TR199802531T2 - Donepezil hidroklorid polimorflar� ve �retim prosesleri. - Google Patents

Donepezil hidroklorid polimorflar� ve �retim prosesleri.

Info

Publication number
TR199802531T2
TR199802531T2 TR1998/02531T TR9802531T TR199802531T2 TR 199802531 T2 TR199802531 T2 TR 199802531T2 TR 1998/02531 T TR1998/02531 T TR 1998/02531T TR 9802531 T TR9802531 T TR 9802531T TR 199802531 T2 TR199802531 T2 TR 199802531T2
Authority
TR
Turkey
Prior art keywords
donepezil hydrochloride
production processes
polymorphs
hydrochloride polymorphs
peaks
Prior art date
Application number
TR1998/02531T
Other languages
English (en)
Turkish (tr)
Inventor
Imai Akio
Watanabe Hideaki
Takashi Kajima
Ishihama Yasushi
Ohtsuka Akiyo
Tanaka Tomohide
Narabu Yukio
Original Assignee
Eisai Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co., Ltd filed Critical Eisai Co., Ltd
Publication of TR199802531T2 publication Critical patent/TR199802531T2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TR1998/02531T 1996-06-07 1997-06-06 Donepezil hidroklorid polimorflar� ve �retim prosesleri. TR199802531T2 (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production

Publications (1)

Publication Number Publication Date
TR199802531T2 true TR199802531T2 (xx) 1999-02-22

Family

ID=26477192

Family Applications (2)

Application Number Title Priority Date Filing Date
TR1998/02531T TR199802531T2 (xx) 1996-06-07 1997-06-06 Donepezil hidroklorid polimorflar� ve �retim prosesleri.
TR2002/02374T TR200202374T2 (tr) 1996-06-07 1997-06-06 Donepezil hidroklorid polimorfları ve üretim prosesleri

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/02374T TR200202374T2 (tr) 1996-06-07 1997-06-06 Donepezil hidroklorid polimorfları ve üretim prosesleri

Country Status (10)

Country Link
CN (1) CN1207282C (xx)
AT (1) ATE230396T1 (xx)
CY (1) CY2316B1 (xx)
CZ (1) CZ296619B6 (xx)
DE (1) DE69718216T2 (xx)
NO (1) NO20060377L (xx)
PL (1) PL330362A1 (xx)
PT (1) PT1019374E (xx)
TR (2) TR199802531T2 (xx)
TW (1) TWI243816B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906066B (zh) * 2010-08-08 2015-03-11 浙江华海药业股份有限公司 一种制备盐酸奈哌齐晶型i的方法
CN102060752B (zh) * 2011-01-24 2013-03-13 上海右手医药科技开发有限公司 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品
CN103012247B (zh) * 2013-01-18 2014-12-10 浙江东亚药业有限公司 一种盐酸多奈哌齐无水i晶型的制备方法
CN103694164B (zh) * 2014-01-23 2015-08-12 天津大学 一种盐酸多奈哌齐新晶型及制备方法
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Also Published As

Publication number Publication date
NO20060377L (no) 1999-01-28
CZ296619B6 (cs) 2006-05-17
ATE230396T1 (de) 2003-01-15
TR200202374T2 (tr) 2003-01-21
PL330362A1 (en) 1999-05-10
DE69718216T2 (de) 2003-10-09
CZ396098A3 (cs) 1999-03-17
CN1221404A (zh) 1999-06-30
DE69718216D1 (de) 2003-02-06
TWI243816B (en) 2005-11-21
CY2316B1 (en) 2003-11-14
CN1207282C (zh) 2005-06-22
PT1019374E (pt) 2003-03-31

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