CN1305530C - 抗龋齿口腔用组合物 - Google Patents
抗龋齿口腔用组合物 Download PDFInfo
- Publication number
- CN1305530C CN1305530C CNB2005100727356A CN200510072735A CN1305530C CN 1305530 C CN1305530 C CN 1305530C CN B2005100727356 A CNB2005100727356 A CN B2005100727356A CN 200510072735 A CN200510072735 A CN 200510072735A CN 1305530 C CN1305530 C CN 1305530C
- Authority
- CN
- China
- Prior art keywords
- arginine
- oral composition
- calcium
- phytate
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 145
- 230000000675 anti-caries Effects 0.000 title claims description 13
- 239000004475 Arginine Substances 0.000 claims abstract description 124
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 119
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 100
- 239000011575 calcium Substances 0.000 claims abstract description 75
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 74
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 36
- 208000002925 dental caries Diseases 0.000 claims abstract description 35
- 150000001450 anions Chemical class 0.000 claims abstract description 33
- 230000000170 anti-cariogenic effect Effects 0.000 claims abstract description 11
- 235000002949 phytic acid Nutrition 0.000 claims description 71
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 70
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 46
- 239000002253 acid Substances 0.000 claims description 29
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 23
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 16
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 15
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 13
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 12
- WPEXVRDUEAJUGY-UHFFFAOYSA-B hexacalcium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C1OP([O-])([O-])=O WPEXVRDUEAJUGY-UHFFFAOYSA-B 0.000 claims description 11
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 5
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
- 239000001569 carbon dioxide Substances 0.000 claims description 4
- 235000011089 carbon dioxide Nutrition 0.000 claims description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical class OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 claims description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 239000004075 cariostatic agent Substances 0.000 abstract description 17
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- 230000001603 reducing effect Effects 0.000 abstract description 10
- 210000003298 dental enamel Anatomy 0.000 description 45
- 239000008103 glucose Substances 0.000 description 26
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 24
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 23
- 229910052698 phosphorus Inorganic materials 0.000 description 23
- 239000011574 phosphorus Substances 0.000 description 23
- 238000005115 demineralization Methods 0.000 description 22
- 238000004090 dissolution Methods 0.000 description 22
- 241000894006 Bacteria Species 0.000 description 21
- 230000002328 demineralizing effect Effects 0.000 description 21
- 238000011534 incubation Methods 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 210000003296 saliva Anatomy 0.000 description 18
- 230000001013 cariogenic effect Effects 0.000 description 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 239000002244 precipitate Substances 0.000 description 14
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 229940068041 phytic acid Drugs 0.000 description 12
- 239000000467 phytic acid Substances 0.000 description 12
- 150000001720 carbohydrates Chemical class 0.000 description 11
- 235000014633 carbohydrates Nutrition 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 150000007513 acids Chemical class 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 239000000551 dentifrice Substances 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- -1 anionic anions Chemical class 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000013049 sediment Substances 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- 229940124597 therapeutic agent Drugs 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 235000011054 acetic acid Nutrition 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
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- 230000004060 metabolic process Effects 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 239000005022 packaging material Substances 0.000 description 4
- 229940083982 sodium phytate Drugs 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 229950005228 bromoform Drugs 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| WO2002045611A2 (en) * | 2000-12-08 | 2002-06-13 | Brown, Dale, G. | Biofilm therapy process and elements |
| AU2004233706A1 (en) * | 2003-04-30 | 2004-11-11 | Asahi Breweries, Ltd. | Material for inhibiting enamel decalcification |
| US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
| US20040258629A1 (en) * | 2003-06-23 | 2004-12-23 | Boyd Thomas J. | Antiplaque confectionery dental composition |
| US8865135B2 (en) | 2003-06-23 | 2014-10-21 | Colgate-Palmolive Company | Stable dentifrice compositions |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| EP1960057A4 (en) * | 2005-12-16 | 2013-03-27 | David Kannar | SURFACE ACTIVE CALCIUM PHOSPHATES |
| US20070212449A1 (en) * | 2006-03-02 | 2007-09-13 | Shamsuddin Abulkalam M | Reduction of the titratable acidity and the prevention of tooth and other bone degeneration |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| AU2007249542B2 (en) | 2006-05-09 | 2009-11-05 | Colgate-Palmolive Company | Oral care regimen |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| EP2091505A2 (en) * | 2006-10-31 | 2009-08-26 | Oroscience, Inc | Process to form nano-sized materials, the compositions and uses thereof |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| EP2070422A1 (en) | 2007-12-05 | 2009-06-17 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products promoting dental health |
| JP2011511667A (ja) | 2008-02-08 | 2011-04-14 | コルゲート・パーモリブ・カンパニー | デンタルフロス |
| JP5606328B2 (ja) * | 2008-02-08 | 2014-10-15 | コルゲート・パーモリブ・カンパニー | 口腔ケア歯ブラシ |
| BRPI0906465A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composição efervesente, e, método |
| US20090202456A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Novel salts and their uses |
| CA2710583C (en) * | 2008-02-08 | 2015-10-06 | Colgate-Palmolive Company | Compositions and devices |
| PE20130148A1 (es) * | 2008-02-08 | 2013-02-11 | Colgate Palmolive Co | Producto para el cuidado oral y metodos de uso y fabricacion de los mismos |
| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| CA2711414C (en) * | 2008-02-08 | 2013-11-19 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| MY155709A (en) * | 2008-02-08 | 2015-11-13 | Colgate Palmolive Co | Oral care regimen |
| AR070355A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Composiciones, metodos para el tratamiento de la xerostomia y uso |
| AR070357A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Producto para cuidado oral y metodos de uso y manufactura del mismo |
| AR070587A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Composiciones efervescentes de limpieza y metodos de aplicacion |
| RU2010137267A (ru) * | 2008-02-08 | 2012-03-20 | Колгейт-Палмолив Компани (US) | Дентальная салфетка |
| EP2249764B1 (en) * | 2008-02-08 | 2019-07-31 | Colgate-Palmolive Company | Tooth sealant |
| WO2009100260A2 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Compositions and methods comprising basic amino acid peptides and proteases |
| AU2015215853B2 (en) * | 2008-02-08 | 2016-11-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| TWI566782B (zh) * | 2008-02-08 | 2017-01-21 | 美國棕欖公司 | 口腔保健產品及其使用方法與製造 |
| RU2476890C2 (ru) * | 2008-02-08 | 2013-02-27 | Колгейт-Палмолив Компани | Способы и системы для ухода за ротовой полостью |
| AR072341A1 (es) | 2008-02-08 | 2010-08-25 | Colgate Palmolive Co | Metodos para la produccion de bicarbonato de arginina |
| RU2469701C2 (ru) * | 2008-02-08 | 2012-12-20 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения |
| AU2012211481B2 (en) * | 2008-02-08 | 2013-08-22 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| RU2519329C2 (ru) * | 2008-02-08 | 2014-06-10 | Колгейт-Палмолив Компани | Композиции и устройства |
| AU2013200182B2 (en) * | 2008-02-08 | 2015-05-21 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| RU2550949C2 (ru) * | 2008-02-08 | 2015-05-20 | Колгей-Палмолив Компани | Композиции, включающие основную аминокислоту и растворимую карбонатную соль |
| EP2249770A4 (en) * | 2008-02-08 | 2014-02-19 | Colgate Palmolive Co | MOUTHPACKAGE PRODUCT WITH TWO COMPONENTS |
| RU2450554C1 (ru) * | 2008-02-08 | 2012-05-20 | Колгейт-Палмолив Компани | Напиток, включающий аргинин |
| RU2481820C2 (ru) * | 2008-02-08 | 2013-05-20 | Колгейт-Палмолив Компани | Средство для ухода за полостью рта и способы его применения и изготовления |
| US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
| RU2487699C2 (ru) * | 2008-11-25 | 2013-07-20 | Дзе Проктер Энд Гэмбл Компани | КОМПОЗИЦИИ ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА, СОДЕРЖАЩИЕ АМОРФНЫЙ КВАРЦ И ОБЛАДАЮЩИЕ НИЗКИМ ЗНАЧЕНИЕМ pH |
| BRPI0924734A2 (pt) | 2009-05-18 | 2016-01-26 | Colgate Palmolive Co | composição oral, e, métodos para preparar a composição oral, para alvejar um ingrediente ativo, para depositar um material bacteriostático ou bactericida sobre superfícies orais, para retardar ou previnir cárie dentária, método para ocluir túbulos dentinais, para tratar uma lesão por cárie, para calcificar uma polpa de dente exposta, e para calcificar a base de ou a totalidade de um buraco ou de uma fissura em um dente. |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| TWI499430B (zh) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | 抗侵蝕的牙膏組成物 |
| WO2011075472A1 (en) | 2009-12-18 | 2011-06-23 | Colgate-Palmolive Company | Methods for production of arginine bicarbonate at low pressure |
| US9035093B2 (en) * | 2009-12-18 | 2015-05-19 | Colgate-Palmolive Company | Methods for production of high concentration of arginine bicarbonate solution at high pressure |
| CN102844018B (zh) | 2009-12-29 | 2021-03-23 | 格雷斯公司 | 用于形成遮蔽膜的组合物及其制备和使用方法 |
| EP2528662B1 (en) | 2010-01-29 | 2018-10-17 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| DE102010003280A1 (de) | 2010-03-25 | 2011-02-03 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit pflanzlichen Peptiden |
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| US9717929B2 (en) * | 2010-12-07 | 2017-08-01 | Colgate-Palmolive Company | Dentifrice compositions containing calcium silicate and a basic amino acid |
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| BR112015012920A2 (pt) | 2012-12-06 | 2017-07-11 | Colgate Palmolive Co | gel oral para dor de dente e sensibilidade |
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| AU2014414756B2 (en) | 2014-12-23 | 2018-04-26 | Colgate-Palmolive Company | Oral care compositions |
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| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| EP4216908A1 (en) | 2020-09-28 | 2023-08-02 | The Procter & Gamble Company | Array of anticavity oral care compositions |
| WO2022067142A1 (en) | 2020-09-28 | 2022-03-31 | The Procter & Gamble Company | Oral care composition comprising hops and flavor |
| WO2022067141A1 (en) | 2020-09-28 | 2022-03-31 | The Procter & Gamble Company | Aqueous compositions comprising hops-metal complex |
| EP4216920A1 (en) | 2020-09-28 | 2023-08-02 | The Procter & Gamble Company | Oral care compositions comprising prenylated flavonoids |
| EP4312956A1 (en) | 2021-03-25 | 2024-02-07 | The Procter & Gamble Company | Oral care compositions comprising hops and sweetener |
| WO2022204715A1 (en) | 2021-03-25 | 2022-09-29 | The Procter & Gamble Company | Edible oral compositions comprising hops |
| BR112023019587A2 (pt) | 2021-03-25 | 2024-02-06 | Procter & Gamble | Composições para tratamento bucal que compreendem lúpulo |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
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| US20250120890A1 (en) | 2023-09-14 | 2025-04-17 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops Beta Acids And Tin |
| WO2025080747A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120891A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080746A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120897A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080743A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025076709A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
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| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| US4154813A (en) * | 1976-06-18 | 1979-05-15 | Israel Kleinberg | Means and method for improving natural defenses against caries |
| US4259316A (en) * | 1979-07-31 | 1981-03-31 | Lion Corporation | Oral composition for caries prophylaxis |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| EP0569666A2 (en) * | 1992-05-15 | 1993-11-18 | Kao Corporation | Composition comprising a monophosphate for use in the oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
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|---|---|---|---|---|
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
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| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
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| JPS61233612A (ja) * | 1985-04-10 | 1986-10-17 | Kao Corp | チユ−インガム |
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- 1996-03-05 US US08/611,206 patent/US5762911A/en not_active Expired - Lifetime
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- 1997-03-04 BR BRPI9711797-8A patent/BR9711797B1/pt not_active IP Right Cessation
- 1997-03-04 CN CNB2005100727356A patent/CN1305530C/zh not_active Expired - Lifetime
- 1997-03-04 NZ NZ332172A patent/NZ332172A/xx not_active IP Right Cessation
- 1997-03-04 JP JP53207497A patent/JP3980645B2/ja not_active Expired - Lifetime
- 1997-03-04 EP EP97917135A patent/EP0928184B1/en not_active Expired - Lifetime
- 1997-03-04 CA CA002252071A patent/CA2252071C/en not_active Expired - Lifetime
- 1997-03-04 AU AU25563/97A patent/AU719465B2/en not_active Expired
- 1997-03-04 CN CNB971969965A patent/CN1206978C/zh not_active Expired - Lifetime
- 1997-03-04 ES ES97917135T patent/ES2328301T3/es not_active Expired - Lifetime
- 1997-03-04 PT PT97917135T patent/PT928184E/pt unknown
- 1997-03-04 DK DK97917135T patent/DK0928184T3/da active
- 1997-03-04 WO PCT/US1997/005273 patent/WO1997032565A1/en not_active Ceased
- 1997-03-04 AT AT97917135T patent/ATE432685T1/de active
- 1997-03-04 DE DE69739440T patent/DE69739440D1/de not_active Expired - Lifetime
-
1998
- 1998-02-19 US US09/026,132 patent/US6217851B1/en not_active Expired - Lifetime
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2006
- 2006-06-26 JP JP2006175656A patent/JP2006265268A/ja not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| US4154813A (en) * | 1976-06-18 | 1979-05-15 | Israel Kleinberg | Means and method for improving natural defenses against caries |
| US4259316A (en) * | 1979-07-31 | 1981-03-31 | Lion Corporation | Oral composition for caries prophylaxis |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| EP0569666A2 (en) * | 1992-05-15 | 1993-11-18 | Kao Corporation | Composition comprising a monophosphate for use in the oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK0928184T3 (da) | 2009-09-28 |
| BR9711797B1 (pt) | 2010-12-14 |
| JP3980645B2 (ja) | 2007-09-26 |
| CN1206978C (zh) | 2005-06-22 |
| WO1997032565A1 (en) | 1997-09-12 |
| ES2328301T3 (es) | 2009-11-11 |
| AU719465B2 (en) | 2000-05-11 |
| ATE432685T1 (de) | 2009-06-15 |
| EP0928184A4 (en) | 1999-10-20 |
| BR9711797A (pt) | 2000-01-18 |
| CN1701815A (zh) | 2005-11-30 |
| PT928184E (pt) | 2009-09-09 |
| JP2001504083A (ja) | 2001-03-27 |
| NZ332172A (en) | 2000-11-24 |
| AU2556397A (en) | 1997-09-22 |
| JP2006265268A (ja) | 2006-10-05 |
| DE69739440D1 (de) | 2009-07-16 |
| EP0928184A1 (en) | 1999-07-14 |
| EP0928184B1 (en) | 2009-06-03 |
| US6217851B1 (en) | 2001-04-17 |
| CA2252071C (en) | 2004-12-21 |
| CA2252071A1 (en) | 1997-09-12 |
| US5762911A (en) | 1998-06-09 |
| CN1227483A (zh) | 1999-09-01 |
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