape memory element
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US20040122353A1 (en) 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US8460243B2 (en) * 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
BRPI0414021B1 (pt) * 2003-08-28 2023-09-26 Becton, Dickinson And Company Dispositivo de injeção intradérmica
EP1673008B1 (en) * 2003-09-12 2012-03-14 Laborie Medical Technologies Inc. Apparatus for medical measurement
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9123077B2 (en) 2003-10-07 2015-09-01 Hospira, Inc. Medication management system
US8065161B2 (en) 2003-11-13 2011-11-22 Hospira, Inc. System for maintaining drug information and communicating with medication delivery devices
US9351680B2 (en) * 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
US7787923B2 (en) 2003-11-26 2010-08-31 Becton, Dickinson And Company Fiber optic device for sensing analytes and method of making same
JP4845739B2 (ja) * 2003-12-12 2011-12-28 フィロメトロン，インコーポレイティド 多重セクション式非経口薬物送達装置
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
CA2554007C (en) * 2004-01-27 2013-03-26 Altivera L.L.C. Diagnostic radio frequency identification sensors and applications thereof
US8954336B2 (en) 2004-02-23 2015-02-10 Smiths Medical Asd, Inc. Server for medical device
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
CA3090413C (en) * 2004-06-04 2023-10-10 Abbott Diabetes Care Inc. Glucose monitoring and graphical representations in a data management system
US20060001538A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Methods of monitoring the concentration of an analyte
US8343074B2 (en) * 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
WO2006009199A1 (ja) * 2004-07-21 2006-01-26 Matsushita Electric Industrial Co., Ltd. 血糖値管理システム
CN1297229C (zh) * 2004-07-27 2007-01-31 天津大学 脉搏阻抗谱血糖或其他血液成分的无创检测装置及其检测方法
US7344500B2 (en) 2004-07-27 2008-03-18 Medtronic Minimed, Inc. Sensing system with auxiliary display
US7837651B2 (en) * 2004-08-31 2010-11-23 Ethicon Endo-Surgery, Inc. Infusion pump
CA2580343A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics, Inc. Imidazoquinoline compounds
WO2006032653A2 (en) * 2004-09-23 2006-03-30 Novo Nordisk A/S Device for self-care support
US20080114299A1 (en) * 2004-09-23 2008-05-15 Camilla Damgaard-Sorensen Remote Commander To Be Used With A Drug Delivery Device
US7303543B1 (en) 2004-12-03 2007-12-04 Medtronic Minimed, Inc. Medication infusion set
US20060211981A1 (en) * 2004-12-27 2006-09-21 Integrated Sensing Systems, Inc. Medical treatment procedure and system in which bidirectional fluid flow is sensed
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US8613703B2 (en) 2007-05-31 2013-12-24 Abbott Diabetes Care Inc. Insertion devices and methods
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US7966051B2 (en) 2005-01-11 2011-06-21 Olympus Corporation Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method
JP4845507B2 (ja) * 2005-10-04 2011-12-28 オリンパス株式会社 蛍光観察システム
US7972279B2 (en) * 2005-01-27 2011-07-05 Instrumentation Laboratory Company Method and system for managing patient data
EP1688085A1 (en) * 2005-02-02 2006-08-09 Disetronic Licensing AG Ambulatory medical device and method of communication between medical devices
US7704229B2 (en) 2005-02-03 2010-04-27 Medtronic Minimed, Inc. Insertion device
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
WO2006102412A2 (en) 2005-03-21 2006-09-28 Abbott Diabetes Care, Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US20060224055A1 (en) * 2005-03-30 2006-10-05 Kermani Mahyar Z Fluorescence measurement analytical kit
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
JP2008544214A (ja) 2005-05-09 2008-12-04 セラノス， インコーポレイテッド ポイントオブケア流体システムおよびその使用
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US20080071580A1 (en) * 2005-06-03 2008-03-20 Marcus Alan O System and method for medical evaluation and monitoring
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US20060276771A1 (en) * 2005-06-06 2006-12-07 Galley Paul J System and method providing for user intervention in a diabetes control arrangement
US8251904B2 (en) 2005-06-09 2012-08-28 Roche Diagnostics Operations, Inc. Device and method for insulin dosing
JP2008546495A (ja) * 2005-06-27 2008-12-25 ノボ・ノルデイスク・エー／エス プロファイルの図式的プログラミング機能を有する送達システムのユーザインターフェース
US20090212966A1 (en) * 2005-06-27 2009-08-27 Novo Nordisk A/S User Interface for Delivery System Providing Dual Setting of Parameters
CN101238464A (zh) * 2005-06-27 2008-08-06 诺沃-诺迪斯克有限公司 提供快捷导航的输送系统用户接口
US20070016170A1 (en) * 2005-06-29 2007-01-18 Medtronic Minimed, Inc. Infusion device with bolus alarm deactivation and method of using the same
US7737581B2 (en) * 2005-08-16 2010-06-15 Medtronic Minimed, Inc. Method and apparatus for predicting end of battery life
US20090227855A1 (en) 2005-08-16 2009-09-10 Medtronic Minimed, Inc. Controller device for an infusion pump
US20070060870A1 (en) * 2005-08-16 2007-03-15 Tolle Mike Charles V Controller device for an infusion pump
WO2007027691A1 (en) 2005-08-31 2007-03-08 University Of Virginia Patent Foundation Improving the accuracy of continuous glucose sensors
US9089713B2 (en) 2005-08-31 2015-07-28 Michael Sasha John Methods and systems for semi-automatic adjustment of medical monitoring and treatment
US7713240B2 (en) * 2005-09-13 2010-05-11 Medtronic Minimed, Inc. Modular external infusion device
US20070062251A1 (en) * 2005-09-19 2007-03-22 Lifescan, Inc. Infusion Pump With Closed Loop Control and Algorithm
US20070066940A1 (en) * 2005-09-19 2007-03-22 Lifescan, Inc. Systems and Methods for Detecting a Partition Position in an Infusion Pump
WO2007035564A2 (en) * 2005-09-19 2007-03-29 Lifescan, Inc. Malfunction detection with derivative calculation
US7725148B2 (en) 2005-09-23 2010-05-25 Medtronic Minimed, Inc. Sensor with layered electrodes
US9072476B2 (en) 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
EP1955240B8 (en) * 2005-11-08 2016-03-30 Bigfoot Biomedical, Inc. Method for manual and autonomous control of an infusion pump
US7704226B2 (en) * 2005-11-17 2010-04-27 Medtronic Minimed, Inc. External infusion device with programmable capabilities to time-shift basal insulin and method of using the same
US20090118592A1 (en) * 2005-12-08 2009-05-07 Novo Nordisk A/S Medical System Comprising a Sensor Device
US7941200B2 (en) * 2005-12-08 2011-05-10 Roche Diagnostics Operations, Inc. System and method for determining drug administration information
EP1801718A1 (de) * 2005-12-21 2007-06-27 F. Hoffmann-La Roche AG Verfahren zum Betrieb einer computergesteuerten Dosiervorrichtung für flüssige Medikamente bei reisebedingter Zeitverschiebung
US8353881B2 (en) 2005-12-28 2013-01-15 Abbott Diabetes Care Inc. Infusion sets for the delivery of a therapeutic substance to a patient
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
EP1968432A4 (en) 2005-12-28 2009-10-21 Abbott Diabetes Care Inc INTRODUCTION OF A MEDICAL DEVICE
US8114269B2 (en) 2005-12-30 2012-02-14 Medtronic Minimed, Inc. System and method for determining the point of hydration and proper time to apply potential to a glucose sensor
US8114268B2 (en) 2005-12-30 2012-02-14 Medtronic Minimed, Inc. Method and system for remedying sensor malfunctions detected by electrochemical impedance spectroscopy
US7985330B2 (en) 2005-12-30 2011-07-26 Medtronic Minimed, Inc. Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy
US7774038B2 (en) 2005-12-30 2010-08-10 Medtronic Minimed, Inc. Real-time self-calibrating sensor system and method
US20070173712A1 (en) 2005-12-30 2007-07-26 Medtronic Minimed, Inc. Method of and system for stabilization of sensors
US20070169533A1 (en) 2005-12-30 2007-07-26 Medtronic Minimed, Inc. Methods and systems for detecting the hydration of sensors
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
US12070574B2 (en) 2006-02-09 2024-08-27 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
US11497846B2 (en) 2006-02-09 2022-11-15 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US11364335B2 (en) 2006-02-09 2022-06-21 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
CA2926975C (en) 2006-02-09 2019-10-29 Deka Products Limited Partnership Peripheral systems
US11478623B2 (en) 2006-02-09 2022-10-25 Deka Products Limited Partnership Infusion pump assembly
US11027058B2 (en) 2006-02-09 2021-06-08 Deka Products Limited Partnership Infusion pump assembly
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
CA2646891A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US20170188898A1 (en) * 2006-03-28 2017-07-06 Arkal, Inc. Devices and methods for enhanced skin perforation for continuous glucose monitoring
EP1839566A1 (de) * 2006-03-29 2007-10-03 F. Hoffmann-La Roche AG Verfahren und Anordnung zur Überwachung eines medizinischen Gerätes
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US9326709B2 (en) 2010-03-10 2016-05-03 Abbott Diabetes Care Inc. Systems, devices and methods for managing glucose levels
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US7630748B2 (en) 2006-10-25 2009-12-08 Abbott Diabetes Care Inc. Method and system for providing analyte monitoring
US9339217B2 (en) 2011-11-25 2016-05-17 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
WO2007116953A1 (en) * 2006-04-10 2007-10-18 Canon Kabushiki Kaisha Ingesta administration device
US8073008B2 (en) 2006-04-28 2011-12-06 Medtronic Minimed, Inc. Subnetwork synchronization and variable transmit synchronization techniques for a wireless medical device network
JP5025159B2 (ja) * 2006-04-28 2012-09-12 シスメックス株式会社 生体成分測定装置
US7942844B2 (en) 2006-04-28 2011-05-17 Medtronic Minimed, Inc. Remote monitoring for networked fluid infusion systems
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20080071157A1 (en) 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
ATE553695T1 (de) * 2006-06-13 2012-05-15 Carefusion 303 Inc System und verfahren zur optimierten steuerung von pca- und pcea-systemen
US9119582B2 (en) 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
WO2008000634A1 (en) * 2006-06-30 2008-01-03 Novo Nordisk A/S Perfusion device with compensation of medical infusion during wear-time
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
US8435206B2 (en) 2006-08-03 2013-05-07 Smiths Medical Asd, Inc. Interface for medical infusion pump
US8858526B2 (en) 2006-08-03 2014-10-14 Smiths Medical Asd, Inc. Interface for medical infusion pump
US8965707B2 (en) 2006-08-03 2015-02-24 Smiths Medical Asd, Inc. Interface for medical infusion pump
US8149131B2 (en) 2006-08-03 2012-04-03 Smiths Medical Asd, Inc. Interface for medical infusion pump
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
WO2008038274A1 (en) * 2006-09-29 2008-04-03 Medingo Ltd. Fluid delivery system with electrochemical sensing of analyte concentration levels
US7706896B2 (en) * 2006-09-29 2010-04-27 Nellcor Puritan Bennett Llc User interface and identification in a medical device system and method
US8506524B2 (en) * 2006-10-04 2013-08-13 Novo Nordisk A/S User interface for delivery system comprising diary function
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20080091466A1 (en) 2006-10-16 2008-04-17 Hospira, Inc. System and method for comparing and utilizing activity information and configuration information from multiple device management systems
US20080124692A1 (en) * 2006-10-26 2008-05-29 Mcevoy Mary Method for tutoring a user during use of a system for determining an analyte in a bodily fluid sample
US8135548B2 (en) 2006-10-26 2012-03-13 Abbott Diabetes Care Inc. Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors
US8579853B2 (en) * 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
FI20065735A0 (fi) * 2006-11-20 2006-11-20 Salla Koski Mittaus-, seuranta- ja hoitojärjestelmä sekä järjestelmään kuuluvia laitteita
CN101578607B (zh) 2006-12-04 2013-07-17 德卡产品有限公司 包括滑动器组件的医疗装置
US20080139910A1 (en) * 2006-12-06 2008-06-12 Metronic Minimed, Inc. Analyte sensor and method of using the same
WO2008071753A1 (en) * 2006-12-14 2008-06-19 Novo Nordisk A/S User interface for medical system comprising diary function with time change feature
US7654127B2 (en) * 2006-12-21 2010-02-02 Lifescan, Inc. Malfunction detection in infusion pumps
US20080214919A1 (en) * 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
MX2009007613A (es) * 2007-01-15 2009-09-22 Deka Products Lp Dispositivo y metodo para manejo de alimentos.
US7734323B2 (en) 2007-01-24 2010-06-08 Smiths Medical Asd, Inc. Correction factor testing using frequent blood glucose input
ATE442081T1 (de) * 2007-01-29 2009-09-15 Hoffmann La Roche Beurteilungsverfahren zum verarbeiten eines glukosekonzentrationssignals
US10154804B2 (en) 2007-01-31 2018-12-18 Medtronic Minimed, Inc. Model predictive method and system for controlling and supervising insulin infusion
EP2121077A1 (en) 2007-02-09 2009-11-25 Deka Products Limited Partnership Automated insertion assembly
US8121857B2 (en) 2007-02-15 2012-02-21 Abbott Diabetes Care Inc. Device and method for automatic data acquisition and/or detection
US20080199894A1 (en) 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8545483B2 (en) * 2007-03-12 2013-10-01 Honeywell International Inc. Physiological sensors with telemonitor and notification systems
US20080228056A1 (en) 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
US9204827B2 (en) 2007-04-14 2015-12-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US8140142B2 (en) 2007-04-14 2012-03-20 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2009096992A1 (en) 2007-04-14 2009-08-06 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
US9008743B2 (en) 2007-04-14 2015-04-14 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
ES2784736T3 (es) 2007-04-14 2020-09-30 Abbott Diabetes Care Inc Procedimiento y aparato para proporcionar el procesamiento y control de datos en un sistema de comunicación médica
CA2683721C (en) 2007-04-14 2017-05-23 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US20080269714A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US10002233B2 (en) 2007-05-14 2018-06-19 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8260558B2 (en) 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7751907B2 (en) 2007-05-24 2010-07-06 Smiths Medical Asd, Inc. Expert system for insulin pump therapy
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system
EP2152350A4 (en) 2007-06-08 2013-03-27 Dexcom Inc INTEGRATED MEDICINE DELIVERY DEVICE FOR USE WITH A CONTINUOUS ANALYZING SUBSTANCE SENSOR
EP2166928B1 (en) * 2007-06-21 2018-09-12 Abbott Diabetes Care Inc. Health monitor
JP5680960B2 (ja) 2007-06-21 2015-03-04 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 健康管理装置および方法
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8085151B2 (en) 2007-06-28 2011-12-27 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
EP2008577A1 (de) * 2007-06-28 2008-12-31 F.Hoffmann-La Roche Ag Anordnung mit Infusionspumpe und Messgerät
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
WO2009005958A2 (en) * 2007-06-29 2009-01-08 Roche Diagnostics Gmbh User interface features for an electronic device
US7768386B2 (en) 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
KR100945735B1 (ko) * 2007-08-13 2010-03-17 김태훈 인슐린 펌프 및 인슐린 펌프를 무선으로 제어하는 무선제어 장치
GB0716427D0 (en) * 2007-08-23 2007-10-03 Smartsensor Telemed Ltd Glucose tolerance test device
US20090069714A1 (en) * 2007-09-11 2009-03-12 Ashlar Holdings, Llc System and method for measuring data for medical applications
US10561845B2 (en) * 2007-09-24 2020-02-18 Medtronic, Inc. Therapy adjustment based on patient event indication
CA3138078C (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
EP4098177A1 (en) 2007-10-09 2022-12-07 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
WO2009046989A2 (en) 2007-10-11 2009-04-16 Roche Diagnostics Gmbh Carrier for an infusion system
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8216138B1 (en) 2007-10-23 2012-07-10 Abbott Diabetes Care Inc. Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration
EP2211974A4 (en) 2007-10-25 2013-02-27 Proteus Digital Health Inc INFORMATION SYSTEM FOR LIQUID FLOW CHANNEL
US8517990B2 (en) 2007-12-18 2013-08-27 Hospira, Inc. User interface improvements for medical devices
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
WO2009081403A2 (en) * 2007-12-26 2009-07-02 Medingo Ltd. Maintaining glycemic control during exercise
US8313467B2 (en) 2007-12-27 2012-11-20 Medtronic Minimed, Inc. Reservoir pressure equalization systems and methods
US8491570B2 (en) 2007-12-31 2013-07-23 Deka Products Limited Partnership Infusion pump assembly
AU2008347241B2 (en) 2007-12-31 2014-09-18 Deka Products Limited Partnership Infusion pump assembly
US8900188B2 (en) 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
US8881774B2 (en) 2007-12-31 2014-11-11 Deka Research & Development Corp. Apparatus, system and method for fluid delivery
US10080704B2 (en) 2007-12-31 2018-09-25 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US9456955B2 (en) 2007-12-31 2016-10-04 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US10188787B2 (en) 2007-12-31 2019-01-29 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US20090177147A1 (en) 2008-01-07 2009-07-09 Michael Blomquist Insulin pump with insulin therapy coaching
US20090177142A1 (en) * 2008-01-09 2009-07-09 Smiths Medical Md, Inc Insulin pump with add-on modules
USD612279S1 (en) 2008-01-18 2010-03-23 Lifescan Scotland Limited User interface in an analyte meter
EP2093685A1 (en) * 2008-02-21 2009-08-26 F.Hoffmann-La Roche Ag Drug administration device having a bolus administration profile controller
RU2508899C2 (ru) * 2008-02-27 2014-03-10 Мон4Д Лтд. Устройство, система и способ для модульного контроля анализируемого вещества
USD615431S1 (en) 2008-03-21 2010-05-11 Lifescan Scotland Limited Analyte test meter
IL197532A0 (en) * 2008-03-21 2009-12-24 Lifescan Scotland Ltd Analyte testing method and system
USD612275S1 (en) 2008-03-21 2010-03-23 Lifescan Scotland, Ltd. Analyte test meter
USD611853S1 (en) 2008-03-21 2010-03-16 Lifescan Scotland Limited Analyte test meter
US9656031B2 (en) 2008-04-01 2017-05-23 Deka Products Limited Partnership Infusion pump methods and systems
US8252229B2 (en) 2008-04-10 2012-08-28 Abbott Diabetes Care Inc. Method and system for sterilizing an analyte sensor
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US20090264720A1 (en) * 2008-04-17 2009-10-22 The Cooper Health System Wearable Automated Blood Sampling and Monitoring System
US8133197B2 (en) 2008-05-02 2012-03-13 Smiths Medical Asd, Inc. Display for pump
US9295786B2 (en) 2008-05-28 2016-03-29 Medtronic Minimed, Inc. Needle protective device for subcutaneous sensors
US7826382B2 (en) 2008-05-30 2010-11-02 Abbott Diabetes Care Inc. Close proximity communication device and methods
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
USD611151S1 (en) 2008-06-10 2010-03-02 Lifescan Scotland, Ltd. Test meter
US20090326509A1 (en) * 2008-06-30 2009-12-31 Muse Philip A Context aware medical monitoring and dosage delivery device
US8502662B2 (en) 2008-06-30 2013-08-06 Animas Corporation Method and system for using status indicators in wireless communication with medical devices
DK2141620T3 (en) * 2008-07-01 2019-02-18 Hoffmann La Roche Insulin pump and method for controlling one of the insulin pump's user interface
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US8876755B2 (en) 2008-07-14 2014-11-04 Abbott Diabetes Care Inc. Closed loop control system interface and methods
CN102548467A (zh) * 2008-07-18 2012-07-04 生命扫描有限公司 分析物测量和管理装置及相关方法
US8140275B2 (en) * 2008-07-18 2012-03-20 Insulet Corporation Calculating insulin on board for extended bolus being delivered by an insulin delivery device
USD611489S1 (en) 2008-07-25 2010-03-09 Lifescan, Inc. User interface display for a glucose meter
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
US9289541B2 (en) 2008-08-22 2016-03-22 Medtronic, Inc. Surgical fluid management system
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
CA2738389C (en) 2008-09-15 2017-01-17 Deka Products Limited Partnership Systems and methods for fluid delivery
US20100095229A1 (en) * 2008-09-18 2010-04-15 Abbott Diabetes Care, Inc. Graphical user interface for glucose monitoring system
USD611372S1 (en) 2008-09-19 2010-03-09 Lifescan Scotland Limited Analyte test meter
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8554579B2 (en) 2008-10-13 2013-10-08 Fht, Inc. Management, reporting and benchmarking of medication preparation
ATE508690T1 (de) 2008-10-16 2011-05-15 Hoffmann La Roche Analysegerät mit benutzerfreundlicher menüsteuerung
US8208973B2 (en) 2008-11-05 2012-06-26 Medtronic Minimed, Inc. System and method for variable beacon timing with wireless devices
US9326707B2 (en) 2008-11-10 2016-05-03 Abbott Diabetes Care Inc. Alarm characterization for analyte monitoring devices and systems
US8527208B2 (en) * 2008-11-17 2013-09-03 Roche Diagnostics International Ag Prandial blood glucose excursion optimization method via computation of time-varying optimal insulin profiles and system thereof
US9330237B2 (en) * 2008-12-24 2016-05-03 Medtronic Minimed, Inc. Pattern recognition and filtering in a therapy management system
US20100161240A1 (en) * 2008-12-24 2010-06-24 Chao-Man Tseng Test strip and device for measuring sample properties and system incorporating the same
US20100160740A1 (en) * 2008-12-24 2010-06-24 Gary Cohen Use of Patterns in a Therapy Management System
CN101785701B (zh) * 2009-01-23 2015-10-07 理康互联科技(北京)有限公司 信息处理的装置、方法、设备及试剂载体
CN101785702B (zh) * 2009-01-23 2013-11-06 理康互联科技(北京)有限公司 健康信息系统、方法及对应装置、设备及试剂载体
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
CA2750049C (en) 2009-02-04 2021-02-23 Sanofi-Aventis Deutschland Gmbh Medical device and method for providing information for glycemic control
US8497777B2 (en) 2009-04-15 2013-07-30 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
EP2419015A4 (en) 2009-04-16 2014-08-20 Abbott Diabetes Care Inc ANALYTE SENSOR CALIBRATION MANAGEMENT
US8271106B2 (en) 2009-04-17 2012-09-18 Hospira, Inc. System and method for configuring a rule set for medical event management and responses
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
WO2010129375A1 (en) 2009-04-28 2010-11-11 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
EP2424426B1 (en) 2009-04-29 2020-01-08 Abbott Diabetes Care, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
EP2425209A4 (en) 2009-04-29 2013-01-09 Abbott Diabetes Care Inc METHOD AND SYSTEM FOR REAL-TIME CALIBRATION OF AN ANALYTICAL SENSOR WITH RETROACTIVE FILLING
US9184490B2 (en) 2009-05-29 2015-11-10 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US9687194B2 (en) 2009-06-17 2017-06-27 Medtronic Minimed, Inc. Closed-loop glucose and/or insulin control system
US20100331650A1 (en) * 2009-06-25 2010-12-30 Roche Diagnostics Operations, Inc. Episodic blood glucose monitoring system with an interactive graphical user interface and methods thereof
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
CA2957078C (en) 2009-06-30 2019-04-30 Lifescan, Inc Analyte testing methods and device for calculating basal insulin therapy
US8344847B2 (en) 2009-07-09 2013-01-01 Medtronic Minimed, Inc. Coordination of control commands in a medical device system having at least one therapy delivery device and at least one wireless controller device
CA2768011C (en) 2009-07-15 2018-07-24 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
DK3936032T3 (da) 2009-07-23 2024-07-29 Abbott Diabetes Care Inc Realtidshåndtering af data relateret til fysiologisk styring af glukoseniveauer
CN104799866A (zh) 2009-07-23 2015-07-29 雅培糖尿病护理公司 分析物监测装置
CN105686807B (zh) 2009-08-31 2019-11-15 雅培糖尿病护理公司 医疗设备
WO2011026148A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
DK3988470T3 (da) 2009-08-31 2023-08-28 Abbott Diabetes Care Inc Visningsindretninger til en medicinsk indretning
US9314195B2 (en) 2009-08-31 2016-04-19 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US8487758B2 (en) 2009-09-02 2013-07-16 Medtronic Minimed, Inc. Medical device having an intelligent alerting scheme, and related operating methods
US20110060202A1 (en) * 2009-09-08 2011-03-10 Seth Adrian Miller Dehydration detector using micro-needles
US8545693B2 (en) 2009-09-29 2013-10-01 Lifescan Scotland Limited Analyte measurment method and system
WO2011041469A1 (en) 2009-09-29 2011-04-07 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
EP2644088B1 (en) 2009-09-29 2017-01-18 Lifescan Scotland Limited Analyte testing method and device for diabetes management
NZ599873A (en) 2009-10-19 2014-09-26 Theranos Inc Integrated health data capture and analysis system
WO2011053881A1 (en) 2009-10-30 2011-05-05 Abbott Diabetes Care Inc. Method and apparatus for detecting false hypoglycemic conditions
US8386042B2 (en) 2009-11-03 2013-02-26 Medtronic Minimed, Inc. Omnidirectional accelerometer device and medical device incorporating same
EP2335755A1 (en) * 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Device and method for delivery of two or more drug agents
US8882701B2 (en) 2009-12-04 2014-11-11 Smiths Medical Asd, Inc. Advanced step therapy delivery for an ambulatory infusion pump and system
US8771251B2 (en) 2009-12-17 2014-07-08 Hospira, Inc. Systems and methods for managing and delivering patient therapy through electronic drug delivery systems
US8574201B2 (en) 2009-12-22 2013-11-05 Medtronic Minimed, Inc. Syringe piston with check valve seal
US8092428B2 (en) * 2009-12-23 2012-01-10 Roche Diagnostics Operations, Inc. Methods and systems for adjusting an insulin delivery profile of an insulin pump
US8755269B2 (en) 2009-12-23 2014-06-17 Medtronic Minimed, Inc. Ranking and switching of wireless channels in a body area network of medical devices
US8803688B2 (en) * 2010-01-07 2014-08-12 Lisa Halff System and method responsive to an event detected at a glucose monitoring device
US20110163880A1 (en) * 2010-01-07 2011-07-07 Lisa Halff System and method responsive to an alarm event detected at an insulin delivery device
CA2787178C (en) 2010-01-22 2019-02-12 Deka Products Limited Partnership Method and system for shape-memory alloy wire control
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc DATA COLLECTION SYSTEM FOR TWO WRIST
JP5841951B2 (ja) 2010-02-01 2016-01-13 プロテウス デジタル ヘルス， インコーポレイテッド データ収集システム
KR101722417B1 (ko) 2010-02-25 2017-04-03 라이프스캔 스코트랜드 리미티드 고혈당 및 저혈당 경향 통지를 갖는 분석물 검사 방법 및 시스템
EP2542276A1 (de) * 2010-03-05 2013-01-09 B. Braun Melsungen AG System und verfahren zur verabreichung von medikamenten für einen patienten
EP4066731A1 (en) 2010-03-24 2022-10-05 Abbott Diabetes Care, Inc. Medical device inserters
JP5671824B2 (ja) 2010-03-25 2015-02-18 セイコーエプソン株式会社 流体注入システム
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8246573B2 (en) * 2010-04-27 2012-08-21 Medtronic, Inc. Detecting empty medical pump reservoir
US10561785B2 (en) 2010-06-22 2020-02-18 Medtronic Minimed, Inc. Method and/or system for closed-loop control of glucose to a treatment range
US8635046B2 (en) 2010-06-23 2014-01-21 Abbott Diabetes Care Inc. Method and system for evaluating analyte sensor response characteristics
US10092229B2 (en) 2010-06-29 2018-10-09 Abbott Diabetes Care Inc. Calibration of analyte measurement system
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
WO2012048168A2 (en) 2010-10-07 2012-04-12 Abbott Diabetes Care Inc. Analyte monitoring devices and methods
US8401194B2 (en) 2010-10-15 2013-03-19 Roche Diagnostics Operations, Inc. Diabetes care kit that is preconfigured to establish a secure bidirectional communication link between a blood glucose meter and insulin pump
US8603032B2 (en) 2010-10-15 2013-12-10 Medtronic Minimed, Inc. Medical device with membrane keypad sealing element, and related manufacturing method
US8454554B2 (en) * 2010-10-15 2013-06-04 Roche Diagnostics Operations, Inc. Use of a handheld medical device as a communications mediator between a personal computer-based configurator and another networked medical device
US8603033B2 (en) 2010-10-15 2013-12-10 Medtronic Minimed, Inc. Medical device and related assembly having an offset element for a piezoelectric speaker
US8562565B2 (en) 2010-10-15 2013-10-22 Medtronic Minimed, Inc. Battery shock absorber for a portable medical device
US8861731B2 (en) 2010-10-15 2014-10-14 Roche Diagnostics Operations, Inc. Efficient procedure for pairing medical devices for wireless communication with limited user interaction
US8495918B2 (en) 2010-10-20 2013-07-30 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US8474332B2 (en) 2010-10-20 2013-07-02 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US8479595B2 (en) 2010-10-20 2013-07-09 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US9192719B2 (en) 2010-11-01 2015-11-24 Medtronic, Inc. Implantable medical pump diagnostics
US8197444B1 (en) 2010-12-22 2012-06-12 Medtronic Minimed, Inc. Monitoring the seating status of a fluid reservoir in a fluid infusion device
US8690855B2 (en) 2010-12-22 2014-04-08 Medtronic Minimed, Inc. Fluid reservoir seating procedure for a fluid infusion device
US10282800B2 (en) 2010-12-22 2019-05-07 Koninklijke Philips N.V. System and method for providing medical caregiver and equipment management patient care
US8628510B2 (en) 2010-12-22 2014-01-14 Medtronic Minimed, Inc. Monitoring the operating health of a force sensor in a fluid infusion device
US8469942B2 (en) 2010-12-22 2013-06-25 Medtronic Minimed, Inc. Occlusion detection for a fluid infusion device
CN106290160A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
US9463309B2 (en) 2011-02-22 2016-10-11 Medtronic Minimed, Inc. Sealing assembly and structure for a fluid infusion device having a needled fluid reservoir
US9283318B2 (en) 2011-02-22 2016-03-15 Medtronic Minimed, Inc. Flanged sealing element and needle guide pin assembly for a fluid infusion device having a needled fluid reservoir
US9393399B2 (en) 2011-02-22 2016-07-19 Medtronic Minimed, Inc. Sealing assembly for a fluid reservoir of a fluid infusion device
US8900206B2 (en) 2011-02-22 2014-12-02 Medtronic Minimed, Inc. Pressure vented fluid reservoir for a fluid infusion device
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US8614596B2 (en) 2011-02-28 2013-12-24 Medtronic Minimed, Inc. Systems and methods for initializing a voltage bus and medical devices incorporating same
EP2680754B1 (en) 2011-02-28 2019-04-24 Abbott Diabetes Care, Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US9101305B2 (en) 2011-03-09 2015-08-11 Medtronic Minimed, Inc. Glucose sensor product and related manufacturing and packaging methods
US8564447B2 (en) 2011-03-18 2013-10-22 Medtronic Minimed, Inc. Battery life indication techniques for an electronic device
US9018893B2 (en) 2011-03-18 2015-04-28 Medtronic Minimed, Inc. Power control techniques for an electronic device
US20120249294A1 (en) * 2011-03-29 2012-10-04 O'connor Sean Biometric pairing for insulin infusion system
EP2691894B1 (en) 2011-03-30 2021-03-17 Novo Nordisk A/S System for optimizing a patient's drug dosage regimen over time
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
EP2745204A4 (en) 2011-08-19 2015-01-07 Hospira Inc SYSTEMS AND METHOD FOR A GRAPHIC INTERFACE WITH A GRAPHICAL PRESENTATION OF MEDICAL DATA
ES2959510T3 (es) 2011-10-21 2024-02-26 Icu Medical Inc Sistema de actualización de dispositivos médicos
US9622691B2 (en) 2011-10-31 2017-04-18 Abbott Diabetes Care Inc. Model based variable risk false glucose threshold alarm prevention mechanism
US9069536B2 (en) 2011-10-31 2015-06-30 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
CA2840640C (en) 2011-11-07 2020-03-24 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
FI4056105T3 (fi) 2011-12-11 2023-12-28 Abbott Diabetes Care Inc Analyyttisensorilaitteita
WO2013090709A1 (en) 2011-12-16 2013-06-20 Hospira, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9610401B2 (en) 2012-01-13 2017-04-04 Medtronic Minimed, Inc. Infusion set component with modular fluid channel element
WO2013134519A2 (en) 2012-03-07 2013-09-12 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US8603026B2 (en) 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Dynamic pulse-width modulation motor control and medical device incorporating same
US8603027B2 (en) 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Occlusion detection using pulse-width modulation and medical device incorporating same
US8523803B1 (en) 2012-03-20 2013-09-03 Medtronic Minimed, Inc. Motor health monitoring and medical device incorporating same
AU2013239778B2 (en) 2012-03-30 2017-09-28 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US10391242B2 (en) 2012-06-07 2019-08-27 Medtronic Minimed, Inc. Diabetes therapy management system for recommending bolus calculator adjustments
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
US9333292B2 (en) 2012-06-26 2016-05-10 Medtronic Minimed, Inc. Mechanically actuated fluid infusion device
US20140025809A1 (en) * 2012-07-19 2014-01-23 Cepheid Remote monitoring of medical devices
CA2880156C (en) 2012-07-31 2020-10-13 Hospira, Inc. Patient care system for critical medications
US8808269B2 (en) 2012-08-21 2014-08-19 Medtronic Minimed, Inc. Reservoir plunger position monitoring and medical device incorporating same
US10130767B2 (en) 2012-08-30 2018-11-20 Medtronic Minimed, Inc. Sensor model supervisor for a closed-loop insulin infusion system
US9878096B2 (en) 2012-08-30 2018-01-30 Medtronic Minimed, Inc. Generation of target glucose values for a closed-loop operating mode of an insulin infusion system
US10132793B2 (en) 2012-08-30 2018-11-20 Abbott Diabetes Care Inc. Dropout detection in continuous analyte monitoring data during data excursions
US20140066884A1 (en) 2012-08-30 2014-03-06 Medtronic Minimed, Inc. Sensor model supervisor for a closed-loop insulin infusion system
US9849239B2 (en) 2012-08-30 2017-12-26 Medtronic Minimed, Inc. Generation and application of an insulin limit for a closed-loop operating mode of an insulin infusion system
US10496797B2 (en) 2012-08-30 2019-12-03 Medtronic Minimed, Inc. Blood glucose validation for a closed-loop operating mode of an insulin infusion system
US9662445B2 (en) 2012-08-30 2017-05-30 Medtronic Minimed, Inc. Regulating entry into a closed-loop operating mode of an insulin infusion system
US9623179B2 (en) 2012-08-30 2017-04-18 Medtronic Minimed, Inc. Safeguarding techniques for a closed-loop insulin infusion system
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
WO2014052136A1 (en) 2012-09-26 2014-04-03 Abbott Diabetes Care Inc. Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data
EP3346444B1 (en) 2012-10-26 2020-09-23 Baxter Corporation Englewood Improved image acquisition for medical dose preparation system
EP3453377A1 (en) 2012-10-26 2019-03-13 Baxter Corporation Englewood Improved work station for medical dose preparation system
US8870818B2 (en) 2012-11-15 2014-10-28 Medtronic Minimed, Inc. Systems and methods for alignment and detection of a consumable component
US9314564B2 (en) * 2012-11-19 2016-04-19 Roche Diabetes Care, Inc. Pump controller that checks operational state of insulin pump for controlling the insulin pump
US9107994B2 (en) 2013-01-18 2015-08-18 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US9033924B2 (en) 2013-01-18 2015-05-19 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US9522223B2 (en) 2013-01-18 2016-12-20 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US10682460B2 (en) 2013-01-28 2020-06-16 Smiths Medical Asd, Inc. Medication safety devices and methods
US9308321B2 (en) 2013-02-18 2016-04-12 Medtronic Minimed, Inc. Infusion device having gear assembly initialization
US9641432B2 (en) 2013-03-06 2017-05-02 Icu Medical, Inc. Medical device communication method
US10357606B2 (en) 2013-03-13 2019-07-23 Tandem Diabetes Care, Inc. System and method for integration of insulin pumps and continuous glucose monitoring
US10433773B1 (en) 2013-03-15 2019-10-08 Abbott Diabetes Care Inc. Noise rejection methods and apparatus for sparsely sampled analyte sensor data
US9474475B1 (en) 2013-03-15 2016-10-25 Abbott Diabetes Care Inc. Multi-rate analyte sensor data collection with sample rate configurable signal processing
RU2017145873A (ru) * 2013-03-15 2019-02-20 Эбботт Дайабитиз Кэр Инк. Способы и системы обработки и передачи данных медицинского устройства
US10016561B2 (en) 2013-03-15 2018-07-10 Tandem Diabetes Care, Inc. Clinical variable determination
US10076285B2 (en) 2013-03-15 2018-09-18 Abbott Diabetes Care Inc. Sensor fault detection using analyte sensor data pattern comparison
TWI558369B (zh) 2013-04-03 2016-11-21 必有方投資股份有限公司 液體攝取管理系統
TWI621094B (zh) * 2013-04-03 2018-04-11 必有方投資股份有限公司 液體攝取管理系統
US8920381B2 (en) 2013-04-12 2014-12-30 Medtronic Minimed, Inc. Infusion set with improved bore configuration
CN105163663B (zh) * 2013-05-02 2018-10-02 Atonarp株式会社 对生物体进行监视的监视器和系统
US10046112B2 (en) 2013-05-24 2018-08-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
EP3003441B1 (en) 2013-05-29 2020-12-02 ICU Medical, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
EP3003442B1 (en) 2013-05-29 2020-12-30 ICU Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
CA2914977C (en) 2013-07-03 2021-11-02 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
WO2015009385A1 (en) 2013-07-19 2015-01-22 Dexcom, Inc. Time averaged basal rate optimizer
US9433731B2 (en) 2013-07-19 2016-09-06 Medtronic Minimed, Inc. Detecting unintentional motor motion and infusion device incorporating same
US9402949B2 (en) 2013-08-13 2016-08-02 Medtronic Minimed, Inc. Detecting conditions associated with medical device operations using matched filters
US9889257B2 (en) 2013-08-21 2018-02-13 Medtronic Minimed, Inc. Systems and methods for updating medical devices
US9880528B2 (en) 2013-08-21 2018-01-30 Medtronic Minimed, Inc. Medical devices and related updating methods and systems
US9259528B2 (en) 2013-08-22 2016-02-16 Medtronic Minimed, Inc. Fluid infusion device with safety coupling
AU2014312122A1 (en) 2013-08-30 2016-04-07 Icu Medical, Inc. System and method of monitoring and managing a remote infusion regimen
US9662436B2 (en) 2013-09-20 2017-05-30 Icu Medical, Inc. Fail-safe drug infusion therapy system
US10311972B2 (en) 2013-11-11 2019-06-04 Icu Medical, Inc. Medical device system performance index
WO2015077320A1 (en) 2013-11-19 2015-05-28 Hospira, Inc. Infusion pump automation system and method
US9750878B2 (en) 2013-12-11 2017-09-05 Medtronic Minimed, Inc. Closed-loop control of glucose according to a predicted blood glucose trajectory
US9750877B2 (en) 2013-12-11 2017-09-05 Medtronic Minimed, Inc. Predicted time to assess and/or control a glycemic state
US9849240B2 (en) 2013-12-12 2017-12-26 Medtronic Minimed, Inc. Data modification for predictive operations and devices incorporating same
US10105488B2 (en) 2013-12-12 2018-10-23 Medtronic Minimed, Inc. Predictive infusion device operations and related methods and systems
US9694132B2 (en) 2013-12-19 2017-07-04 Medtronic Minimed, Inc. Insertion device for insertion set
EP3086828B1 (en) 2013-12-26 2023-08-09 Tandem Diabetes Care, Inc. Integration of infusion pump with remote electronic device
WO2015102745A1 (en) 2013-12-31 2015-07-09 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
US10086138B1 (en) * 2014-01-28 2018-10-02 Masimo Corporation Autonomous drug delivery system
US11259745B2 (en) 2014-01-28 2022-03-01 Masimo Corporation Autonomous drug delivery system
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
US9399096B2 (en) 2014-02-06 2016-07-26 Medtronic Minimed, Inc. Automatic closed-loop control adjustments and infusion systems incorporating same
US9861748B2 (en) 2014-02-06 2018-01-09 Medtronic Minimed, Inc. User-configurable closed-loop notifications and infusion systems incorporating same
ES2776363T3 (es) 2014-02-28 2020-07-30 Icu Medical Inc Sistema de infusión y método que utiliza detección óptica de aire en línea de doble longitud de onda
US8952818B1 (en) 2014-03-18 2015-02-10 Jack Ke Zhang Fall detection apparatus with floor and surface elevation learning capabilites
US9293023B2 (en) 2014-03-18 2016-03-22 Jack Ke Zhang Techniques for emergency detection and emergency alert messaging
US9987422B2 (en) 2014-03-24 2018-06-05 Medtronic Minimed, Inc. Fluid infusion patch pump device with automatic startup feature
WO2015153482A1 (en) 2014-03-30 2015-10-08 Abbott Diabetes Care Inc. Method and apparatus for determining meal start and peak events in analyte monitoring systems
US10001450B2 (en) 2014-04-18 2018-06-19 Medtronic Minimed, Inc. Nonlinear mapping technique for a physiological characteristic sensor
US10232113B2 (en) 2014-04-24 2019-03-19 Medtronic Minimed, Inc. Infusion devices and related methods and systems for regulating insulin on board
JP6853669B2 (ja) 2014-04-30 2021-03-31 アイシーユー・メディカル・インコーポレーテッド 条件付きの警報転送を用いた患者治療システム
US9681828B2 (en) 2014-05-01 2017-06-20 Medtronic Minimed, Inc. Physiological characteristic sensors and methods for forming such sensors
US10275572B2 (en) 2014-05-01 2019-04-30 Medtronic Minimed, Inc. Detecting blockage of a reservoir cavity during a seating operation of a fluid infusion device
US10152049B2 (en) 2014-05-19 2018-12-11 Medtronic Minimed, Inc. Glucose sensor health monitoring and related methods and systems
US10274349B2 (en) 2014-05-19 2019-04-30 Medtronic Minimed, Inc. Calibration factor adjustments for infusion devices and related methods and systems
US10007765B2 (en) 2014-05-19 2018-06-26 Medtronic Minimed, Inc. Adaptive signal processing for infusion devices and related methods and systems
CA2947045C (en) 2014-05-29 2022-10-18 Hospira, Inc. Infusion system and pump with configurable closed loop delivery rate catch-up
US9724470B2 (en) 2014-06-16 2017-08-08 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9669160B2 (en) 2014-07-30 2017-06-06 Tandem Diabetes Care, Inc. Temporary suspension for closed-loop medicament therapy
TWI673497B (zh) * 2014-08-29 2019-10-01 亞多納富有限公司 監視生物體的監視器及其控制方法及健康管理系統
US9539383B2 (en) 2014-09-15 2017-01-10 Hospira, Inc. System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein
US9833563B2 (en) 2014-09-26 2017-12-05 Medtronic Minimed, Inc. Systems for managing reservoir chamber pressure
US9839753B2 (en) 2014-09-26 2017-12-12 Medtronic Minimed, Inc. Systems for managing reservoir chamber pressure
US11107574B2 (en) 2014-09-30 2021-08-31 Baxter Corporation Englewood Management of medication preparation with formulary management
US10279126B2 (en) 2014-10-07 2019-05-07 Medtronic Minimed, Inc. Fluid conduit assembly with gas trapping filter in the fluid flow path
US9833564B2 (en) 2014-11-25 2017-12-05 Medtronic Minimed, Inc. Fluid conduit assembly with air venting features
US9987420B2 (en) 2014-11-26 2018-06-05 Medtronic Minimed, Inc. Systems and methods for fluid infusion device with automatic reservoir fill
US10195341B2 (en) 2014-11-26 2019-02-05 Medtronic Minimed, Inc. Systems and methods for fluid infusion device with automatic reservoir fill
US9636453B2 (en) 2014-12-04 2017-05-02 Medtronic Minimed, Inc. Advance diagnosis of infusion device operating mode viability
US9943645B2 (en) 2014-12-04 2018-04-17 Medtronic Minimed, Inc. Methods for operating mode transitions and related infusion devices and systems
SG11201704359VA (en) 2014-12-05 2017-06-29 Baxter Corp Englewood Dose preparation data analytics
US9197082B1 (en) 2014-12-09 2015-11-24 Jack Ke Zhang Techniques for power source management using a wrist-worn device
US9937292B2 (en) 2014-12-09 2018-04-10 Medtronic Minimed, Inc. Systems for filling a fluid infusion device reservoir
US10307535B2 (en) 2014-12-19 2019-06-04 Medtronic Minimed, Inc. Infusion devices and related methods and systems for preemptive alerting
US10265031B2 (en) 2014-12-19 2019-04-23 Medtronic Minimed, Inc. Infusion devices and related methods and systems for automatic alert clearing
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
CN107405446B (zh) 2015-02-18 2020-09-29 英赛罗公司 流体输送和输注装置及其使用方法
US9872954B2 (en) * 2015-03-02 2018-01-23 Medtronic Minimed, Inc. Belt clip
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
JP2018507487A (ja) 2015-03-03 2018-03-15 バクスター・コーポレーション・イングルウッドＢａｘｔｅｒ Ｃｏｒｐｏｒａｔｉｏｎ Ｅｎｇｌｅｗｏｏｄ アラート統合を伴う薬局ワークフロー管理
US10307528B2 (en) 2015-03-09 2019-06-04 Medtronic Minimed, Inc. Extensible infusion devices and related methods
US10449298B2 (en) 2015-03-26 2019-10-22 Medtronic Minimed, Inc. Fluid injection devices and related methods
US9300925B1 (en) 2015-05-04 2016-03-29 Jack Ke Zhang Managing multi-user access to controlled locations in a facility
EP3294134B1 (en) 2015-05-14 2020-07-08 Abbott Diabetes Care Inc. Inserter system for a compact medical device and corresponding method
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
US9993595B2 (en) * 2015-05-18 2018-06-12 Tandem Diabetes Care, Inc. Patch pump cartridge attachment
WO2016189417A1 (en) 2015-05-26 2016-12-01 Hospira, Inc. Infusion pump system and method with multiple drug library editor source capability
US10137243B2 (en) 2015-05-26 2018-11-27 Medtronic Minimed, Inc. Infusion devices with distributed motor control and related operating methods
US9999721B2 (en) 2015-05-26 2018-06-19 Medtronic Minimed, Inc. Error handling in infusion devices with distributed motor control and related operating methods
US10575767B2 (en) 2015-05-29 2020-03-03 Medtronic Minimed, Inc. Method for monitoring an analyte, analyte sensor and analyte monitoring apparatus
US9879668B2 (en) 2015-06-22 2018-01-30 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and an optical sensor
US9993594B2 (en) 2015-06-22 2018-06-12 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and rotor position sensors
US9987425B2 (en) 2015-06-22 2018-06-05 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and sensor contact elements
US10010668B2 (en) 2015-06-22 2018-07-03 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and a force sensor
US9878095B2 (en) 2015-06-22 2018-01-30 Medtronic Minimed, Inc. Occlusion detection techniques for a fluid infusion device having a rotary pump mechanism and multiple sensor contact elements
WO2016207206A1 (en) 2015-06-25 2016-12-29 Gambro Lundia Ab Medical device system and method having a distributed database
CN113349766A (zh) 2015-07-10 2021-09-07 雅培糖尿病护理公司 对于生理参数进行动态葡萄糖曲线响应的系统、装置和方法
US10478557B2 (en) 2015-08-21 2019-11-19 Medtronic Minimed, Inc. Personalized parameter modeling methods and related devices and systems
US10664569B2 (en) 2015-08-21 2020-05-26 Medtronic Minimed, Inc. Data analytics and generation of recommendations for controlling glycemic outcomes associated with tracked events
US10293108B2 (en) 2015-08-21 2019-05-21 Medtronic Minimed, Inc. Infusion devices and related patient ratio adjustment methods
US10201657B2 (en) 2015-08-21 2019-02-12 Medtronic Minimed, Inc. Methods for providing sensor site rotation feedback and related infusion devices and systems
US10463297B2 (en) 2015-08-21 2019-11-05 Medtronic Minimed, Inc. Personalized event detection methods and related devices and systems
US10117992B2 (en) 2015-09-29 2018-11-06 Medtronic Minimed, Inc. Infusion devices and related rescue detection methods
US11501867B2 (en) 2015-10-19 2022-11-15 Medtronic Minimed, Inc. Medical devices and related event pattern presentation methods
US11666702B2 (en) 2015-10-19 2023-06-06 Medtronic Minimed, Inc. Medical devices and related event pattern treatment recommendation methods
US10146911B2 (en) 2015-10-23 2018-12-04 Medtronic Minimed, Inc. Medical devices and related methods and systems for data transfer
US10037722B2 (en) 2015-11-03 2018-07-31 Medtronic Minimed, Inc. Detecting breakage in a display element
WO2017091624A1 (en) 2015-11-24 2017-06-01 Insulet Corporation Wearable automated medication delivery system
US10449306B2 (en) 2015-11-25 2019-10-22 Medtronics Minimed, Inc. Systems for fluid delivery with wicking membrane
US10569016B2 (en) 2015-12-29 2020-02-25 Tandem Diabetes Care, Inc. System and method for switching between closed loop and open loop control of an ambulatory infusion pump
US10275573B2 (en) 2016-01-13 2019-04-30 Bigfoot Biomedical, Inc. User interface for diabetes management system
US10610643B2 (en) 2016-01-14 2020-04-07 Bigfoot Biomedical, Inc. Occlusion resolution in medication delivery devices, systems, and methods
CA3009351A1 (en) 2016-01-14 2017-07-20 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
US10589038B2 (en) 2016-04-27 2020-03-17 Medtronic Minimed, Inc. Set connector systems for venting a fluid reservoir
EP3451926A4 (en) * 2016-05-02 2019-12-04 Dexcom, Inc. SYSTEM AND METHOD FOR PROVIDING OPTIMIZED ALERTS TO A USER
EP3454922B1 (en) 2016-05-13 2022-04-06 ICU Medical, Inc. Infusion pump system with common line auto flush
EP3468635B1 (en) 2016-06-10 2024-09-25 ICU Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
WO2018013842A1 (en) 2016-07-14 2018-01-18 Icu Medical, Inc. Multi-communication path selection and security system for a medical device
KR101928297B1 (ko) * 2016-09-08 2018-12-12 이오플로우(주) 약액 주입장치
US10765807B2 (en) 2016-09-23 2020-09-08 Insulet Corporation Fluid delivery device with sensor
US11097051B2 (en) 2016-11-04 2021-08-24 Medtronic Minimed, Inc. Methods and apparatus for detecting and reacting to insufficient hypoglycemia response
US20180150614A1 (en) 2016-11-28 2018-05-31 Medtronic Minimed, Inc. Interactive patient guidance for medical devices
US10238030B2 (en) 2016-12-06 2019-03-26 Medtronic Minimed, Inc. Wireless medical device with a complementary split ring resonator arrangement for suppression of electromagnetic interference
WO2018111928A1 (en) 2016-12-12 2018-06-21 Mazlish Bryan Alarms and alerts for medication delivery devices and related systems and methods
BR112019012719A2 (pt) 2016-12-21 2019-11-26 Gambro Lundia Ab sistema de dispositivo médico incluindo infraestrutura de tecnologia de informação tendo domínio de agrupamento seguro suportando domínio externo
US10272201B2 (en) 2016-12-22 2019-04-30 Medtronic Minimed, Inc. Insertion site monitoring methods and related infusion devices and systems
US10881792B2 (en) 2017-01-13 2021-01-05 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US11033682B2 (en) 2017-01-13 2021-06-15 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
US11071478B2 (en) 2017-01-23 2021-07-27 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
US10500135B2 (en) 2017-01-30 2019-12-10 Medtronic Minimed, Inc. Fluid reservoir and systems for filling a fluid reservoir of a fluid infusion device
US10532165B2 (en) 2017-01-30 2020-01-14 Medtronic Minimed, Inc. Fluid reservoir and systems for filling a fluid reservoir of a fluid infusion device
US10552580B2 (en) 2017-02-07 2020-02-04 Medtronic Minimed, Inc. Infusion system consumables and related calibration methods
US10363365B2 (en) 2017-02-07 2019-07-30 Medtronic Minimed, Inc. Infusion devices and related consumable calibration methods
US10646649B2 (en) 2017-02-21 2020-05-12 Medtronic Minimed, Inc. Infusion devices and fluid identification apparatuses and methods
US11207463B2 (en) 2017-02-21 2021-12-28 Medtronic Minimed, Inc. Apparatuses, systems, and methods for identifying an infusate in a reservoir of an infusion device
EP3600014A4 (en) 2017-03-21 2020-10-21 Abbott Diabetes Care Inc. METHODS, DEVICES AND SYSTEM FOR PROVIDING DIAGNOSIS AND THERAPY FOR DIABETIC CONDITION
USD853583S1 (en) 2017-03-29 2019-07-09 Becton, Dickinson And Company Hand-held device housing
JP2020523091A (ja) * 2017-06-08 2020-08-06 エドワーズ ライフサイエンシーズ コーポレイションＥｄｗａｒｄｓ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ 薬液供給支援システムおよび方法
US20180361066A1 (en) * 2017-06-20 2018-12-20 Accugentix, LLC Hand-held volume displacement dosage dispenser
US11943876B2 (en) 2017-10-24 2024-03-26 Dexcom, Inc. Pre-connected analyte sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US10089055B1 (en) 2017-12-27 2018-10-02 Icu Medical, Inc. Synchronized display of screen content on networked devices
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
WO2019199952A1 (en) 2018-04-10 2019-10-17 Tandem Diabetes Care, Inc. System and method for inductively charging a medical device
US11523972B2 (en) 2018-04-24 2022-12-13 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
AU2019263490A1 (en) 2018-05-04 2020-11-26 Insulet Corporation Safety constraints for a control algorithm-based drug delivery system
US11152108B2 (en) 2018-07-17 2021-10-19 Icu Medical, Inc. Passing authentication token to authorize access to rest calls via web sockets
CA3106519A1 (en) 2018-07-17 2020-01-23 Icu Medical, Inc. Systems and methods for facilitating clinical messaging in a network environment
US11139058B2 (en) 2018-07-17 2021-10-05 Icu Medical, Inc. Reducing file transfer between cloud environment and infusion pumps
NZ771914A (en) 2018-07-17 2023-04-28 Icu Medical Inc Updating infusion pump drug libraries and operational software in a networked environment
EP3827337A4 (en) 2018-07-26 2022-04-13 ICU Medical, Inc. MEDICATION LIBRARY MANAGEMENT SYSTEM
US10692595B2 (en) 2018-07-26 2020-06-23 Icu Medical, Inc. Drug library dynamic version management
EP3856285A1 (en) 2018-09-28 2021-08-04 Insulet Corporation Activity mode for artificial pancreas system
WO2020077223A1 (en) 2018-10-11 2020-04-16 Insulet Corporation Event detection for drug delivery system
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
GB2589298B (en) * 2019-10-02 2023-08-09 Nottingham Univ Hospitals Nhs Trust Patient-Maintained Sedation
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
WO2021113647A1 (en) 2019-12-06 2021-06-10 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
WO2021141941A1 (en) 2020-01-06 2021-07-15 Insulet Corporation Prediction of meal and/or exercise events based on persistent residuals
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
WO2022020184A1 (en) 2020-07-21 2022-01-27 Icu Medical, Inc. Fluid transfer devices and methods of use
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
CN112137588B (zh) * 2020-09-27 2023-05-23 甘肃省人民医院 一种综合创面管理系统及方法
EP4221588A1 (en) 2020-09-30 2023-08-09 Insulet Corporation Secure wireless communications between a glucose monitor and other devices
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
CN112870485A (zh) * 2021-01-11 2021-06-01 创意银航(山东)技术有限公司 输液报警器的共享方法和系统
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
WO2023287698A1 (en) * 2021-07-14 2023-01-19 Baker Hughes Holdings Llc Configuration of asset monitoring systems
US11844544B2 (en) 2021-08-25 2023-12-19 Medtronic Ps Medical, Inc. Irrigation devices in debridement systems
US11738144B2 (en) 2021-09-27 2023-08-29 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery
WO2024147928A1 (en) 2023-01-06 2024-07-11 Insulet Corporation Automatically or manually initiated meal bolus delivery with subsequent automatic safety constraint relaxation

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935099A (en) 1992-09-09 1999-08-10 Sims Deltec, Inc. Drug pump systems and methods
US3923426A (en) * 1974-08-15 1975-12-02 Alza Corp Electroosmotic pump and fluid dispenser including same
AU546785B2 (en) * 1980-07-23 1985-09-19 Commonwealth Of Australia, The Open-loop controlled infusion of diabetics
US4443218A (en) * 1982-09-09 1984-04-17 Infusaid Corporation Programmable implantable infusate pump
US4900666A (en) * 1983-07-12 1990-02-13 Lifescan, Inc. Colorimetric ethanol analysis method and test device
US4734360A (en) * 1983-07-12 1988-03-29 Lifescan, Inc. Colorimetric ethanol analysis method and test device
US4562751A (en) * 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4678903A (en) * 1986-01-27 1987-07-07 General Motors Corporation Self aligning fiber optic microbend sensor
US5059394A (en) * 1986-08-13 1991-10-22 Lifescan, Inc. Analytical device for the automated determination of analytes in fluids
US4935346A (en) * 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US5306623A (en) * 1989-08-28 1994-04-26 Lifescan, Inc. Visual blood glucose concentration test strip
AU640162B2 (en) * 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5620863A (en) * 1989-08-28 1997-04-15 Lifescan, Inc. Blood glucose strip having reduced side reactions
US5097122A (en) * 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
GR1002549B (el) * 1992-05-12 1997-01-28 Lifescan Inc. Λωρις εξετασεως με μεταφορικο μεσο δια μεταφορα ρευστου.
US5544651A (en) * 1992-09-08 1996-08-13 Wilk; Peter J. Medical system and associated method for automatic treatment
US5843691A (en) * 1993-05-15 1998-12-01 Lifescan, Inc. Visually-readable reagent test strip
US5536249A (en) * 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
EP0672427A1 (en) * 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
US5569186A (en) * 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
US5526120A (en) * 1994-09-08 1996-06-11 Lifescan, Inc. Test strip with an asymmetrical end insuring correct insertion for measuring
DE69524108T2 (de) * 1994-09-08 2002-06-06 Lifescan, Inc. Analyt-nachweisstreifen mit einem standard auf dem streifen
US5515170A (en) * 1994-09-08 1996-05-07 Lifescan, Inc. Analyte detection device having a serpentine passageway for indicator strips
US5772635A (en) * 1995-05-15 1998-06-30 Alaris Medical Systems, Inc. Automated infusion system with dose rate calculator
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
AUPN363995A0 (en) * 1995-06-19 1995-07-13 Memtec Limited Electrochemical cell
AU722471B2 (en) * 1995-10-17 2000-08-03 Lifescan, Inc. Blood glucose strip having reduced sensitivity to hematocrit
US5708247A (en) * 1996-02-14 1998-01-13 Selfcare, Inc. Disposable glucose test strips, and methods and compositions for making same
US6241862B1 (en) * 1996-02-14 2001-06-05 Inverness Medical Technology, Inc. Disposable test strips with integrated reagent/blood separation layer
IL120587A (en) * 1996-04-04 2000-10-31 Lifescan Inc Reagent test strip for determination of blood glucose
US5753452A (en) * 1996-04-04 1998-05-19 Lifescan, Inc. Reagent test strip for blood glucose determination
US5846486A (en) * 1996-08-09 1998-12-08 Lifescan, Inc. Hollow frustum reagent test device
ATE231971T1 (de) * 1996-09-27 2003-02-15 Inverness Medical Switzerland Test-kit und vorrichtungen
US6558351B1 (en) * 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
WO2000029047A1 (de) * 1998-11-18 2000-05-25 Phiscience Gmbh, Entwicklung Von Sensoren Tragbare vorrichtung und verfahren zur mobilen medikamentenversorgung mit drahtloser übermittlung von daten zur steuerung bzw. programmierung
US6558320B1 (en) * 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6554798B1 (en) * 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6248093B1 (en) * 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US6475372B1 (en) * 2000-02-02 2002-11-05 Lifescan, Inc. Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
US6406605B1 (en) * 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
US6193873B1 (en) * 1999-06-15 2001-02-27 Lifescan, Inc. Sample detection to initiate timing of an electrochemical assay
DK1248661T3 (da) * 2000-01-21 2012-11-26 Medtronic Minimed Inc Medicinsk apparat til ambulant anvendelse og fremgangsmåde med styringssoftware, der kan modificeres ved hjælp af telemetri
GB0005564D0 (en) * 2000-03-08 2000-05-03 Inverness Medical Ltd Measurjement of substances in liquid
US6444115B1 (en) * 2000-07-14 2002-09-03 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
WO2002028454A2 (en) * 2000-10-04 2002-04-11 Insulet Corporation Data collection assembly for patient infusion system
US6544212B2 (en) * 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
US6780756B1 (en) * 2003-02-28 2004-08-24 Texas Instruments Incorporated Etch back of interconnect dielectrics

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101128229B (zh) * 2005-02-28 2011-05-25 诺和诺德公司 用于改变输药速率的装置
CN101743550B (zh) * 2007-06-27 2014-12-17 霍夫曼-拉罗奇有限公司 具有开放结构的治疗传递系统及其方法
CN101743550A (zh) * 2007-06-27 2010-06-16 霍夫曼-拉罗奇有限公司 具有开放结构的治疗传递系统及其方法
CN101789229A (zh) * 2009-01-23 2010-07-28 李秀 健康信息显示控制的装置、方法及对应设备和试剂载体
CN102138800B (zh) * 2010-12-30 2012-09-05 中国人民解放军第三军医大学第一附属医院 人体血液活塞式便携检测系统
CN102048546A (zh) * 2010-12-30 2011-05-11 中国人民解放军第三军医大学第一附属医院 人体血液生物信息实时监测、采集及检测系统
CN102138800A (zh) * 2010-12-30 2011-08-03 中国人民解放军第三军医大学第一附属医院 人体血液活塞式便携检测系统
CN102648992B (zh) * 2011-02-24 2013-11-20 上海微创生命科技有限公司 一种胰岛素输注控制装置
WO2012113275A1 (zh) * 2011-02-24 2012-08-30 上海微创生命科技有限公司 一种胰岛素输注控制方法及应用该方法的输注控制装置
CN102648992A (zh) * 2011-02-24 2012-08-29 上海微创生命科技有限公司 一种胰岛素输注控制方法及应用该方法的输注控制装置
CN105339023A (zh) * 2013-03-15 2016-02-17 普迈针药物公司 用于经皮递送化合物的设备、系统和方法
CN103495232A (zh) * 2013-10-16 2014-01-08 李秀 智能药物释放装置
CN110461391A (zh) * 2017-03-23 2019-11-15 泰尔茂株式会社 便携医疗设备以及便携医疗设备的控制方法
CN110461391B (zh) * 2017-03-23 2021-12-07 泰尔茂株式会社 便携医疗设备以及便携医疗设备的控制方法
CN114786744A (zh) * 2019-09-25 2022-07-22 杨森制药公司 与外部系统和/或其它装置通信的药物施用装置
CN114828918A (zh) * 2019-10-04 2022-07-29 阿诺·查斯 基于生活方式事件检测的控制器
US12059553B2 (en) 2019-10-04 2024-08-13 Arnold Chase Intelligent drug delivery system
CN111317889A (zh) * 2020-02-14 2020-06-23 微泰医疗器械(杭州)有限公司 一种胰岛素泵输注控制方法
CN111317889B (zh) * 2020-02-14 2022-06-24 微泰医疗器械(杭州)股份有限公司 一种胰岛素泵输注控制方法

Also Published As

Publication number Publication date
SG155760A1 (en) 2009-10-29
AU2003200685A1 (en) 2003-09-11
KR20030070857A (ko) 2003-09-02
WO2003071930A2 (en) 2003-09-04
RU2003105304A (ru) 2004-09-20
NO20030850L (no) 2003-08-27
CA2420136A1 (en) 2003-08-26
TW200307571A (en) 2003-12-16
NO20030850D0 (no) 2003-02-24
AU2003213593A8 (en) 2003-09-09
US20030212379A1 (en) 2003-11-13
JP2003290345A (ja) 2003-10-14
IL154635A (en) 2008-07-08
MXPA03001781A (es) 2005-08-16
IL154635A0 (en) 2003-09-17
WO2003071930A3 (en) 2004-02-19
EP1338295A1 (en) 2003-08-27
PL358897A1 (en) 2003-09-08
AU2003213593A1 (en) 2003-09-09

Similar Documents

Publication Publication Date Title
CN1449840A (zh) 遥控药物输注和分析物监视的系统和方法
US8663201B2 (en) Infusion device
US20080139910A1 (en) Analyte sensor and method of using the same
EP1525014B1 (en) System for providing blood glucose measurements to an infusion device
CN102300501B (zh) 多功能分析物测试装置及其方法
US7278983B2 (en) Physiological monitoring device for controlling a medication infusion device
US20070060869A1 (en) Controller device for an infusion pump
US20070060870A1 (en) Controller device for an infusion pump
EP2106815B1 (en) External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US20070100222A1 (en) Analyte sensing apparatus for hospital use
CN1860989A (zh) 医疗系统和患者使用该系统进行自我医疗的控制方法
CN107073207A (zh) 连续葡萄糖监测注射装置
CN1476566A (zh) 病人输液系统的数据采集装置
WO2008016486A2 (en) Watch controller for a medical device
CN101401314A (zh) 包括双重用途通信装置的医疗系统
CN1612761A (zh) 具有遥控设备的医学装置
CN110868927B (zh) 保持闭环胰岛素管理系统的最大剂量限制
WO2009034100A1 (en) User interface for displaying predicted values
CN1812821A (zh) 射频医疗装置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication