CN1257893C - 具有优异降糖降酯活性的芳烷基氨基酸类ppar全激活剂 - Google Patents
具有优异降糖降酯活性的芳烷基氨基酸类ppar全激活剂 Download PDFInfo
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- CN1257893C CN1257893C CN 03126974 CN03126974A CN1257893C CN 1257893 C CN1257893 C CN 1257893C CN 03126974 CN03126974 CN 03126974 CN 03126974 A CN03126974 A CN 03126974A CN 1257893 C CN1257893 C CN 1257893C
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- ring
- compound
- ppar
- phenyl
- phenyl ring
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Abstract
Description
大鼠分类 | 给药剂量(mg/kg) | 甘油三酯(mg/dl) | 胆固醇(mg/dl) |
正常组对照组CS038CS038Ros | --4304 | 149.6±39.8*233.9±101.6150.3±52.1*143.2±61.8*273.3±87.4 | 73.1±7.8**109.4±26.798.4±29.486.6±37.7112.7±25.5 |
大鼠分类 | 给药剂量(mg/kg) | 大鼠体重(克) | 腹脂重量(克) | |||
0天 | 6天 | 9天 | 15天 | |||
对照组CS038CS038Ros | -4304 | 576.5±138.0591.5±130.0580.5±134.9594.9±169.3 | 569.4±142.1580.8±130.2586.1±143.2604.5±181.4 | 568.5±145.3575.2±130.6586.5±144.2601.6±183.9 | 562.7±136.5569.4±122.9578.3±176.8596.4±176.8 | 60.4±21.055.8±16.856.6±21.163.1±31.4 |
Claims (18)
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CN 03126974 CN1257893C (zh) | 2003-06-17 | 2003-06-17 | 具有优异降糖降酯活性的芳烷基氨基酸类ppar全激活剂 |
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CN111437393A (zh) * | 2020-04-30 | 2020-07-24 | 深圳微芯生物科技股份有限公司 | 用于糖尿病及其并发症治疗的联合用药及其药物组合物 |
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CN105801468B (zh) * | 2014-12-31 | 2018-08-17 | 深圳微芯生物科技股份有限公司 | 一种苯丙氨酸类化合物的盐及其无定形体 |
CN104744282A (zh) * | 2015-02-17 | 2015-07-01 | 南通恒盛精细化工有限公司 | 一种胰岛素增敏剂的制备工艺 |
CN112479977B (zh) * | 2016-09-27 | 2022-07-19 | 深圳微芯生物科技股份有限公司 | 一种取代的苯基丙酸化合物对映异构体及其制备方法、组合物和应用 |
CN107868033B (zh) * | 2016-09-27 | 2021-05-18 | 深圳微芯生物科技股份有限公司 | 一种苯丙氨酸类化合物的制备方法 |
CN109276543B (zh) * | 2017-07-19 | 2021-01-08 | 深圳微芯生物科技股份有限公司 | 一种西格列他固体分散体及其制备方法和应用 |
CN109316601B (zh) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | 药物组合物及其用途 |
CN110467560A (zh) * | 2018-05-09 | 2019-11-19 | 深圳微芯生物科技股份有限公司 | 一种苯基氨基丙酸钠衍生物、其制备方法和应用 |
CN112516137A (zh) * | 2019-09-19 | 2021-03-19 | 深圳微芯生物科技股份有限公司 | 西格列羧及其衍生物用于伴有脂代谢异常的2型糖尿病治疗的用途 |
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CN111437393A (zh) * | 2020-04-30 | 2020-07-24 | 深圳微芯生物科技股份有限公司 | 用于糖尿病及其并发症治疗的联合用药及其药物组合物 |
WO2021218638A1 (zh) | 2020-04-30 | 2021-11-04 | 深圳微芯生物科技股份有限公司 | 用于糖尿病及其并发症治疗的联合用药及其药物组合物 |
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Application publication date: 20050112 Assignee: Chengdu Weixin Pharmaceutical Co.,Ltd. Assignor: SHENZHEN CHIPSCREEN BIOSCIENCES, Ltd. Contract record no.: 2016440020075 Denomination of invention: PPAR full activator of amino acids of aralkyl possessing excellent activity for lowering sugar and ester Granted publication date: 20060531 License type: Exclusive License Record date: 20160818 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
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Address after: 518057 room 601-606, building 2, Shenzhen biological incubator, ten Nanshan District high tech Middle Road, Shenzhen, Guangdong, China Patentee after: SHENZHEN CHIPSCREEN BIOSCIENCES Co.,Ltd. Address before: 518052 C301,28 Research Office, Tsinghua University Research Institute, Nanshan District science and Technology Park, Shenzhen, Guangdong Patentee before: SHENZHEN CHIPSCREEN BIOSCIENCES, Ltd. |
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Date of cancellation: 20190409 Granted publication date: 20060531 Pledgee: Bank of Chongqing Limited by Share Ltd. Chengdu Binjiang branch Pledgor: SHENZHEN CHIPSCREEN BIOSCIENCES Co.,Ltd. Registration number: 2016440020003 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20190409 Registration number: 2016440020003 Pledgor after: SHENZHEN CHIPSCREEN BIOSCIENCES Co.,Ltd. Pledgor before: SHENZHEN CHIPSCREEN BIOSCIENCES, Ltd. |
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PM01 | Change of the registration of the contract for pledge of patent right | ||
IP01 | Partial invalidation of patent right | ||
IP01 | Partial invalidation of patent right |
Commission number: 4W112266 Conclusion of examination: Maintaining the validity of patent rights based on claims 2-4, 6-9, and 15-18 Decision date of declaring invalidation: 20220104 Decision number of declaring invalidation: 53333 Denomination of invention: Aromatic alkyl amino acid type PPAR full activator with excellent hypoglycemic and ester lowering activity Granted publication date: 20060531 Patentee: SHENZHEN CHIPSCREEN BIOSCIENCES Co.,Ltd. |