TR199802531T2 - Donepezil hidroklorid polimorflar� ve �retim prosesleri. - Google Patents
Donepezil hidroklorid polimorflar� ve �retim prosesleri.Info
- Publication number
- TR199802531T2 TR199802531T2 TR1998/02531T TR9802531T TR199802531T2 TR 199802531 T2 TR199802531 T2 TR 199802531T2 TR 1998/02531 T TR1998/02531 T TR 1998/02531T TR 9802531 T TR9802531 T TR 9802531T TR 199802531 T2 TR199802531 T2 TR 199802531T2
- Authority
- TR
- Turkey
- Prior art keywords
- donepezil hydrochloride
- production processes
- polymorphs
- hydrochloride polymorphs
- peaks
- Prior art date
Links
- 229960003135 donepezil hydrochloride Drugs 0.000 title abstract 2
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14629396 | 1996-06-07 | ||
| PCT/JP1996/003881 WO1997046526A1 (en) | 1996-06-07 | 1996-12-27 | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| US08/774,802 US6140321A (en) | 1996-06-07 | 1996-12-30 | Polymorphs of donepezil hydrochloride and process for production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199802531T2 true TR199802531T2 (xx) | 1999-02-22 |
Family
ID=26477192
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1998/02531T TR199802531T2 (xx) | 1996-06-07 | 1997-06-06 | Donepezil hidroklorid polimorflar� ve �retim prosesleri. |
| TR2002/02374T TR200202374T2 (tr) | 1996-06-07 | 1997-06-06 | Donepezil hidroklorid polimorfları ve üretim prosesleri |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/02374T TR200202374T2 (tr) | 1996-06-07 | 1997-06-06 | Donepezil hidroklorid polimorfları ve üretim prosesleri |
Country Status (10)
| Country | Link |
|---|---|
| CN (1) | CN1207282C (cs) |
| AT (1) | ATE230396T1 (cs) |
| CY (1) | CY2316B1 (cs) |
| CZ (1) | CZ296619B6 (cs) |
| DE (1) | DE69718216T2 (cs) |
| NO (1) | NO20060377L (cs) |
| PL (1) | PL330362A1 (cs) |
| PT (1) | PT1019374E (cs) |
| TR (2) | TR199802531T2 (cs) |
| TW (1) | TWI243816B (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101906066B (zh) * | 2010-08-08 | 2015-03-11 | 浙江华海药业股份有限公司 | 一种制备盐酸奈哌齐晶型i的方法 |
| CN102060752B (zh) * | 2011-01-24 | 2013-03-13 | 上海右手医药科技开发有限公司 | 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品 |
| CN103012247B (zh) * | 2013-01-18 | 2014-12-10 | 浙江东亚药业有限公司 | 一种盐酸多奈哌齐无水i晶型的制备方法 |
| CN103694164B (zh) * | 2014-01-23 | 2015-08-12 | 天津大学 | 一种盐酸多奈哌齐新晶型及制备方法 |
| CN107550884B (zh) * | 2017-09-19 | 2018-06-05 | 扬子江药业集团上海海尼药业有限公司 | 一种盐酸多奈哌齐胶囊及其制备方法 |
-
1997
- 1997-06-05 TW TW089110397A patent/TWI243816B/zh not_active IP Right Cessation
- 1997-06-06 DE DE69718216T patent/DE69718216T2/de not_active Expired - Lifetime
- 1997-06-06 CZ CZ0396098A patent/CZ296619B6/cs not_active IP Right Cessation
- 1997-06-06 TR TR1998/02531T patent/TR199802531T2/xx unknown
- 1997-06-06 TR TR2002/02374T patent/TR200202374T2/xx unknown
- 1997-06-06 PL PL97330362A patent/PL330362A1/xx unknown
- 1997-06-06 AT AT97924337T patent/ATE230396T1/de active
- 1997-06-06 CN CNB971952639A patent/CN1207282C/zh not_active Expired - Lifetime
- 1997-06-06 PT PT97924337T patent/PT1019374E/pt unknown
-
2003
- 2003-02-07 CY CY0300012A patent/CY2316B1/xx unknown
-
2006
- 2006-01-24 NO NO20060377A patent/NO20060377L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CY2316B1 (en) | 2003-11-14 |
| ATE230396T1 (de) | 2003-01-15 |
| NO20060377L (no) | 1999-01-28 |
| DE69718216D1 (de) | 2003-02-06 |
| CN1221404A (zh) | 1999-06-30 |
| TR200202374T2 (tr) | 2003-01-21 |
| PL330362A1 (en) | 1999-05-10 |
| CZ396098A3 (cs) | 1999-03-17 |
| CN1207282C (zh) | 2005-06-22 |
| DE69718216T2 (de) | 2003-10-09 |
| TWI243816B (en) | 2005-11-21 |
| PT1019374E (pt) | 2003-03-31 |
| CZ296619B6 (cs) | 2006-05-17 |
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