CN1351597A - 抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物 - Google Patents

抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物 Download PDF

Info

Publication number
CN1351597A
CN1351597A CN00807705A CN00807705A CN1351597A CN 1351597 A CN1351597 A CN 1351597A CN 00807705 A CN00807705 A CN 00807705A CN 00807705 A CN00807705 A CN 00807705A CN 1351597 A CN1351597 A CN 1351597A
Authority
CN
China
Prior art keywords
polymorph
ethoxy
phenoxazine
phenyl
oxyethyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00807705A
Other languages
English (en)
Chinese (zh)
Inventor
O·R·戈达姆
R·K·波特拉帕里
R·西里西拉
V·克里斯纳默斯
S·R·达哈玛拉贾
R·S·玛米拉帕里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Research Foundation
Original Assignee
Dr Reddys Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB1999/000681 external-priority patent/WO2000063191A1/en
Application filed by Dr Reddys Research Foundation filed Critical Dr Reddys Research Foundation
Publication of CN1351597A publication Critical patent/CN1351597A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN00807705A 1999-04-16 2000-04-17 抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物 Pending CN1351597A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/IB1999/000681 WO2000063191A1 (en) 1999-04-16 1999-04-16 Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them
WOPCT/IB99/00681 1999-04-16
IN436/MAS/99 1999-04-19
IN436MA1999 1999-04-19

Publications (1)

Publication Number Publication Date
CN1351597A true CN1351597A (zh) 2002-05-29

Family

ID=26318745

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00807705A Pending CN1351597A (zh) 1999-04-16 2000-04-17 抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物

Country Status (17)

Country Link
EP (1) EP1171430A1 (bg)
CN (1) CN1351597A (bg)
AU (1) AU3831300A (bg)
BG (1) BG106022A (bg)
BR (1) BR0010683A (bg)
CA (1) CA2370401A1 (bg)
CZ (1) CZ20013711A3 (bg)
EE (1) EE200100529A (bg)
HR (1) HRP20010748A2 (bg)
HU (1) HUP0200758A3 (bg)
IL (1) IL145958A0 (bg)
MX (1) MXPA01010472A (bg)
NO (1) NO20015016L (bg)
PL (1) PL351492A1 (bg)
RU (1) RU2001130883A (bg)
TR (1) TR200103851T2 (bg)
WO (1) WO2000063192A1 (bg)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1263458B1 (en) 2000-03-08 2005-11-16 Novo Nordisk A/S Lowering serum cholesterol
US6897199B2 (en) * 2001-02-05 2005-05-24 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds
JP4563675B2 (ja) 2001-10-12 2010-10-13 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 置換ピペリジン類、およびヒスタミンｈ３受容体関連疾患の治療のためのその使用
RU2374236C2 (ru) 2001-12-21 2009-11-27 Ново Нордиск А/С Амидные производные в качестве активаторов gk
ATE347550T1 (de) * 2002-04-19 2006-12-15 Faes Farma Sa Polymorph von 4-(2-(4-(1-(2-ethoxyethyl)-1h- benzimidazol-2-yl)-1-piperidinyl)ethyl)-alpha, alpha-dimethylbenzolessigsäure
BR0312023A (pt) 2002-06-27 2005-03-22 Novo Nordisk As Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica
WO2004101505A1 (en) 2003-05-14 2004-11-25 Novo Nordisk A/S Novel compounds for treatment of obesity
RU2381233C2 (ru) 2003-09-30 2010-02-10 Ново Нордиск А/С Агонисты рецептора меланокортина
JP4865565B2 (ja) 2003-12-09 2012-02-01 ノヴォ ノルディスク アー／エス Ｇｌｐ−１アゴニストを用いた食物選択の制御
MXPA06007667A (es) 2004-01-06 2006-09-01 Novo Nordisk As Heteroaril-ureas y su uso como activadores de glucocinasa.
EP1758856A2 (en) 2004-05-04 2007-03-07 Novo Nordisk A/S Indole derivatives for the treatment of obesity
JP2008501765A (ja) 2004-06-11 2008-01-24 ノボ　ノルディスク　アクティーゼルスカブ Ｇｌｐ−１アゴニストを用いた薬剤誘発性肥満の中和
US8263551B2 (en) 2004-11-22 2012-09-11 Novo Nordisk A/S Soluble, stable insulin-containing formulations with a protamine salt
US8148412B2 (en) 2004-12-03 2012-04-03 Novo Nordisk A/S Heteroaromatic glucokinase activators
ATE536344T1 (de) 2005-07-04 2011-12-15 High Point Pharmaceuticals Llc Histamine h3 receptor antagonisten
US7884210B2 (en) 2005-07-14 2011-02-08 Novo Nordisk A/S Ureido-thiazole glucokinase activators
EP1910317B1 (en) 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino linked compounds
EP1951658B1 (en) 2005-11-17 2012-09-26 Eli Lilly & Company Glucagon receptor antagonists, preparation and therapeutic uses
JP2009531376A (ja) 2006-03-28 2009-09-03 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ヒスタミンｈ３受容体活性を有するベンゾチアゾール
ES2375872T3 (es) 2006-05-29 2012-03-07 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperacin-1-il)-piridacina, sus sales y solvatos, y su uso como antagonista del receptor h3 de la histamina.
ATE538109T1 (de) 2006-11-15 2012-01-15 High Point Pharmaceuticals Llc Neue für die behandlung von obesitas und diabetes geeignete 2-(2-hydroxyphenyl)benzothiadiazine
WO2008059026A1 (en) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
CA2675111C (en) 2007-01-11 2016-04-05 Novo Nordisk A\S Urea glucokinase activators
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
BR112012021231A2 (pt) 2010-02-26 2015-09-08 Basf Plant Science Co Gmbh método para acentuar o rendimento em plantas, planta, construto, uso de um construto, método para a produção de uma planta transgênica, partes coletáveis de uma planta, produtos derivados de uma planta, uso de um ácido nucleíco e método para a produção de um produto
US20130012432A1 (en) 2010-02-26 2013-01-10 Novo Nordisk A/S Peptides for Treatment of Obesity
JP6026993B2 (ja) 2010-03-26 2016-11-16 ノヴォ ノルディスク アー／エス 新規のグルカゴンアナログ
WO2012104834A1 (en) 2011-02-03 2012-08-09 Pharmedica Ltd. New oral dissolving films for insulin administration, for treating diabetes
RU2013145013A (ru) 2011-03-28 2015-05-10 Ново Нордиск А/С Новые аналоги глюкагона
RU2610175C2 (ru) 2011-09-23 2017-02-08 Ново Нордиск А/С Новые аналоги глюкагона
US20150004144A1 (en) 2011-12-02 2015-01-01 The General Hospital Corporation Differentiation into brown adipocytes
WO2014170496A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
WO2015185640A1 (en) 2014-06-04 2015-12-10 Novo Nordisk A/S Glp-1/glucagon receptor co-agonists for medical use
US20200223889A1 (en) 2017-03-15 2020-07-16 Novo Nordisk A/S Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor
US20210221867A1 (en) 2018-05-15 2021-07-22 Novo Nordisk A/S Compounds Capable of Binding to Melanocortin 4 Receptor
WO2020053414A1 (en) 2018-09-14 2020-03-19 Novo Nordisk A/S Bicyclic compounds capable of acting as melanocortin 4 receptor agonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
WO1997027191A1 (en) * 1996-06-19 1997-07-31 Dr. Reddy's Research Foundation Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
IN182496B (bg) * 1996-02-20 1999-04-17 Reddy Research Foundation
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
FR2746099B1 (fr) * 1996-03-13 1998-04-30 Procede ameliore pour la preparation de derives de l'acide 3-(10-phenothiazyl)-propanoique ou 3-(10-phenoxazyl)-propanoique
WO1999019313A1 (en) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
EP1051403A1 (en) * 1998-01-29 2000-11-15 Dr. Reddy's Research Foundation Novel alkanoic acids and their use in medicine, process for their preparation and pharmaceutical compositions containing them
EP1082313A1 (en) * 1998-05-27 2001-03-14 Dr. Reddy's Research Foundation Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HUP0200758A2 (hu) 2002-07-29
TR200103851T2 (tr) 2002-04-22
NO20015016D0 (no) 2001-10-15
MXPA01010472A (es) 2002-05-06
BG106022A (bg) 2002-04-30
CZ20013711A3 (cs) 2002-07-17
NO20015016L (no) 2001-12-11
HRP20010748A2 (en) 2003-02-28
AU3831300A (en) 2000-11-02
HUP0200758A3 (en) 2003-07-28
EP1171430A1 (en) 2002-01-16
PL351492A1 (en) 2003-04-22
CA2370401A1 (en) 2000-10-26
WO2000063192A1 (en) 2000-10-26
BR0010683A (pt) 2003-07-01
IL145958A0 (en) 2002-07-25
EE200100529A (et) 2002-12-16
RU2001130883A (ru) 2004-03-20

Similar Documents

Publication Publication Date Title
CN1351597A (zh) 抗糖尿病的新型多晶形物、其制备方法和含有它们的药物组合物
CN100344616C (zh) 用于治疗代谢失调的化合物
CN1046722C (zh) 杂环化合物及其制备和应用
CN1280574A (zh) 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
CN1750758A (zh) 用于治疗代谢紊乱的化合物
CN1221417A (zh) 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物
CN1489463A (zh) 阿托伐他汀半钙的新晶型及其制备方法,以及其它晶型的新制备方法
CN1311767A (zh) 治疗代谢性疾病的糖皮质激素和甲状腺激素受体的配体
CN88101642A (zh) 哌嗪基-杂环化合物
CN1266129C (zh) 具有降血脂和降低血中胆固醇活性的新化合物、其制备方法和含有它们的药物组合物
CN1774244A (zh) 用于治疗代谢紊乱的化合物
CN86106428A (zh) 抗肿瘤方法及其化合物
CN1355790A (zh) 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法
CN1780614A (zh) 用于治疗代谢紊乱的化合物
CN1358175A (zh) 嘧啶酮化合物
CN1026234C (zh) 用于降血糖的噻唑烷二酮衍生物的制备方法
CN1777576A (zh) 用于治疗代谢紊乱的化合物
CN87102891A (zh) 硫化内酰胺-n-乙酸衍生物的生产及使用
CN1968687A (zh) 预防和治疗代谢性骨病的含有α－芳基甲氧基丙烯酸酯衍生物的药物组合物
CN101039921A (zh) 3－[5－氯－4－[(2,4－二氟苄基)氧基]－6－氧代嘧啶－1(6h)－基]－n－(2－羟乙基)－4－甲基苯甲酰胺的晶形
CN1728992A (zh) 具有降低血清葡萄糖和降低血清脂质活性的α－苯硫基羧酸和α－苯氧基羧酸的用途
CN1205704A (zh) 2,7－取代的八氢－吡咯并[1,2－a]吡嗪衍生物
CN1257893C (zh) 具有优异降糖降酯活性的芳烷基氨基酸类ppar全激活剂
CN1310912C (zh) 5－[4－[2－(n－甲基－n－(2－吡啶基)氨基)乙氧基]苄基]噻唑烷－2,4－二酮甲磺酸盐
CN1849306A (zh) 基质金属蛋白酶抑制剂

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
ASS Succession or assignment of patent right

Owner name: REDDY LAB CO LTD

Free format text: FORMER OWNER: DR. LEI DI RESEARCH FOUNDATION

Effective date: 20020524

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20020524

Address after: Hyderabad

Applicant after: Dr. Reddy's Research Foundation

Address before: Andhra Pradesh

Applicant before: Dr. Reddy's research Foundation

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication