CN1199968C - 新的地洛他定盐、其合成方法及其药物组合物 - Google Patents

新的地洛他定盐、其合成方法及其药物组合物 Download PDF

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Publication number
CN1199968C
CN1199968C CNB018193382A CN01819338A CN1199968C CN 1199968 C CN1199968 C CN 1199968C CN B018193382 A CNB018193382 A CN B018193382A CN 01819338 A CN01819338 A CN 01819338A CN 1199968 C CN1199968 C CN 1199968C
Authority
CN
China
Prior art keywords
formula
desloratadine
acid
loratadine
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018193382A
Other languages
English (en)
Chinese (zh)
Other versions
CN1476443A (zh
Inventor
J·菲舍尔
T·福多尔
F·特里施勒
S·莱瓦伊
E·派泰尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUANGARY GIRUI GYOGYSZERGYAR
Original Assignee
HUANGARY GIRUI GYOGYSZERGYAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUANGARY GIRUI GYOGYSZERGYAR filed Critical HUANGARY GIRUI GYOGYSZERGYAR
Publication of CN1476443A publication Critical patent/CN1476443A/zh
Application granted granted Critical
Publication of CN1199968C publication Critical patent/CN1199968C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018193382A 2000-11-23 2001-11-14 新的地洛他定盐、其合成方法及其药物组合物 Expired - Lifetime CN1199968C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0004701A HU226998B1 (en) 2000-11-23 2000-11-23 Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
HUP0004701 2000-11-23

Publications (2)

Publication Number Publication Date
CN1476443A CN1476443A (zh) 2004-02-18
CN1199968C true CN1199968C (zh) 2005-05-04

Family

ID=89978790

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018193382A Expired - Lifetime CN1199968C (zh) 2000-11-23 2001-11-14 新的地洛他定盐、其合成方法及其药物组合物

Country Status (19)

Country Link
US (1) US7196195B2 (enExample)
EP (1) EP1347965B1 (enExample)
JP (1) JP4427249B2 (enExample)
CN (1) CN1199968C (enExample)
AT (1) ATE316525T1 (enExample)
AU (1) AU2002218422A1 (enExample)
CA (1) CA2425422C (enExample)
CY (1) CY1105595T1 (enExample)
CZ (1) CZ304694B6 (enExample)
DE (1) DE60116902T2 (enExample)
DK (1) DK1347965T3 (enExample)
ES (1) ES2257467T3 (enExample)
HU (1) HU226998B1 (enExample)
NO (1) NO325155B1 (enExample)
PL (1) PL206973B1 (enExample)
RU (1) RU2285001C2 (enExample)
SK (1) SK285715B6 (enExample)
UA (1) UA74858C2 (enExample)
WO (1) WO2002042290A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086275A2 (en) * 2002-04-15 2003-10-23 Sun Pharmaceutical Industries Limited Preperation of desloratatine
HRP20050110A2 (en) * 2002-08-05 2006-02-28 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate
JP4501015B2 (ja) 2004-03-17 2010-07-14 味の素株式会社 アミノピリミジン化合物の製造方法
EA011894B1 (ru) * 2004-07-07 2009-06-30 Эгиш Дьёдьсердьяр Нирт. Новая псевдополиморфная форма деслоратадина, образованная с диоксидом углерода
CA2541045A1 (en) * 2006-03-24 2007-09-24 Pharmascience Inc. A descarbonylethoxyloratadine containing pharmaceutical composition
EP2837631A1 (en) * 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2020372682A1 (en) * 2019-10-31 2022-06-09 Jd Bioscience Inc. Tricyclic compound and pharmaceutical use thereof
CN115785065A (zh) * 2022-12-02 2023-03-14 山东达因海洋生物制药股份有限公司 一种地氯雷他定共晶及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
PT656348E (pt) * 1993-12-03 2000-10-31 Hoffmann La Roche Derivados do acido acetico como medicamentos
GB9709945D0 (en) * 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
SK287105B6 (sk) * 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
RU2164796C1 (ru) * 2000-05-25 2001-04-10 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Противогистаминное средство и способ его получения

Also Published As

Publication number Publication date
AU2002218422A1 (en) 2002-06-03
HUP0004701A2 (hu) 2002-11-28
DE60116902D1 (de) 2006-04-13
PL206973B1 (pl) 2010-10-29
NO20032314L (no) 2003-07-18
HU0004701D0 (enExample) 2001-02-28
JP2004514675A (ja) 2004-05-20
ES2257467T3 (es) 2006-08-01
CZ304694B6 (cs) 2014-09-03
US20050203116A1 (en) 2005-09-15
PL362126A1 (en) 2004-10-18
JP4427249B2 (ja) 2010-03-03
CA2425422A1 (en) 2002-05-30
SK285715B6 (sk) 2007-06-07
CZ20031321A3 (cs) 2003-08-13
CN1476443A (zh) 2004-02-18
SK5662003A3 (en) 2003-10-07
DE60116902T2 (de) 2006-08-24
NO325155B1 (no) 2008-02-11
DK1347965T3 (da) 2006-06-06
US7196195B2 (en) 2007-03-27
CA2425422C (en) 2009-11-10
EP1347965B1 (en) 2006-01-25
UA74858C2 (en) 2006-02-15
EP1347965A1 (en) 2003-10-01
HU226998B1 (en) 2010-04-28
NO20032314D0 (no) 2003-05-22
RU2285001C2 (ru) 2006-10-10
CY1105595T1 (el) 2010-07-28
WO2002042290A1 (en) 2002-05-30
ATE316525T1 (de) 2006-02-15

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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CX01 Expiry of patent term

Granted publication date: 20050504