CN1335849A - 作为蛋白激酶抑制剂的吡咯并嘧啶 - Google Patents
作为蛋白激酶抑制剂的吡咯并嘧啶 Download PDFInfo
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- CN1335849A CN1335849A CN99813217A CN99813217A CN1335849A CN 1335849 A CN1335849 A CN 1335849A CN 99813217 A CN99813217 A CN 99813217A CN 99813217 A CN99813217 A CN 99813217A CN 1335849 A CN1335849 A CN 1335849A
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
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- Pulmonology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10083398P | 1998-09-18 | 1998-09-18 | |
| US10083298P | 1998-09-18 | 1998-09-18 | |
| US10094698P | 1998-09-18 | 1998-09-18 | |
| US10083498P | 1998-09-18 | 1998-09-18 | |
| US60/100,946 | 1998-09-18 | ||
| US60/100,834 | 1998-09-18 | ||
| US60/100,832 | 1998-09-18 | ||
| US60/100,833 | 1998-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1335849A true CN1335849A (zh) | 2002-02-13 |
Family
ID=27493158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99813217A Pending CN1335849A (zh) | 1998-09-18 | 1999-09-17 | 作为蛋白激酶抑制剂的吡咯并嘧啶 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1114053A1 (id) |
| JP (1) | JP2002526500A (id) |
| KR (1) | KR20010085824A (id) |
| CN (1) | CN1335849A (id) |
| AU (1) | AU753555C (id) |
| BG (1) | BG105346A (id) |
| BR (1) | BR9913887A (id) |
| CA (1) | CA2344249A1 (id) |
| CZ (1) | CZ2001960A3 (id) |
| HK (1) | HK1039326A1 (id) |
| HU (1) | HUP0200403A3 (id) |
| ID (1) | ID29028A (id) |
| IL (1) | IL141866A0 (id) |
| NO (1) | NO20011356L (id) |
| NZ (1) | NZ510588A (id) |
| PL (1) | PL346700A1 (id) |
| SK (1) | SK3842001A3 (id) |
| TR (1) | TR200101186T2 (id) |
| WO (1) | WO2000017203A1 (id) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100439365C (zh) * | 2003-08-28 | 2008-12-03 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| CN102007125B (zh) * | 2008-01-15 | 2016-05-25 | 安姆根有限公司 | 稠合杂环衍生物及使用方法 |
| CN105829313A (zh) * | 2013-11-19 | 2016-08-03 | 制药科学公司 | 蛋白激酶抑制剂 |
| CN112961158A (zh) * | 2020-03-05 | 2021-06-15 | 四川大学华西医院 | 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途 |
| CN112961159A (zh) * | 2020-03-05 | 2021-06-15 | 四川大学华西医院 | 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途 |
| WO2024008128A1 (zh) * | 2022-07-06 | 2024-01-11 | 上海科恩泰生物医药科技有限公司 | 一种具有fgfr抑制作用的亚砜亚胺类化合物、包含其的药物组合物及其用途 |
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| DE69932828T2 (de) | 1998-08-29 | 2007-10-18 | Astrazeneca Ab | Pyrimidine verbindungen |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| EE05351B1 (et) | 1999-12-10 | 2010-10-15 | Pfizer Products Inc. | Prrolo[2,3-d]primidiinhendid |
| ES2293980T3 (es) * | 2000-01-13 | 2008-04-01 | Amgen Inc. | Agentes antibacterianos. |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| WO2001072751A1 (en) * | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| US7369946B2 (en) | 2000-03-29 | 2008-05-06 | Abbott Gmbh & Co. Kg | Method of identifying inhibitors of Tie-2 |
| ATE423120T1 (de) | 2000-06-26 | 2009-03-15 | Pfizer Prod Inc | Pyrroloä2,3-düpyrimidin verbindungen als immunosuppressive wirkstoffe |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| GB0121033D0 (en) * | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
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| GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
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| AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
| GB0226370D0 (en) * | 2002-11-12 | 2002-12-18 | Novartis Ag | Organic compounds |
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| GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
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- 1999-09-17 EP EP99969415A patent/EP1114053A1/en not_active Withdrawn
- 1999-09-17 HU HU0200403A patent/HUP0200403A3/hu unknown
- 1999-09-17 IL IL14186699A patent/IL141866A0/xx unknown
- 1999-09-17 TR TR2001/01186T patent/TR200101186T2/xx unknown
- 1999-09-17 KR KR1020017003532A patent/KR20010085824A/ko not_active Application Discontinuation
- 1999-09-17 CA CA002344249A patent/CA2344249A1/en not_active Abandoned
- 1999-09-17 ID IDW20010652A patent/ID29028A/id unknown
- 1999-09-17 CN CN99813217A patent/CN1335849A/zh active Pending
- 1999-09-17 AU AU60484/99A patent/AU753555C/en not_active Ceased
- 1999-09-17 BR BR9913887-5A patent/BR9913887A/pt not_active IP Right Cessation
- 1999-09-17 WO PCT/US1999/021560 patent/WO2000017203A1/en not_active Application Discontinuation
- 1999-09-17 SK SK384-2001A patent/SK3842001A3/sk unknown
- 1999-09-17 PL PL99346700A patent/PL346700A1/xx unknown
- 1999-09-17 CZ CZ2001960A patent/CZ2001960A3/cs unknown
- 1999-09-17 JP JP2000574112A patent/JP2002526500A/ja active Pending
- 1999-09-17 NZ NZ510588A patent/NZ510588A/en unknown
-
2001
- 2001-03-15 BG BG105346A patent/BG105346A/xx unknown
- 2001-03-16 NO NO20011356A patent/NO20011356L/no not_active Application Discontinuation
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2002
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100439365C (zh) * | 2003-08-28 | 2008-12-03 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| CN102007125B (zh) * | 2008-01-15 | 2016-05-25 | 安姆根有限公司 | 稠合杂环衍生物及使用方法 |
| CN105829313A (zh) * | 2013-11-19 | 2016-08-03 | 制药科学公司 | 蛋白激酶抑制剂 |
| CN112961158A (zh) * | 2020-03-05 | 2021-06-15 | 四川大学华西医院 | 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途 |
| CN112961159A (zh) * | 2020-03-05 | 2021-06-15 | 四川大学华西医院 | 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途 |
| CN112961158B (zh) * | 2020-03-05 | 2022-07-01 | 四川大学华西医院 | 氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途 |
| WO2024008128A1 (zh) * | 2022-07-06 | 2024-01-11 | 上海科恩泰生物医药科技有限公司 | 一种具有fgfr抑制作用的亚砜亚胺类化合物、包含其的药物组合物及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU753555B2 (en) | 2002-10-24 |
| CZ2001960A3 (cs) | 2001-10-17 |
| HK1039326A1 (zh) | 2002-04-19 |
| AU753555C (en) | 2003-07-03 |
| SK3842001A3 (en) | 2002-04-04 |
| AU6048499A (en) | 2000-04-10 |
| BR9913887A (pt) | 2001-10-23 |
| CA2344249A1 (en) | 2000-03-30 |
| NZ510588A (en) | 2003-08-29 |
| TR200101186T2 (tr) | 2001-10-22 |
| EP1114053A1 (en) | 2001-07-11 |
| BG105346A (en) | 2001-12-29 |
| IL141866A0 (en) | 2002-03-10 |
| NO20011356D0 (no) | 2001-03-16 |
| NO20011356L (no) | 2001-05-16 |
| ID29028A (id) | 2001-07-26 |
| KR20010085824A (ko) | 2001-09-07 |
| HUP0200403A3 (en) | 2004-07-28 |
| JP2002526500A (ja) | 2002-08-20 |
| PL346700A1 (en) | 2002-02-25 |
| WO2000017203A1 (en) | 2000-03-30 |
| HUP0200403A2 (en) | 2002-06-29 |
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