CN1341211A - 基因检测芯片、检测装置及检测方法 - Google Patents
基因检测芯片、检测装置及检测方法 Download PDFInfo
- Publication number
- CN1341211A CN1341211A CN00803998A CN00803998A CN1341211A CN 1341211 A CN1341211 A CN 1341211A CN 00803998 A CN00803998 A CN 00803998A CN 00803998 A CN00803998 A CN 00803998A CN 1341211 A CN1341211 A CN 1341211A
- Authority
- CN
- China
- Prior art keywords
- chip
- gene
- electrode
- post electrode
- detect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
dT20 | dT10dAdT9 | dT8dA4dT8 | dAdT19 | dA3dT17 | dT19dA | dT17dA3 | |
电流变化(%) | 37 | 22 | 15 | 14 | 14 | 20 | 12 |
Tm(度) | 46 | 36 | 21 | 45 | 46 | 42 | 41 |
Claims (32)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP298917/99 | 1999-10-20 | ||
JP29891799 | 1999-10-20 | ||
JP298917/1999 | 1999-10-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1341211A true CN1341211A (zh) | 2002-03-20 |
CN1223851C CN1223851C (zh) | 2005-10-19 |
Family
ID=17865860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008039984A Expired - Fee Related CN1223851C (zh) | 1999-10-20 | 2000-10-20 | 基因检测芯片、检测装置及检测方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6916614B1 (zh) |
EP (1) | EP1146331B1 (zh) |
KR (1) | KR20010099859A (zh) |
CN (1) | CN1223851C (zh) |
AT (1) | ATE408141T1 (zh) |
AU (1) | AU7952700A (zh) |
DE (1) | DE60040205D1 (zh) |
WO (1) | WO2001029550A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100436600C (zh) * | 2005-06-03 | 2008-11-26 | 横河电机株式会社 | 化学反应盒 |
CN105296351A (zh) * | 2015-12-02 | 2016-02-03 | 北京大学 | 用于聚合酶链式反应的芯片、实时检测装置和系统 |
CN106153940A (zh) * | 2014-10-17 | 2016-11-23 | 广州瑞博奥生物科技有限公司 | 一种用于检测血管生成因子的抗体芯片试剂盒 |
CN106153939A (zh) * | 2014-10-17 | 2016-11-23 | 广州瑞博奥生物科技有限公司 | 一种用于检测凋亡因子的抗体芯片试剂盒 |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2002066969A1 (ja) * | 2001-02-19 | 2004-06-24 | 協和メデックス株式会社 | 荷電成分検出装置及びその使用方法並びに検出パネル |
JP2002372533A (ja) * | 2001-06-13 | 2002-12-26 | Kiwamu Akagi | 血液の検査方法、検査用チップ、並びに検査装置 |
DE10208794A1 (de) * | 2002-02-28 | 2003-09-04 | Degussa Bioactives Gmbh | Verfahren zum Sortieren einsträngiger Nucleinsäuren |
EP1550718B1 (en) * | 2002-07-30 | 2011-06-22 | Toppan Printing Co., Ltd. | Method of detecting base mutation |
CN1232816C (zh) * | 2002-08-23 | 2005-12-21 | 株式会社东芝 | 碱基序列的检测电极与装置及其检测方法 |
ATE544867T1 (de) * | 2002-12-11 | 2012-02-15 | Centre Nat Rech Scient | Methode zur elektronischen detektion wenigstens einer spezifischen interaktion zwischen einem proben- und einem zielmolekül |
KR101126845B1 (ko) | 2003-05-19 | 2012-03-28 | 도레이 카부시키가이샤 | 선택 결합성 물질 고정화 담체 |
JP4285119B2 (ja) * | 2003-07-07 | 2009-06-24 | ソニー株式会社 | 生化学反応装置、生化学反応用基板、ハイブリダイゼーション用基板の製造方法及びハイブリダイゼーション方法 |
JP4466074B2 (ja) * | 2003-12-26 | 2010-05-26 | 株式会社日立製作所 | 微細金属構造体とその製造方法、並びに微細金型とデバイス |
KR101050468B1 (ko) * | 2004-02-14 | 2011-07-19 | 삼성에스디아이 주식회사 | 바이오 칩 및 이를 이용한 바이오 분자 검출 시스템 |
JP4353958B2 (ja) * | 2005-09-15 | 2009-10-28 | 株式会社日立製作所 | Dna計測装置、及びdna計測方法 |
CA3135182C (en) | 2007-04-04 | 2024-01-23 | Ande Corporation | Plastic microfluidic separation and detection platforms |
US7871571B2 (en) * | 2007-10-25 | 2011-01-18 | Parker John A | Biomolecule analyzing system |
JP2010011791A (ja) * | 2008-07-03 | 2010-01-21 | Toshiba Corp | 複数核酸の検出方法 |
GB0822733D0 (en) * | 2008-12-12 | 2009-01-21 | Univ Warwick | Nanotube electrochemistry |
JP2012529908A (ja) | 2009-06-15 | 2012-11-29 | ネットバイオ・インコーポレーテッド | 法医学的dnaの定量化のための改善された方法 |
JP2011232328A (ja) * | 2010-04-09 | 2011-11-17 | Hitachi Ltd | 生体物質検出アレイ、計測装置および計測方法 |
US9310304B2 (en) | 2011-05-12 | 2016-04-12 | Netbio, Inc. | Methods and compositions for rapid multiplex amplification of STR loci |
CN104049011B (zh) * | 2014-06-30 | 2016-10-12 | 安徽师范大学 | 一种电化学生物传感器,其制备方法,用途以及检测血小板源生长因子的方法 |
US10488365B2 (en) * | 2015-06-17 | 2019-11-26 | Qualcomm Incorporated | Current sensors using bipolar transistors |
CA3021580A1 (en) | 2015-06-25 | 2016-12-29 | Barry L. Merriman | Biomolecular sensors and methods |
JP7280590B2 (ja) | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
CN109328301B (zh) | 2016-01-28 | 2021-03-12 | 罗斯韦尔生物技术股份有限公司 | 大规模并行dna测序装置 |
JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 電子的、標識フリーのdnaおよびゲノムシークエンシング |
US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
KR102622275B1 (ko) | 2017-01-10 | 2024-01-05 | 로스웰 바이오테크놀로지스 인코포레이티드 | Dna 데이터 저장을 위한 방법들 및 시스템들 |
WO2018136148A1 (en) | 2017-01-19 | 2018-07-26 | Roswell Biotechnologies, Inc. | Solid state sequencing devices comprising two dimensional layer materials |
US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
KR102692957B1 (ko) | 2017-04-25 | 2024-08-06 | 로스웰 엠이 아이엔씨. | 분자 센서들을 위한 효소 회로들 |
EP4023764A3 (en) | 2017-05-09 | 2022-09-21 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
TWI745392B (zh) * | 2017-06-29 | 2021-11-11 | 瑞禾生物科技股份有限公司 | 生物感測元件及其製造方法以及生物分子檢測方法 |
WO2019046589A1 (en) | 2017-08-30 | 2019-03-07 | Roswell Biotechnologies, Inc. | PROCESSIVE ENZYME MOLECULAR ELECTRONIC SENSORS FOR STORING DNA DATA |
WO2019075100A1 (en) | 2017-10-10 | 2019-04-18 | Roswell Biotechnologies, Inc. | METHODS, APPARATUS AND SYSTEMS FOR STORING DNA DATA WITHOUT AMPLIFICATION |
CN110227565B (zh) | 2019-06-25 | 2021-03-19 | 京东方科技集团股份有限公司 | 微流控器件及制作方法、生物分子数量检测方法及系统 |
WO2021141151A1 (ko) * | 2020-01-07 | 2021-07-15 | 엘지전자 주식회사 | 전기장 인가용 커버 및 이를 포함하는 전기장 인가 장치 |
Family Cites Families (24)
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JPS56152958A (en) | 1980-04-30 | 1981-11-26 | Mitsubishi Electric Corp | Electroless gold plating solution |
US4343684A (en) | 1980-12-19 | 1982-08-10 | Stanley Lechtzin | Method of electroforming and product |
EP0149339B1 (en) | 1983-12-16 | 1989-08-23 | MediSense, Inc. | Assay for nucleic acids |
US4857831A (en) | 1986-12-29 | 1989-08-15 | Schlumberger Technology Corporation | Borehole casing diagnostic apparatus and method |
US5108576A (en) | 1988-06-13 | 1992-04-28 | Ohmicron Corporation | Pyroelectric thermometric device |
US5776672A (en) * | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
GB9201481D0 (en) | 1992-01-23 | 1992-03-11 | Scient Generics Ltd | Treatment of nucleic acid material |
US6071394A (en) | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
JP3331261B2 (ja) | 1994-08-19 | 2002-10-07 | 日本エレクトロプレイテイング・エンジニヤース株式会社 | 無電解金めっき液 |
WO1996033298A1 (en) | 1995-04-17 | 1996-10-24 | The Board Of Trustees Of The University Of Arkansas | Method of electroplating a substrate, and products made thereby |
JP3671100B2 (ja) | 1996-02-23 | 2005-07-13 | 日本碍子株式会社 | 酸化物センサ |
JP3764779B2 (ja) | 1996-03-30 | 2006-04-12 | 株式会社東北テクノアーチ | 凸状領域を用いた分析方法 |
JP3233851B2 (ja) | 1996-04-24 | 2001-12-04 | 繁織 竹中 | 遺伝子の電気化学的検出法およびその装置 |
ZA975891B (en) * | 1996-07-05 | 1998-07-23 | Combimatrix Corp | Electrochemical solid phase synthesis of polymers |
PL335226A1 (en) | 1997-02-21 | 2000-04-10 | Burstein Lab | Gene sequencer and related methods |
FR2764385B1 (fr) | 1997-06-06 | 1999-07-16 | Commissariat Energie Atomique | Microsysteme d'analyse de liquides a cuvette integree |
US6048692A (en) * | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
US6287776B1 (en) * | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Method for detecting and classifying nucleic acid hybridization |
DE19841337C1 (de) * | 1998-05-27 | 1999-09-23 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle |
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JP3888807B2 (ja) * | 1999-08-06 | 2007-03-07 | 凸版印刷株式会社 | 遺伝子を検出する方法、並びに検出装置及び検出用チップ |
US6749731B2 (en) | 2001-01-31 | 2004-06-15 | Kyocera Corporation | Gene detection chip and detection device |
-
2000
- 2000-10-20 US US09/868,576 patent/US6916614B1/en not_active Expired - Fee Related
- 2000-10-20 AU AU79527/00A patent/AU7952700A/en not_active Abandoned
- 2000-10-20 EP EP00969958A patent/EP1146331B1/en not_active Expired - Lifetime
- 2000-10-20 KR KR1020017007821A patent/KR20010099859A/ko not_active Application Discontinuation
- 2000-10-20 AT AT00969958T patent/ATE408141T1/de not_active IP Right Cessation
- 2000-10-20 WO PCT/JP2000/007342 patent/WO2001029550A1/ja active IP Right Grant
- 2000-10-20 CN CNB008039984A patent/CN1223851C/zh not_active Expired - Fee Related
- 2000-10-20 DE DE60040205T patent/DE60040205D1/de not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100436600C (zh) * | 2005-06-03 | 2008-11-26 | 横河电机株式会社 | 化学反应盒 |
CN106153940A (zh) * | 2014-10-17 | 2016-11-23 | 广州瑞博奥生物科技有限公司 | 一种用于检测血管生成因子的抗体芯片试剂盒 |
CN106153939A (zh) * | 2014-10-17 | 2016-11-23 | 广州瑞博奥生物科技有限公司 | 一种用于检测凋亡因子的抗体芯片试剂盒 |
CN105296351A (zh) * | 2015-12-02 | 2016-02-03 | 北京大学 | 用于聚合酶链式反应的芯片、实时检测装置和系统 |
Also Published As
Publication number | Publication date |
---|---|
WO2001029550A1 (fr) | 2001-04-26 |
ATE408141T1 (de) | 2008-09-15 |
CN1223851C (zh) | 2005-10-19 |
EP1146331A4 (en) | 2006-08-30 |
EP1146331B1 (en) | 2008-09-10 |
AU7952700A (en) | 2001-04-30 |
KR20010099859A (ko) | 2001-11-09 |
EP1146331A1 (en) | 2001-10-17 |
US6916614B1 (en) | 2005-07-12 |
DE60040205D1 (de) | 2008-10-23 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: TAKENAKA SHIGERU; CHATHAM GENE CO.,LTD. Free format text: FORMER OWNER: KAZUHIKO UCHIDA; JUN TAKASHI MIYAHARA Effective date: 20030403 Owner name: KAZUHIKO UCHIDA Free format text: FORMER OWNER: TAKENAKA SHIGERU |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20030403 Address after: Ibaraki Applicant after: Uchida Kazuhiko Co-applicant after: Takenaka Shigeori Co-applicant after: The company's gene Address before: Fukuoka Prefecture Applicant before: Takenaka Shigeori Co-applicant before: Uchida Kazuhiko Co-applicant before: Miyahara Takatoshi |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: KAZUHIKO UCHIDA; TAKENAKA SHIGERU; TOPPAN PRINTIN Free format text: FORMER OWNER: KAZUHIKO UCHIDA; TAKENAKA SHIGERU; CHATHAM GENE CO.,LTD. Effective date: 20060421 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20060421 Address after: Ibaraki Co-patentee after: Takenaka Shigeori Patentee after: Uchida Kazuhiko Co-patentee after: Toppan Printing Co. Ltd. Address before: Ibaraki Co-patentee before: Takenaka Shigeori Patentee before: Uchida Kazuhiko Co-patentee before: The company's gene |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051019 Termination date: 20141020 |
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EXPY | Termination of patent right or utility model |