CY2316B1 - Polymorphs of donepezil hydrochloride and process for production. - Google Patents

Polymorphs of donepezil hydrochloride and process for production.

Info

Publication number
CY2316B1
CY2316B1 CY0300012A CY0300012A CY2316B1 CY 2316 B1 CY2316 B1 CY 2316B1 CY 0300012 A CY0300012 A CY 0300012A CY 0300012 A CY0300012 A CY 0300012A CY 2316 B1 CY2316 B1 CY 2316B1
Authority
CY
Cyprus
Prior art keywords
polymorphs
donepezil hydrochloride
production
peaks
hydrochloride
Prior art date
Application number
CY0300012A
Other languages
English (en)
Inventor
Akio Imai
Takashi Kajima
Akiyo Ohtsuka
Yukio Narabu
Hideaki Watanabe
Yasushi Ishihama
Tomohide Tanaka
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of CY2316B1 publication Critical patent/CY2316B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY0300012A 1996-06-07 2003-02-07 Polymorphs of donepezil hydrochloride and process for production. CY2316B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production

Publications (1)

Publication Number Publication Date
CY2316B1 true CY2316B1 (en) 2003-11-14

Family

ID=26477192

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300012A CY2316B1 (en) 1996-06-07 2003-02-07 Polymorphs of donepezil hydrochloride and process for production.

Country Status (10)

Country Link
CN (1) CN1207282C (xx)
AT (1) ATE230396T1 (xx)
CY (1) CY2316B1 (xx)
CZ (1) CZ296619B6 (xx)
DE (1) DE69718216T2 (xx)
NO (1) NO20060377L (xx)
PL (1) PL330362A1 (xx)
PT (1) PT1019374E (xx)
TR (2) TR200202374T2 (xx)
TW (1) TWI243816B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906066B (zh) * 2010-08-08 2015-03-11 浙江华海药业股份有限公司 一种制备盐酸奈哌齐晶型i的方法
CN102060752B (zh) * 2011-01-24 2013-03-13 上海右手医药科技开发有限公司 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品
CN103012247B (zh) * 2013-01-18 2014-12-10 浙江东亚药业有限公司 一种盐酸多奈哌齐无水i晶型的制备方法
CN103694164B (zh) * 2014-01-23 2015-08-12 天津大学 一种盐酸多奈哌齐新晶型及制备方法
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Also Published As

Publication number Publication date
PL330362A1 (en) 1999-05-10
TR199802531T2 (xx) 1999-02-22
CN1221404A (zh) 1999-06-30
CZ296619B6 (cs) 2006-05-17
PT1019374E (pt) 2003-03-31
CN1207282C (zh) 2005-06-22
NO20060377L (no) 1999-01-28
CZ396098A3 (cs) 1999-03-17
DE69718216D1 (de) 2003-02-06
TR200202374T2 (tr) 2003-01-21
ATE230396T1 (de) 2003-01-15
DE69718216T2 (de) 2003-10-09
TWI243816B (en) 2005-11-21

Similar Documents

Publication Publication Date Title
HK1080078A1 (en) Polymorphs of donepezil hydrochloride and process for production
CA2252806A1 (en) Polymorphs of donepezil hydrochloride and process for production
HUP0000610A3 (en) Piperidine derivatives, with analgesic effect, process for producing them and pharmaceutical compositions containing them
NO20060377L (no) Polymorfer av donepezilhydroklorid og fremgangsmater for deres fremstilling
HUP0000613A3 (en) Piperidine derivatives with analgesic effect process for producing them and pharmaceutical compositions containing them
ZA9610533B (en) Processes and intermediates for preparing 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methylpiperidine.
GB8904163D0 (en) Piperazine derivative or its sait,process for producing the same and pharmaceutical composition comprising the same as active ingredient
HU9600624D0 (en) Piperidine derivatives, process for producing them and their pharmaceutical use
AR242975A1 (es) Procedimiento para preparar un pigmento de dioxido de titanio recubierto.
GB2304714B (en) New piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them
HU9302727D0 (en) Piperidine derivatives, process for producing them and their therapeutical use
HUP0002270A2 (hu) Donepezil-hidroklorid polimorf módosulatai, eljárás ezek előállítására, valamint e módosulatokat tartalmazó gyógyászati készítmények
WO1992005152A3 (en) Process for producing polyhydroxylated piperidines and pyrrolidines and compounds thereof
HUT68249A (en) 2,6-methano-2h-quinolizin derivative as 5-ht3-receptor and pharmaceutical composition containing it and process for producing thereof
NO941134L (no) 1,2,5,6-tetrahydropyridin-derivat, fremgangsmåte for dets fremstilling, og dets terapeutiske anvendelser
BR1100141A (pt) Composto de 1-benzil-4-[(5,6-dimetoxi-1-indanona)-2-il]metilpiperidin a, agente inibidor de acetilcolinesterase, agente para prevenir e tratar vários tipos de demências senis e processo para produzir 1-benzil-4-[(5,6-dimetoxi-1-indanona)-2-il]metilpiperidin a
HU908095D0 (en) Process for the production of meat products in mobilizable room, and apparatus for the process
FI101356B1 (fi) Laite energiapuun tuottamiseksi
HUP0302910A3 (en) Process for the racemisation of 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine to be used as intermediate in the synthesis of paroxetine
AU5837296A (en) Piperidine derivatives and process for their production