CN1177831C - 作为离子通道调节剂的新的苯并咪唑啉酮一、苯并噁唑酮一或苯并噻唑啉酮衍生物 - Google Patents
作为离子通道调节剂的新的苯并咪唑啉酮一、苯并噁唑酮一或苯并噻唑啉酮衍生物 Download PDFInfo
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- CN1177831C CN1177831C CNB99813936XA CN99813936A CN1177831C CN 1177831 C CN1177831 C CN 1177831C CN B99813936X A CNB99813936X A CN B99813936XA CN 99813936 A CN99813936 A CN 99813936A CN 1177831 C CN1177831 C CN 1177831C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801610 | 1998-12-04 | ||
| DKPA199801610 | 1998-12-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1329601A CN1329601A (zh) | 2002-01-02 |
| CN1177831C true CN1177831C (zh) | 2004-12-01 |
Family
ID=8106528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB99813936XA Expired - Fee Related CN1177831C (zh) | 1998-12-04 | 1999-12-03 | 作为离子通道调节剂的新的苯并咪唑啉酮一、苯并噁唑酮一或苯并噻唑啉酮衍生物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6624186B2 (enExample) |
| EP (1) | EP1144387A1 (enExample) |
| JP (1) | JP2002531552A (enExample) |
| CN (1) | CN1177831C (enExample) |
| AU (1) | AU760250B2 (enExample) |
| CA (1) | CA2349616A1 (enExample) |
| NZ (1) | NZ511334A (enExample) |
| WO (1) | WO2000034248A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0021487D0 (en) * | 2000-09-01 | 2000-10-18 | Pfizer Ltd | Pharmaceutical |
| EP1345618B1 (de) * | 2000-12-28 | 2005-03-23 | Switch Biotech Aktiengesellschaft | Chlorzoxazon zur behandlung von psoriasis |
| CA2438805A1 (en) * | 2001-02-20 | 2002-08-29 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators of kcnq potassium channels |
| US7541443B2 (en) * | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
| US7022480B1 (en) | 2001-10-11 | 2006-04-04 | The Regents Of The University Of California | Exons of the hSKCa3/KCNN3 gene |
| DE10231105A1 (de) | 2002-07-10 | 2004-01-22 | Clariant Gmbh | Neue Diketopyrrolopyrrolpigmente |
| AU2005201685B2 (en) * | 2002-10-21 | 2008-10-09 | Ramot At Tel Aviv University Ltd. | Derivatives of N-Phenylanthranilic Acid and 2-Benzimidazolon as Potassium Channel and/or Cortical Neuron Activity Modulators |
| AU2003272068A1 (en) * | 2002-10-21 | 2004-05-04 | Ramot At Tel Aviv University Ltd. | Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| DE10250870A1 (de) * | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
| WO2004064835A1 (en) * | 2003-01-17 | 2004-08-05 | Neurosearch A/S | Use of ion channel modulating agents for treating pain |
| US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
| CN101868443A (zh) | 2007-09-20 | 2010-10-20 | 特拉维夫大学拉莫特有限公司 | N-苯基邻氨基苯甲酸衍生物及其用途 |
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| KR20140095067A (ko) | 2011-10-28 | 2014-07-31 | 머크 샤프 앤드 돔 코포레이션 | 전압-게이팅 나트륨 채널에서의 선택적 활성을 갖는 벤족사졸리논 화합물 |
| SG11201500585XA (en) * | 2012-10-29 | 2015-04-29 | Hoffmann La Roche | 3,4-disubstituted oxazolidinone derivatives and their use as inhibitors of the calcium activated potassium channel |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2015004533A2 (en) * | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| PL3010503T3 (pl) | 2013-06-21 | 2020-08-24 | Zenith Epigenetics Ltd. | Nowe bicykliczne inhibitory bromodomen |
| EP3027604B1 (en) | 2013-07-31 | 2019-02-20 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| CN107207474B (zh) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | 被取代的杂环作为溴结构域抑制剂 |
| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| CN105294591B (zh) * | 2015-11-17 | 2017-05-10 | 河南大学 | 一种高立体和高对映选择性噁唑啉二酮类化合物、制备方法及其应用 |
| KR101751486B1 (ko) | 2016-03-02 | 2017-06-28 | 광주과학기술원 | BKCa 채널 활성화용 조성물 |
| JP7493454B2 (ja) | 2018-04-13 | 2024-05-31 | キャンサー・リサーチ・テクノロジー・リミテッド | Bcl6阻害剤 |
| CN109701024B (zh) * | 2019-03-04 | 2020-12-11 | 复旦大学 | Bk通道开放剂的新用途 |
| NZ789439A (en) * | 2019-12-10 | 2025-07-25 | Shanghai Zhimeng Biopharma Inc | Compound having neuroprotective effect, preparation method therefor and use thereof |
| EP4466253A4 (en) * | 2022-01-17 | 2025-07-02 | Univ Ramot | SK4 POTASSIUM CHANNEL MODULATORS AND THEIR USES |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2927116A (en) * | 1960-03-01 | Chlorobenzimidazolone compounds | ||
| GB1363735A (en) * | 1970-10-23 | 1974-08-14 | Hoechst Ag | Process for the manufacture of benzimidazolones |
| CA1058191A (en) * | 1974-08-31 | 1979-07-10 | Karl Kuffner | Color photographic material containing new 2-equivalent yellow couplers |
| IT1106962B (it) * | 1977-01-17 | 1985-11-18 | Sumitomo Chemical Co | Composit derivati del benzossa tiazolone utilizzabili particolarmente come fungicidi |
| US4420486A (en) * | 1981-01-22 | 1983-12-13 | Hokko Chemical Industry Co., Ltd. | Benzoxazolone derivatives, processes for preparation thereof and compositions containing them |
| DE3839743A1 (de) | 1988-11-25 | 1990-05-31 | Hoechst Ag | Verfahren zur herstellung von benzimidazolonen |
| EP0401582B1 (de) * | 1989-06-01 | 1994-07-20 | BASF Aktiengesellschaft | Fünfring-heterocyclisch anellierte Chinolinderivate |
| ATE159251T1 (de) * | 1990-08-29 | 1997-11-15 | Upjohn Co | Tropolonderivate und pharmazeutische zubereitungen davon zur vorbeugung und behandlung von ischämischen krankheiten |
| NZ239540A (en) * | 1990-09-24 | 1993-11-25 | Neurosearch As | 1-phenyl benzimidazole derivatives and medicaments |
| US5296493A (en) * | 1991-05-23 | 1994-03-22 | Neurosearch A/S | 1-substituted-2-(N-phenyl-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells |
| US5314903A (en) * | 1991-12-03 | 1994-05-24 | Neurosearch A/S | Benzimidazole compounds useful as calcium channel blockers |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| DE19539114C1 (de) | 1995-10-20 | 1997-04-17 | Hoechst Ag | Verfahren zur Aufarbeitung von Benzimidazolone enthaltenden Reaktionsgemischen |
| AR019678A1 (es) | 1998-06-18 | 2002-03-13 | Novartis Ag | Compuestos organicos |
| GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
-
1999
- 1999-12-03 CN CNB99813936XA patent/CN1177831C/zh not_active Expired - Fee Related
- 1999-12-03 AU AU15498/00A patent/AU760250B2/en not_active Ceased
- 1999-12-03 JP JP2000586696A patent/JP2002531552A/ja active Pending
- 1999-12-03 EP EP99957967A patent/EP1144387A1/en not_active Withdrawn
- 1999-12-03 NZ NZ511334A patent/NZ511334A/xx not_active IP Right Cessation
- 1999-12-03 WO PCT/DK1999/000681 patent/WO2000034248A1/en not_active Ceased
- 1999-12-03 CA CA002349616A patent/CA2349616A1/en not_active Abandoned
-
2001
- 2001-05-15 US US09/854,357 patent/US6624186B2/en not_active Expired - Fee Related
-
2003
- 2003-07-01 US US10/609,607 patent/US20040029937A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1144387A1 (en) | 2001-10-17 |
| CA2349616A1 (en) | 2000-06-15 |
| AU760250B2 (en) | 2003-05-08 |
| US20040029937A1 (en) | 2004-02-12 |
| CN1329601A (zh) | 2002-01-02 |
| US20020055526A1 (en) | 2002-05-09 |
| WO2000034248A1 (en) | 2000-06-15 |
| JP2002531552A (ja) | 2002-09-24 |
| NZ511334A (en) | 2003-06-30 |
| US6624186B2 (en) | 2003-09-23 |
| AU1549800A (en) | 2000-06-26 |
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