CN1207282C - 盐酸多奈哌齐的多晶型物（iii），其制备方法及用途 - Google Patents

盐酸多奈哌齐的多晶型物（iii），其制备方法及用途 Download PDF

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Publication number
CN1207282C
CN1207282C CNB971952639A CN97195263A CN1207282C CN 1207282 C CN1207282 C CN 1207282C CN B971952639 A CNB971952639 A CN B971952639A CN 97195263 A CN97195263 A CN 97195263A CN 1207282 C CN1207282 C CN 1207282C
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CN
China
Prior art keywords
dissolved
polymorphic form
gram
perhaps
solution
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB971952639A
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English (en)
Chinese (zh)
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CN1221404A (zh
Inventor
今井昭生
渡边英明
梶间隆
石滨泰
大塚昭代
田中智英
奈良部幸夫
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Eisai Co Ltd
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Eisai Co Ltd
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Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of CN1221404A publication Critical patent/CN1221404A/zh
Application granted granted Critical
Publication of CN1207282C publication Critical patent/CN1207282C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB971952639A 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物（iii），其制备方法及用途 Expired - Lifetime CN1207282C (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP146293/1996 1996-06-07
JP146293/96 1996-06-07
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
WOPCT/JP96/03881 1996-12-27
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production
US08/774,802 1996-12-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB200510075915XA Division CN1312129C (zh) 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物及其制备方法

Publications (2)

Publication Number Publication Date
CN1221404A CN1221404A (zh) 1999-06-30
CN1207282C true CN1207282C (zh) 2005-06-22

Family

ID=26477192

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971952639A Expired - Lifetime CN1207282C (zh) 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物（iii），其制备方法及用途

Country Status (10)

Country Link
CN (1) CN1207282C (cs)
AT (1) ATE230396T1 (cs)
CY (1) CY2316B1 (cs)
CZ (1) CZ296619B6 (cs)
DE (1) DE69718216T2 (cs)
NO (1) NO20060377L (cs)
PL (1) PL330362A1 (cs)
PT (1) PT1019374E (cs)
TR (2) TR199802531T2 (cs)
TW (1) TWI243816B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906066B (zh) * 2010-08-08 2015-03-11 浙江华海药业股份有限公司 一种制备盐酸奈哌齐晶型i的方法
CN102060752B (zh) * 2011-01-24 2013-03-13 上海右手医药科技开发有限公司 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品
CN103012247B (zh) * 2013-01-18 2014-12-10 浙江东亚药业有限公司 一种盐酸多奈哌齐无水i晶型的制备方法
CN103694164B (zh) * 2014-01-23 2015-08-12 天津大学 一种盐酸多奈哌齐新晶型及制备方法
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Also Published As

Publication number Publication date
NO20060377L (no) 1999-01-28
CZ296619B6 (cs) 2006-05-17
ATE230396T1 (de) 2003-01-15
TR200202374T2 (tr) 2003-01-21
PL330362A1 (en) 1999-05-10
DE69718216T2 (de) 2003-10-09
CZ396098A3 (cs) 1999-03-17
CN1221404A (zh) 1999-06-30
DE69718216D1 (de) 2003-02-06
TWI243816B (en) 2005-11-21
CY2316B1 (en) 2003-11-14
TR199802531T2 (xx) 1999-02-22
PT1019374E (pt) 2003-03-31

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Granted publication date: 20050622

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