JPH11512439A - リン脂質の混合物を含む抗アポトーシス活性を有する組成物 - Google Patents

リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Info

Publication number
JPH11512439A
JPH11512439A JP9512148A JP51214897A JPH11512439A JP H11512439 A JPH11512439 A JP H11512439A JP 9512148 A JP9512148 A JP 9512148A JP 51214897 A JP51214897 A JP 51214897A JP H11512439 A JPH11512439 A JP H11512439A
Authority
JP
Japan
Prior art keywords
composition
phospholipid
cells
effective amount
lpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9512148A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11512439A5 (enExample
Inventor
シー． バサースト，イアン
ダブリュー． フォーアー，マシュー
ジー． ゴダード，ジョン
デイビッド トメル，ルイス
Original Assignee
エルエックスアール バイオテクノロジー インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エルエックスアール バイオテクノロジー インコーポレイテッド filed Critical エルエックスアール バイオテクノロジー インコーポレイテッド
Publication of JPH11512439A publication Critical patent/JPH11512439A/ja
Publication of JPH11512439A5 publication Critical patent/JPH11512439A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP9512148A 1995-09-14 1996-09-13 リン脂質の混合物を含む抗アポトーシス活性を有する組成物 Ceased JPH11512439A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US378995P 1995-09-14 1995-09-14
US60/003,789 1995-09-14
PCT/US1996/014752 WO1997009989A1 (en) 1995-09-14 1996-09-13 Compositions with anti-apoptotic activity, containing a mixture of phospholipids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007297344A Division JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Publications (2)

Publication Number Publication Date
JPH11512439A true JPH11512439A (ja) 1999-10-26
JPH11512439A5 JPH11512439A5 (enExample) 2004-09-16

Family

ID=21707614

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9512148A Ceased JPH11512439A (ja) 1995-09-14 1996-09-13 リン脂質の混合物を含む抗アポトーシス活性を有する組成物
JP2007297344A Pending JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007297344A Pending JP2008101009A (ja) 1995-09-14 2007-11-15 リン脂質の混合物を含む抗アポトーシス活性を有する組成物

Country Status (7)

Country Link
US (1) US6004579A (enExample)
EP (1) EP0850064A1 (enExample)
JP (2) JPH11512439A (enExample)
CN (1) CN1200036A (enExample)
AU (1) AU7071896A (enExample)
CA (1) CA2229435A1 (enExample)
WO (1) WO1997009989A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506108A (ja) * 2005-08-31 2009-02-12 モダス・バイオロジカル・メンブランズ・リミテッド 好酸球増加症および関連障害の治療用組成物
JP2009539826A (ja) * 2006-06-09 2009-11-19 エラスムス ユニバーシティ メディカル センター ロッテルダム イノシトールリン脂質による免疫系の調節

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US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US5756126A (en) * 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
PT737207E (pt) * 1994-01-11 2005-02-28 Dyax Corp Inibidores de plasmina humana derivados de dominios kunitz
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
WO1999008514A1 (en) * 1997-08-20 1999-02-25 Lxr Biotechnology, Inc. Compositions containing polyethylene glycol and uses thereof
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US6413556B1 (en) * 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
US6270781B1 (en) * 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
EP1214928A4 (en) * 1999-08-18 2004-03-24 Kyowa Hakko Kogyo Kk HAIR GROWTH FUNDS
US6500810B2 (en) * 1999-12-14 2002-12-31 Sky High, Llc Method of regulating expression of adhesion molecules on circulating leukocytes
US20060063738A1 (en) * 2000-02-28 2006-03-23 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
CA2371398A1 (en) 2001-02-16 2002-08-16 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
CA2371400A1 (en) 2001-02-16 2002-08-16 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent
JP4836345B2 (ja) * 2001-04-13 2011-12-14 きみ子 室伏 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
EP1425020A4 (en) * 2001-08-20 2005-05-18 Tatton Technologies Llc METHOD AND COMPOSITIONS FOR TREATING APOPTOSIS-RELATED DISEASES
US20050058698A1 (en) * 2002-01-21 2005-03-17 Nolan Yvonne Mairead Pharmaceutically acceptable phosphate-glycerol carrying bodies and uses relating to Parkinson's Disease
CA2368656A1 (en) * 2002-01-21 2003-07-21 Vasogen Ireland Limited Receptor-ligand pairing for anti-inflammatory response
US20050147660A1 (en) * 2002-01-21 2005-07-07 Bolton Anthony E. Peptide-carrying bodies for immune response
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7064107B2 (en) 2002-06-07 2006-06-20 Dyax Corp. Prevention and reduction of blood loss
ITMI20021280A1 (it) * 2002-06-11 2003-12-11 Carlo Ghisalberti Metodo di trattamento anticellulite
DE10238831A1 (de) * 2002-08-23 2004-03-11 Siemens Ag Verfahren und Vorrichtung zur Prozessoptimierung
ES2395014T3 (es) * 2002-08-28 2013-02-07 Dyax Corp. Métodos para conservar órganos y tejidos
EP1398019A1 (de) 2002-09-13 2004-03-17 Cognis France S.A. Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions
DE602004031589D1 (de) * 2003-01-07 2011-04-14 Dyax Corp Kunitz-domäne-bibliothek
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
CA2536873C (en) * 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
WO2005102526A1 (en) * 2004-04-09 2005-11-03 Research Think Tank, Inc. Devices and methods for collection, storage and transportation of biological specimens
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
US9511075B2 (en) 2007-01-12 2016-12-06 The University Of Maryland, Baltimore Targeting NCCA-ATP channel for organ protection following ischemic episode
CN101358609A (zh) * 2007-08-03 2009-02-04 富准精密工业(深圳)有限公司 风扇转子
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
KR101237927B1 (ko) 2009-05-07 2013-03-04 (주)문엔제이 신경손상 및 신경질환 예방 또는 치료용 약학조성물
AU2011204349C1 (en) 2010-01-06 2017-02-16 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
WO2012094587A1 (en) 2011-01-06 2012-07-12 Dyax Corp. Plasma kallikrein binding proteins
US9034820B2 (en) 2011-03-14 2015-05-19 Hsinyu Lee Method and composition for modulating erythropoiesis
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CN106032912A (zh) * 2015-03-11 2016-10-19 潍坊桂禾散热片科技有限公司 一种原子介质二次传导散热器
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
WO2021173535A1 (en) 2020-02-26 2021-09-02 Finless Foods Inc. Systems and methods for live fish tissue preservation
CN112843072A (zh) * 2021-01-12 2021-05-28 山东省科学院生物研究所 磷脂在调控血管生成方面的应用
WO2023023309A1 (en) 2021-08-20 2023-02-23 Finless Foods Inc. Systems and methods for fish tissue preservation

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JPS6351335A (ja) * 1986-08-20 1988-03-04 Fuji Oil Co Ltd 肥満細胞脱顆粒抑制剤
US5053327A (en) * 1988-09-20 1991-10-01 The United States Of America As Represented By The Secretary Of Agriculture High affinity monoclonal antibodies to bowman-birk inhibitor and immunoassay methods
US5376373A (en) * 1990-09-06 1994-12-27 Trustees Of The University Of Pennsylvania Method of inhibiting radiation induced weight and hair loss
JPH06500128A (ja) * 1991-05-08 1994-01-06 シュバイツ・ゼルム―・ウント・インプフィンスティテュート・ベルン 免疫刺激及び免疫増強性再構成インフルエンザウイロソーム及びそれを含有するワクチン
JPH08507677A (ja) * 1992-12-10 1996-08-20 エンゾン，インコーポレーテッド 糖脂質酵素−ポリマー結合体
CA2161771C (en) * 1993-04-30 2009-01-13 L. David Tomei Methods of identifying potentially therapeutically effective agents and cell strains for use therein
NZ248603A (en) * 1993-05-28 1994-12-22 Abbott Lab Nutritional product for enteral nutritional support of hiv victims comprising proteins and fat
US5759548A (en) * 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
JPH10505320A (ja) * 1994-05-31 1998-05-26 イネックス ファーマシューティカルズ コーポレイション 治療剤のビロゾーム媒介細胞内輸送

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506108A (ja) * 2005-08-31 2009-02-12 モダス・バイオロジカル・メンブランズ・リミテッド 好酸球増加症および関連障害の治療用組成物
JP2009539826A (ja) * 2006-06-09 2009-11-19 エラスムス ユニバーシティ メディカル センター ロッテルダム イノシトールリン脂質による免疫系の調節

Also Published As

Publication number Publication date
WO1997009989A1 (en) 1997-03-20
AU7071896A (en) 1997-04-01
JP2008101009A (ja) 2008-05-01
CA2229435A1 (en) 1997-03-20
CN1200036A (zh) 1998-11-25
US6004579A (en) 1999-12-21
EP0850064A1 (en) 1998-07-01

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