CN1274687C - 恩曲他滨适合工业化的制备方法 - Google Patents
恩曲他滨适合工业化的制备方法 Download PDFInfo
- Publication number
- CN1274687C CN1274687C CN 200410023745 CN200410023745A CN1274687C CN 1274687 C CN1274687 C CN 1274687C CN 200410023745 CN200410023745 CN 200410023745 CN 200410023745 A CN200410023745 A CN 200410023745A CN 1274687 C CN1274687 C CN 1274687C
- Authority
- CN
- China
- Prior art keywords
- carboxylic acid
- oxathiolane
- menthyl ester
- acid
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 title claims abstract description 17
- 229960000366 emtricitabine Drugs 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical class OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 18
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 11
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims abstract description 11
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 10
- -1 menthol ester Chemical class 0.000 claims abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 6
- 230000002829 reductive effect Effects 0.000 claims abstract description 5
- 238000007670 refining Methods 0.000 claims abstract description 5
- 239000003054 catalyst Substances 0.000 claims abstract description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 150000002148 esters Chemical class 0.000 claims description 66
- LOWHAEXKCMFUMV-VVJJHMBFSA-N (2r,5r)-5-hydroxy-1,3-oxathiolane-2-carboxylic acid Chemical compound O[C@H]1CS[C@H](C(O)=O)O1 LOWHAEXKCMFUMV-VVJJHMBFSA-N 0.000 claims description 13
- 229960003328 benzoyl peroxide Drugs 0.000 claims description 8
- 238000009833 condensation Methods 0.000 claims description 7
- 230000005494 condensation Effects 0.000 claims description 7
- CSRZQMIRAZTJOY-UHFFFAOYSA-N trimethylsilyl iodide Chemical compound C[Si](C)(C)I CSRZQMIRAZTJOY-UHFFFAOYSA-N 0.000 claims description 6
- PFTIVKCRALCOLB-UHFFFAOYSA-N [SiH4].[N] Chemical compound [SiH4].[N] PFTIVKCRALCOLB-UHFFFAOYSA-N 0.000 claims description 5
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 4
- 230000008025 crystallization Effects 0.000 claims description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 4
- LOWHAEXKCMFUMV-UHFFFAOYSA-N 5-hydroxy-1,3-oxathiolane-2-carboxylic acid Chemical compound OC1CSC(C(O)=O)O1 LOWHAEXKCMFUMV-UHFFFAOYSA-N 0.000 claims description 2
- 238000005917 acylation reaction Methods 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 239000004411 aluminium Substances 0.000 claims description 2
- 238000005660 chlorination reaction Methods 0.000 claims description 2
- 239000011968 lewis acid catalyst Substances 0.000 claims description 2
- 238000002444 silanisation Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 11
- 229910052760 oxygen Inorganic materials 0.000 abstract description 9
- 239000001301 oxygen Substances 0.000 abstract description 9
- 229960004413 flucytosine Drugs 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 101150064138 MAP1 gene Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 20
- 239000000243 solution Substances 0.000 description 18
- 239000007787 solid Substances 0.000 description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 239000012074 organic phase Substances 0.000 description 5
- 238000010992 reflux Methods 0.000 description 5
- 238000007710 freezing Methods 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 229960001866 silicon dioxide Drugs 0.000 description 2
- 229930192474 thiophene Natural products 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000036436 anti-hiv Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
Images
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- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410023745 CN1274687C (zh) | 2004-03-17 | 2004-03-17 | 恩曲他滨适合工业化的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410023745 CN1274687C (zh) | 2004-03-17 | 2004-03-17 | 恩曲他滨适合工业化的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1563002A CN1563002A (zh) | 2005-01-12 |
CN1274687C true CN1274687C (zh) | 2006-09-13 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 200410023745 Expired - Lifetime CN1274687C (zh) | 2004-03-17 | 2004-03-17 | 恩曲他滨适合工业化的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN1274687C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011120927A1 (en) | 2010-03-29 | 2011-10-06 | Esteve Química, S.A. | Process for obtaining emtricitabine |
CN101597281B (zh) * | 2009-07-01 | 2012-09-05 | 济南久创化学有限责任公司 | 拉米夫定及其中间体的制备方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007077505A2 (en) * | 2005-12-30 | 2007-07-12 | Ranbaxy Laboratories Limited | Crystalline l-menthyl (2r, 5s)-5-(4-amino-5-fluoro-2-oxo-2h-pyrimidin-1-yl)[1, 3]oxathiolan-2-carboxylate and process for preparation thereof |
CN101391997B (zh) * | 2008-09-18 | 2010-12-22 | 江苏科本医药化学有限公司 | 一种恩曲他滨中间体的合成方法 |
CN102516078B (zh) * | 2011-12-31 | 2014-06-04 | 浙江先锋科技有限公司 | 乙醛酸l-薄荷醇酯及其一水合物的制备方法 |
CN111253215B (zh) * | 2018-11-30 | 2023-04-11 | 上海科胜药物研发有限公司 | 一种l-薄荷醇回收工艺方法 |
CN110437216B (zh) * | 2019-08-21 | 2023-04-11 | 武汉工程大学 | 一种拉米夫定的合成方法 |
CN110437217B (zh) * | 2019-08-21 | 2023-04-11 | 武汉工程大学 | 一种拉米夫定的不对称制备方法 |
CN110343097B (zh) * | 2019-08-21 | 2023-04-07 | 武汉工程大学 | 一种恩曲他滨的不对称合成方法 |
CN110467608B (zh) * | 2019-08-21 | 2023-04-07 | 武汉工程大学 | 一种恩曲他滨的合成方法 |
CN110437215B (zh) * | 2019-08-21 | 2023-04-11 | 武汉工程大学 | 一种恩曲他滨的制备方法 |
CN110437218B (zh) * | 2019-08-21 | 2023-04-11 | 武汉工程大学 | 一种恩曲他滨的不对称制备方法 |
-
2004
- 2004-03-17 CN CN 200410023745 patent/CN1274687C/zh not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101597281B (zh) * | 2009-07-01 | 2012-09-05 | 济南久创化学有限责任公司 | 拉米夫定及其中间体的制备方法 |
WO2011120927A1 (en) | 2010-03-29 | 2011-10-06 | Esteve Química, S.A. | Process for obtaining emtricitabine |
Also Published As
Publication number | Publication date |
---|---|
CN1563002A (zh) | 2005-01-12 |
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Legal Events
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PB01 | Publication | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANDONG WEIFANG PHARMACEUTICAL FACTORY CO., LTD. Free format text: FORMER OWNER: JIUCHUANG CHEMICAL CO., LTD., JINAN Effective date: 20140109 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 250100 JINAN, SHANDONG PROVINCE TO: 251021 WEIFANG, SHANDONG PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20140109 Address after: 251021 No. 1 West Palace Street, Weicheng District, Shandong, Weifang Patentee after: SHANDONG WEIFANG PHARMACEUTICAL FACTORY Co.,Ltd. Address before: 250100 A, Pioneer Park, Huayang Road, Licheng District, Shandong, Ji'nan 417 Patentee before: Jinan Inovas Chemical Co.,Ltd. |
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C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: Yu Shandong city in Weifang Province, 251021 North Street Hanting District No. 2709 Patentee after: SHANDONG WEIFANG PHARMACEUTICAL FACTORY Co.,Ltd. Address before: 251021 No. 1 West Palace Street, Weicheng District, Shandong, Weifang Patentee before: SHANDONG WEIFANG PHARMACEUTICAL FACTORY Co.,Ltd. |
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C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: Yu Shandong city in Weifang Province, 261100 North Street Hanting District No. 2709 Patentee after: Zhongfu industry Limited by Share Ltd. Address before: Yu Shandong city in Weifang Province, 251021 North Street Hanting District No. 2709 Patentee before: SHANDONG WEIFANG PHARMACEUTICAL FACTORY Co.,Ltd. |
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CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20060913 |