JPH11512439A - リン脂質の混合物を含む抗アポトーシス活性を有する組成物 - Google Patents

リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Info

Publication number
JPH11512439A
JPH11512439A JP9512148A JP51214897A JPH11512439A JP H11512439 A JPH11512439 A JP H11512439A JP 9512148 A JP9512148 A JP 9512148A JP 51214897 A JP51214897 A JP 51214897A JP H11512439 A JPH11512439 A JP H11512439A
Authority
JP
Japan
Prior art keywords
composition
phospholipid
cells
effective amount
lpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9512148A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11512439A5 (enExample
Inventor
シー． バサースト，イアン
ダブリュー． フォーアー，マシュー
ジー． ゴダード，ジョン
デイビッド トメル，ルイス
Original Assignee
エルエックスアール バイオテクノロジー インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エルエックスアール バイオテクノロジー インコーポレイテッド filed Critical エルエックスアール バイオテクノロジー インコーポレイテッド
Publication of JPH11512439A publication Critical patent/JPH11512439A/ja
Publication of JPH11512439A5 publication Critical patent/JPH11512439A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP9512148A 1995-09-14 1996-09-13 リン脂質の混合物を含む抗アポトーシス活性を有する組成物 Ceased JPH11512439A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US378995P 1995-09-14 1995-09-14
US60/003,789 1995-09-14
PCT/US1996/014752 WO1997009989A1 (en) 1995-09-14 1996-09-13 Compositions with anti-apoptotic activity, containing a mixture of phospholipids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007297344A Division JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Publications (2)

Publication Number Publication Date
JPH11512439A true JPH11512439A (ja) 1999-10-26
JPH11512439A5 JPH11512439A5 (enExample) 2004-09-16

Family

ID=21707614

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9512148A Ceased JPH11512439A (ja) 1995-09-14 1996-09-13 リン脂質の混合物を含む抗アポトーシス活性を有する組成物
JP2007297344A Pending JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007297344A Pending JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Country Status (7)

Country Link
US (1) US6004579A (enExample)
EP (1) EP0850064A1 (enExample)
JP (2) JPH11512439A (enExample)
CN (1) CN1200036A (enExample)
AU (1) AU7071896A (enExample)
CA (1) CA2229435A1 (enExample)
WO (1) WO1997009989A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506108A (ja) * 2005-08-31 2009-02-12 モダス・バイオロジカル・メンブランズ・リミテッド 好酸球増加症および関連障害の治療用組成物
JP2009539826A (ja) * 2006-06-09 2009-11-19 エラスムス ユニバーシティ メディカル センター ロッテルダム イノシトールリン脂質による免疫系の調節

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US5756126A (en) * 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP1489097B1 (en) 1994-01-11 2011-10-19 Dyax Corporation Inhibitors of human plasmin derived from kunitz domains and nucleic acids encoding the same
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
AU9027298A (en) * 1997-08-20 1999-03-08 Lxr Biotechnology Inc. Compositions containing polyethylene glycol and uses thereof
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US6270781B1 (en) * 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
US6413556B1 (en) * 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
KR20020020274A (ko) * 1999-08-18 2002-03-14 히라타 다다시 육모제
EP1248628A4 (en) * 1999-12-14 2004-08-04 Sky High Llc PHOSPHOLIPID COMPOSITIONS AS AN INFLAMMATORY INHIBITOR
US20060063738A1 (en) * 2000-02-28 2006-03-23 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
US6562804B2 (en) 2001-02-16 2003-05-13 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
US6562803B2 (en) 2001-02-16 2003-05-13 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
JP4836345B2 (ja) * 2001-04-13 2011-12-14 きみ子 室伏 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
JP2005504768A (ja) * 2001-08-20 2005-02-17 ウィリアム ジー． タットン アポトーシスに関連した疾患を治療するための方法および組成物
CA2368656A1 (en) * 2002-01-21 2003-07-21 Vasogen Ireland Limited Receptor-ligand pairing for anti-inflammatory response
US20050058698A1 (en) * 2002-01-21 2005-03-17 Nolan Yvonne Mairead Pharmaceutically acceptable phosphate-glycerol carrying bodies and uses relating to Parkinson's Disease
US20050147660A1 (en) * 2002-01-21 2005-07-07 Bolton Anthony E. Peptide-carrying bodies for immune response
US7064107B2 (en) 2002-06-07 2006-06-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ITMI20021280A1 (it) * 2002-06-11 2003-12-11 Carlo Ghisalberti Metodo di trattamento anticellulite
DE10238831A1 (de) * 2002-08-23 2004-03-11 Siemens Ag Verfahren und Vorrichtung zur Prozessoptimierung
US7166576B2 (en) * 2002-08-28 2007-01-23 Dyax Corp. Methods for preserving organs and tissues
EP1398019A1 (de) 2002-09-13 2004-03-17 Cognis France S.A. Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions
DK1587907T3 (da) * 2003-01-07 2011-04-04 Dyax Corp Kunitz-domænebibliotek
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
ES2447423T3 (es) * 2003-08-29 2014-03-12 Dyax Corp. Inhibidores de proteasa poli-pegilados
CA2604075C (en) * 2004-04-09 2011-03-29 Research Think Tank, Inc. Devices and methods for collection, storage and transportation of biological specimens
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
WO2008089103A2 (en) 2007-01-12 2008-07-24 University Of Maryland, Baltimore Targeting ncca-atp channel for organ protection following ischemic episode
CN101358609A (zh) * 2007-08-03 2009-02-04 富准精密工业(深圳)有限公司 风扇转子
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
WO2010128807A2 (ko) * 2009-05-07 2010-11-11 (주)문엔제이 신경손상 및 신경질환 예방 또는 치료용 약학조성물
PL3459564T3 (pl) 2010-01-06 2022-04-19 Takeda Pharmaceutical Company Limited Białka wiążące kalikreinę osocza
KR102502293B1 (ko) 2011-01-06 2023-02-21 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US9034820B2 (en) 2011-03-14 2015-05-19 Hsinyu Lee Method and composition for modulating erythropoiesis
EP3122782A4 (en) 2014-03-27 2017-09-13 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CN106032912A (zh) * 2015-03-11 2016-10-19 潍坊桂禾散热片科技有限公司 一种原子介质二次传导散热器
KR20250139401A (ko) 2015-12-11 2025-09-23 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 저해제 및 유전성 혈관부종 발작을 치료하기 위한 이의 용도
CA3167336A1 (en) 2020-01-13 2021-07-22 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
US20230081507A1 (en) 2020-02-26 2023-03-16 Finless Foods Inc. Systems and methods for live fish tissue preservation
CN112843072A (zh) * 2021-01-12 2021-05-28 山东省科学院生物研究所 磷脂在调控血管生成方面的应用
WO2023023309A1 (en) 2021-08-20 2023-02-23 Finless Foods Inc. Systems and methods for fish tissue preservation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1165238A (en) * 1980-03-12 1984-04-10 Demetrios P. Papahadjopoulos Activated liposomes and method
DE3173713D1 (en) * 1980-09-05 1986-03-20 Frappier Armand Inst Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
JP2524586B2 (ja) * 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
JPS6351335A (ja) * 1986-08-20 1988-03-04 Fuji Oil Co Ltd 肥満細胞脱顆粒抑制剤
US5053327A (en) * 1988-09-20 1991-10-01 The United States Of America As Represented By The Secretary Of Agriculture High affinity monoclonal antibodies to bowman-birk inhibitor and immunoassay methods
US5376373A (en) * 1990-09-06 1994-12-27 Trustees Of The University Of Pennsylvania Method of inhibiting radiation induced weight and hair loss
CA2086831C (en) * 1991-05-08 1999-03-16 Reinhard Gluck Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
DE69331805T2 (de) * 1992-12-10 2002-11-28 Enzon, Inc. Glycolipid enzym-polymer konjugate
WO1994025621A1 (en) * 1993-04-30 1994-11-10 Lxr Biotechnology Inc. Methods of identifying potentially therapeutically effective agents and cell strains for use therein
NZ248603A (en) * 1993-05-28 1994-12-22 Abbott Lab Nutritional product for enteral nutritional support of hiv victims comprising proteins and fat
US5759548A (en) * 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
JPH10505320A (ja) * 1994-05-31 1998-05-26 イネックス ファーマシューティカルズ コーポレイション 治療剤のビロゾーム媒介細胞内輸送

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506108A (ja) * 2005-08-31 2009-02-12 モダス・バイオロジカル・メンブランズ・リミテッド 好酸球増加症および関連障害の治療用組成物
JP2009539826A (ja) * 2006-06-09 2009-11-19 エラスムス ユニバーシティ メディカル センター ロッテルダム イノシトールリン脂質による免疫系の調節

Also Published As

Publication number Publication date
CN1200036A (zh) 1998-11-25
WO1997009989A1 (en) 1997-03-20
JP2008101009A (ja) 2008-05-01
US6004579A (en) 1999-12-21
CA2229435A1 (en) 1997-03-20
EP0850064A1 (en) 1998-07-01
AU7071896A (en) 1997-04-01

Similar Documents

Publication Publication Date Title
JPH11512439A (ja) リン脂質の混合物を含む抗アポトーシス活性を有する組成物
US5624672A (en) Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
US6949529B2 (en) Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US9757422B2 (en) Methods and compositions for regenerating and repairing damaged or aged tissue or organs using nonviable irradiated or lyophilized pluripotent stem cells
KR100617929B1 (ko) 환원된 조효소 ｑ 의 안정한 용액
JPH11502514A (ja) サメ軟骨の抽出物、その製造法および使用
US11931458B2 (en) Exosome systems, products and methods
AU751876B2 (en) Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US7259273B1 (en) Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof
US12409136B2 (en) Exosome systems, products and methods
US20060063738A1 (en) Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US20260000607A1 (en) Polymer-polymer Matrix for the Stabilization of Exosomes
TW202448415A (zh) 包含油鞘氨醇單胞菌培養提取物的脂質體組合物及化妝品組合物
RU98104073A (ru) Композиция, обладающая антиапоптотической активностью, содержащая смесь фосфолипидов

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070522

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070820

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071001

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071001

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20071019

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071115

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080701

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080922

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090707

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20091026

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20091201