SI1246809T1 - 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them - Google Patents

5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Info

Publication number
SI1246809T1
SI1246809T1 SI200030220T SI200030220T SI1246809T1 SI 1246809 T1 SI1246809 T1 SI 1246809T1 SI 200030220 T SI200030220 T SI 200030220T SI 200030220 T SI200030220 T SI 200030220T SI 1246809 T1 SI1246809 T1 SI 1246809T1
Authority
SI
Slovenia
Prior art keywords
inhibitors
aryl
pharmaceutical compositions
cyclooxygenase
compositions containing
Prior art date
Application number
SI200030220T
Other languages
English (en)
Slovenian (sl)
Inventor
Jean-Claude Pascal
Denis Carniato
Original Assignee
Laboratoire Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex filed Critical Laboratoire Theramex
Publication of SI1246809T1 publication Critical patent/SI1246809T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200030220T 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them SI1246809T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (en) 1999-11-09 1999-11-09 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
PCT/EP2000/010956 WO2001034577A1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
EP00983110A EP1246809B1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
SI1246809T1 true SI1246809T1 (en) 2004-02-29

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030220T SI1246809T1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US6803380B1 (es)
EP (2) EP1099695A1 (es)
JP (1) JP4786846B2 (es)
CN (1) CN1198807C (es)
AT (1) ATE245148T1 (es)
AU (1) AU778819B2 (es)
BR (1) BR0015440A (es)
CA (1) CA2390649C (es)
CZ (1) CZ20021591A3 (es)
DE (1) DE60003949T2 (es)
DK (1) DK1246809T3 (es)
ES (1) ES2203538T3 (es)
HU (1) HUP0203376A3 (es)
IL (2) IL149370A0 (es)
MX (1) MXPA01012903A (es)
NO (1) NO328008B1 (es)
NZ (1) NZ518682A (es)
PL (1) PL204230B1 (es)
PT (1) PT1246809E (es)
RU (1) RU2249588C2 (es)
SI (1) SI1246809T1 (es)
TW (1) TWI268925B (es)
WO (1) WO2001034577A1 (es)
ZA (1) ZA200203165B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1273580B1 (en) * 2001-07-05 2005-06-15 Pfizer Products Inc. Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents
ATE298749T1 (de) 2001-07-05 2005-07-15 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
KR100824233B1 (ko) 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
CN101171239B (zh) * 2005-04-28 2013-08-14 西巴特殊化学品控股有限公司 场致发光器件
WO2008017932A2 (en) * 2006-08-09 2008-02-14 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
CN103347886A (zh) * 2010-11-26 2013-10-09 株式会社半导体能源研究所 有机金属配合物、发光元件、发光装置、电子设备以及照明装置
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
US20200404919A1 (en) 2018-03-08 2020-12-31 Bayer Aktiengesellschaft Use of heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides in plant protection
ES2965494T3 (es) 2018-04-12 2024-04-15 Bayer Ag Derivados de N-(ciclopropilmetil)-5-(metilsulfonil)-n-{1-[1-(pirimidin-2-il)-1H-1,2,4-triazol-5-il]etil}benzamida y los correspondientes derivados de piridina-carboxamida como plaguicidas
DK3919486T3 (da) 2018-04-25 2023-09-04 Bayer Ag Hidtil ukendte heteroaryl-triazol- og heteroaryl-tetrazolforbindelser som pesticider
TW202118754A (zh) 2019-07-23 2021-05-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基三唑化合物（一）
CA3148209A1 (en) 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
BR112022006791A2 (pt) 2019-10-09 2022-06-28 Bayer Ag Novos compostos heteroaril-triazol como pesticidas
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
JP2023513624A (ja) 2020-02-18 2023-03-31 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としてのヘテロアリール－トリアゾール化合物
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (es) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
NO20022202D0 (no) 2002-05-08
EP1099695A1 (en) 2001-05-16
EP1246809A1 (en) 2002-10-09
ES2203538T3 (es) 2004-04-16
PL356120A1 (en) 2004-06-14
JP4786846B2 (ja) 2011-10-05
EP1246809B1 (en) 2003-07-16
CA2390649A1 (en) 2001-05-17
PL204230B1 (pl) 2009-12-31
NZ518682A (en) 2003-07-25
JP2003513961A (ja) 2003-04-15
IL149370A (en) 2007-06-17
WO2001034577A1 (en) 2001-05-17
MXPA01012903A (es) 2002-11-07
BR0015440A (pt) 2002-07-02
ATE245148T1 (de) 2003-08-15
DE60003949T2 (de) 2004-05-27
NO20022202L (no) 2002-05-08
CN1198807C (zh) 2005-04-27
HUP0203376A2 (hu) 2003-01-28
TWI268925B (en) 2006-12-21
AU778819B2 (en) 2004-12-23
IL149370A0 (en) 2002-11-10
CA2390649C (en) 2008-05-06
US6803380B1 (en) 2004-10-12
CZ20021591A3 (cs) 2002-07-17
NO328008B1 (no) 2009-11-09
PT1246809E (pt) 2003-11-28
CN1387517A (zh) 2002-12-25
DE60003949D1 (de) 2003-08-21
AU1998501A (en) 2001-06-06
HUP0203376A3 (en) 2004-12-28
ZA200203165B (en) 2003-06-25
RU2249588C2 (ru) 2005-04-10
DK1246809T3 (da) 2003-10-20

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