DE60209029T2 - Polycyclische verbindungen mit antitumor-wirkung - Google Patents

Polycyclische verbindungen mit antitumor-wirkung Download PDF

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Publication number
DE60209029T2
DE60209029T2 DE60209029T DE60209029T DE60209029T2 DE 60209029 T2 DE60209029 T2 DE 60209029T2 DE 60209029 T DE60209029 T DE 60209029T DE 60209029 T DE60209029 T DE 60209029T DE 60209029 T2 DE60209029 T2 DE 60209029T2
Authority
DE
Germany
Prior art keywords
diaza
benzo
ethylamino
dimethylamino
fluoren
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60209029T
Other languages
German (de)
English (en)
Other versions
DE60209029D1 (de
Inventor
Tsunehisał701 Park-front Residence Yokohama-shi AOYAMA
Kenichi Fujisawa-shi KAWASAKI
Miyako Yokohama-shi MASUBUCHI
Tatsuo Kamakura-shi OHTSUKA
Kiyoaki Sagamihara-shi SAKATA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60209029D1 publication Critical patent/DE60209029D1/de
Application granted granted Critical
Publication of DE60209029T2 publication Critical patent/DE60209029T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60209029T 2001-10-05 2002-09-25 Polycyclische verbindungen mit antitumor-wirkung Expired - Lifetime DE60209029T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01123908 2001-10-05
EP01123908 2001-10-05
PCT/EP2002/010722 WO2003031444A1 (en) 2001-10-05 2002-09-25 Polycyclic compounds having anti-tumor activity

Publications (2)

Publication Number Publication Date
DE60209029D1 DE60209029D1 (de) 2006-04-13
DE60209029T2 true DE60209029T2 (de) 2006-09-28

Family

ID=8178868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209029T Expired - Lifetime DE60209029T2 (de) 2001-10-05 2002-09-25 Polycyclische verbindungen mit antitumor-wirkung

Country Status (16)

Country Link
US (1) US6680326B2 (https=)
EP (1) EP1436293B1 (https=)
JP (1) JP4369229B2 (https=)
KR (1) KR100676114B1 (https=)
CN (1) CN1284781C (https=)
AR (1) AR037327A1 (https=)
AT (1) ATE316971T1 (https=)
AU (1) AU2002342752B2 (https=)
BR (1) BR0213122A (https=)
CA (1) CA2461572C (https=)
DE (1) DE60209029T2 (https=)
ES (1) ES2256552T3 (https=)
MX (1) MXPA04003173A (https=)
PL (1) PL370530A1 (https=)
RU (1) RU2315050C2 (https=)
WO (1) WO2003031444A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
CN103204781B (zh) * 2013-03-14 2015-04-01 武汉大学 2,7–二取代芴酮衍生物及其制备方法与应用
CN110448555B (zh) * 2019-09-10 2020-10-23 河南省人民医院 多环化合物在制备抗肿瘤药物中的应用及抗肿瘤药物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW440562B (en) * 1994-05-20 2001-06-16 Taiho Pharmaceutical Co Ltd Condensed-indan derivative and pharmaceutically acceptable salts thereof
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors
FR2801309B1 (fr) 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ES2256552T3 (es) 2006-07-16
US6680326B2 (en) 2004-01-20
CA2461572A1 (en) 2003-04-17
WO2003031444A1 (en) 2003-04-17
AR037327A1 (es) 2004-11-03
JP4369229B2 (ja) 2009-11-18
US20030073691A1 (en) 2003-04-17
CN1610681A (zh) 2005-04-27
CN1284781C (zh) 2006-11-15
PL370530A1 (en) 2005-05-30
RU2004114245A (ru) 2005-06-27
MXPA04003173A (es) 2004-07-27
CA2461572C (en) 2011-02-15
KR100676114B1 (ko) 2007-02-02
BR0213122A (pt) 2004-09-21
RU2315050C2 (ru) 2008-01-20
EP1436293A1 (en) 2004-07-14
JP2005504846A (ja) 2005-02-17
AU2002342752B2 (en) 2007-11-15
EP1436293B1 (en) 2006-02-01
DE60209029D1 (de) 2006-04-13
ATE316971T1 (de) 2006-02-15
KR20040048926A (ko) 2004-06-10

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