CN1276911C - 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法 - Google Patents

具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法 Download PDF

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Publication number
CN1276911C
CN1276911C CNB011282347A CN01128234A CN1276911C CN 1276911 C CN1276911 C CN 1276911C CN B011282347 A CNB011282347 A CN B011282347A CN 01128234 A CN01128234 A CN 01128234A CN 1276911 C CN1276911 C CN 1276911C
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CN
China
Prior art keywords
compound
amino
preparation
dmso
novel
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB011282347A
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English (en)
Chinese (zh)
Other versions
CN1408703A (zh
Inventor
程卯生
潘莉
冀蕾
张莉
沈建民
宋桂兰
李志清
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiutai Pharmaceutical Co Ltd Jinzhou City
Shenyang Pharmaceutical University
Original Assignee
Jiutai Pharmaceutical Co Ltd Jinzhou City
Shenyang Pharmaceutical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CNB011282347A priority Critical patent/CN1276911C/zh
Application filed by Jiutai Pharmaceutical Co Ltd Jinzhou City, Shenyang Pharmaceutical University filed Critical Jiutai Pharmaceutical Co Ltd Jinzhou City
Priority to PCT/CN2002/000676 priority patent/WO2003093219A1/zh
Priority to EP02771983A priority patent/EP1439164B1/en
Priority to RU2004112212/04A priority patent/RU2264382C1/ru
Priority to DK02771983T priority patent/DK1439164T3/da
Priority to JP2004501359A priority patent/JP3990399B2/ja
Priority to AU2002338124A priority patent/AU2002338124A1/en
Priority to HK04107530.8A priority patent/HK1064664B/en
Priority to DE60219500T priority patent/DE60219500T2/de
Priority to AT02771983T priority patent/ATE359261T1/de
Priority to ES02771983T priority patent/ES2284926T3/es
Priority to US10/491,028 priority patent/US7098364B2/en
Publication of CN1408703A publication Critical patent/CN1408703A/zh
Application granted granted Critical
Publication of CN1276911C publication Critical patent/CN1276911C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB011282347A 2001-09-30 2001-09-30 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法 Expired - Fee Related CN1276911C (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CNB011282347A CN1276911C (zh) 2001-09-30 2001-09-30 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法
DE60219500T DE60219500T2 (de) 2001-09-30 2002-09-25 Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung
RU2004112212/04A RU2264382C1 (ru) 2001-09-30 2002-09-25 Новые фенилэтаноламиновые соединения в качестве агонистов и бета2-рецептора и способ их получения
DK02771983T DK1439164T3 (da) 2001-09-30 2002-09-25 Hidtil ukendte phenylethanolaminforbindelser, der har beta2- acceptorexcitatorisk funktion, og deres fremstillingsmetode
JP2004501359A JP3990399B2 (ja) 2001-09-30 2002-09-25 β２−受容体興奮作用を有する新規フェニルエタノールアミン類化合物及びそれらの製造方法
AU2002338124A AU2002338124A1 (en) 2001-09-30 2002-09-25 NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING Beta2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD
PCT/CN2002/000676 WO2003093219A1 (en) 2001-09-30 2002-09-25 NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING β2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD
EP02771983A EP1439164B1 (en) 2001-09-30 2002-09-25 Novel phenylethanolamine compounds having beta2-acceptor excitatory function and their preparation method
AT02771983T ATE359261T1 (de) 2001-09-30 2002-09-25 Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung
ES02771983T ES2284926T3 (es) 2001-09-30 2002-09-25 Nuevos compuestos de feniltanolaminas con una funcion de exticion de un receptor beta2 y metodo para su preparacion.
US10/491,028 US7098364B2 (en) 2001-09-30 2002-09-25 Phenylethanolamine compounds as β2-receptor agonists, and methods of use and preparation thereof
HK04107530.8A HK1064664B (en) 2001-09-30 2002-09-25 Novel phenylethanolamine compounds having beta2-acceptor excitatory function and their preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB011282347A CN1276911C (zh) 2001-09-30 2001-09-30 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法

Publications (2)

Publication Number Publication Date
CN1408703A CN1408703A (zh) 2003-04-09
CN1276911C true CN1276911C (zh) 2006-09-27

Family

ID=4668112

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB011282347A Expired - Fee Related CN1276911C (zh) 2001-09-30 2001-09-30 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法

Country Status (11)

Country Link
US (1) US7098364B2 (https=)
EP (1) EP1439164B1 (https=)
JP (1) JP3990399B2 (https=)
CN (1) CN1276911C (https=)
AT (1) ATE359261T1 (https=)
AU (1) AU2002338124A1 (https=)
DE (1) DE60219500T2 (https=)
DK (1) DK1439164T3 (https=)
ES (1) ES2284926T3 (https=)
RU (1) RU2264382C1 (https=)
WO (1) WO2003093219A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100497296C (zh) * 2006-07-07 2009-06-10 沈阳药科大学 旋光活性的苯乙醇胺类化合物及其制法
CN100431535C (zh) * 2006-09-18 2008-11-12 锦州九泰药业有限责任公司 一种盐酸川丁特罗气雾剂
EP1969929A1 (de) * 2007-03-12 2008-09-17 Bayer CropScience AG Substituierte Phenylamidine und deren Verwendung als Fungizide
CN102477000B (zh) * 2010-11-24 2013-11-06 沈阳药科大学 一种苯乙醇胺类化合物的合成方法
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
CN106279018B (zh) * 2015-06-26 2019-01-29 沈阳药科大学 β2-受体兴奋剂及其制备方法和应用
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses
EP4651867A1 (en) 2023-01-20 2025-11-26 Atrogi AB Beta 2-adrenergic receptor agonists for treatment or prevention of muscle wasting
GB202302225D0 (en) 2023-02-16 2023-04-05 Atrogi Ab New medical uses
GB202303229D0 (en) 2023-03-06 2023-04-19 Atrogi Ab New medical uses
GB202403169D0 (en) 2024-03-05 2024-04-17 Atrogi Ab New medical uses
WO2025238248A1 (en) 2024-05-17 2025-11-20 Atrogi Ab USE OF β2-ADRENERGIC RECEPTOR AGONISTS IN TREATING MUSCLE WASTING

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4028398A1 (de) * 1990-09-07 1992-03-12 Thomae Gmbh Dr K Phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SG55296A1 (en) * 1996-04-12 1998-12-21 Kissei Pharmaceutical Phenylethalolaminotetralincarboxamide derivatives
CN1237574A (zh) * 1998-05-29 1999-12-08 中国科学院成都有机化学研究所 合成苯乙醇胺类化合物的方法

Also Published As

Publication number Publication date
EP1439164A1 (en) 2004-07-21
US7098364B2 (en) 2006-08-29
CN1408703A (zh) 2003-04-09
DK1439164T3 (da) 2007-08-20
ES2284926T3 (es) 2007-11-16
WO2003093219A1 (en) 2003-11-13
JP2005519989A (ja) 2005-07-07
JP3990399B2 (ja) 2007-10-10
DE60219500T2 (de) 2007-12-13
HK1064664A1 (en) 2005-02-04
ATE359261T1 (de) 2007-05-15
EP1439164A4 (en) 2005-12-21
RU2004112212A (ru) 2005-09-10
AU2002338124A8 (en) 2003-11-17
US20040266867A1 (en) 2004-12-30
EP1439164B1 (en) 2007-04-11
RU2264382C1 (ru) 2005-11-20
AU2002338124A1 (en) 2003-11-17
DE60219500D1 (de) 2007-05-24

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