CN1200036A - 含有磷脂混合物并具有抗细胞程序死亡活性的组合物 - Google Patents

含有磷脂混合物并具有抗细胞程序死亡活性的组合物 Download PDF

Info

Publication number
CN1200036A
CN1200036A CN96197739A CN96197739A CN1200036A CN 1200036 A CN1200036 A CN 1200036A CN 96197739 A CN96197739 A CN 96197739A CN 96197739 A CN96197739 A CN 96197739A CN 1200036 A CN1200036 A CN 1200036A
Authority
CN
China
Prior art keywords
composition
phospholipid
sonication
elirex
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96197739A
Other languages
English (en)
Chinese (zh)
Inventor
I·C·巴特斯特
M·W·弗尔
J·G·古达德
L·D·托美尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LXR Biotechnology Inc
Original Assignee
LXR Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LXR Biotechnology Inc filed Critical LXR Biotechnology Inc
Publication of CN1200036A publication Critical patent/CN1200036A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN96197739A 1995-09-14 1996-09-13 含有磷脂混合物并具有抗细胞程序死亡活性的组合物 Pending CN1200036A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US378995P 1995-09-14 1995-09-14
US08/003,789 1995-09-14

Publications (1)

Publication Number Publication Date
CN1200036A true CN1200036A (zh) 1998-11-25

Family

ID=21707614

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96197739A Pending CN1200036A (zh) 1995-09-14 1996-09-13 含有磷脂混合物并具有抗细胞程序死亡活性的组合物

Country Status (7)

Country Link
US (1) US6004579A (enExample)
EP (1) EP0850064A1 (enExample)
JP (2) JPH11512439A (enExample)
CN (1) CN1200036A (enExample)
AU (1) AU7071896A (enExample)
CA (1) CA2229435A1 (enExample)
WO (1) WO1997009989A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106032912A (zh) * 2015-03-11 2016-10-19 潍坊桂禾散热片科技有限公司 一种原子介质二次传导散热器
CN112843072A (zh) * 2021-01-12 2021-05-28 山东省科学院生物研究所 磷脂在调控血管生成方面的应用

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756126A (en) * 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2375561T3 (es) * 1994-01-11 2012-03-02 Dyax Corporation Inhibidores de la plasmina humana derivados de dominios kunitz y �?cidos nucleicos que codifican los mismos.
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO1999008514A1 (en) * 1997-08-20 1999-02-25 Lxr Biotechnology, Inc. Compositions containing polyethylene glycol and uses thereof
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US6413556B1 (en) * 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
US6270781B1 (en) * 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
EP1214928A4 (en) * 1999-08-18 2004-03-24 Kyowa Hakko Kogyo Kk HAIR GROWTH FUNDS
EP1248628A4 (en) * 1999-12-14 2004-08-04 Sky High Llc PHOSPHOLIPID COMPOSITIONS AS AN INFLAMMATORY INHIBITOR
US20060063738A1 (en) * 2000-02-28 2006-03-23 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
US6562803B2 (en) 2001-02-16 2003-05-13 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
US6562804B2 (en) 2001-02-16 2003-05-13 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
JP4836345B2 (ja) * 2001-04-13 2011-12-14 きみ子 室伏 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
JP2005504768A (ja) * 2001-08-20 2005-02-17 ウィリアム ジー． タットン アポトーシスに関連した疾患を治療するための方法および組成物
CA2368656A1 (en) * 2002-01-21 2003-07-21 Vasogen Ireland Limited Receptor-ligand pairing for anti-inflammatory response
US20050147660A1 (en) * 2002-01-21 2005-07-07 Bolton Anthony E. Peptide-carrying bodies for immune response
US20050058698A1 (en) * 2002-01-21 2005-03-17 Nolan Yvonne Mairead Pharmaceutically acceptable phosphate-glycerol carrying bodies and uses relating to Parkinson's Disease
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE477020T1 (de) * 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
ITMI20021280A1 (it) * 2002-06-11 2003-12-11 Carlo Ghisalberti Metodo di trattamento anticellulite
DE10238831A1 (de) * 2002-08-23 2004-03-11 Siemens Ag Verfahren und Vorrichtung zur Prozessoptimierung
ES2709103T3 (es) * 2002-08-28 2019-04-15 Dyax Corp Métodos para conservar órganos y tejidos
EP1398019A1 (de) 2002-09-13 2004-03-17 Cognis France S.A. Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions
JP2007524348A (ja) * 2003-01-07 2007-08-30 ダイアックス、コープ クニッツドメインライブラリー
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
WO2005021557A2 (en) * 2003-08-29 2005-03-10 Dyax Corp. Poly-pegylated protease inhibitors
WO2005102526A1 (en) * 2004-04-09 2005-11-03 Research Think Tank, Inc. Devices and methods for collection, storage and transportation of biological specimens
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20090306019A1 (en) * 2005-08-31 2009-12-10 Modus Biological Membranes Ltd. Compositions for treatment of eosinophilia and related disorders
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
WO2007142510A1 (en) * 2006-06-09 2007-12-13 Erasmus University Medical Center Rotterdam Modulation of the immune system by inositol phospholipids
US9511075B2 (en) 2007-01-12 2016-12-06 The University Of Maryland, Baltimore Targeting NCCA-ATP channel for organ protection following ischemic episode
CN101358609A (zh) * 2007-08-03 2009-02-04 富准精密工业(深圳)有限公司 风扇转子
EP2385843A4 (en) * 2009-01-06 2013-02-27 Dyax Corp TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS
CN102421440B (zh) * 2009-05-07 2017-06-09 东国制药（株） 用于预防或治疗神经病理性疼痛的药学组合物
EP4011917A1 (en) 2010-01-06 2022-06-15 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
US9034820B2 (en) 2011-03-14 2015-05-19 Hsinyu Lee Method and composition for modulating erythropoiesis
KR20230109785A (ko) 2014-03-27 2023-07-20 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
WO2021173535A1 (en) 2020-02-26 2021-09-02 Finless Foods Inc. Systems and methods for live fish tissue preservation
WO2023023309A1 (en) 2021-08-20 2023-02-23 Finless Foods Inc. Systems and methods for fish tissue preservation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1165238A (en) * 1980-03-12 1984-04-10 Demetrios P. Papahadjopoulos Activated liposomes and method
DE3173713D1 (en) * 1980-09-05 1986-03-20 Frappier Armand Inst Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
JP2524586B2 (ja) * 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
JPS6351335A (ja) * 1986-08-20 1988-03-04 Fuji Oil Co Ltd 肥満細胞脱顆粒抑制剤
US5053327A (en) * 1988-09-20 1991-10-01 The United States Of America As Represented By The Secretary Of Agriculture High affinity monoclonal antibodies to bowman-birk inhibitor and immunoassay methods
US5376373A (en) * 1990-09-06 1994-12-27 Trustees Of The University Of Pennsylvania Method of inhibiting radiation induced weight and hair loss
DE69229703T2 (de) * 1991-05-08 2000-04-27 Schweiz Serum & Impfinst Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende Impfstoffe
DK0675727T3 (da) * 1992-12-10 2002-08-05 Enzon Inc Glycolipidenzympolymerkonjugater
AU6782494A (en) * 1993-04-30 1994-11-21 Lxr Biotechnology Inc. Methods of identifying potentially therapeutically effective agents and cell strains for use therein
NZ248603A (en) * 1993-05-28 1994-12-22 Abbott Lab Nutritional product for enteral nutritional support of hiv victims comprising proteins and fat
US5759548A (en) * 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
JPH10505320A (ja) * 1994-05-31 1998-05-26 イネックス ファーマシューティカルズ コーポレイション 治療剤のビロゾーム媒介細胞内輸送

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106032912A (zh) * 2015-03-11 2016-10-19 潍坊桂禾散热片科技有限公司 一种原子介质二次传导散热器
CN112843072A (zh) * 2021-01-12 2021-05-28 山东省科学院生物研究所 磷脂在调控血管生成方面的应用

Also Published As

Publication number Publication date
EP0850064A1 (en) 1998-07-01
US6004579A (en) 1999-12-21
CA2229435A1 (en) 1997-03-20
WO1997009989A1 (en) 1997-03-20
AU7071896A (en) 1997-04-01
JP2008101009A (ja) 2008-05-01
JPH11512439A (ja) 1999-10-26

Similar Documents

Publication Publication Date Title
CN1200036A (zh) 含有磷脂混合物并具有抗细胞程序死亡活性的组合物
ES2305256T3 (es) Acido lipoteicoico derivado de bacterias de acido lactico para el uso como medicamento y en el tratamiento de enfermedades bacterianas.
US6793945B2 (en) Aqueous anti-apoptotic compositions
EP0374390B1 (en) Whey protein composition, a method for producing it and application of the whey protein composition
KR100439166B1 (ko) 괴사성 소장 결장염의 발병률을 감소시키기 위한 조성물
CN1140998A (zh) 抑制编程性细胞死亡的组合物、其纯化方法及其用途
EP1040833B1 (en) Bone resorption suppressing agent
JP2002535288A (ja) リポタンパク質複合体およびそれらを含む組成物
Laoli et al. Productivity of snakehead fish (Channa striata) as a source of wound healing
JPH01287040A (ja) 免疫系を刺激する方法
US4666893A (en) Methods of inducing resistance to bacterial and viral infections
KR20090104089A (ko) 피부미용제
JPH0427964B2 (enExample)
CN105558435A (zh) 一种用于防治鲢鱼出血病的饲料添加剂
JP3979543B2 (ja) 抗アレルギー剤及びその製造法
EP1529784A1 (en) Polymeric anhydride of magnesium and proteic ammonium phospholinoleate-palmitoleate.
JP2009143854A (ja) 創傷治癒促進剤
RU2311171C1 (ru) Противоинфекционный липосомный препарат и фармацевтическая композиция на его основе
SULLIVAN et al. Nutritional dermatoses in the rat: V. signs and symptoms resulting from a diet containing unheated dried egg white as the source of protein
JPH0665041A (ja) 皮膚外用剤
RU2376978C2 (ru) Комплексный апипрепарат в виде суппозиториев для лечения андрологических заболеваний и способ его получения
JP2010202569A (ja) 抗アレルギー及び抗炎症用組成物
JP2002000229A (ja) 健康食品
CN101505763A (zh) 通过肌醇磷脂调节免疫系统
CN108142929A (zh) 一种含蚕蛹健康营养食品

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication