CN119258073A - 抑制软性隐形眼镜变质的眼科用组合物 - Google Patents
抑制软性隐形眼镜变质的眼科用组合物 Download PDFInfo
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- CN119258073A CN119258073A CN202411382579.2A CN202411382579A CN119258073A CN 119258073 A CN119258073 A CN 119258073A CN 202411382579 A CN202411382579 A CN 202411382579A CN 119258073 A CN119258073 A CN 119258073A
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- ophthalmic composition
- salt
- acid
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- epinastine
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- 229940069338 potassium sorbate Drugs 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C13/00—Assembling; Repairing; Cleaning
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Inorganic Chemistry (AREA)
- Optics & Photonics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018205215A JP2019108320A (ja) | 2018-10-31 | 2018-10-31 | ソフトコンタクトレンズの変質を抑制する眼科用組成物 |
| JP2018-205215 | 2018-10-31 | ||
| PCT/JP2019/042590 WO2020090895A1 (ja) | 2018-10-31 | 2019-10-30 | ソフトコンタクトレンズの変質を抑制する眼科用組成物 |
| CN201980071142.8A CN112969465B (zh) | 2018-10-31 | 2019-10-30 | 抑制软性隐形眼镜变质的眼科用组合物 |
Related Parent Applications (1)
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|---|---|---|---|
| CN201980071142.8A Division CN112969465B (zh) | 2018-10-31 | 2019-10-30 | 抑制软性隐形眼镜变质的眼科用组合物 |
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|---|---|
| CN119258073A true CN119258073A (zh) | 2025-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411382579.2A Pending CN119258073A (zh) | 2018-10-31 | 2019-10-30 | 抑制软性隐形眼镜变质的眼科用组合物 |
| CN201980071142.8A Active CN112969465B (zh) | 2018-10-31 | 2019-10-30 | 抑制软性隐形眼镜变质的眼科用组合物 |
| CN202411383513.5A Pending CN119236081A (zh) | 2018-10-31 | 2019-10-30 | 花粉破裂抑制剂在制造用于治疗及/或预防过敏性疾病的药物中的用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201980071142.8A Active CN112969465B (zh) | 2018-10-31 | 2019-10-30 | 抑制软性隐形眼镜变质的眼科用组合物 |
| CN202411383513.5A Pending CN119236081A (zh) | 2018-10-31 | 2019-10-30 | 花粉破裂抑制剂在制造用于治疗及/或预防过敏性疾病的药物中的用途 |
Country Status (4)
| Country | Link |
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| JP (3) | JP2019108320A (enExample) |
| CN (3) | CN119258073A (enExample) |
| TW (1) | TWI832920B (enExample) |
| WO (1) | WO2020090895A1 (enExample) |
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| JP6963651B2 (ja) * | 2020-04-16 | 2021-11-10 | 参天製薬株式会社 | エピナスチン又はその塩を含有する水性組成物 |
| JP7118579B1 (ja) | 2020-04-16 | 2022-08-16 | 参天製薬株式会社 | エピナスチン又はその塩を含有する水性組成物 |
| JP7114668B2 (ja) * | 2020-10-08 | 2022-08-08 | 参天製薬株式会社 | エピナスチン又はその塩を含有する花粉破裂抑制剤 |
| KR20230124625A (ko) * | 2020-12-24 | 2023-08-25 | 산텐 세이야꾸 가부시키가이샤 | 에피나스틴 또는 그의 염과 황계 항산화제를 함유하는경피 투여용 의약 조성물 |
| CN113608363B (zh) * | 2021-08-24 | 2023-04-14 | 江苏康耐特光学有限公司 | 一种制备高折射率树脂镜片的前弯弯度设计方法 |
| JP2023166315A (ja) * | 2022-05-09 | 2023-11-21 | ロート製薬株式会社 | 眼科組成物 |
| WO2024135837A1 (ja) * | 2022-12-23 | 2024-06-27 | 参天製薬株式会社 | 組織移行性及び防腐効力を向上させるエピナスチン含有水性組成物 |
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| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| WO2007088783A1 (ja) * | 2006-02-02 | 2007-08-09 | Menicon Co., Ltd. | ソフトコンタクトレンズ用点眼・装着液 |
| JP6751016B2 (ja) * | 2014-03-31 | 2020-09-02 | ロート製薬株式会社 | 眼科用又は耳鼻科用水性組成物 |
| US20180161438A1 (en) * | 2015-05-28 | 2018-06-14 | Rohto Pharmaceutical Co., Ltd. | Aqueous Ophthalmic Composition |
| JP6134853B1 (ja) * | 2016-10-28 | 2017-05-24 | 参天製薬株式会社 | エピナスチン含有点眼液 |
| JP6940276B2 (ja) * | 2016-12-26 | 2021-09-22 | 小林製薬株式会社 | 花粉破裂抑制剤 |
| JP6971570B2 (ja) * | 2016-12-26 | 2021-11-24 | 小林製薬株式会社 | 花粉破裂抑制剤 |
| JP7313181B2 (ja) * | 2018-04-23 | 2023-07-24 | ロート製薬株式会社 | 眼科組成物 |
| JP7382731B2 (ja) * | 2018-04-23 | 2023-11-17 | ロート製薬株式会社 | 眼科組成物 |
| JP7355539B2 (ja) * | 2018-07-20 | 2023-10-03 | ロート製薬株式会社 | 眼科組成物 |
| JP7458159B2 (ja) * | 2018-09-28 | 2024-03-29 | ロート製薬株式会社 | 眼科組成物 |
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| JP7429681B2 (ja) | 2024-02-08 |
| CN112969465A (zh) | 2021-06-15 |
| JP6992033B2 (ja) | 2022-01-13 |
| TWI832920B (zh) | 2024-02-21 |
| TW202031263A (zh) | 2020-09-01 |
| CN112969465B (zh) | 2024-10-25 |
| JP2019108320A (ja) | 2019-07-04 |
| JP2022022379A (ja) | 2022-02-03 |
| JP2020070301A (ja) | 2020-05-07 |
| WO2020090895A1 (ja) | 2020-05-07 |
| CN119236081A (zh) | 2025-01-03 |
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