CN1284781C - 具有抗肿瘤活性的多环化合物 - Google Patents

具有抗肿瘤活性的多环化合物 Download PDF

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Publication number
CN1284781C
CN1284781C CNB028197712A CN02819771A CN1284781C CN 1284781 C CN1284781 C CN 1284781C CN B028197712 A CNB028197712 A CN B028197712A CN 02819771 A CN02819771 A CN 02819771A CN 1284781 C CN1284781 C CN 1284781C
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CN
China
Prior art keywords
diaza
benzo
fluoren
ethylamino
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028197712A
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English (en)
Chinese (zh)
Other versions
CN1610681A (zh
Inventor
青山恒久
川崎健一
增渕宫子
大塚达男
坂田清朗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CN1610681A publication Critical patent/CN1610681A/zh
Application granted granted Critical
Publication of CN1284781C publication Critical patent/CN1284781C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB028197712A 2001-10-05 2002-09-25 具有抗肿瘤活性的多环化合物 Expired - Fee Related CN1284781C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123908 2001-10-05
EP01123908.4 2001-10-05

Publications (2)

Publication Number Publication Date
CN1610681A CN1610681A (zh) 2005-04-27
CN1284781C true CN1284781C (zh) 2006-11-15

Family

ID=8178868

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028197712A Expired - Fee Related CN1284781C (zh) 2001-10-05 2002-09-25 具有抗肿瘤活性的多环化合物

Country Status (16)

Country Link
US (1) US6680326B2 (https=)
EP (1) EP1436293B1 (https=)
JP (1) JP4369229B2 (https=)
KR (1) KR100676114B1 (https=)
CN (1) CN1284781C (https=)
AR (1) AR037327A1 (https=)
AT (1) ATE316971T1 (https=)
AU (1) AU2002342752B2 (https=)
BR (1) BR0213122A (https=)
CA (1) CA2461572C (https=)
DE (1) DE60209029T2 (https=)
ES (1) ES2256552T3 (https=)
MX (1) MXPA04003173A (https=)
PL (1) PL370530A1 (https=)
RU (1) RU2315050C2 (https=)
WO (1) WO2003031444A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
CN103204781B (zh) * 2013-03-14 2015-04-01 武汉大学 2,7–二取代芴酮衍生物及其制备方法与应用
CN110448555B (zh) * 2019-09-10 2020-10-23 河南省人民医院 多环化合物在制备抗肿瘤药物中的应用及抗肿瘤药物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW440562B (en) * 1994-05-20 2001-06-16 Taiho Pharmaceutical Co Ltd Condensed-indan derivative and pharmaceutically acceptable salts thereof
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors
FR2801309B1 (fr) 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ES2256552T3 (es) 2006-07-16
US6680326B2 (en) 2004-01-20
CA2461572A1 (en) 2003-04-17
WO2003031444A1 (en) 2003-04-17
AR037327A1 (es) 2004-11-03
JP4369229B2 (ja) 2009-11-18
US20030073691A1 (en) 2003-04-17
CN1610681A (zh) 2005-04-27
PL370530A1 (en) 2005-05-30
RU2004114245A (ru) 2005-06-27
MXPA04003173A (es) 2004-07-27
CA2461572C (en) 2011-02-15
KR100676114B1 (ko) 2007-02-02
BR0213122A (pt) 2004-09-21
RU2315050C2 (ru) 2008-01-20
EP1436293A1 (en) 2004-07-14
JP2005504846A (ja) 2005-02-17
AU2002342752B2 (en) 2007-11-15
EP1436293B1 (en) 2006-02-01
DE60209029D1 (de) 2006-04-13
ATE316971T1 (de) 2006-02-15
KR20040048926A (ko) 2004-06-10
DE60209029T2 (de) 2006-09-28

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061115

Termination date: 20130925