CN118325899A - Hsd17b13变体及其应用 - Google Patents
Hsd17b13变体及其应用 Download PDFInfo
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- CN118325899A CN118325899A CN202410406162.9A CN202410406162A CN118325899A CN 118325899 A CN118325899 A CN 118325899A CN 202410406162 A CN202410406162 A CN 202410406162A CN 118325899 A CN118325899 A CN 118325899A
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
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- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4704—Inhibitors; Supressors
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
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| PCT/US2018/014454 WO2018136758A1 (en) | 2017-01-23 | 2018-01-19 | Hsd17b13 variants and uses thereof |
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| US11479802B2 (en) | 2017-04-11 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family |
| AU2018348195B2 (en) | 2017-10-11 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| EP3768854A4 (en) * | 2018-03-21 | 2022-03-02 | Ionis Pharmaceuticals, Inc. | HSD17B13 EXPRESSION MODULATORS |
| BR112020018758A2 (pt) * | 2018-03-21 | 2021-01-26 | Regeneron Pharmaceuticals, Inc. | agente de ácido ribonucleico de fita dupla, célula, vetor, composição farmacêutica, e, métodos para inibição da expressão de 17¿-hidroxiesteroide desidrogenases tipo 13, para tratamento de um indivíduo, para prevenção de um sintoma em um indivíduo, para redução do risco de desenvolver doença hepática crônica, para inibição da progressão de esteatose, para inibição do acúmulo de gotículas de lipídios |
| CN112334577B (zh) | 2018-04-19 | 2023-10-17 | 加利福尼亚大学董事会 | 用于基因编辑的组合物和方法 |
| SG11202101698WA (en) * | 2018-09-19 | 2021-04-29 | Arrowhead Pharmaceuticals Inc | Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use |
| UA128236C2 (uk) * | 2018-12-21 | 2024-05-15 | Айоніс Фармасутікалз, Інк. | Модулятори експресії hsd17b13 |
| US11957687B2 (en) | 2019-07-02 | 2024-04-16 | Regeneron Pharmaceuticals, Inc. | Modulators of HSD17B13 and methods of use thereof |
| WO2021178556A1 (en) * | 2020-03-04 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for sensitization of tumor cells to immune therapy |
| KR20240004092A (ko) * | 2020-06-01 | 2024-01-11 | 암젠 인크 | Hsd17b13 발현을 억제하기 위한 rnai 작제물 및 이의 사용 방법 |
| EP4240866A4 (en) * | 2020-11-06 | 2024-10-30 | Inipharm, Inc. | H17B13 SPECIFIC SUBSTRATES AND PRODUCTS AS LIVER DISEASE MARKERS AND BIOMARKERS FOR THE TREATMENT OF LIVER DISEASES |
| CN112626199A (zh) * | 2021-01-04 | 2021-04-09 | 杭州艾迪康医学检验中心有限公司 | 检测慢性肝炎转化为肝硬化的风险预测位点的引物和方法 |
| WO2022223015A1 (zh) * | 2021-04-22 | 2022-10-27 | 上海拓界生物医药科技有限公司 | 靶向第13型17β-羟基类固醇脱氢酶的siRNA和siRNA缀合物 |
| CN118103038A (zh) | 2021-08-20 | 2024-05-28 | 英安塔制药有限公司 | 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法 |
| JP2024545602A (ja) * | 2021-11-19 | 2024-12-10 | ウェイブ ライフ サイエンシズ リミテッド | Hsd17b13関連二本鎖オリゴヌクレオチド組成物及びそれに関連する方法 |
| WO2024131916A1 (en) * | 2022-12-22 | 2024-06-27 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of 17beta-hydroxysteroid dehydrogenase type 13 (hsd17b13) |
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