CN1240374C - 快速崩解的甲基纤维素片剂 - Google Patents

快速崩解的甲基纤维素片剂 Download PDF

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Publication number
CN1240374C
CN1240374C CNB988102935A CN98810293A CN1240374C CN 1240374 C CN1240374 C CN 1240374C CN B988102935 A CNB988102935 A CN B988102935A CN 98810293 A CN98810293 A CN 98810293A CN 1240374 C CN1240374 C CN 1240374C
Authority
CN
China
Prior art keywords
tablet
methylcellulose
starch
grain
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988102935A
Other languages
English (en)
Chinese (zh)
Other versions
CN1276718A (zh
Inventor
B·达盖
N·I·梅塔
P·纳亚克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1276718A publication Critical patent/CN1276718A/zh
Application granted granted Critical
Publication of CN1240374C publication Critical patent/CN1240374C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CNB988102935A 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂 Expired - Fee Related CN1240374C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US5689997P 1997-08-22 1997-08-22
US60/056,899 1997-08-22
US60/056899 1997-08-22
US8164498P 1998-04-14 1998-04-14
US60/081644 1998-04-14
US60/081,644 1998-04-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200510113769 Division CN1762335A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Publications (2)

Publication Number Publication Date
CN1276718A CN1276718A (zh) 2000-12-13
CN1240374C true CN1240374C (zh) 2006-02-08

Family

ID=26735830

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988102935A Expired - Fee Related CN1240374C (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Country Status (18)

Country Link
US (2) US6372253B1 (https=)
EP (1) EP1014949A4 (https=)
JP (1) JP2001513546A (https=)
KR (1) KR20010023198A (https=)
CN (1) CN1240374C (https=)
AR (3) AR016827A1 (https=)
AU (1) AU745682B2 (https=)
BR (1) BR9811987A (https=)
CA (1) CA2301132C (https=)
CO (1) CO4960646A1 (https=)
EA (1) EA003663B1 (https=)
HU (1) HUP0003186A3 (https=)
MY (1) MY137768A (https=)
NZ (1) NZ502890A (https=)
PL (1) PL338786A1 (https=)
TW (1) TWI228421B (https=)
UA (1) UA70926C2 (https=)
WO (1) WO1999009959A1 (https=)

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AR016827A1 (es) * 1997-08-22 2001-08-01 Smithkline Beecham Corp PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
AR017512A1 (es) * 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
US6348264B1 (en) 1998-04-27 2002-02-19 Roquette Freres Process for producing low de starch hydrolysates by nanofiltration fractionation, products obtained thereby, and use of such products
CA2342625A1 (en) * 1998-09-08 2000-03-16 Smithkline Beecham Corporation Lipstatin derivative-soluble fiber tablets
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Also Published As

Publication number Publication date
CA2301132C (en) 2007-11-13
HUP0003186A2 (hu) 2001-02-28
UA70926C2 (uk) 2004-11-15
CO4960646A1 (es) 2000-09-25
HUP0003186A3 (en) 2001-04-28
AR049055A2 (es) 2006-06-21
AR016827A1 (es) 2001-08-01
AU9114698A (en) 1999-03-16
NZ502890A (en) 2002-03-01
US7132114B2 (en) 2006-11-07
CA2301132A1 (en) 1999-03-04
US6372253B1 (en) 2002-04-16
CN1276718A (zh) 2000-12-13
EP1014949A1 (en) 2000-07-05
PL338786A1 (en) 2000-11-20
AU745682B2 (en) 2002-03-28
AR049057A2 (es) 2006-06-21
BR9811987A (pt) 2000-09-05
EA003663B1 (ru) 2003-08-28
EA200000245A1 (ru) 2000-08-28
US20030049315A1 (en) 2003-03-13
WO1999009959A1 (en) 1999-03-04
MY137768A (en) 2009-03-31
JP2001513546A (ja) 2001-09-04
EP1014949A4 (en) 2006-06-21
TWI228421B (en) 2005-03-01
KR20010023198A (ko) 2001-03-26

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Granted publication date: 20060208

Termination date: 20110821