CN1193230C - 液体样品中物质浓度的测量方法和装置及测试件 - Google Patents

液体样品中物质浓度的测量方法和装置及测试件 Download PDF

Info

Publication number
CN1193230C
CN1193230C CNB018086462A CN01808646A CN1193230C CN 1193230 C CN1193230 C CN 1193230C CN B018086462 A CNB018086462 A CN B018086462A CN 01808646 A CN01808646 A CN 01808646A CN 1193230 C CN1193230 C CN 1193230C
Authority
CN
China
Prior art keywords
sensor part
working sensor
working
partly
fluid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018086462A
Other languages
English (en)
Other versions
CN1426535A (zh
Inventor
O·W·H·达维斯
C·P·利奇
M·阿尔瓦雷茨-伊卡扎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeScan Scotland Ltd
Original Assignee
Inverness Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32827011&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1193230(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inverness Medical Ltd filed Critical Inverness Medical Ltd
Publication of CN1426535A publication Critical patent/CN1426535A/zh
Application granted granted Critical
Publication of CN1193230C publication Critical patent/CN1193230C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

一种测量例如血液或隙间流体一类液体样品中的葡萄糖之类的物质浓度的方法。所用的测量装置具有一个工作传感器部分(6b)、第二个工作传感器部分(8b)和一个参考传感器部分(4b)。液体样品放入测量装置中，并测量在每一个传感器部分(6b、8b)上的与液体样品中的物质浓度成正比的电流。比较测得的电流建立差值。如果误差值大于预先确定的阈值，则给出误差指示。另外还说明了带有两个工作传感器(6b、8b)的一次性使用的测试带。

Description

液体样品中物质浓度的测量方法和装置及测试件
技术领域
本发明涉及测量液体中物质的浓度的装置，更具体地说但不是唯一地，涉及测量血液或隙间流体中的葡萄糖浓度的装置和方法。
背景技术
测量血液中葡萄糖值的装置对糖尿病患者是非常宝贵的，特别是患者自己可以使用的装置更是宝贵，因为他们可以监测自己的葡萄糖值，并服用相应剂量的胰岛素。因此，这种装置的精确性非常重要，因为读数不精确会导致服用错误剂量的胰岛素，这可能是非常有害的。
还有，在所有实际的血液中葡萄糖的测量系统中，至少装置的一部分，即与血液样品接触的部分，是一次性使用的。因为使用者一般需要大量的一次性使用零件，因此，降低一次性使用零件的成本就特别重要。
现在已知的葡萄糖测量装置更多地是使用电化学测量方法，而不是老式的比色测定法。一般的原理是测量分别称为工作传感器部分和参考传感器部分的两个传感器部分之间的电流。工作传感器部分包括上面涂有一层酶试剂层的电极，该试剂包括酶和一种电子媒质的化合物。当将一个电位加在传感器部分上时，由于电子通过酶从要测量的物质(酶基片)转移至电极表面而产生电流。所产生的电流与传感器部分的面积和测试样品中的葡萄糖浓度成正比。由于假设已知工作传感器部分的面积，因此，电流与葡萄糖浓度成正比。
技术上已发现，如果工作传感器部分不是完全被血液覆盖，由于传感器有效面积减小，因此得出不精确的结果。提出了解决这个问题的各种方法，其中二种方法公布在US 5628890和US 5582697中。这两种方法都是依靠血液在测试带的表面上的单向流动，并且两种方法都是通过检测在工作传感器部分下游的电极或传感器部分上有液体样品存在而开始测试测量的。
通过减小工作传感器部分的尺寸，当然可以减小液体样品不够和工作传感器部分不能完全被覆盖的问题。然而，工作传感器部分面积小使标定结果有更大的可变性。
本发明者发现，除了工作传感器部分覆盖不完全以外，不精确的结果也可由生产这种装置的测试带时偶然的缺陷和例如使用者对工作传感器部分意外的损坏造成。根据发明者所知，以前解决这个问题的唯一实际的方法是保证用于生产测试带的印刷过程尽可能的精确，并依靠适当的质量控制措施。
发明内容
本发明的目的是至少部分地克服上述缺点，并且当从本发明的第一个方面看时，要提供一种测量液体样品中物质浓度的方法。该方法包括：提供具有第一个工作传感器部分，与第一个工作传感器部分的面积相同的第二个工作传感器部分和一个参考传感器部分的测量装置；将液体样品装入所述测量装置中；测量在每一个工作传感器部分上产生与液体样品中的所述物质的浓度成正比的电荷载体的电流；比较以每一个工作传感器部分上测得的电流，建立参数差值；和如果所述参数差值大于预先确定的阈值，则给出误差指示；并且如果所述的参数差在预先确定的阈值内，则记录所述工作传感器部分的电流，作为有效结果。
根据本发明，有效地测量二次与物质浓度有关的电流，并将两次测量进行比较，其中每一次测量都可用来作为另一次测量的检查。
在电化学分析方面，本发明是特别有利的。这时，要测量浓度的物质例如血液中的葡萄糖与工作传感器部分上的元素例如酶试剂起反应，产生载体电荷，从而产生与液体中物质的浓度成正比的电流。
另外，本方法所用的测量装置是新颖的和具有创造性的。因此，从本发明的第二个方面来看，它提供了一种测量在液体样品中的物质浓度的装置，所述装置包括用于产生与液体样品中所述物质的浓度成正比的载体电荷的一个参考传感器部分和一个工作传感器部分，其中，所述装置还包括也是用于产生与液体样品中的所述物质和浓度成正比的载体电荷的第二个工作传感器部分，每一个所述传感器部分的面积相同。
可以看出，根据本发明，该测量装置对比由于产生电荷载体，而通过两个工作传感器部分的电流；并且如果两个电流大不相同，即一个传感器部分上的电流与另一个传感器部分上的电流相差太大，则给出误差指示。这种方法不但可以检测一个传感器部分是否被液体样品适当地覆盖，而且可以检测在每一个传感器部分中的制造缺陷，或者在制造以后，是否被损坏，因为在这种情况下，即使完全覆盖工作传感器部分，在受影响的传感器部分上将产生异常的电流。
根据本发明，唯一可以不需要考虑的缺陷或损坏的形式是，对两个工作传感器部分影响程度相同的缺陷或损坏。然而，与影响一个工作传感器部分的缺陷比较，从逻辑上说这是不太可能的，因此要对先前技术进行改进。实际上，这种相似性可以忽略不计。在任何情况下，本发明不是限于提供两个工作传感器部分。技术熟练的人可以选择三个或更多个工作传感器部分，以进一步减少所有这些工作传感器部分受到相同的缺陷影响的概率。
用另一种方式来看本发明时可看出，本发明提供了一种结构，对于工作传感器部分的给定的总面积和给定的样品最小容积，可通过将工作传感器部分的面积分成二个，可以检测工作传感器部分不适当的充满和缺陷或损坏的情况。
一些或全部传感器部分可以作为一个整体装置的一部分。但最好至少将工作传感器部分作在可除去的测验件上。因此，当从另一个方面看时，本发明提供了一种用于测量在液体样品中的物质浓度的测试件，它包括一个基底件；一个参考传感器部分；和两个设置在基底件上的工作传感器部分，每一个工作传感器部分使用中可产生与液体样品中所述物质浓度成正比的载体电荷，每一个所述工作传感器部分的面积相同。
最好，在基底件上设置一个参考传感器部分。
技术熟练的人知道，所提供的测量装置对于正确的使用是可以自动进行测试的，它对克服损坏和某些制造缺陷是有效的。特别有利的是，由于可以大量制造例如测量血液中葡萄糖值的测试带，因此该装置中的传感器部分设置在单独的测验件上。一般，这种测试带可被懒人使用，他不需要非常小心地对待这些带以防止损坏。因此，在优选实施例中，可除去的试验件包括一次性使用的测试带。
由于根据本发明，可以发现损坏或有缺陷的测试带而拒绝它，因此最终结果的精确性和使用者的安全不再只取决于高度的制造精度和正确小心的使用。至少在后一种情况下，本发明的优选实施例，与已知的结构比较，有一个附加的安全层。虽然不希望有大量的试验被拒绝，但在许多情况下，不给出不精确的结果更重要。
两个工作传感器部分在装置内可以方便地布置，或根据优选实施例，布置在试验件上。布置该装置或试验件时，应使液体样品在工作传感器部分上自由流动。最好是，液体样品受到约束，使它在工作传感器部分上单向流动。
最好，两个工作传感器部分，一个放在另一个的下游。这可以保证在另一个工作传感器部分开始被覆盖以前，一个传感器部分总是完全被覆盖，这样可以避免液体样品不够覆盖二个传感器部分，和每一个传感器部分只是部分地被覆盖相同的量的这种那怕是很小的可能性。然而，如果上述小的危险可以接受，根据本发明的结构可使放置传感器部分比已知装置有更大的灵活性，同时还可以防止使用容积不合适的液体样品或使用其他不正确的产品或产品损坏。最好，两个工作传感器部分位于参考传感器部分的下游。
由两个工作传感器部分产生的电流可能不能直接进行比较，这是因为传感器部分不相同。在这种情况下，测量装置最好对由一个或两个工作传感器部分得出的测量值进行加权，使该二个测量值标准化。这时，参数差可以是标准化的电流值之间的简单的算术差。最好，两个传感器部分包括相同的工作材料和具有相同的面积。最好，两个工作传感器部分基本上相同。这可以使得参数差直接就是传感器部分上相应电流之间的比较，以便确定物质浓度的测量是否可靠。
用于确定不精确测量的阈值可以适当地选择。一般，因为适当的值取决于测量过程固有的可变性，结果所希望的精度等，因此阈值可根据经验选择。在一定程度上，在因阈值设定得低而得出的精确度，与因太不精确而不予考虑的测量的比例之间进行折衷。阈值可以设定在这样的值上，即根据结果服用的胰岛素不会对病人造成严重的伤害。
参数差可以是一个绝对值，例如，在每一个传感器部分上测量的电流之差，但最好为无量纲的，例如一个或另一个测量电流的百分数。
虽然不是一定需要，最好是在经过预先确定的时间以后，测量电流。
用于计算物质浓度的实际电流值可以只是从一个工作传感器部分得到的值，但最好是电流值的综合—例如二个电流的和或平均值。这样做的优点是可以利用最大的有效工作面积，这有助提高所得结果的精确度。
本发明的优选实施例为测量血液中葡萄糖浓度的装置，其中两个工作传感器部分和参考传感器部分设置在一次性使用的测试带上。
现用例子，参照附图来说明本发明的优选实施例。其中：
附图说明
图1表示根据本发明的测试带的基底件；
图2表示加在基底件上的碳轨迹的布局；
图3表示加在测试带上的绝缘层；
图4表示酶试剂层；
图5表示粘接剂层；
图6表示亲水性薄膜层；
图7表示测试带的覆盖层；
图8为没有使用根据本发明的方法得到的结果的图；和
图9为使用根据本发明的方法得出的，与图8相同的图。
具体实施方式
图1表示形成用于测量血液样品中的葡萄糖浓度的测试带的基底的一个长方形聚酯带2。图中孤立的表示一个基底件2，然而在实际中，在制造结束时，可从一张大的标准片材上切出一组这种测试带。
图2表示在这个例子中是用网板印刷加在基底件上的碳素墨水图形，但也可以使用技术上已知的任何适当的沉积方法。碳层包括4个互相电气绝缘的不同区域。在第一个轨迹4的远端形成参考/计数器传感器部分的电极4b。轨迹4沿长度方向延伸，在其近端形成一个连接终端4a。在第二和第三个轨迹6、8的远端，形成二个工作传感器部分的电极6b、8b；而在其近端，形成相应的连接终端6a、8a。第4个碳区域为一个连接桥10，它是在插入测试带时，使测量装置的电路封闭，以接通测量装置用的。
图3表示也可以用网板印刷法加上的下一个层。这是一个不溶于水的绝缘掩膜12，它在电极4b、6b、8b上形成一个窗口。该窗口控制露出的碳的尺寸，因而也是酶试剂层14(图4)与碳电极接触的尺寸。该窗口的尺寸和形状可使印刷在两个电极6b、8b上的酶斑点的面积完全相同。这表示，对于给足的电位，在有血液样品的情况下，通过每一个工作传感器部分的电流理论上相同。
酶层—在本实施例中为葡萄糖氧化酶试剂层14(图4)-印刷在掩膜12上，因而可通过掩膜上的窗口，印刷在电极4b、6b、8b上，分别形成参考/计数器传感器部分和二个工作传感器部分。然后，按照图5所示的图形，在测试带上印刷一个150微米厚的粘接剂层。为了清楚起见，与先前的图形比较，该图形放大了。三个分开的粘接剂区16a、16b、16c在一起，形成了它们之间的一个样品腔18。
在测试带的远端，层叠两块亲水性薄膜20(图6)，并用粘接剂16固定就位。第一块薄膜的作用是该样品腔18成为通过毛细管作用，可吸入液体和液体沿着它运动的一个细的通道。最后一个层表示在图7中，它是一个在远端有一个透明部分24的塑料保护覆盖带22。这可让使用者立刻知道是否使用了测试带，还可以粗略地用肉眼检查，血液加得是否够。
现在来说明测试带的使用。将测试带插入测量装置中。桥10使该装置中的电路完成闭合，因此可自动接通该装置。该装置有触点，与测试带上的终端4a、6a、8a连接。测量装置通过上述的终端，将400mv的电位加在计数器/参考传感器部分和两个工作传感器部分中的每一个部分之间。
然后将一滴血放在测试带的远端上。毛细管作用沿着上述样品腔18和在计数器/参考传感器部分和二个工作传感器部分上吸入血液。
经过预先确定的时间后，测量通过每一个工作传感器部分的电流和比较两个测量值。如果二个测量值的差大于10％，则在测量装置上显示误差信息，必需重复试验。然而，如果二个测量值彼此的差别在10％以内，则在该装置中将二个电流相加，并转换成葡萄糖值，显示在液晶显示器上。
为了举例说明根据本发明所得到的优点，利用上述这样制造的测试带进行比较试验。在试验中，将容积以幅度为0.2微升，从1微升增加至2微升的血滴，在保持葡萄糖浓度固定不变的条件下，加在测试带上。每一个容积重复8次试验。测量和记录在每一个工作传感器部分上测出的电流。结果表示在本说明书所附的表1中。
对于第一部分试验，将二个电流简单地加在一起，模拟具有综合面积的单一一个工作传感器部分。这些结果绘在图8中。
在试验的第二部分中，首先比较二个电流。只有当二个电流相差小于10％，才将它们加在一起，作为有效的结果。相差大于10％的值不予考虑。这个第二部分试验的结果绘在图9中。
立即可以看出，第二组结果精确得多，即它们变化小得多。另外，由于如果两个工作传感器部分完全被覆盖。则它们只给出彼此一致的结果，因此可以安全地假设，只有当二个工作传感器部分完全被覆盖时，实际上才给出结果，因此，第二组结果也比第一组结果精确得多。
这样，本发明的优选实施例可以检测和拒绝加在测试带上的样品不充分的那些试验，即测试带使用不正确的那些试验。同样，还可以检测和拒绝因损坏或制造缺陷而有缺陷的测验带。
在技术领域内，技术熟练的人会理解，在本发明的范围内，可以对上述说明的内容作许多变更。例如，本发明可用于测量任何液体中的任何适当物质的值，不仅仅是血液中的葡萄糖。另外，工作传感器部分不需要设在测试带上，而可以是整个装置的一部分。上述实施例中所用的10％的数值差纯粹是示例性的，可以选择任何适当的数值。
                              表1
  容积μL  工作电流1：μA  工作电流2：μA     差别％   检验到的误差     无误差检验
  1  7.07  0.00     -706800     7.07
1 6.94 5.98 -16.2175732 12.92
  1  5.53  0.01     -92050     5.54
  1  6.99  7.09     1.42393909   14.09     14.09
  1  7.34  7.02     -4.59016393   14.35     14.35
  1  7.16  6.79     -5.49742078   13.94     13.94
  1  7.01  3.47     -102.13441     10.48
  1  7.07  5.69     -24.2578605     12.77
  1.2  7.18  4.54     -58.2286847     11.72
  1.2  7.00  6.78     -3.35055351   13.78     13.78
  1.2  7.09  1.79     -297.032475     8.88
  1.2  6.31  0.00     -157550     6.31
  1.2  6.78  6.79     0.11788977   13.56     13.56
  1.2  6.95  6.59     -5.4029443   13.53     13.53
  1.2  6.62  6.28     -5.36795158   12.89     12.89
  1.2  7.23  3.78     -91.2721502     11.01
  1.4  7.16  6.90     -3.76811594   14.06     14.06
  1.4  7.14  6.94     -2.88184438   14.08     14.08
  1.4  7.17  7.02     -2.13675214   14.19     14.19
  1.4  7.02  6.01     -1.5918958   13.93     13.93
  1.4  6.95  6.91     -0.5788712   13.86     13.86
  1.4  6.93  6.88     -0.72674419   13.81     13.81
  1.4  7.09  6.92     -2.4566474   14.01     14.01
  1.4  7.25  7.40     2.02702703   14.65     14.65
  1.6  7.808  6.59     -18.4825493     14.40
  1.6  6.774  6.589     -2.80770982   13.36     13.36
  1.6  6.928  6.904     -0.34762457   13.83     13.83
  1.6     6.892     6.453     -6.80303735   13.35     13.35
  1.6     7.087     7.314     3.10363686   14.40     14.40
1.6 7.257 6.947 -4.46235785 14.20 14.20
  1.6     6.501     6.306     -3.09229305   12.81     12.81
  1.6     6.811     6.755     -0.82901554   13.57     13.57
  1.8     7.145     6.536     -9.31762546   13.68     13.68
  1.8     7.021     6.612     -6.18572293   13.63     13.63
  1.8     6.917     6.828     -1.30345636   13.75     13.75
  1.8     6.971     6.78     -2.81710914   13.75     13.75
1.8 7.016 6.941 -1.08053595 13.96 13.96
  1.8     6.977     7.179     2.81376236   14.16     14.16
  1.8     6.946     6.794     -2.23726828   13.74     13.74
  1.8     7.203     7.183     -0.27843519   14.39     14.39
2 7.145 6.536 -9.31762546 13.68 13.68
  2     7.021     6.621     -6.18572293   13.63     13.63
  2     6.917     6.828     -1.30345636   13.75     13.75
  2     6.971     6.78     -2.81710914   13.75     13.75
  2     7.016     6.941     -1.08053595   13.96     13.96
2 6.977 7.179 2.81376236 14.16 14.16
  2     6.946     6.794     -2.23726818   13.74     13.74
  2     7.203     7.183     -0.27843519   14.39     14.39

Claims (20)

1.一种测量在液体样品中的物质浓度的方法，该方法包括：
提供具有第一个工作传感器部分、与第一个工作传感器部分的面积相同的第二个工作传感器部分和参考传感器部分的测量装置；
将液体样品注入所述测量装置中；
测量在每一个工作传感器部分上产生与液体样品中所述物质的浓度成正比的电荷载体的电流；
比较从每一个工作传感器部分上测得的电流，形成参数差；
如果所述的参数差大于预先确定的阈值，则给出误差指示；并且
如果所述的参数差在预先确定的阈值内，则记录所述工作传感器部分的电流，作为有效结果。
2.如权利要求1所述的方法，其特征为，所述工作传感器部分设置在可除去的试验件上。
3.如权利要求2所述的方法，其特征为，所述参考传感器部分设在所述可除去的试验件上。
4.如上述权利要求1-3中任何一项所述的方法，其特征为它包括在预先确定的时间以后，测量在每一个传感器部分上的电流。
5.一种测量在液体样品中的物质浓度的装置，所述装置包括用于产生与液体样品中所述物质的浓度成正比的电荷载体的一个参考传感器部分和一个工作传感器部分，其中，所述装置还包括也是用于产生与液体样品中的所述物质的浓度成正比的电荷载体的第二个工作传感器部分，每一个所述传感器部分的面积相同。
6.如权利要求5所述的装置，其特征为，液体样品受到约束，横贯所述工作传感器部分单向流动。
7.如权利要求6所述的装置，其特征为，所述工作传感器部分，一个设置在另一个的下游。
8.如权利要求6或7所述的装置，其特征为，所述二个工作传感器部分都设在参考传感器部分的下游。
9.如权利要求8所述的装置，其特征为，所述二个工作传感器部分是相同。
10.如权利要求5～7中任何一项所述的装置，其特征为，所述工作传感器部分设置在可除去的试验件上。
11.如权利要求10所述的装置，其特征为，所述可除去的试验件包括一次性使用的测试带。
12.如权利要求5～7中任何一项所述的装置，其特征为，在预先确定的时间以后，测量所述电流。
13.如权利要求5～7中任何一项所述的装置，其特征为，所述工作传感器部分包括电化学电极。
14.一种用于测量在液体样品中的物质浓度的测试件，它包括：
一个基底件；
一个参考传感器部分；和
两个设置在基底件上的工作传感器部分，将每一个工作传感器部分设置成在使用中产生与液体样品中所述物质浓度成正比的电荷载体，每一个所述工作传感器部分的面积相同。
15.如权利要求14所述的测试件，其特征为，液体样品受到约束，横贯所述工作传感器部分上单向流动。
16.如权利要求15所述的测试件，其特征为，所述工作传感器部分，一个设在另一个的下游。
17.如权利要求14～16中任何一项所述的测试件，其特征为，两个所述的工作传感器部分设在所述参考传感器部分的下游。
18.如权利要求14～16中任何一项所述的测试件，其特征为，每个所述工作传感器部分完全相同。
19.如权利要求14～16中任何一项所述的测试件，它包括一个一次性使用的测试带。
20.如权利要求14～16中任何一项所述的测试件，其特征为，所述工作传感器部分包括电化学电极。
CNB018086462A 2000-03-08 2001-03-07 液体样品中物质浓度的测量方法和装置及测试件 Expired - Lifetime CN1193230C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0005564.0 2000-03-08
GBGB0005564.0A GB0005564D0 (en) 2000-03-08 2000-03-08 Measurjement of substances in liquid
US09/521,163 US6733655B1 (en) 2000-03-08 2000-03-08 Measurement of substances in liquids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100789911A Division CN100383519C (zh) 2000-03-08 2001-03-07 测量施加到测试带的测量装置的液体样品容积不充分方法

Publications (2)

Publication Number Publication Date
CN1426535A CN1426535A (zh) 2003-06-25
CN1193230C true CN1193230C (zh) 2005-03-16

Family

ID=32827011

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2004100789911A Expired - Lifetime CN100383519C (zh) 2000-03-08 2001-03-07 测量施加到测试带的测量装置的液体样品容积不充分方法
CNB018086462A Expired - Lifetime CN1193230C (zh) 2000-03-08 2001-03-07 液体样品中物质浓度的测量方法和装置及测试件

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB2004100789911A Expired - Lifetime CN100383519C (zh) 2000-03-08 2001-03-07 测量施加到测试带的测量装置的液体样品容积不充分方法

Country Status (20)

Country Link
US (3) US6733655B1 (zh)
EP (4) EP2056107B1 (zh)
JP (1) JP4832695B2 (zh)
KR (1) KR100872009B1 (zh)
CN (2) CN100383519C (zh)
AT (3) ATE423969T1 (zh)
AU (3) AU2001237587B2 (zh)
CA (1) CA2402139C (zh)
CZ (1) CZ20023332A3 (zh)
DE (2) DE60137802D1 (zh)
DK (2) DK1261868T3 (zh)
ES (2) ES2249413T3 (zh)
GB (1) GB0005564D0 (zh)
HK (2) HK1049696A1 (zh)
IL (2) IL151643A0 (zh)
MX (1) MXPA02008821A (zh)
PL (1) PL364990A1 (zh)
PT (1) PT1600773E (zh)
RU (1) RU2269779C2 (zh)
WO (1) WO2001067099A1 (zh)

Families Citing this family (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6071391A (en) 1997-09-12 2000-06-06 Nok Corporation Enzyme electrode structure
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6841052B2 (en) 1999-08-02 2005-01-11 Bayer Corporation Electrochemical-sensor design
US20050103624A1 (en) 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
US7276146B2 (en) 2001-11-16 2007-10-02 Roche Diagnostics Operations, Inc. Electrodes, methods, apparatuses comprising micro-electrode arrays
WO2001036953A1 (en) 1999-11-15 2001-05-25 Matsushita Electric Industrial Co., Ltd. Biosensor, method of forming thin-film electrode, and method and apparatus for quantitative determination
GB0005564D0 (en) * 2000-03-08 2000-05-03 Inverness Medical Ltd Measurjement of substances in liquid
ES2312719T3 (es) * 2000-03-28 2009-03-01 Diabetes Diagnostics, Inc. Medidor con sensor de glucosa de respuesta rapida.
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002044705A1 (en) * 2000-11-30 2002-06-06 Matsushita Electric Industrial Co., Ltd. Biosensor, measuring instrument for biosensor, and method of quantifying substrate
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
EP1395185B1 (en) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Electric lancet actuator
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US20030116447A1 (en) 2001-11-16 2003-06-26 Surridge Nigel A. Electrodes, methods, apparatuses comprising micro-electrode arrays
US20030212379A1 (en) * 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
CA2419213C (en) * 2002-03-07 2011-06-21 Bayer Healthcare Llc Improved electrical sensor
US20030186446A1 (en) 2002-04-02 2003-10-02 Jerry Pugh Test strip containers and methods of using the same
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US6964871B2 (en) * 2002-04-25 2005-11-15 Home Diagnostics, Inc. Systems and methods for blood glucose sensing
US20080112852A1 (en) * 2002-04-25 2008-05-15 Neel Gary T Test Strips and System for Measuring Analyte Levels in a Fluid Sample
US6743635B2 (en) 2002-04-25 2004-06-01 Home Diagnostics, Inc. System and methods for blood glucose sensing
US6946299B2 (en) 2002-04-25 2005-09-20 Home Diagnostics, Inc. Systems and methods for blood glucose sensing
US7303726B2 (en) 2002-05-09 2007-12-04 Lifescan, Inc. Minimal procedure analyte test system
KR100485671B1 (ko) 2002-09-30 2005-04-27 주식회사 인포피아 바이오 센서의 시료 반응결과 측정장치 및 그 방법
US9017544B2 (en) 2002-10-04 2015-04-28 Roche Diagnostics Operations, Inc. Determining blood glucose in a small volume sample receiving cavity and in a short time period
JP3878993B2 (ja) * 2002-10-31 2007-02-07 アークレイ株式会社 分析用具
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040193202A1 (en) 2003-03-28 2004-09-30 Allen John J. Integrated lance and strip for analyte measurement
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
US7462265B2 (en) * 2003-06-06 2008-12-09 Lifescan, Inc. Reduced volume electrochemical sensor
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US20040251132A1 (en) * 2003-06-06 2004-12-16 Leach Christopher Philip Reduced volume strip
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
JP4619359B2 (ja) 2003-06-20 2011-01-26 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト フレア状に形成された試料受入チャンバーを持つ試験片
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
GB0314944D0 (en) * 2003-06-26 2003-07-30 Univ Cranfield Electrochemical detector for metabolites in physiological fluids
US8060173B2 (en) 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8788006B2 (en) 2003-08-01 2014-07-22 Dexcom, Inc. System and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7655119B2 (en) 2003-10-31 2010-02-02 Lifescan Scotland Limited Meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials
PT1678489E (pt) 2003-10-31 2007-06-19 Lifescan Scotland Ltd Método de redução do efeito da corrente de interferência directa numa tira de teste electroquímica
CA2511746C (en) * 2003-11-06 2013-03-26 Lifescan, Inc. Drug delivery pen with event notification means
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP1711790B1 (en) 2003-12-05 2010-09-08 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
WO2005078118A1 (en) 2004-02-06 2005-08-25 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
DE102004024432A1 (de) * 2004-05-14 2005-12-08 Tesa Ag Verwendung einer Folie mit hydrophiler Oberfläche in medizinischen Diagnosestreifen
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
DE112005001154B4 (de) 2004-06-23 2011-09-29 Tesa Se Medizinischer Biosensor, mittels dem biologische Flüssigkeiten untersucht werden
US20050284773A1 (en) 2004-06-29 2005-12-29 Allen John J Method of preventing reuse in an analyte measuring system
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US7905833B2 (en) 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US7713392B2 (en) * 2005-04-15 2010-05-11 Agamatrix, Inc. Test strip coding and quality measurement
US20060246214A1 (en) * 2005-04-28 2006-11-02 Plotkin Elliot V Method for manufacturing an electrochemical-based analytical test strip with hydrophilicity enhanced metal electrodes
US20060243591A1 (en) * 2005-04-28 2006-11-02 Plotkin Elliot V Electrochemical-based analytical test strip with hydrophilicity enhanced metal electrodes
US20070017824A1 (en) * 2005-07-19 2007-01-25 Rippeth John J Biosensor and method of manufacture
MX2008000836A (es) 2005-07-20 2008-03-26 Bayer Healthcare Llc Amperimetria regulada.
EP1934591B1 (en) 2005-09-30 2019-01-02 Ascensia Diabetes Care Holdings AG Gated voltammetry
US7429865B2 (en) 2005-10-05 2008-09-30 Roche Diagnostics Operations, Inc. Method and system for error checking an electrochemical sensor
US7468125B2 (en) 2005-10-17 2008-12-23 Lifescan, Inc. System and method of processing a current sample for calculating a glucose concentration
US8066866B2 (en) * 2005-10-17 2011-11-29 Lifescan, Inc. Methods for measuring physiological fluids
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
EP3756537B1 (en) 2006-02-22 2023-08-02 DexCom, Inc. Analyte sensor
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
EP4218548A1 (en) 2006-03-09 2023-08-02 Dexcom, Inc. Systems and methods for processing analyte sensor data
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
US7738264B2 (en) 2006-03-31 2010-06-15 Lifescan Scotland Ltd. Devices and methods for protecting handheld electronic devices from electrostatic discharge
US20100021940A1 (en) * 2006-04-12 2010-01-28 Astrazeneca Ab Method for Determining the Activity of a Protease in a Sample
JP5121822B2 (ja) * 2006-05-08 2013-01-16 バイエル・ヘルスケア・エルエルシー バイオセンサ用異常出力検出システム
US7589828B2 (en) * 2006-05-26 2009-09-15 Lifescan Scotland Limited System for analyte determination that includes a permutative grey scale calibration pattern
US7593097B2 (en) * 2006-05-26 2009-09-22 Lifescan Scotland Limited Method for determining a test strip calibration code for use in a meter
US7474391B2 (en) * 2006-05-26 2009-01-06 Lifescan Scotland Limited Method for determining a test strip calibration code using a calibration strip
US7586590B2 (en) * 2006-05-26 2009-09-08 Lifescan, Scotland, Ltd. Calibration code strip with permutative grey scale calibration pattern
US7474390B2 (en) * 2006-05-26 2009-01-06 Lifescan Scotland Limited Test strip with permutative grey scale calibration pattern
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9046480B2 (en) 2006-10-05 2015-06-02 Lifescan Scotland Limited Method for determining hematocrit corrected analyte concentrations
EP2957908A1 (en) 2006-10-05 2015-12-23 Lifescan Scotland Limited Methods for determining an analyte concentration using signal processing algorithms
EP2074415A1 (en) 2006-10-05 2009-07-01 Lifescan Scotland Limited A test strip comprising patterned electrodes
ES2397663T3 (es) 2006-10-05 2013-03-08 Lifescan Scotland Limited Sistemas y procedimientos para determinar una concentración de un analito sustancialmente independiente del hematocrito
US8388821B2 (en) 2006-10-05 2013-03-05 Lifescan Scotland Limited Method for determining hematocrit corrected analyte concentrations
EP3753481B1 (en) 2006-10-24 2024-07-17 Ascensia Diabetes Care Holdings AG Transient decay amperometry device
US20080124693A1 (en) * 2006-10-26 2008-05-29 Mcevoy Mary System for determining an analyte in a bodily fluid sample that includes a graphics-based step-by-step tutorial module
US20080164142A1 (en) 2006-10-27 2008-07-10 Manuel Alvarez-Icaza Surface treatment of carbon composite material to improve electrochemical properties
TW200823456A (en) * 2006-11-24 2008-06-01 Health & Life Co Ltd Biosensor
DE102007003755A1 (de) 2007-01-19 2008-07-31 Tesa Ag Bahnförmiges Material mit einer Beschichtung, die ein dauerhaftes schnelles Spreiten beziehungsweise einen dauerhaften sehr schnellen Transport von Flüssigkeiten ermöglicht
CA2681412A1 (en) 2007-03-26 2008-10-02 Dexcom, Inc. Analyte sensor
DE102007018383A1 (de) 2007-04-17 2008-10-23 Tesa Ag Flächenförmiges Material mit hydrophilen und hydrophoben Bereichen und deren Herstellung
DE102007026998A1 (de) 2007-06-07 2008-12-11 Tesa Ag Hydrophiler Beschichtungslack
US7875461B2 (en) 2007-07-24 2011-01-25 Lifescan Scotland Limited Test strip and connector
US8762624B2 (en) * 2007-08-29 2014-06-24 Lifescan Scotland Limited Data management system and method using nonvolatile and volatile memories and linked lists to sequentially store data records of different category types
US7943022B2 (en) 2007-09-04 2011-05-17 Lifescan, Inc. Analyte test strip with improved reagent deposition
EP2108125A1 (en) * 2007-09-05 2009-10-14 Lifescan Scotland Limited Strip for an electrochemical meter
EP2040079B1 (de) 2007-09-19 2009-05-20 F. Hoffman-la Roche AG Markierungsverfahren zur Ausschussmarkierung von Testelementen
EP2040072B1 (de) * 2007-09-22 2013-01-02 Roche Diagnostics GmbH Analysesystem zur Bestimmung der Konzentration eines Analyten in einer Körperflüssigkeit
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
USD612279S1 (en) 2008-01-18 2010-03-23 Lifescan Scotland Limited User interface in an analyte meter
DE102008006225A1 (de) 2008-01-25 2009-07-30 Tesa Ag Biosensor und dessen Herstellung
USD612275S1 (en) 2008-03-21 2010-03-23 Lifescan Scotland, Ltd. Analyte test meter
USD615431S1 (en) 2008-03-21 2010-05-11 Lifescan Scotland Limited Analyte test meter
IL197532A0 (en) 2008-03-21 2009-12-24 Lifescan Scotland Ltd Analyte testing method and system
USD611853S1 (en) 2008-03-21 2010-03-16 Lifescan Scotland Limited Analyte test meter
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
USD611151S1 (en) 2008-06-10 2010-03-02 Lifescan Scotland, Ltd. Test meter
USD611489S1 (en) 2008-07-25 2010-03-09 Lifescan, Inc. User interface display for a glucose meter
USD611372S1 (en) 2008-09-19 2010-03-09 Lifescan Scotland Limited Analyte test meter
US8994395B2 (en) * 2008-10-27 2015-03-31 Lifescan Scotland Limited Methods and devices for mitigating ESD events
US8012428B2 (en) 2008-10-30 2011-09-06 Lifescan Scotland, Ltd. Analytical test strip with minimal fill-error sample viewing window
US20100112612A1 (en) * 2008-10-30 2010-05-06 John William Dilleen Method for determining an analyte using an analytical test strip with a minimal fill-error viewing window
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
EP2228658A1 (de) 2009-03-13 2010-09-15 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Verbrauchsmittels
US20100270152A1 (en) * 2009-04-24 2010-10-28 Lifescan Scotland Limited Enzymatic reagent ink
US20100273249A1 (en) 2009-04-24 2010-10-28 Lifescan Scotland Limited Analytical test strips
US8025788B2 (en) 2009-04-24 2011-09-27 Lifescan Scotland Limited Method for manufacturing an enzymatic reagent ink
US20110057671A1 (en) 2009-09-04 2011-03-10 Lifescan Scotland, Ltd. Methods, system and device to identify a type of test strip
IL209760A (en) 2009-12-11 2015-05-31 Lifescan Scotland Ltd A system and method for measuring filling is satisfactory
TWI440853B (zh) * 2009-12-14 2014-06-11 Taidoc Technology Corp 具有校正血容比功能之分析物測量電化學生物感測試紙、生物感測器裝置、系統以及測量方法
EP2365329A1 (en) * 2010-03-12 2011-09-14 Hivox Biotek Inc. Method of manufacturing planar bio-test strip and product thereof
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8940141B2 (en) 2010-05-19 2015-01-27 Lifescan Scotland Limited Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution
US20110290668A1 (en) 2010-05-27 2011-12-01 Lifescan Scotland Limited Analytical test strip with crossroads exposed electrode configuration
US8239582B2 (en) 2010-05-27 2012-08-07 Cilag Gmbh International Hand-held test meter with disruption avoidance circuitry
US20110315564A1 (en) 2010-06-28 2011-12-29 Cilag Gmbh International Hand-held test meter with deep power conservation mode
US9618517B2 (en) * 2010-09-28 2017-04-11 Lifescan Scotland Limited Analyte measurement method and system with error trapping
US20120199498A1 (en) 2011-02-07 2012-08-09 Manuel Alvarez-Icaza Electrochemical-based analytical test strip with graded enzymatic reagent layer and related methods
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
WO2012164271A1 (en) * 2011-05-27 2012-12-06 Lifescan Scotland Limited Peak offset correction for analyte test strip
US20130006536A1 (en) 2011-06-28 2013-01-03 Lifescan, Inc. Hand-held test meter with unpowered usb connection detection circuit
US20130002266A1 (en) 2011-06-28 2013-01-03 Lifescan, Inc. Hand-held test meter with electromagnetic interference detection circuit
US10739337B2 (en) * 2011-08-30 2020-08-11 Board Of Trustees Of Michigan State University Extraction and detection of pathogens using carbohydrate-functionalized biosensors
US8603309B2 (en) 2011-09-12 2013-12-10 Nova Biomedical Corporation Disposable sensor for electrochemical detection of hemoglobin
US20130084590A1 (en) 2011-09-30 2013-04-04 Lifescan Scotland Ltd. Analytical test strip with bodily fluid phase-shift measurement electrodes
US20130084591A1 (en) 2011-09-30 2013-04-04 Lifescan Scotland Ltd. Analytical test strip with isolated bodily fluid phase-shift and analyte determination sample chambers
US9970933B2 (en) * 2011-10-06 2018-05-15 Ingibio, Ltd. Method for manufacturing multiple-diagnosis membrane sensor by using screen printing
KR101367262B1 (ko) * 2011-11-11 2014-02-26 주식회사 아이센스 자가혈당측정기 및 이를 이용한 측정 이상 감지 방법
US9572922B2 (en) 2012-12-21 2017-02-21 Larry Leonard Inventive diabetic systems, tools, kits, and supplies for better diabetic living and mobility
US9903830B2 (en) 2011-12-29 2018-02-27 Lifescan Scotland Limited Accurate analyte measurements for electrochemical test strip based on sensed physical characteristic(s) of the sample containing the analyte
US20130199942A1 (en) 2012-02-07 2013-08-08 Lifescan Scotland Limited Electrochemical-based analytical test strip with fill-speed configured reagent layer
US11798685B2 (en) 2012-05-15 2023-10-24 James M. Minor Diagnostic methods and devices for controlling acute glycemia
US9465910B2 (en) 2012-05-15 2016-10-11 James Minor Diagnostic methods and devices for monitoring chronic glycemia
US20130341207A1 (en) 2012-06-21 2013-12-26 Lifescan Scotland Limited Analytical test strip with capillary sample-receiving chambers separated by stop junctions
US9128038B2 (en) 2012-06-21 2015-09-08 Lifescan Scotland Limited Analytical test strip with capillary sample-receiving chambers separated by a physical barrier island
US8877023B2 (en) 2012-06-21 2014-11-04 Lifescan Scotland Limited Electrochemical-based analytical test strip with intersecting sample-receiving chambers
GB201218555D0 (en) * 2012-10-16 2012-11-28 Mode Diagnostics Ltd Immunoassay using electrochemical detection
US9211087B2 (en) 2012-10-18 2015-12-15 Animas Corporation Self-contained hand-held test device for single-use
US9157883B2 (en) 2013-03-07 2015-10-13 Lifescan Scotland Limited Methods and systems to determine fill direction and fill error in analyte measurements
US9097659B2 (en) * 2013-03-14 2015-08-04 Bayer Healthcare Llc Maintaining electrode function during manufacture with a protective layer
US10371660B2 (en) 2013-05-17 2019-08-06 Lifescan Ip Holdings, Llc Accurate analyte measurements for electrochemical test strip based on multiple calibration parameters
GB2514846B (en) 2013-06-07 2015-09-30 Lifescan Scotland Ltd Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode
US9243276B2 (en) * 2013-08-29 2016-01-26 Lifescan Scotland Limited Method and system to determine hematocrit-insensitive glucose values in a fluid sample
US9459231B2 (en) 2013-08-29 2016-10-04 Lifescan Scotland Limited Method and system to determine erroneous measurement signals during a test measurement sequence
US9828621B2 (en) * 2013-09-10 2017-11-28 Lifescan Scotland Limited Anomalous signal error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte
US9453812B2 (en) 2014-06-24 2016-09-27 Lifescan Scotland Limited End-fill electrochemical-based analytical test strip with perpendicular intersecting sample-receiving chambers
CN105445341B (zh) * 2014-09-12 2018-10-16 达尔生技股份有限公司 电化学的检测试片异常的检测方法
US20160091451A1 (en) 2014-09-25 2016-03-31 Lifescan Scotland Limited Accurate analyte measurements for electrochemical test strip to determine analyte measurement time based on measured temperature, physical characteristic and estimated analyte value
US20160091450A1 (en) 2014-09-25 2016-03-31 Lifescan Scotland Limited Accurate analyte measurements for electrochemical test strip to determine analyte measurement time based on measured temperature, physical characteristic and estimated analyte value and their temperature compensated values
CN106990232B (zh) * 2016-01-01 2019-05-28 海南欣泰康医药科技有限公司 血液试剂分析系统以及分析方法
CN110770574B (zh) 2017-06-08 2022-07-15 豪夫迈·罗氏有限公司 电极断裂检测
US20190094170A1 (en) 2017-09-22 2019-03-28 Cilag Gmbh International Analytical test strip with integrated electrical resistor
CN108132284B (zh) * 2017-12-26 2019-11-29 三诺生物传感股份有限公司 一种电化学传感器的测试方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5682884A (en) 1983-05-05 1997-11-04 Medisense, Inc. Strip electrode with screen printing
DE68924026T3 (de) * 1988-03-31 2008-01-10 Matsushita Electric Industrial Co., Ltd., Kadoma Biosensor und dessen herstellung.
JP2577981B2 (ja) * 1988-12-14 1997-02-05 株式会社堀場製作所 プロセス用イオン測定装置
US5234813A (en) 1989-05-17 1993-08-10 Actimed Laboratories, Inc. Method and device for metering of fluid samples and detection of analytes therein
JP2960265B2 (ja) * 1991-10-18 1999-10-06 松下電器産業株式会社 バイオセンサおよびそれを用いた測定方法
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
JP3189416B2 (ja) * 1992-09-25 2001-07-16 松下電器産業株式会社 液体の成分測定装置
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
US5791344A (en) * 1993-11-19 1998-08-11 Alfred E. Mann Foundation For Scientific Research Patient monitoring system
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
KR0151203B1 (ko) * 1994-12-08 1998-12-01 이헌조 다중전극형 바이오센서
US5650062A (en) 1995-03-17 1997-07-22 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same
JP3102627B2 (ja) * 1995-03-17 2000-10-23 松下電器産業株式会社 バイオセンサ、それを用いた定量法および定量装置
US5582697A (en) 1995-03-17 1996-12-10 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same
US5786584A (en) 1995-09-06 1998-07-28 Eli Lilly And Company Vial and cartridge reading device providing audio feedback for a blood glucose monitoring system
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
JP3365184B2 (ja) * 1996-01-10 2003-01-08 松下電器産業株式会社 バイオセンサ
US5708247A (en) 1996-02-14 1998-01-13 Selfcare, Inc. Disposable glucose test strips, and methods and compositions for making same
TW591230B (en) * 1997-10-14 2004-06-11 Bayer Ag Method for improving the accuracy of the semi-quantitative determination of analyte in fluid samples
JP3267933B2 (ja) * 1998-01-27 2002-03-25 松下電器産業株式会社 基質の定量法
US6587705B1 (en) 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
GB2337122B (en) 1998-05-08 2002-11-13 Medisense Inc Test strip
US6258229B1 (en) * 1999-06-02 2001-07-10 Handani Winarta Disposable sub-microliter volume sensor and method of making
US6287451B1 (en) * 1999-06-02 2001-09-11 Handani Winarta Disposable sensor and method of making
GB0005564D0 (en) * 2000-03-08 2000-05-03 Inverness Medical Ltd Measurjement of substances in liquid

Also Published As

Publication number Publication date
JP4832695B2 (ja) 2011-12-07
KR100872009B1 (ko) 2008-12-05
HK1049696A1 (en) 2003-05-23
HK1085267A1 (en) 2006-08-18
ATE423969T1 (de) 2009-03-15
AU3758701A (en) 2001-09-17
CZ20023332A3 (cs) 2003-06-18
US6733655B1 (en) 2004-05-11
EP1600773B1 (en) 2009-02-25
EP1600773A1 (en) 2005-11-30
IL151643A (en) 2006-09-05
EP2056107B1 (en) 2012-01-18
EP2261657A3 (en) 2013-12-04
EP1261868B1 (en) 2005-10-19
AU2005218034A1 (en) 2005-10-20
RU2269779C2 (ru) 2006-02-10
US7250105B1 (en) 2007-07-31
CA2402139A1 (en) 2001-09-13
AU2005218034B2 (en) 2008-11-20
CN100383519C (zh) 2008-04-23
EP2261657A2 (en) 2010-12-15
ES2249413T3 (es) 2006-04-01
CN1426535A (zh) 2003-06-25
IL151643A0 (en) 2003-04-10
DE60114159T2 (de) 2006-06-29
ES2321416T3 (es) 2009-06-05
EP2261657B1 (en) 2016-10-19
MXPA02008821A (es) 2004-10-15
GB0005564D0 (en) 2000-05-03
CN1591000A (zh) 2005-03-09
CA2402139C (en) 2011-07-05
US20080011059A1 (en) 2008-01-17
PT1600773E (pt) 2009-04-08
ATE307336T1 (de) 2005-11-15
DE60114159D1 (de) 2006-03-02
DE60137802D1 (de) 2009-04-09
EP2056107A3 (en) 2009-07-22
ATE542132T1 (de) 2012-02-15
DK1600773T3 (da) 2009-06-22
RU2002126614A (ru) 2004-03-27
DK1261868T3 (da) 2005-11-21
WO2001067099A1 (en) 2001-09-13
KR20070092335A (ko) 2007-09-12
PL364990A1 (en) 2004-12-27
EP1261868A1 (en) 2002-12-04
EP2056107A2 (en) 2009-05-06
AU2001237587B2 (en) 2005-08-04
JP2003526785A (ja) 2003-09-09

Similar Documents

Publication Publication Date Title
CN1193230C (zh) 液体样品中物质浓度的测量方法和装置及测试件
EP1447452B1 (en) Method of detecting bias in enzyme electrode measurements
US7949473B2 (en) Method for detecting erroneous measurement results obtained with ion-selective electrodes
US8916040B2 (en) System and method for measuring an analyte in a sample
EP2602620A1 (en) An electronic lateral flow test arrangement and method
DE60224863T2 (de) Elektrochemischer Sensor mit einem Mittel zum Nachweis von Unterfüllung
WO2009061568A1 (en) Biosensor coding system
EP2752661A2 (en) Test strip coding and quality measurement
EP1666879A2 (en) Read-write assay system
CN112229884A (zh) 基于碳糊修饰工艺的维生素检测印刷电极及其制备工艺
WO1998009160A1 (en) Sodium ion selective electrode membrane having extended uselife
EP1906180B1 (en) Method for detecting erroneous measurement results obtained with ion selective electrodes
EP1906179A1 (en) Method for detecting erroneous measurement results obtained with ion selective electrodes
KR20180111739A (ko) 검사 스트립
US20080169799A1 (en) Method for biosensor analysis
CN117990768B (zh) 一种体液测定方法、装置和电子设备
CN1220397A (zh) 一检多项一步免疫检测方法与半定量一步免疫检测方法
KR100795322B1 (ko) 액체 내의 물질 농도 측정 방법 및 장치
GB2621635A (en) An electrochemical lateral flow device
FI65676C (fi) Metod och anlaeggning foer analyser
CN2762138Y (zh) 生物感测器测试片结构
TWM474136U (zh) 雙面結構檢測試片及其檢測裝置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20050316