CN118652336A - Cd33特异性嵌合抗原受体 - Google Patents
Cd33特异性嵌合抗原受体 Download PDFInfo
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- CN118652336A CN118652336A CN202410513486.2A CN202410513486A CN118652336A CN 118652336 A CN118652336 A CN 118652336A CN 202410513486 A CN202410513486 A CN 202410513486A CN 118652336 A CN118652336 A CN 118652336A
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
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- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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- A61K2239/13—Antibody-based
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2319/00—Fusion polypeptide
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C12N2510/00—Genetically modified cells
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- Molecular Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Hematology (AREA)
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- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347503P | 2016-06-08 | 2016-06-08 | |
| US62/347,503 | 2016-06-08 | ||
| PCT/US2017/036440 WO2017214333A1 (en) | 2016-06-08 | 2017-06-07 | Cd33 specific chimeric antigen receptors |
| CN201780048487.2A CN110191898B (zh) | 2016-06-08 | 2017-06-07 | Cd33特异性嵌合抗原受体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780048487.2A Division CN110191898B (zh) | 2016-06-08 | 2017-06-07 | Cd33特异性嵌合抗原受体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118652336A true CN118652336A (zh) | 2024-09-17 |
Family
ID=59071136
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780048487.2A Active CN110191898B (zh) | 2016-06-08 | 2017-06-07 | Cd33特异性嵌合抗原受体 |
| CN202410513486.2A Pending CN118652336A (zh) | 2016-06-08 | 2017-06-07 | Cd33特异性嵌合抗原受体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780048487.2A Active CN110191898B (zh) | 2016-06-08 | 2017-06-07 | Cd33特异性嵌合抗原受体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11787848B2 (enExample) |
| EP (1) | EP3468994A1 (enExample) |
| JP (3) | JP7591342B2 (enExample) |
| KR (3) | KR20240111740A (enExample) |
| CN (2) | CN110191898B (enExample) |
| AU (2) | AU2017279548B2 (enExample) |
| CA (1) | CA3025667A1 (enExample) |
| IL (2) | IL321834A (enExample) |
| SG (1) | SG11201810640RA (enExample) |
| WO (1) | WO2017214333A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| AU2017279548B2 (en) | 2016-06-08 | 2024-08-08 | Precigen, Inc. | CD33 specific chimeric antigen receptors |
| BR112019017751A2 (pt) | 2017-02-28 | 2020-04-07 | Vor Biopharma, Inc. | composições e métodos de inibição de proteínas de linhagem específica |
| IL269553B2 (en) | 2017-03-27 | 2025-10-01 | Nat Univ Singapore | Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| US11118168B2 (en) | 2017-06-07 | 2021-09-14 | Precigen, Inc. | Expression of novel cell tags |
| JP2021500882A (ja) * | 2017-10-18 | 2021-01-14 | プレシゲン,インコーポレイテッド | スペーサーを含むポリペプチド組成物 |
| WO2019084234A1 (en) * | 2017-10-26 | 2019-05-02 | St. Jude Childen's Research Hospital, Inc. | METHODS AND COMPOSITIONS FOR TREATING CD33 + CANCERS AND IMPROVING IN VIVO PERSISTENCE OF CHIMERIC ANTIGEN RECEPTOR T CELLS |
| EP3720559A4 (en) * | 2017-12-04 | 2021-10-06 | Actinium Pharmaceuticals, Inc. | METHODS OF TREATMENT OF PATIENTS WITH MYELODYSPLASIC SYNDROMES |
| CN111712516A (zh) * | 2018-02-09 | 2020-09-25 | 新加坡国立大学 | 粘附受体构建体及其在自然杀伤细胞免疫疗法中的用途 |
| US12258381B2 (en) | 2018-02-09 | 2025-03-25 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| EP3752203A1 (en) * | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| EP3743446A1 (en) * | 2018-03-12 | 2020-12-02 | Nantkwest, Inc. | Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity) |
| MX2020009472A (es) * | 2018-03-14 | 2020-12-07 | Us Health | Receptores de antigenos quimericos anti-cd33 y sus usos. |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| JP2021525534A (ja) | 2018-06-04 | 2021-09-27 | プレシゲン,インコーポレイテッド | Muc16特異的キメラ抗原受容体およびそれらの使用 |
| US20210230543A1 (en) * | 2018-06-05 | 2021-07-29 | H.Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising protein l for expanding immune cells for immunotherapy |
| US20210236547A1 (en) * | 2018-06-05 | 2021-08-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid production, expansion, and increased purity of car-t cells using beads with protein l |
| CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
| CN110699318A (zh) * | 2018-07-09 | 2020-01-17 | 广西慧宝源健康产业有限公司 | T细胞培养基及培养方法 |
| AU2019301147A1 (en) * | 2018-07-10 | 2021-01-21 | Precigen, Inc. | ROR-1 specific chimeric antigen receptors and uses thereof |
| CN110862967A (zh) * | 2018-08-27 | 2020-03-06 | 天津天锐生物科技有限公司 | 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk |
| CN113423725A (zh) | 2018-08-28 | 2021-09-21 | Vor生物制药股份有限公司 | 遗传工程化造血干细胞及其用途 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CN110950954B (zh) * | 2018-09-26 | 2021-06-25 | 重庆精准生物技术有限公司 | 抗cd123人源化单链抗体及其应用 |
| US11701408B2 (en) * | 2018-10-11 | 2023-07-18 | Nantcell, Inc. | Treatment of immunosuppressed subjects |
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