CN1267437C - 微粒形式的克拉维酸或其盐 - Google Patents

微粒形式的克拉维酸或其盐 Download PDF

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Publication number
CN1267437C
CN1267437C CNB018175538A CN01817553A CN1267437C CN 1267437 C CN1267437 C CN 1267437C CN B018175538 A CNB018175538 A CN B018175538A CN 01817553 A CN01817553 A CN 01817553A CN 1267437 C CN1267437 C CN 1267437C
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CN
China
Prior art keywords
clavulanic acid
particulate
particle diameter
sylvite
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018175538A
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English (en)
Chinese (zh)
Other versions
CN1469880A (zh
Inventor
S·霍尔科维茨－科瓦茨
J·拉内伯格
F·X·施瓦茨
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Sandoz AG
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Sandoz AG
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Application filed by Sandoz AG filed Critical Sandoz AG
Publication of CN1469880A publication Critical patent/CN1469880A/zh
Application granted granted Critical
Publication of CN1267437C publication Critical patent/CN1267437C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D503/12—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6
    • C07D503/14—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, attached in position 3
    • C07D503/16—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical
    • C07D503/18—Radicals substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB018175538A 2000-10-20 2001-10-18 微粒形式的克拉维酸或其盐 Expired - Lifetime CN1267437C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT18062000 2000-10-20
ATA1806/2000 2000-10-20

Publications (2)

Publication Number Publication Date
CN1469880A CN1469880A (zh) 2004-01-21
CN1267437C true CN1267437C (zh) 2006-08-02

Family

ID=3689001

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018175538A Expired - Lifetime CN1267437C (zh) 2000-10-20 2001-10-18 微粒形式的克拉维酸或其盐

Country Status (13)

Country Link
US (1) US20040043981A1 (fr)
EP (1) EP1328528B1 (fr)
JP (2) JP2004511561A (fr)
KR (1) KR20030069995A (fr)
CN (1) CN1267437C (fr)
AT (1) ATE286057T1 (fr)
AU (1) AU2002221702A1 (fr)
CA (1) CA2424462C (fr)
DE (1) DE60108154T2 (fr)
ES (1) ES2234919T3 (fr)
MX (1) MXPA03003312A (fr)
PL (1) PL360254A1 (fr)
WO (1) WO2002032906A1 (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8045512B2 (en) 2005-10-27 2011-10-25 Qualcomm Incorporated Scalable frequency band operation in wireless communication systems
US8098568B2 (en) 2000-09-13 2012-01-17 Qualcomm Incorporated Signaling method in an OFDM multiple access system
US8462859B2 (en) 2005-06-01 2013-06-11 Qualcomm Incorporated Sphere decoding apparatus
US8477684B2 (en) 2005-10-27 2013-07-02 Qualcomm Incorporated Acknowledgement of control messages in a wireless communication system
US8547951B2 (en) 2005-03-16 2013-10-01 Qualcomm Incorporated Channel structures for a quasi-orthogonal multiple-access communication system
US8582509B2 (en) 2005-10-27 2013-11-12 Qualcomm Incorporated Scalable frequency band operation in wireless communication systems
US8599945B2 (en) 2005-06-16 2013-12-03 Qualcomm Incorporated Robust rank prediction for a MIMO system
US8644292B2 (en) 2005-08-24 2014-02-04 Qualcomm Incorporated Varied transmission time intervals for wireless communication system
US8693405B2 (en) 2005-10-27 2014-04-08 Qualcomm Incorporated SDMA resource management
US8879511B2 (en) 2005-10-27 2014-11-04 Qualcomm Incorporated Assignment acknowledgement for a wireless communication system
US8885628B2 (en) 2005-08-08 2014-11-11 Qualcomm Incorporated Code division multiplexing in a single-carrier frequency division multiple access system
US9036538B2 (en) 2005-04-19 2015-05-19 Qualcomm Incorporated Frequency hopping design for single carrier FDMA systems
US9088384B2 (en) 2005-10-27 2015-07-21 Qualcomm Incorporated Pilot symbol transmission in wireless communication systems
US9130810B2 (en) 2000-09-13 2015-09-08 Qualcomm Incorporated OFDM communications methods and apparatus
US9136974B2 (en) 2005-08-30 2015-09-15 Qualcomm Incorporated Precoding and SDMA support
US9143305B2 (en) 2005-03-17 2015-09-22 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9144060B2 (en) 2005-10-27 2015-09-22 Qualcomm Incorporated Resource allocation for shared signaling channels
US9154211B2 (en) 2005-03-11 2015-10-06 Qualcomm Incorporated Systems and methods for beamforming feedback in multi antenna communication systems
US9179319B2 (en) 2005-06-16 2015-11-03 Qualcomm Incorporated Adaptive sectorization in cellular systems
US9184870B2 (en) 2005-04-01 2015-11-10 Qualcomm Incorporated Systems and methods for control channel signaling
US9210651B2 (en) 2005-10-27 2015-12-08 Qualcomm Incorporated Method and apparatus for bootstraping information in a communication system
US9225488B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Shared signaling channel
US9225416B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Varied signaling channels for a reverse link in a wireless communication system
US9240877B2 (en) 2005-08-22 2016-01-19 Qualcomm Incorporated Segment sensitive scheduling
US9246560B2 (en) 2005-03-10 2016-01-26 Qualcomm Incorporated Systems and methods for beamforming and rate control in a multi-input multi-output communication systems
US9408220B2 (en) 2005-04-19 2016-08-02 Qualcomm Incorporated Channel quality reporting for adaptive sectorization
US9520972B2 (en) 2005-03-17 2016-12-13 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255099A1 (en) * 2007-10-26 2010-10-07 Rexahn Pharmaceuticals, Inc. Clavulanate formulation for neuroprotection and treatment of neurodegenerative disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29038A (en) * 1860-07-03 George a
NZ189022A (en) * 1977-12-08 1981-11-19 Beecham Group Ltd Pharmaceutically acceptable particles of clavulanates dispersed in a polymeric binder
US5288861A (en) * 1987-01-29 1994-02-22 Beecham Group Plc Potassium clavulanate in rosette form
US5750685A (en) * 1987-01-29 1998-05-12 Smithkline Beecham, P.L.C. Process for preparing potassium clavulanate in rossette form
GB9109862D0 (en) * 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
ES2215628T5 (es) * 1999-04-01 2011-11-28 Dsm Ip Assets B.V. Aglomerados obtenidos por cristalización.

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8098568B2 (en) 2000-09-13 2012-01-17 Qualcomm Incorporated Signaling method in an OFDM multiple access system
US8098569B2 (en) 2000-09-13 2012-01-17 Qualcomm Incorporated Signaling method in an OFDM multiple access system
US9130810B2 (en) 2000-09-13 2015-09-08 Qualcomm Incorporated OFDM communications methods and apparatus
US9246560B2 (en) 2005-03-10 2016-01-26 Qualcomm Incorporated Systems and methods for beamforming and rate control in a multi-input multi-output communication systems
US9154211B2 (en) 2005-03-11 2015-10-06 Qualcomm Incorporated Systems and methods for beamforming feedback in multi antenna communication systems
US8547951B2 (en) 2005-03-16 2013-10-01 Qualcomm Incorporated Channel structures for a quasi-orthogonal multiple-access communication system
US9520972B2 (en) 2005-03-17 2016-12-13 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9143305B2 (en) 2005-03-17 2015-09-22 Qualcomm Incorporated Pilot signal transmission for an orthogonal frequency division wireless communication system
US9184870B2 (en) 2005-04-01 2015-11-10 Qualcomm Incorporated Systems and methods for control channel signaling
US9036538B2 (en) 2005-04-19 2015-05-19 Qualcomm Incorporated Frequency hopping design for single carrier FDMA systems
US9408220B2 (en) 2005-04-19 2016-08-02 Qualcomm Incorporated Channel quality reporting for adaptive sectorization
US8462859B2 (en) 2005-06-01 2013-06-11 Qualcomm Incorporated Sphere decoding apparatus
US8599945B2 (en) 2005-06-16 2013-12-03 Qualcomm Incorporated Robust rank prediction for a MIMO system
US9179319B2 (en) 2005-06-16 2015-11-03 Qualcomm Incorporated Adaptive sectorization in cellular systems
US8885628B2 (en) 2005-08-08 2014-11-11 Qualcomm Incorporated Code division multiplexing in a single-carrier frequency division multiple access system
US9246659B2 (en) 2005-08-22 2016-01-26 Qualcomm Incorporated Segment sensitive scheduling
US9240877B2 (en) 2005-08-22 2016-01-19 Qualcomm Incorporated Segment sensitive scheduling
US8644292B2 (en) 2005-08-24 2014-02-04 Qualcomm Incorporated Varied transmission time intervals for wireless communication system
US8787347B2 (en) 2005-08-24 2014-07-22 Qualcomm Incorporated Varied transmission time intervals for wireless communication system
US9136974B2 (en) 2005-08-30 2015-09-15 Qualcomm Incorporated Precoding and SDMA support
US8693405B2 (en) 2005-10-27 2014-04-08 Qualcomm Incorporated SDMA resource management
US9144060B2 (en) 2005-10-27 2015-09-22 Qualcomm Incorporated Resource allocation for shared signaling channels
US8842619B2 (en) 2005-10-27 2014-09-23 Qualcomm Incorporated Scalable frequency band operation in wireless communication systems
US9210651B2 (en) 2005-10-27 2015-12-08 Qualcomm Incorporated Method and apparatus for bootstraping information in a communication system
US9225488B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Shared signaling channel
US9225416B2 (en) 2005-10-27 2015-12-29 Qualcomm Incorporated Varied signaling channels for a reverse link in a wireless communication system
US9088384B2 (en) 2005-10-27 2015-07-21 Qualcomm Incorporated Pilot symbol transmission in wireless communication systems
US8879511B2 (en) 2005-10-27 2014-11-04 Qualcomm Incorporated Assignment acknowledgement for a wireless communication system
US8045512B2 (en) 2005-10-27 2011-10-25 Qualcomm Incorporated Scalable frequency band operation in wireless communication systems
US8582509B2 (en) 2005-10-27 2013-11-12 Qualcomm Incorporated Scalable frequency band operation in wireless communication systems
US8477684B2 (en) 2005-10-27 2013-07-02 Qualcomm Incorporated Acknowledgement of control messages in a wireless communication system

Also Published As

Publication number Publication date
CN1469880A (zh) 2004-01-21
EP1328528B1 (fr) 2004-12-29
US20040043981A1 (en) 2004-03-04
MXPA03003312A (es) 2004-12-03
PL360254A1 (en) 2004-09-06
CA2424462A1 (fr) 2002-04-25
DE60108154D1 (de) 2005-02-03
JP2004511561A (ja) 2004-04-15
EP1328528A1 (fr) 2003-07-23
ATE286057T1 (de) 2005-01-15
DE60108154T2 (de) 2005-12-22
CA2424462C (fr) 2010-03-30
ES2234919T3 (es) 2005-07-01
WO2002032906A1 (fr) 2002-04-25
KR20030069995A (ko) 2003-08-27
JP2009197020A (ja) 2009-09-03
AU2002221702A1 (en) 2002-04-29

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: SANDOZ AG

Free format text: FORMER OWNER: BIOCHEMIE CO., LTD.

Effective date: 20050415

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TA01 Transfer of patent application right

Effective date of registration: 20050415

Address after: Basel

Applicant after: Sandoz AG

Address before: Austria Kundera

Applicant before: Biochemie Gesellschaft MBH

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GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20060802