CN1305896C - 用离子交换层析纯化蛋白质 - Google Patents

用离子交换层析纯化蛋白质 Download PDF

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Publication number
CN1305896C
CN1305896C CNB2004100687918A CN200410068791A CN1305896C CN 1305896 C CN1305896 C CN 1305896C CN B2004100687918 A CNB2004100687918 A CN B2004100687918A CN 200410068791 A CN200410068791 A CN 200410068791A CN 1305896 C CN1305896 C CN 1305896C
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China
Prior art keywords
antibody
polypeptide
electric conductivity
karb
zeo
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Expired - Lifetime
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CNB2004100687918A
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English (en)
Chinese (zh)
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CN1626548A (zh
Inventor
C·D·贝斯
G·S·布兰克
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Genentech Inc
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Genentech Inc
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Publication of CN1626548A publication Critical patent/CN1626548A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB2004100687918A 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质 Expired - Lifetime CN1305896C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8445998P 1998-05-06 1998-05-06
US60/084,459 1998-05-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB99805836XA Division CN1260249C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质

Publications (2)

Publication Number Publication Date
CN1626548A CN1626548A (zh) 2005-06-15
CN1305896C true CN1305896C (zh) 2007-03-21

Family

ID=22185093

Family Applications (6)

Application Number Title Priority Date Filing Date
CN201310590762.7A Pending CN103641885A (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNB99805836XA Ceased CN1260249C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNB2004100687918A Expired - Lifetime CN1305896C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNA2006100092583A Pending CN1810292A (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNB2004100687903A Expired - Lifetime CN100404547C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CN2008101087539A Expired - Lifetime CN101333244B (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN201310590762.7A Pending CN103641885A (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNB99805836XA Ceased CN1260249C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质

Family Applications After (3)

Application Number Title Priority Date Filing Date
CNA2006100092583A Pending CN1810292A (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CNB2004100687903A Expired - Lifetime CN100404547C (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质
CN2008101087539A Expired - Lifetime CN101333244B (zh) 1998-05-06 1999-05-03 用离子交换层析纯化蛋白质

Country Status (21)

Country Link
US (10) US6489447B1 (sl)
EP (1) EP1075488B2 (sl)
JP (6) JP4469933B2 (sl)
KR (3) KR100960211B1 (sl)
CN (6) CN103641885A (sl)
AT (2) ATE370961T1 (sl)
AU (1) AU760048B2 (sl)
BR (1) BRPI9910332B8 (sl)
CA (1) CA2329829C (sl)
CY (1) CY1107000T1 (sl)
DE (3) DE69907439T3 (sl)
DK (2) DK1075488T4 (sl)
ES (3) ES2198913T5 (sl)
GE (1) GEP20104997B (sl)
HK (2) HK1055308A1 (sl)
IL (4) IL139035A0 (sl)
NZ (1) NZ507557A (sl)
PT (2) PT1308455E (sl)
SI (1) SI1308455T1 (sl)
WO (1) WO1999057134A1 (sl)
ZA (1) ZA200005879B (sl)

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