CN1202173A - 表鬼臼毒素2″,3″二脱氧糖苷的新型胺衍生物,其制备方法其作为药物的应用及其抗癌治疗的应用 - Google Patents

表鬼臼毒素2″,3″二脱氧糖苷的新型胺衍生物,其制备方法其作为药物的应用及其抗癌治疗的应用 Download PDF

Info

Publication number
CN1202173A
CN1202173A CN96198199A CN96198199A CN1202173A CN 1202173 A CN1202173 A CN 1202173A CN 96198199 A CN96198199 A CN 96198199A CN 96198199 A CN96198199 A CN 96198199A CN 1202173 A CN1202173 A CN 1202173A
Authority
CN
China
Prior art keywords
compound
epipodophyllotoxin
formula
demethyl
ethylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96198199A
Other languages
English (en)
Chinese (zh)
Inventor
C·莫尼里特
L·达利
Y·古米斯基
T·艾比尔特
B·希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of CN1202173A publication Critical patent/CN1202173A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN96198199A 1995-10-12 1996-10-11 表鬼臼毒素2″,3″二脱氧糖苷的新型胺衍生物,其制备方法其作为药物的应用及其抗癌治疗的应用 Pending CN1202173A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9511978A FR2739857B1 (fr) 1995-10-12 1995-10-12 Nouveaux derives amines de 2",3"-didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux
FR95/11978 1995-10-21

Publications (1)

Publication Number Publication Date
CN1202173A true CN1202173A (zh) 1998-12-16

Family

ID=9483465

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96198199A Pending CN1202173A (zh) 1995-10-12 1996-10-11 表鬼臼毒素2″,3″二脱氧糖苷的新型胺衍生物,其制备方法其作为药物的应用及其抗癌治疗的应用

Country Status (10)

Country Link
EP (1) EP0873347A2 (ja)
JP (1) JP2000505053A (ja)
KR (1) KR19990064166A (ja)
CN (1) CN1202173A (ja)
AU (1) AU7304096A (ja)
BR (1) BR9610851A (ja)
CA (1) CA2234484A1 (ja)
FR (1) FR2739857B1 (ja)
NZ (1) NZ320323A (ja)
WO (1) WO1997013776A2 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102115483B (zh) * 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
CN109369667A (zh) * 2018-12-05 2019-02-22 南通大学 2，3，6-三脱氧糖基去甲表鬼臼毒素化合物及其制备方法和用途
CN110294764A (zh) * 2019-07-15 2019-10-01 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN112079879A (zh) * 2020-08-21 2020-12-15 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2800374B1 (fr) * 1999-10-28 2002-06-28 Adir Nouveaux derives de 9-(3,5-dimethoxyphenyl)-5,8,8a,9- tetrahydrofuro[3',4':6,7]naphto[2,3-d] [1,3]dioxol-6(5ah)- one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
TWI307341B (en) * 2002-10-11 2009-03-11 Plantaceutica Inc Anticancer compounds
FR2859208B1 (fr) 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102115483B (zh) * 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
CN109369667A (zh) * 2018-12-05 2019-02-22 南通大学 2，3，6-三脱氧糖基去甲表鬼臼毒素化合物及其制备方法和用途
CN109369667B (zh) * 2018-12-05 2021-04-13 南通大学 2，3，6-三脱氧糖基去甲表鬼臼毒素化合物及其制备方法和用途
CN110294764A (zh) * 2019-07-15 2019-10-01 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN112079879A (zh) * 2020-08-21 2020-12-15 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法

Also Published As

Publication number Publication date
WO1997013776A2 (fr) 1997-04-17
JP2000505053A (ja) 2000-04-25
MX9802933A (es) 1998-11-29
FR2739857A1 (fr) 1997-04-18
KR19990064166A (ko) 1999-07-26
CA2234484A1 (fr) 1997-04-17
AU7304096A (en) 1997-04-30
EP0873347A2 (fr) 1998-10-28
WO1997013776A3 (fr) 1997-06-05
BR9610851A (pt) 1999-07-13
NZ320323A (en) 1999-07-29
FR2739857B1 (fr) 1998-01-02

Similar Documents

Publication Publication Date Title
CN1277830C (zh) 作为抗寄生虫药的对郝青酰胺
CN1241931C (zh) 大环内酯抗感染药物
CN1056849C (zh) 抗真菌的粪壳菌素衍生物及其制备方法和其在制药中的应用
CN88102038A (zh) 脱氮杂嘌呤核苷衍生物及其制备方法药物组合物、用于核酸顺序和用作抗病毒剂
CN1137275A (zh) 具有免疫抑制活性的o-芳基、o-烷基、o-烯基和o-炔基大环内酯物
CN1464880A (zh) 具有抗细菌活性的新的大环内酯
CN1017153B (zh) 嘌呤取代的氧杂环丁烷类化合物的制备方法
CN1300289A (zh) 新的三尖杉烷衍生物及其制备方法
CN1281615C (zh) 从9a－氮杂大环内酯类衍生的新3,6－半缩酮类
CN1037441C (zh) 二环胺衍生物及含有该衍生物的抗菌剂
CN1077575C (zh) 喜树碱衍生物及其制备方法和用途及其中间体
CN1278266A (zh) 6,11－桥连红霉素衍生物
CN1202173A (zh) 表鬼臼毒素2″,3″二脱氧糖苷的新型胺衍生物,其制备方法其作为药物的应用及其抗癌治疗的应用
CN1022569C (zh) 制备泰乐菌素和10，11，12，13-四氢泰乐菌素衍生物的方法
CN1099038A (zh) 3-脱氧低聚糖，其制备方法和含有它们的药物组合物
CN1106401A (zh) 新的大环内酯类化合物及其应用
CN1050719A (zh) 表鬼臼毒素阿卓糖苷衍生物的制备方法
CN1052482C (zh) 喜树碱衍生物及其制备方法和抗肿瘤剂
CN1045976A (zh) 新的取代的替考拉宁的烷基酰胺衍生物
CN1028997C (zh) 新蒽环型药物衍生物或其药学上允许的酸加成盐的制法
CN1260801A (zh) 银杏内酯的新型糖基化衍生物,它们作为药物的用途及包含该衍生物的药物组合物
CN1333765A (zh) 环烷基取代的氨甲基吡咯烷衍生物
CN1896065A (zh) 1－(3′,4′,5′－三取代苯基)－异喹啉类化合物及其制备方法和用途
CN1106398A (zh) 七叶亭衍生物和其制造方法与用途及其医药组合物
CN1052114A (zh) 新的非离子射线照相造影剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication