CN1198807C - 作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物 - Google Patents

作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物 Download PDF

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Publication number
CN1198807C
CN1198807C CNB008154732A CN00815473A CN1198807C CN 1198807 C CN1198807 C CN 1198807C CN B008154732 A CNB008154732 A CN B008154732A CN 00815473 A CN00815473 A CN 00815473A CN 1198807 C CN1198807 C CN 1198807C
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China
Prior art keywords
alkyl
phenyl
amino
compound
triazole
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Expired - Fee Related
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CNB008154732A
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English (en)
Chinese (zh)
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CN1387517A (zh
Inventor
J-C·帕斯卡尔
D·卡尼阿托
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Laboratoire Theramex SAM
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Laboratoire Theramex SAM
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Publication of CN1387517A publication Critical patent/CN1387517A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008154732A 1999-11-09 2000-11-06 作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物 Expired - Fee Related CN1198807C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (en) 1999-11-09 1999-11-09 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
EP99402784.5 1999-11-09

Publications (2)

Publication Number Publication Date
CN1387517A CN1387517A (zh) 2002-12-25
CN1198807C true CN1198807C (zh) 2005-04-27

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Family Applications (1)

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CNB008154732A Expired - Fee Related CN1198807C (zh) 1999-11-09 2000-11-06 作为环加氧酶－2抑制剂的5－芳基－1h－1,2,4－三唑化合物及含有它们的药物组合物

Country Status (24)

Country Link
US (1) US6803380B1 (es)
EP (2) EP1099695A1 (es)
JP (1) JP4786846B2 (es)
CN (1) CN1198807C (es)
AT (1) ATE245148T1 (es)
AU (1) AU778819B2 (es)
BR (1) BR0015440A (es)
CA (1) CA2390649C (es)
CZ (1) CZ20021591A3 (es)
DE (1) DE60003949T2 (es)
DK (1) DK1246809T3 (es)
ES (1) ES2203538T3 (es)
HU (1) HUP0203376A3 (es)
IL (2) IL149370A0 (es)
MX (1) MXPA01012903A (es)
NO (1) NO328008B1 (es)
NZ (1) NZ518682A (es)
PL (1) PL204230B1 (es)
PT (1) PT1246809E (es)
RU (1) RU2249588C2 (es)
SI (1) SI1246809T1 (es)
TW (1) TWI268925B (es)
WO (1) WO2001034577A1 (es)
ZA (1) ZA200203165B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480073A (zh) * 2020-12-02 2021-03-12 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2240661T3 (es) 2001-07-05 2005-10-16 Pfizer Products Inc. Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos.
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
EP1273582B1 (en) 2001-07-05 2005-06-29 Pfizer Products Inc. Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents
KR100824233B1 (ko) 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) * 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
WO2006114377A1 (en) * 2005-04-28 2006-11-02 Ciba Specialty Chemicals Holding Inc. Electroluminescent device
JP2010500336A (ja) * 2006-08-09 2010-01-07 ファイザー・プロダクツ・インク 炭酸脱水酵素阻害剤として有用な複素環
KR101893624B1 (ko) * 2010-11-26 2018-08-30 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기금속 착물, 발광 엘리먼트, 발광 디바이스, 전자 디바이스 및 조명 디바이스
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
CN111818801A (zh) 2018-03-08 2020-10-23 拜耳公司 杂芳基-三唑和杂芳基-四唑化合物在植物保护中用作农药的用途
CN116925043A (zh) 2018-04-12 2023-10-24 拜耳公司 杂芳基-三唑化合物
MX2020011275A (es) 2018-04-25 2020-11-13 Bayer Ag Novedosos compuestos de heteroaril-triazol y hetroaril[-]tetrazol como plaguicidas.
BR112022000915A2 (pt) 2019-07-23 2022-05-17 Bayer Ag Compostos de heteroaril-triazol como pesticidas
MX2022000954A (es) 2019-07-23 2022-02-14 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas.
KR20220081359A (ko) 2019-10-09 2022-06-15 바이엘 악티엔게젤샤프트 살충제로서의 신규 헤테로아릴-트리아졸 화합물
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
KR20220143072A (ko) 2020-02-18 2022-10-24 바이엘 악티엔게젤샤프트 살충제로서의 헤테로아릴-트리아졸 화합물
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (es) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480073A (zh) * 2020-12-02 2021-03-12 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Also Published As

Publication number Publication date
DE60003949T2 (de) 2004-05-27
EP1246809A1 (en) 2002-10-09
PL204230B1 (pl) 2009-12-31
CZ20021591A3 (cs) 2002-07-17
DK1246809T3 (da) 2003-10-20
AU778819B2 (en) 2004-12-23
RU2249588C2 (ru) 2005-04-10
HUP0203376A3 (en) 2004-12-28
EP1099695A1 (en) 2001-05-16
JP2003513961A (ja) 2003-04-15
CA2390649C (en) 2008-05-06
CN1387517A (zh) 2002-12-25
PL356120A1 (en) 2004-06-14
HUP0203376A2 (hu) 2003-01-28
BR0015440A (pt) 2002-07-02
MXPA01012903A (es) 2002-11-07
EP1246809B1 (en) 2003-07-16
CA2390649A1 (en) 2001-05-17
NO20022202L (no) 2002-05-08
ZA200203165B (en) 2003-06-25
IL149370A0 (en) 2002-11-10
NZ518682A (en) 2003-07-25
NO20022202D0 (no) 2002-05-08
AU1998501A (en) 2001-06-06
US6803380B1 (en) 2004-10-12
PT1246809E (pt) 2003-11-28
ES2203538T3 (es) 2004-04-16
DE60003949D1 (de) 2003-08-21
ATE245148T1 (de) 2003-08-15
SI1246809T1 (en) 2004-02-29
WO2001034577A1 (en) 2001-05-17
JP4786846B2 (ja) 2011-10-05
NO328008B1 (no) 2009-11-09
TWI268925B (en) 2006-12-21
IL149370A (en) 2007-06-17

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Granted publication date: 20050427

Termination date: 20111106