SG11201702451WA - An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof - Google Patents
An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereofInfo
- Publication number
- SG11201702451WA SG11201702451WA SG11201702451WA SG11201702451WA SG11201702451WA SG 11201702451W A SG11201702451W A SG 11201702451WA SG 11201702451W A SG11201702451W A SG 11201702451WA SG 11201702451W A SG11201702451W A SG 11201702451WA SG 11201702451W A SG11201702451W A SG 11201702451WA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugation
- improved process
- protein conjugates
- novel synthetic
- synthetic oligosaccharide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2884DE2014 | 2014-10-09 | ||
PCT/IB2015/057682 WO2016055957A1 (en) | 2014-10-09 | 2015-10-08 | An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201702451WA true SG11201702451WA (en) | 2017-04-27 |
Family
ID=55652678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201702451WA SG11201702451WA (en) | 2014-10-09 | 2015-10-08 | An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof |
Country Status (18)
Country | Link |
---|---|
US (1) | US10105438B2 (en) |
EP (1) | EP3204396A4 (en) |
JP (1) | JP2017531662A (en) |
KR (1) | KR20170065030A (en) |
CN (1) | CN106795194A (en) |
AU (1) | AU2015329590B2 (en) |
BR (1) | BR112017006447A2 (en) |
CA (1) | CA2963900A1 (en) |
CL (1) | CL2017000844A1 (en) |
CO (1) | CO2017003291A2 (en) |
CU (1) | CU20170046A7 (en) |
EA (1) | EA201700177A1 (en) |
IL (1) | IL251511A0 (en) |
MX (1) | MX2017004495A (en) |
PH (1) | PH12017500579A1 (en) |
SG (1) | SG11201702451WA (en) |
TN (1) | TN2017000126A1 (en) |
WO (1) | WO2016055957A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170198004A1 (en) * | 2014-05-24 | 2017-07-13 | Biological E Limited | Novel semi-synthetic meningococcal conjugate vaccine |
WO2017017509A1 (en) * | 2015-07-28 | 2017-02-02 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel neisseria meningitidis serogroup y oligomer and process for synthesizing thereof |
CA3033364A1 (en) | 2016-09-02 | 2018-03-08 | Sanofi Pasteur, Inc. | Neisseria meningitidis vaccine |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
EP3634481A4 (en) | 2017-06-10 | 2021-07-21 | Inventprise, LLC. | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
CU20200068A7 (en) * | 2018-03-23 | 2021-04-07 | Koranex Capital | PRECISION GLYCOCONJUGATES AS THERAPEUTIC TOOLS |
JP2023537945A (en) | 2020-08-10 | 2023-09-06 | インベントプライズ・インコーポレイテッド | Multivalent pneumococcal glycoconjugate vaccine containing emerging serotype 24F |
CN113274488B (en) * | 2021-04-30 | 2023-08-29 | 山东省药学科学院 | Oligosaccharide vaccine for specifically preventing fungal infection and preparation method thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2434668A1 (en) * | 2003-07-04 | 2005-01-04 | Laurence Mulard | Novel approach to design glycopeptides based on o-specific polysaccharide of shigella flexneri serotype 2a |
NZ563940A (en) * | 2005-05-06 | 2010-11-26 | Novartis Vaccines & Diagnostic | Immunogens for meningitidis-A vaccines comprising oligosaccharides linked by a phosphonate |
FR2904627B1 (en) * | 2006-08-04 | 2008-11-07 | Pasteur Institut | NOVEL ACTIVE, PURIFIED AND ISOLATED PEPTIDES, CD4 RECEPTOR DERIVATIVES (MINI-CD4) AND THEIR PREPARATION PROCESS |
KR20140005892A (en) * | 2010-12-10 | 2014-01-15 | 머크 샤프 앤드 돔 코포레이션 | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
GB201103836D0 (en) * | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
-
2015
- 2015-10-08 TN TN2017000126A patent/TN2017000126A1/en unknown
- 2015-10-08 CN CN201580054739.3A patent/CN106795194A/en active Pending
- 2015-10-08 SG SG11201702451WA patent/SG11201702451WA/en unknown
- 2015-10-08 CU CUP2017000046A patent/CU20170046A7/en unknown
- 2015-10-08 BR BR112017006447A patent/BR112017006447A2/en not_active Application Discontinuation
- 2015-10-08 KR KR1020177012154A patent/KR20170065030A/en unknown
- 2015-10-08 JP JP2017518942A patent/JP2017531662A/en active Pending
- 2015-10-08 EP EP15849268.6A patent/EP3204396A4/en not_active Withdrawn
- 2015-10-08 US US15/516,445 patent/US10105438B2/en not_active Expired - Fee Related
- 2015-10-08 AU AU2015329590A patent/AU2015329590B2/en not_active Expired - Fee Related
- 2015-10-08 WO PCT/IB2015/057682 patent/WO2016055957A1/en active Application Filing
- 2015-10-08 CA CA2963900A patent/CA2963900A1/en not_active Abandoned
- 2015-10-08 MX MX2017004495A patent/MX2017004495A/en unknown
- 2015-10-08 EA EA201700177A patent/EA201700177A1/en unknown
-
2017
- 2017-03-29 PH PH12017500579A patent/PH12017500579A1/en unknown
- 2017-04-02 IL IL251511A patent/IL251511A0/en unknown
- 2017-04-04 CO CONC2017/0003291A patent/CO2017003291A2/en unknown
- 2017-04-06 CL CL2017000844A patent/CL2017000844A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2015329590A1 (en) | 2017-05-04 |
CU20170046A7 (en) | 2017-06-05 |
CL2017000844A1 (en) | 2017-12-22 |
KR20170065030A (en) | 2017-06-12 |
BR112017006447A2 (en) | 2017-12-12 |
EA201700177A1 (en) | 2017-07-31 |
EP3204396A1 (en) | 2017-08-16 |
CO2017003291A2 (en) | 2017-06-30 |
JP2017531662A (en) | 2017-10-26 |
CA2963900A1 (en) | 2016-04-14 |
US10105438B2 (en) | 2018-10-23 |
TN2017000126A1 (en) | 2018-10-19 |
EP3204396A4 (en) | 2018-03-28 |
US20170246313A1 (en) | 2017-08-31 |
MX2017004495A (en) | 2017-12-18 |
IL251511A0 (en) | 2017-05-29 |
PH12017500579A1 (en) | 2017-08-30 |
AU2015329590B2 (en) | 2019-08-22 |
WO2016055957A1 (en) | 2016-04-14 |
CN106795194A (en) | 2017-05-31 |
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