CN1296359C - 杂芳基衍生物及其作为药物的应用 - Google Patents

杂芳基衍生物及其作为药物的应用 Download PDF

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Publication number
CN1296359C
CN1296359C CNB018131379A CN01813137A CN1296359C CN 1296359 C CN1296359 C CN 1296359C CN B018131379 A CNB018131379 A CN B018131379A CN 01813137 A CN01813137 A CN 01813137A CN 1296359 C CN1296359 C CN 1296359C
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CN
China
Prior art keywords
alkyl
aryl
mono
acridine
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018131379A
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English (en)
Chinese (zh)
Other versions
CN1443172A (zh
Inventor
P·艾米格
E·甘瑟尔
B·尼克尔
S·巴斯尼尔
G·巴施尔
T·拜克尔斯
B·奥伊
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Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
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Filing date
Publication date
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Publication of CN1443172A publication Critical patent/CN1443172A/zh
Application granted granted Critical
Publication of CN1296359C publication Critical patent/CN1296359C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018131379A 2000-07-21 2001-07-18 杂芳基衍生物及其作为药物的应用 Expired - Fee Related CN1296359C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035927.2 2000-07-21
DE10035927A DE10035927A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
CN1443172A CN1443172A (zh) 2003-09-17
CN1296359C true CN1296359C (zh) 2007-01-24

Family

ID=7649979

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018131379A Expired - Fee Related CN1296359C (zh) 2000-07-21 2001-07-18 杂芳基衍生物及其作为药物的应用

Country Status (28)

Country Link
US (1) US6706722B2 (https=)
EP (1) EP1301485B1 (https=)
JP (1) JP2004504382A (https=)
KR (1) KR20030022296A (https=)
CN (1) CN1296359C (https=)
AR (1) AR033383A1 (https=)
AT (1) ATE365717T1 (https=)
AU (2) AU2001289675B2 (https=)
BG (1) BG107507A (https=)
BR (1) BR0112591A (https=)
CA (1) CA2353360A1 (https=)
CY (1) CY1106890T1 (https=)
CZ (1) CZ2003427A3 (https=)
DE (2) DE10035927A1 (https=)
DK (1) DK1301485T3 (https=)
ES (1) ES2291349T3 (https=)
HU (1) HUP0303729A3 (https=)
IL (1) IL153476A0 (https=)
MX (1) MXPA02012564A (https=)
NO (1) NO324939B1 (https=)
NZ (1) NZ524155A (https=)
PL (1) PL358808A1 (https=)
PT (1) PT1301485E (https=)
RU (1) RU2267488C2 (https=)
SK (1) SK1932003A3 (https=)
UA (1) UA75085C2 (https=)
WO (1) WO2002008194A1 (https=)
ZA (1) ZA200210411B (https=)

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DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
CN100509790C (zh) * 2002-06-29 2009-07-08 赞塔里斯有限公司 芳基羰基哌嗪和杂芳基羰基哌嗪及其治疗良性和恶性肿瘤疾病的用途
AU2003232785A1 (en) * 2002-07-17 2004-02-02 Zentaris Gmbh Novel anthracene derivatives and the use thereof as a medicament
US7125461B2 (en) * 2003-05-07 2006-10-24 L & L Products, Inc. Activatable material for sealing, baffling or reinforcing and method of forming same
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7249415B2 (en) * 2003-06-26 2007-07-31 Zephyros, Inc. Method of forming members for sealing or baffling
DE10331500A1 (de) * 2003-07-11 2005-02-24 Zentaris Gmbh Neue Acridin-Derivate und deren Verwendung als Arzneimittel
WO2006080043A2 (en) * 2005-01-27 2006-08-03 Alma Mater Studiorum- Universita' Di Bologna Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2183228B1 (en) * 2007-07-26 2014-08-20 Vitae Pharmaceuticals, Inc. CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001059A1 (es) * 2008-05-01 2010-11-12 Boehringer Ingelheim Int Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
PH12013500808A1 (en) 2010-11-02 2015-10-07 Boehringer Ingelheim Int Pharmaceutical combinations for the treatment of metabolic disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196724A (zh) * 1996-06-29 1998-10-21 三进制药株式会社 新哌嗪衍生物及其制造方法

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FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
RU2126001C1 (ru) * 1995-01-10 1999-02-10 Самдзин Фармасьютикал Ко., Лтд Производные пиперазина и фармацевтическая композиция на их основе
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
CA2342251A1 (en) 1998-08-28 2000-03-09 Scios Inc. Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase
WO2000051614A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1196724A (zh) * 1996-06-29 1998-10-21 三进制药株式会社 新哌嗪衍生物及其制造方法

Also Published As

Publication number Publication date
ES2291349T3 (es) 2008-03-01
CN1443172A (zh) 2003-09-17
US6706722B2 (en) 2004-03-16
AR033383A1 (es) 2003-12-17
DE10035927A1 (de) 2002-03-07
IL153476A0 (en) 2003-07-06
MXPA02012564A (es) 2003-09-22
WO2002008194A1 (de) 2002-01-31
EP1301485B1 (de) 2007-06-27
US20020132821A1 (en) 2002-09-19
JP2004504382A (ja) 2004-02-12
KR20030022296A (ko) 2003-03-15
EP1301485A1 (de) 2003-04-16
NZ524155A (en) 2005-04-29
CA2353360A1 (en) 2002-01-21
HUP0303729A2 (hu) 2004-03-01
DE50112669D1 (de) 2007-08-09
ZA200210411B (en) 2003-02-26
RU2267488C2 (ru) 2006-01-10
NO20030301L (no) 2003-03-11
CY1106890T1 (el) 2012-09-26
NO20030301D0 (no) 2003-01-20
BR0112591A (pt) 2003-07-22
NO324939B1 (no) 2008-01-07
DK1301485T3 (da) 2007-11-05
PT1301485E (pt) 2007-08-30
WO2002008194A8 (de) 2003-05-08
HUP0303729A3 (en) 2009-01-28
UA75085C2 (en) 2006-03-15
BG107507A (bg) 2003-09-30
SK1932003A3 (en) 2003-10-07
AU2001289675B2 (en) 2005-04-07
PL358808A1 (en) 2004-08-23
HK1057549A1 (en) 2004-04-08
ATE365717T1 (de) 2007-07-15
CZ2003427A3 (cs) 2003-06-18
AU8967501A (en) 2002-02-05

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070124

Termination date: 20090818