AU2002342752B2 - Polycyclic compounds having anti-tumor activity - Google Patents

Polycyclic compounds having anti-tumor activity Download PDF

Info

Publication number
AU2002342752B2
AU2002342752B2 AU2002342752A AU2002342752A AU2002342752B2 AU 2002342752 B2 AU2002342752 B2 AU 2002342752B2 AU 2002342752 A AU2002342752 A AU 2002342752A AU 2002342752 A AU2002342752 A AU 2002342752A AU 2002342752 B2 AU2002342752 B2 AU 2002342752B2
Authority
AU
Australia
Prior art keywords
benzo
diaza
fluoren
ethylamino
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002342752A
Other languages
English (en)
Other versions
AU2002342752A1 (en
Inventor
Tsunehisa Aoyama
Kenichi Kawasaki
Miyako Masubuchi
Tatsuo Ohtsuka
Kiyoaki Sakata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2002342752A1 publication Critical patent/AU2002342752A1/en
Application granted granted Critical
Publication of AU2002342752B2 publication Critical patent/AU2002342752B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2002342752A 2001-10-05 2002-09-25 Polycyclic compounds having anti-tumor activity Ceased AU2002342752B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01123908 2001-10-05
EP01123908.4 2001-10-05
PCT/EP2002/010722 WO2003031444A1 (en) 2001-10-05 2002-09-25 Polycyclic compounds having anti-tumor activity

Publications (2)

Publication Number Publication Date
AU2002342752A1 AU2002342752A1 (en) 2003-07-03
AU2002342752B2 true AU2002342752B2 (en) 2007-11-15

Family

ID=8178868

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002342752A Ceased AU2002342752B2 (en) 2001-10-05 2002-09-25 Polycyclic compounds having anti-tumor activity

Country Status (16)

Country Link
US (1) US6680326B2 (https=)
EP (1) EP1436293B1 (https=)
JP (1) JP4369229B2 (https=)
KR (1) KR100676114B1 (https=)
CN (1) CN1284781C (https=)
AR (1) AR037327A1 (https=)
AT (1) ATE316971T1 (https=)
AU (1) AU2002342752B2 (https=)
BR (1) BR0213122A (https=)
CA (1) CA2461572C (https=)
DE (1) DE60209029T2 (https=)
ES (1) ES2256552T3 (https=)
MX (1) MXPA04003173A (https=)
PL (1) PL370530A1 (https=)
RU (1) RU2315050C2 (https=)
WO (1) WO2003031444A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
CN103204781B (zh) * 2013-03-14 2015-04-01 武汉大学 2,7–二取代芴酮衍生物及其制备方法与应用
CN110448555B (zh) * 2019-09-10 2020-10-23 河南省人民医院 多环化合物在制备抗肿瘤药物中的应用及抗肿瘤药物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713870A1 (en) * 1994-05-20 1996-05-29 Taiho Pharmaceutical Co., Ltd. Novel fused indan derivative and pharmaceutically acceptable salt thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors
FR2801309B1 (fr) 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713870A1 (en) * 1994-05-20 1996-05-29 Taiho Pharmaceutical Co., Ltd. Novel fused indan derivative and pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
ES2256552T3 (es) 2006-07-16
US6680326B2 (en) 2004-01-20
CA2461572A1 (en) 2003-04-17
WO2003031444A1 (en) 2003-04-17
AR037327A1 (es) 2004-11-03
JP4369229B2 (ja) 2009-11-18
US20030073691A1 (en) 2003-04-17
CN1610681A (zh) 2005-04-27
CN1284781C (zh) 2006-11-15
PL370530A1 (en) 2005-05-30
RU2004114245A (ru) 2005-06-27
MXPA04003173A (es) 2004-07-27
CA2461572C (en) 2011-02-15
KR100676114B1 (ko) 2007-02-02
BR0213122A (pt) 2004-09-21
RU2315050C2 (ru) 2008-01-20
EP1436293A1 (en) 2004-07-14
JP2005504846A (ja) 2005-02-17
EP1436293B1 (en) 2006-02-01
DE60209029D1 (de) 2006-04-13
ATE316971T1 (de) 2006-02-15
KR20040048926A (ko) 2004-06-10
DE60209029T2 (de) 2006-09-28

Similar Documents

Publication Publication Date Title
AU2020219797B2 (en) Process for preparing enantiomerically enriched jak inhibitors
FI113765B (fi) Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi
JP3457737B2 (ja) 三環式誘導体、その製造方法及び温血動物において抗癌作用を発生させるために使用する薬剤学的組成物
US6395733B1 (en) Heterocyclic ring-fused pyrimidine derivatives
CN117800976A (zh) 一类含氮杂环类化合物、制备方法和用途
EP0831829A1 (en) Heterocyclic ring-fused pyrimidine derivatives
RU2137774C1 (ru) Способ получения 9-аминокамптотецина и сульфонилоксипроизводные 9-нитро- или 9-амино-20(s)-камптотецина
CN116528871A (zh) 一种吡唑并喹唑啉类化合物、其制备方法及应用
AU2002342752B2 (en) Polycyclic compounds having anti-tumor activity
CN117645598A (zh) 氮杂二并多元稠环化合物及其药物组合物和应用
FI81099B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva mitomycinanaloger.
Wahe et al. Heterocycles of biological importance. Part 6. The formation of novel biologically active pyrimido [1, 2-a] benzimid-azoles from electron deficient alkynes and 2-aminobenzimidazoles
CN110156817B (zh) 双吴茱萸碱分子抗肿瘤衍生物及其制备与应用
AU2002342752A1 (en) Polycyclic compounds having anti-tumor activity
AU680431B2 (en) 2,5-disubstituted isoquindazole-6-(2H)-ones
US3819627A (en) 1-substituted-3,4-dihydro-2(1h)-quinazolinones
CA2271940C (en) Novel phenanthridinium derivatives
CN101544636A (zh) 多卤代异喹啉类衍生物及其合成方法
US6946472B2 (en) Polycyclic compounds exhibiting anti-tumor activities
Moinet-Hedin et al. In vitro cytotoxicity of carbazole derivatives. V. 9-Halogeno-substituted 5, 11-dimethyl-6H-pyrido [3, 2-b] carbazoles
El-Hiti A Convenient Synthesis of 1, 2-Dihydro-1, 2, 4-triazolo (3, 2-b) quinazolin-9 (1H)-ones and Their 1, 2, 4-Triazolo Derivatives.
AU713107B2 (en) New pyrido-thiopyranoindazoles with antitumor activity
Hajpál et al. Synthesis of as‐triazino [5, 6‐b] quinoline, a new heterocyclic ring system
CN118206507A (zh) 一种含硒化合物及其制备方法与用途
ES2273088T3 (es) Procedimiento para la preparacion de compuestos de imidazolilo.

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired