CN1298709C - 用作抗肿瘤剂的噻吩和噻唑磺酰胺化合物 - Google Patents
用作抗肿瘤剂的噻吩和噻唑磺酰胺化合物 Download PDFInfo
- Publication number
- CN1298709C CN1298709C CNB028212150A CN02821215A CN1298709C CN 1298709 C CN1298709 C CN 1298709C CN B028212150 A CNB028212150 A CN B028212150A CN 02821215 A CN02821215 A CN 02821215A CN 1298709 C CN1298709 C CN 1298709C
- Authority
- CN
- China
- Prior art keywords
- sulphonamide
- compound
- alkyl
- halogen
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35201201P | 2001-10-25 | 2001-10-25 | |
US60/352,012 | 2001-10-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1575286A CN1575286A (zh) | 2005-02-02 |
CN1298709C true CN1298709C (zh) | 2007-02-07 |
Family
ID=23383421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028212150A Expired - Fee Related CN1298709C (zh) | 2001-10-25 | 2002-10-15 | 用作抗肿瘤剂的噻吩和噻唑磺酰胺化合物 |
Country Status (34)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1401825E (pt) * | 2001-06-11 | 2009-10-23 | Virochem Pharma Inc | Compostos e métodos para o tratamento ou para a prevenção de infecções com flavivírus |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
WO2003104218A1 (en) * | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Nf-:b inhibitors |
ES2345438T3 (es) | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
WO2006030941A1 (ja) * | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
AU2006217690B2 (en) * | 2005-02-28 | 2012-03-15 | Eisai R & D Management Co., Ltd. | Novel use of sulfonamide compound in combination with angiogenesis inhibitor |
WO2006090921A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物のリンパ球活性化抑制作用 |
AU2006217692A1 (en) | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | Novel combinational use of sulfonamide compound |
JP5030947B2 (ja) | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
US7208506B2 (en) * | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
US7625896B2 (en) | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
US7939532B2 (en) | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
KR20090086081A (ko) * | 2006-11-15 | 2009-08-10 | 바이로켐 파마 인코포레이티드 | 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체 |
CN101675033A (zh) | 2007-05-16 | 2010-03-17 | 霍夫曼-拉罗奇有限公司 | 芳基吡啶基磺酰胺衍生物,它们的制备和作为药剂的应用 |
CN101899008B (zh) * | 2010-05-20 | 2012-10-17 | 中国人民解放军第二军医大学 | N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途 |
CN103450149B (zh) * | 2012-06-01 | 2015-10-14 | 中国科学院上海有机化学研究所 | 苯基噻吩磺酰胺类化合物及其制备方法和用途 |
JP6364967B2 (ja) * | 2014-05-30 | 2018-08-01 | 東ソー株式会社 | ジチエノベンゾジチオフェンの製造方法 |
CN106588868A (zh) * | 2016-11-16 | 2017-04-26 | 武汉理工大学 | 一种2‑溴‑3‑噻吩甲酸中间体的合成方法 |
CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
CN110835345A (zh) * | 2018-08-17 | 2020-02-25 | 中国科学院上海药物研究所 | 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途 |
CN109265437A (zh) * | 2018-10-19 | 2019-01-25 | 凯莱英医药集团(天津)股份有限公司 | 一种3-羟基噻吩-2-羧酸酯类化合物的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1058401A (zh) * | 1990-07-17 | 1992-02-05 | 伊莱利利公司 | 抗肿瘤组合物和治疗方法 |
EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
CN1076447A (zh) * | 1992-03-13 | 1993-09-22 | 伊莱利利公司 | 抗肿瘤组合物及治疗方法 |
WO1998001440A2 (en) * | 1996-07-05 | 1998-01-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA813332B (en) * | 1980-06-21 | 1982-05-26 | Pfizer | Larvicides and isecticides |
EP0929540A4 (en) * | 1996-10-04 | 2001-12-12 | Lilly Co Eli | ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS |
JP4316787B2 (ja) | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
-
2002
- 2002-10-11 TW TW091123452A patent/TWI281916B/zh not_active IP Right Cessation
- 2002-10-15 HU HU0401638A patent/HUP0401638A3/hu unknown
- 2002-10-15 BR BR0212386-0A patent/BR0212386A/pt not_active IP Right Cessation
- 2002-10-15 UA UA20040403046A patent/UA75716C2/uk unknown
- 2002-10-15 IL IL16085102A patent/IL160851A0/xx unknown
- 2002-10-15 PT PT02802117T patent/PT1442030E/pt unknown
- 2002-10-15 MX MXPA04003886A patent/MXPA04003886A/es active IP Right Grant
- 2002-10-15 EA EA200400582A patent/EA006081B1/ru not_active IP Right Cessation
- 2002-10-15 ES ES02802117T patent/ES2269816T3/es not_active Expired - Lifetime
- 2002-10-15 DK DK02802117T patent/DK1442030T3/da active
- 2002-10-15 AU AU2002334817A patent/AU2002334817B2/en not_active Ceased
- 2002-10-15 NZ NZ531136A patent/NZ531136A/en not_active IP Right Cessation
- 2002-10-15 CN CNB028212150A patent/CN1298709C/zh not_active Expired - Fee Related
- 2002-10-15 KR KR1020047006058A patent/KR100913471B1/ko not_active IP Right Cessation
- 2002-10-15 SI SI200230399T patent/SI1442030T1/sl unknown
- 2002-10-15 EP EP02802117A patent/EP1442030B1/en not_active Expired - Lifetime
- 2002-10-15 PL PL368234A patent/PL208083B1/pl not_active IP Right Cessation
- 2002-10-15 AT AT02802117T patent/ATE338033T1/de active
- 2002-10-15 CA CA2463300A patent/CA2463300C/en not_active Expired - Fee Related
- 2002-10-15 DE DE60214413T patent/DE60214413T2/de not_active Expired - Lifetime
- 2002-10-15 JP JP2003538145A patent/JP4464681B2/ja not_active Expired - Fee Related
- 2002-10-15 US US10/490,935 patent/US7084170B2/en not_active Expired - Fee Related
- 2002-10-15 WO PCT/US2002/031568 patent/WO2003035629A1/en active IP Right Grant
- 2002-10-21 EG EG2002101152A patent/EG26021A/en active
- 2002-10-23 AR ARP020104007A patent/AR037248A1/es active IP Right Grant
- 2002-10-23 MY MYPI20023959A patent/MY130718A/en unknown
- 2002-10-24 SV SV2002001367A patent/SV2004001367A/es unknown
- 2002-10-25 PE PE2002001051A patent/PE20030574A1/es not_active Application Discontinuation
-
2004
- 2004-03-11 IL IL160851A patent/IL160851A/en not_active IP Right Cessation
- 2004-03-30 NO NO20041316A patent/NO20041316L/no not_active Application Discontinuation
- 2004-04-22 ZA ZA200403089A patent/ZA200403089B/en unknown
- 2004-04-23 EC EC2004005078A patent/ECSP045078A/es unknown
- 2004-04-26 HR HRP20040371AA patent/HRP20040371B1/xx not_active IP Right Cessation
-
2005
- 2005-01-14 HK HK05100403A patent/HK1068337A1/xx not_active IP Right Cessation
-
2006
- 2006-06-06 US US11/447,457 patent/US7250430B2/en not_active Expired - Fee Related
- 2006-11-16 CY CY20061101669T patent/CY1106247T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1058401A (zh) * | 1990-07-17 | 1992-02-05 | 伊莱利利公司 | 抗肿瘤组合物和治疗方法 |
EP0513979A1 (en) * | 1991-03-26 | 1992-11-19 | Merck & Co. Inc. | Angiotensin II antagonists incorporating a substituted thiophene or furan |
CN1076447A (zh) * | 1992-03-13 | 1993-09-22 | 伊莱利利公司 | 抗肿瘤组合物及治疗方法 |
WO1998001440A2 (en) * | 1996-07-05 | 1998-01-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070207 Termination date: 20131015 |