CN118236477B - 脑膜炎奈瑟氏菌疫苗 - Google Patents
脑膜炎奈瑟氏菌疫苗 Download PDFInfo
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- CN118236477B CN118236477B CN202410220667.6A CN202410220667A CN118236477B CN 118236477 B CN118236477 B CN 118236477B CN 202410220667 A CN202410220667 A CN 202410220667A CN 118236477 B CN118236477 B CN 118236477B
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130122810A (ko) * | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| LT3506935T (lt) | 2016-09-02 | 2024-04-25 | Sanofi Pasteur, Inc. | Vakcina nuo neisseria meningitidis |
| EP3632465A1 (en) | 2018-10-03 | 2020-04-08 | Sanofi Pasteur Inc. | Combined immunization against meningococcal disease and human papillomavirus |
| MX2022006054A (es) | 2019-11-22 | 2022-06-24 | Glaxosmithkline Biologicals Sa | Dosificacion y administracion de una vacuna de glucoconjugados de sacaridos bacterianos. |
| AU2022223712A1 (en) | 2021-02-19 | 2023-10-05 | Sanofi Pasteur Inc. | Meningococcal b recombinant vaccine |
| JP2025512330A (ja) | 2022-04-11 | 2025-04-17 | サノフィ パスツール インコーポレイテッド | シアノ水素化ホウ素ナトリウムとのタンパク質-糖コンジュゲーション |
| TW202423477A (zh) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物 |
| JP2024075506A (ja) * | 2022-11-22 | 2024-06-03 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101208101A (zh) * | 2005-06-27 | 2008-06-25 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
| CN101208102A (zh) * | 2005-06-27 | 2008-06-25 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5097020A (en) | 1983-07-05 | 1992-03-17 | The University Of Rochester | Immunogenic conjugates |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4882317A (en) | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US5371197A (en) | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
| FR2682388B1 (fr) | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
| ES2171418T3 (es) * | 1992-08-31 | 2002-09-16 | Baxter Healthcare Sa | Vacunas contra neisseria meningitidis del grupo c. |
| ES2200059T3 (es) | 1995-03-22 | 2004-03-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos. |
| US20030157129A1 (en) | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
| US6309646B1 (en) | 1996-05-09 | 2001-10-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates |
| US5965714A (en) | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
| US6645503B1 (en) | 1998-03-10 | 2003-11-11 | Wyeth Holdings Corporation | Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria |
| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 |
| US6585973B1 (en) | 1998-10-29 | 2003-07-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method for preparing solid phase conjugated vaccine |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| FR2791895B1 (fr) | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
| CA2838395C (en) | 1999-05-19 | 2016-07-19 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| DE10012370A1 (de) | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| HU227893B1 (en) | 2000-06-29 | 2012-05-29 | Glaxosmithkline Biolog Sa | Vaccine compositions |
| US6673905B2 (en) | 2000-08-09 | 2004-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugation of biomolecules using Diels-Alder cycloaddition |
| DK1355673T3 (da) * | 2001-01-23 | 2012-09-17 | Sanofi Pasteur Inc | Multivalent meningococvaccine bestående af et polysaccharid/proteinkonjugat |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| AU2002330681C1 (en) | 2001-07-26 | 2015-04-02 | Glaxosmithkline Biologicals S.A. | Vaccines comprising aluminium adjuvants and histidine |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| CU23031A1 (es) | 2002-01-24 | 2005-02-23 | Ct Ingenieria Genetica Biotech | Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes |
| CA2480389C (en) | 2002-03-26 | 2012-10-09 | Chiron Srl | Modified saccharides having improved stability in water |
| WO2003094961A1 (en) | 2002-05-09 | 2003-11-20 | Massimo Porro | Improved polysaccharide and glycoconjugate vaccines_____________ |
| AU2003299501A1 (en) | 2002-05-16 | 2004-05-04 | Aventis Pasteur, Inc. | Animal component free meningococcal polysaccharide fermentation and seedbank development |
| WO2004011027A1 (en) | 2002-07-30 | 2004-02-05 | Baxter International Inc. | Chimeric multivalent polysaccharide conjugate vaccines |
| GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| WO2004039399A1 (en) | 2002-11-01 | 2004-05-13 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| ES2411080T3 (es) | 2003-01-30 | 2013-07-04 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| EP1624888B1 (en) | 2003-05-07 | 2016-10-12 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccine |
| US6933137B2 (en) | 2003-05-16 | 2005-08-23 | Aventis Pasteur | Animal component free meningococcal polysaccharide fermentation and seedbank development |
| KR101206544B1 (ko) | 2003-06-23 | 2012-11-30 | 박스터 헬쓰케어 에스.에이. | 백신용 담체 단백질 |
| BRPI0411815A (pt) | 2003-06-23 | 2006-08-08 | Baxter Int | vacinas contra neisseria meningitidis do tipo y e suas combinações meningocócicas |
| CN102151331B (zh) | 2003-08-06 | 2013-10-30 | 美国政府健康及人类服务部 | 多糖-蛋白轭合物疫苗 |
| US8048432B2 (en) | 2003-08-06 | 2011-11-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Polysaccharide-protein conjugate vaccines |
| US7807824B2 (en) | 2003-08-12 | 2010-10-05 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
| EP1961426B1 (en) | 2003-10-02 | 2011-04-27 | Novartis Vaccines and Diagnostics S.r.l. | Combined meningitis vaccines |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| CU23236A1 (es) | 2003-12-03 | 2007-09-26 | Ct Ingenieria Genetica Biotech | PROTEINA NMB0928 Y SU USO EN FORMULACIONES FARMACéUTICAS P |
| EP2272531A3 (en) | 2004-04-30 | 2011-04-13 | Novartis Vaccines and Diagnostics S.r.l. | Integration of meningococcal conjugate vaccination |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| EP1776389B1 (en) | 2004-08-12 | 2016-06-29 | Lipoxen Technologies Limited | Sialic acid derivatives |
| EP1784214A4 (en) | 2004-08-30 | 2009-09-23 | Sanofi Pasteur Inc | POLYSACCHARIDE / PROTEIN CONJUGATES MULTIVALENT MENINGOCOCCUS DERIVATIVE AND VACCINE |
| CN101072586A (zh) | 2004-09-21 | 2007-11-14 | 圣诺菲·帕斯图尔公司 | 多价脑膜炎球菌源性多糖-蛋白质缀合物及疫苗 |
| WO2006042542A2 (en) | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
| GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| AU2006245440B2 (en) | 2005-05-06 | 2012-04-19 | Novartis Vaccines And Diagnostics Srl | Immunogens for meningitidis-A vaccines |
| KR20130122810A (ko) | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| AU2012203419B2 (en) * | 2005-06-27 | 2014-06-26 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| BRPI0615420A2 (pt) | 2005-09-01 | 2011-05-17 | Novartis Vaccines & Diagnostic | vacinação múltipla que inclui meningococo do sorogrupo c |
| ATE485516T1 (de) | 2005-09-05 | 2010-11-15 | Glaxosmithkline Biolog Sa | Bakterizidie-serumtest für n. meningitidis spezifische antiseren |
| DK2384765T3 (en) | 2005-12-22 | 2017-01-09 | Glaxosmithkline Biologicals Sa | Vaccine against Streptococcus pneumoniae. |
| WO2007102797A2 (en) | 2005-12-22 | 2007-09-13 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| WO2007084856A2 (en) | 2006-01-13 | 2007-07-26 | Baxter International Inc. | Method for purifying polysaccharides |
| BRPI0708849B1 (pt) | 2006-03-17 | 2022-05-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para a preparação de conjugados imunogênicos multivalentes complexos, os referidos conjugados, e composições farmacêuticas |
| ES2670231T3 (es) | 2006-03-22 | 2018-05-29 | Glaxosmithkline Biologicals S.A. | Regímenes para inmunización con conjugados meningocócicos |
| CU23572A1 (es) | 2006-03-31 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Composición farmacéutica que comprende la proteína nmb0938 |
| CU23575A1 (es) | 2006-03-31 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Composición farmacéutica que comprende la proteína nmb0606 |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| EP2032161B1 (en) | 2006-06-12 | 2012-07-11 | GlaxoSmithKline Biologicals S.A. | L3v los vaccines |
| US7491517B2 (en) | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| EP3260134A1 (en) | 2006-08-07 | 2017-12-27 | President and Fellows of Harvard College | Protein matrix vaccines and methods of making and administering such vaccines |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0700135D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| WO2008129559A2 (en) | 2007-04-23 | 2008-10-30 | Serum Institute Of India Ltd | Antigenic polysaccharides and process for their preparation |
| IN2009KN04098A (enExample) | 2007-06-04 | 2015-08-28 | Novartis Ag | |
| US20100189740A1 (en) | 2007-06-20 | 2010-07-29 | Francis Michon | Modified polysaccharides for conjugate vaccines |
| EP2173759A4 (en) | 2007-07-03 | 2014-01-29 | Childrens Hosp & Res Ct Oak | OLIGOSIAL INSERTS, PROCESS FOR THEIR PREPARATION AND ITS IMMUNOLOGICAL USE |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| PT2200642E (pt) | 2007-10-19 | 2012-05-30 | Novartis Ag | Formulações de vacinas meningocócicas |
| ES2615390T3 (es) | 2008-03-05 | 2017-06-06 | Sanofi Pasteur | Proceso para estabilizar una composición de vacuna que contiene adyuvante |
| GB0810894D0 (en) | 2008-06-13 | 2008-07-23 | Novartis Vaccines & Diagnostic | Conjugated saccharide |
| CA2731384C (en) | 2008-07-21 | 2015-03-10 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| WO2010110931A2 (en) | 2009-03-23 | 2010-09-30 | The Brigham And Women's Hospital, Inc. | Glycoconjugate vaccines |
| BR112012004275A2 (pt) | 2009-08-27 | 2016-11-16 | Novartis Ag | polipeptídios híbridos incluindo sequências meningocócicas de fhbp |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| JP5781542B2 (ja) | 2009-12-30 | 2015-09-24 | ノバルティス アーゲー | E.coliキャリアタンパク質に結合体化した多糖免疫原 |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| US10478483B2 (en) * | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| CA2752980C (en) | 2010-09-23 | 2018-06-19 | Anhydrovac Inc. | Non-aqueous synthesis of polysaccharide-protein conjugates for vaccines |
| CA2828844C (en) * | 2011-03-02 | 2020-07-14 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
| US9724401B2 (en) | 2011-05-18 | 2017-08-08 | Matrivax, Inc. | Protein matrix vaccine compositions including polycations |
| US9358284B2 (en) | 2011-09-14 | 2016-06-07 | Glaxosmithkline Biologicals Sa | Methods for making saccharide-protein glycoconjugates |
| AU2012335208B2 (en) | 2011-11-07 | 2017-08-31 | Glaxosmithkline Biologicals S.A. | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| IN2012MU00206A (enExample) * | 2012-01-20 | 2013-08-09 | ||
| SI2809349T1 (sl) * | 2012-01-30 | 2019-03-29 | Serum Institute Of India Private Limited | Imunogeni sestavek |
| RU2665841C2 (ru) | 2012-03-09 | 2018-09-04 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их применения |
| ES2820898T3 (es) | 2012-05-22 | 2021-04-22 | Glaxosmithkline Biologicals Sa | Conjugado del serogrupo X de meningococos |
| US9427476B2 (en) | 2012-05-24 | 2016-08-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Multivalent meningococcal conjugates and methods for preparing conjugates |
| SG10201911609XA (en) | 2012-05-30 | 2020-01-30 | Brigham & Womens Hospital Inc | Polysaccharide compositions and methods of use |
| WO2014009971A2 (en) | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof |
| CA2881420C (en) | 2012-08-16 | 2016-11-15 | Pfizer Inc. | Glycoconjugation processes and compositions |
| CN102809656B (zh) | 2012-08-26 | 2014-09-03 | 云南沃森生物技术股份有限公司 | 一种脑膜炎球菌多糖结合疫苗成品各群游离多糖含量的测定方法 |
| CN104602705A (zh) * | 2012-09-06 | 2015-05-06 | 诺华股份有限公司 | 血清组b脑膜炎球菌和d/t/p的联合疫苗 |
| BR112015007126A2 (pt) | 2012-10-02 | 2017-08-08 | Glaxosmithkline Biologicals Sa | composição, método para induzir uma resposta imune, e, uso de uma composição |
| MX364644B (es) | 2012-11-21 | 2019-05-03 | Serum Inst India Ltd | Produccion de altos rendimientos de polisacaridos bacteriales. |
| FI3363806T3 (fi) | 2012-12-20 | 2023-01-31 | Glykokonjugaatiomenetelmä | |
| ITMI20130142A1 (it) | 2013-01-31 | 2014-08-01 | Biosynth Srl | Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati |
| JP6747968B2 (ja) * | 2013-03-18 | 2020-08-26 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 治療方法 |
| EP2999709A4 (en) | 2013-05-20 | 2016-12-07 | Shantha Biotechnics Private Ltd | PURIFICATION OF PROTEIN-POLYSACCHARIDE CONJUGATES |
| US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
| EP3613755A1 (en) | 2013-07-11 | 2020-02-26 | Novartis AG | Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase |
| WO2015052684A2 (en) | 2013-10-11 | 2015-04-16 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Polysaccharide-protein conjugates with enhanced immunogenicity and rapid high yielding process thereof |
| US10378017B2 (en) | 2013-12-02 | 2019-08-13 | Brandeis University | High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides |
| EP3443983B1 (en) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
| AU2015221820B2 (en) | 2014-02-25 | 2019-01-31 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel synthetic oligomers of Neisseria meningitis serogroup X and process of preparing them |
| MY186874A (en) | 2014-02-25 | 2021-08-26 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | A novel downstream process for purifying polysaccharides |
| WO2015158898A2 (en) | 2014-04-17 | 2015-10-22 | Medizinische Hochschule Hannover | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity |
| CN104069504B (zh) | 2014-05-11 | 2019-09-24 | 江苏康泰生物医学技术有限公司 | 一种增强多糖蛋白结合物免疫原性的方法 |
| WO2015179270A2 (en) | 2014-05-19 | 2015-11-26 | Board Of Regents, The University Of Texas System | Combinatorial platform for the display of surface adjuvants and antigens |
| WO2015181834A2 (en) | 2014-05-24 | 2015-12-03 | Biological E Limited | Novel semi-synthetic meningococcal conjugate vaccine |
| SG11201702451WA (en) * | 2014-10-09 | 2017-04-27 | Msd Wellcome Trust Hilleman Lab Pvt Ltd | An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP3288983B1 (en) | 2015-04-28 | 2025-10-29 | Biological E Limited | Method for separation of protein and other impurities from microbial capsular polysaccharides |
| CN104998255B (zh) | 2015-06-30 | 2018-08-28 | 北京祥瑞生物制品有限公司 | 新型acyw135群脑膜炎球菌结合疫苗及其制备方法 |
| AU2016290233A1 (en) | 2015-07-04 | 2018-01-25 | Bharat Biotech International Limited | Polysaccharide vaccine formulations and processes for industrial production of bacterial polysaccharides |
| CN105061629A (zh) | 2015-08-31 | 2015-11-18 | 成都欧林生物科技股份有限公司 | A群脑膜炎球菌荚膜粗多糖纯化工艺 |
| US10947494B2 (en) | 2015-11-17 | 2021-03-16 | Pfizer Inc. | Media and fermentation methods for producing polysaccharides in bacterial cell culture |
| MX2018010920A (es) | 2016-03-15 | 2019-03-06 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | Nuevos conjugados de polisacarido-proteina, y procedimiento para obtener los mismos. |
| LT3506935T (lt) | 2016-09-02 | 2024-04-25 | Sanofi Pasteur, Inc. | Vakcina nuo neisseria meningitidis |
| WO2018156467A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
-
2017
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- 2017-09-01 ES ES17765045T patent/ES2974992T3/es active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101208101A (zh) * | 2005-06-27 | 2008-06-25 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
| CN101208102A (zh) * | 2005-06-27 | 2008-06-25 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
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