JP4369229B2 - 抗腫瘍活性を有する多環式化合物 - Google Patents

抗腫瘍活性を有する多環式化合物 Download PDF

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Publication number
JP4369229B2
JP4369229B2 JP2003534427A JP2003534427A JP4369229B2 JP 4369229 B2 JP4369229 B2 JP 4369229B2 JP 2003534427 A JP2003534427 A JP 2003534427A JP 2003534427 A JP2003534427 A JP 2003534427A JP 4369229 B2 JP4369229 B2 JP 4369229B2
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JP
Japan
Prior art keywords
diaza
benzo
fluoren
ethylamino
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003534427A
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English (en)
Japanese (ja)
Other versions
JP2005504846A5 (https=
JP2005504846A (ja
Inventor
恒久 青山
建一 川崎
みや子 増渕
達男 大塚
清明 坂田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
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Filing date
Publication date
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Publication of JP2005504846A publication Critical patent/JP2005504846A/ja
Publication of JP2005504846A5 publication Critical patent/JP2005504846A5/ja
Application granted granted Critical
Publication of JP4369229B2 publication Critical patent/JP4369229B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2003534427A 2001-10-05 2002-09-25 抗腫瘍活性を有する多環式化合物 Expired - Fee Related JP4369229B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01123908 2001-10-05
PCT/EP2002/010722 WO2003031444A1 (en) 2001-10-05 2002-09-25 Polycyclic compounds having anti-tumor activity

Publications (3)

Publication Number Publication Date
JP2005504846A JP2005504846A (ja) 2005-02-17
JP2005504846A5 JP2005504846A5 (https=) 2008-11-13
JP4369229B2 true JP4369229B2 (ja) 2009-11-18

Family

ID=8178868

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003534427A Expired - Fee Related JP4369229B2 (ja) 2001-10-05 2002-09-25 抗腫瘍活性を有する多環式化合物

Country Status (16)

Country Link
US (1) US6680326B2 (https=)
EP (1) EP1436293B1 (https=)
JP (1) JP4369229B2 (https=)
KR (1) KR100676114B1 (https=)
CN (1) CN1284781C (https=)
AR (1) AR037327A1 (https=)
AT (1) ATE316971T1 (https=)
AU (1) AU2002342752B2 (https=)
BR (1) BR0213122A (https=)
CA (1) CA2461572C (https=)
DE (1) DE60209029T2 (https=)
ES (1) ES2256552T3 (https=)
MX (1) MXPA04003173A (https=)
PL (1) PL370530A1 (https=)
RU (1) RU2315050C2 (https=)
WO (1) WO2003031444A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
CN103204781B (zh) * 2013-03-14 2015-04-01 武汉大学 2,7–二取代芴酮衍生物及其制备方法与应用
CN110448555B (zh) * 2019-09-10 2020-10-23 河南省人民医院 多环化合物在制备抗肿瘤药物中的应用及抗肿瘤药物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW440562B (en) * 1994-05-20 2001-06-16 Taiho Pharmaceutical Co Ltd Condensed-indan derivative and pharmaceutically acceptable salts thereof
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors
FR2801309B1 (fr) 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ES2256552T3 (es) 2006-07-16
US6680326B2 (en) 2004-01-20
CA2461572A1 (en) 2003-04-17
WO2003031444A1 (en) 2003-04-17
AR037327A1 (es) 2004-11-03
US20030073691A1 (en) 2003-04-17
CN1610681A (zh) 2005-04-27
CN1284781C (zh) 2006-11-15
PL370530A1 (en) 2005-05-30
RU2004114245A (ru) 2005-06-27
MXPA04003173A (es) 2004-07-27
CA2461572C (en) 2011-02-15
KR100676114B1 (ko) 2007-02-02
BR0213122A (pt) 2004-09-21
RU2315050C2 (ru) 2008-01-20
EP1436293A1 (en) 2004-07-14
JP2005504846A (ja) 2005-02-17
AU2002342752B2 (en) 2007-11-15
EP1436293B1 (en) 2006-02-01
DE60209029D1 (de) 2006-04-13
ATE316971T1 (de) 2006-02-15
KR20040048926A (ko) 2004-06-10
DE60209029T2 (de) 2006-09-28

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