ZA201806043B - Novel polysaccharide-protein conjugates and process to obtain thereof - Google Patents
Novel polysaccharide-protein conjugates and process to obtain thereofInfo
- Publication number
- ZA201806043B ZA201806043B ZA2018/06043A ZA201806043A ZA201806043B ZA 201806043 B ZA201806043 B ZA 201806043B ZA 2018/06043 A ZA2018/06043 A ZA 2018/06043A ZA 201806043 A ZA201806043 A ZA 201806043A ZA 201806043 B ZA201806043 B ZA 201806043B
- Authority
- ZA
- South Africa
- Prior art keywords
- protein conjugates
- novel polysaccharide
- polysaccharide
- novel
- conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201611008901 | 2016-03-15 | ||
PCT/IB2017/051408 WO2017158480A1 (en) | 2016-03-15 | 2017-03-10 | Novel polysaccharide-protein conjugates and process to obtain thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201806043B true ZA201806043B (en) | 2019-05-29 |
Family
ID=59851687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2018/06043A ZA201806043B (en) | 2016-03-15 | 2018-09-10 | Novel polysaccharide-protein conjugates and process to obtain thereof |
Country Status (9)
Country | Link |
---|---|
JP (1) | JP2019508468A (en) |
KR (1) | KR102428253B1 (en) |
CN (1) | CN108883192A (en) |
AU (1) | AU2017234319B2 (en) |
BR (1) | BR112018068523A2 (en) |
MX (1) | MX2018010920A (en) |
RU (1) | RU2758090C2 (en) |
WO (1) | WO2017158480A1 (en) |
ZA (1) | ZA201806043B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201901394XA (en) | 2016-09-02 | 2019-03-28 | Sanofi Pasteur Inc | Neisseria meningitidis vaccine |
WO2019003238A1 (en) * | 2017-06-27 | 2019-01-03 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel multivalent polysaccharide – protein conjugate vaccine composition and formulation thereof |
CN110652585B (en) * | 2018-10-26 | 2023-05-26 | 武汉博沃生物科技有限公司 | Polysaccharide-protein conjugate immune preparation and application thereof |
CN110302375A (en) * | 2019-06-27 | 2019-10-08 | 康希诺生物股份公司 | A kind of glycoconjugate and application thereof |
RU2770877C1 (en) * | 2021-04-08 | 2022-04-22 | Федеральное бюджетное учреждение науки "Ростовский научно-исследовательский институт микробиологии и паразитологии" | Method of producing antigenic conjugated substance of haemophilic type b microbe for creating vaccine preparations |
CN114965784B (en) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | Method for measuring polysaccharide activation degree |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
RU2233172C2 (en) * | 1997-07-17 | 2004-07-27 | Бакстэ Хелскеа С.А. | Haemophilus influenzae immunogenic conjugate polysaccharide - porin of meningococcus group b (variants), method for its preparing, pharmaceutical composition and method for immune response induction in animal with regards to haemophilus influenzae |
GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
US8431136B2 (en) * | 2005-06-27 | 2013-04-30 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
CN1709505B (en) * | 2005-07-13 | 2010-06-16 | 北京绿竹生物制药有限公司 | Polyvalent bacteria capsule polysaccharide-protein conjugate combined vaccine |
AU2010301043B2 (en) * | 2009-06-22 | 2014-01-09 | Wyeth Llc | Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
CA2863178C (en) * | 2012-01-30 | 2021-04-06 | Serum Institute Of India Ltd. | Immunogenic composition |
EP2870974A1 (en) * | 2013-11-08 | 2015-05-13 | Novartis AG | Salmonella conjugate vaccines |
-
2017
- 2017-03-10 JP JP2018548790A patent/JP2019508468A/en active Pending
- 2017-03-10 RU RU2018135066A patent/RU2758090C2/en active
- 2017-03-10 WO PCT/IB2017/051408 patent/WO2017158480A1/en active Application Filing
- 2017-03-10 MX MX2018010920A patent/MX2018010920A/en unknown
- 2017-03-10 BR BR112018068523A patent/BR112018068523A2/en not_active IP Right Cessation
- 2017-03-10 KR KR1020187027889A patent/KR102428253B1/en active IP Right Grant
- 2017-03-10 CN CN201780017800.6A patent/CN108883192A/en active Pending
- 2017-03-10 AU AU2017234319A patent/AU2017234319B2/en not_active Expired - Fee Related
-
2018
- 2018-09-10 ZA ZA2018/06043A patent/ZA201806043B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2018010920A (en) | 2019-03-06 |
AU2017234319B2 (en) | 2021-11-04 |
RU2018135066A (en) | 2020-04-06 |
RU2018135066A3 (en) | 2020-11-10 |
WO2017158480A1 (en) | 2017-09-21 |
KR20180121564A (en) | 2018-11-07 |
CN108883192A (en) | 2018-11-23 |
JP2019508468A (en) | 2019-03-28 |
KR102428253B1 (en) | 2022-08-02 |
RU2758090C2 (en) | 2021-10-26 |
AU2017234319A1 (en) | 2018-09-27 |
BR112018068523A2 (en) | 2019-01-22 |
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