GB1363735A - Process for the manufacture of benzimidazolones - Google Patents

Process for the manufacture of benzimidazolones

Info

Publication number
GB1363735A
GB1363735A GB4878671A GB4878671A GB1363735A GB 1363735 A GB1363735 A GB 1363735A GB 4878671 A GB4878671 A GB 4878671A GB 4878671 A GB4878671 A GB 4878671A GB 1363735 A GB1363735 A GB 1363735A
Authority
GB
United Kingdom
Prior art keywords
benzimidazolones
oct
alkyl
general formula
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4878671A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19702052026 external-priority patent/DE2052026C3/en
Priority claimed from DE19712131367 external-priority patent/DE2131367C3/en
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB1363735A publication Critical patent/GB1363735A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1363735 Benzimidazolones FARBWERKE HOECHST AG 20 Oct 1971 [23 Oct 1970 24 June 1971] 48786/71 Heading C2C Compounds of general Formula (I) in which R 1 represents H or C 1-4 alkyl, and R 2 and R 3 (which may be the same or different) each represent H, halogen, or a C 1-4 alkyl, alkoxy or acyl group, or a hydroxy, carboxylic acid or sulphonic acid group, are prepared by reacting an o-phenylene diamine of general Formula (II) with urea in solution in water at 80-180‹ C.
GB4878671A 1970-10-23 1971-10-20 Process for the manufacture of benzimidazolones Expired GB1363735A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19702052026 DE2052026C3 (en) 1970-10-23 Process for the preparation of Benzimidazolone)
DE19712131367 DE2131367C3 (en) 1971-06-24 1971-06-24 Process for the preparation of benzimidazolones- (2)

Publications (1)

Publication Number Publication Date
GB1363735A true GB1363735A (en) 1974-08-14

Family

ID=25759948

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4878671A Expired GB1363735A (en) 1970-10-23 1971-10-20 Process for the manufacture of benzimidazolones

Country Status (7)

Country Link
JP (1) JPS558974B1 (en)
BR (1) BR7107095D0 (en)
CA (1) CA940933A (en)
CH (1) CH559729A5 (en)
FR (1) FR2113192A5 (en)
GB (1) GB1363735A (en)
IT (1) IT995020B (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624186B2 (en) * 1998-12-04 2003-09-23 Neurosearch A/S Ion channel modulating agents comprising novel benzimidazolone derivatives
US7851465B2 (en) 2007-03-09 2010-12-14 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7994313B2 (en) 2005-06-01 2011-08-09 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US8088759B2 (en) 2005-11-01 2012-01-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US8097612B2 (en) 2006-06-09 2012-01-17 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US8168626B2 (en) 1999-04-30 2012-05-01 The Regents Of The University Of Michigan Benzodiazepine compositions for treating epidermal hyperplasia and related disorders
US8188072B2 (en) 2007-11-06 2012-05-29 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8324258B2 (en) 2007-09-14 2012-12-04 The Regents Of The University Of Michigan F1F0-ATPase inhibitors and related methods
US8415343B2 (en) 1999-04-30 2013-04-09 The Regents Of The University Of Michigan Compositions and methods for inhibiting the proliferation of cells
US8497307B2 (en) 2008-09-11 2013-07-30 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
US8809323B2 (en) 1999-04-30 2014-08-19 The Regents Of The University Of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US8815845B2 (en) 2009-11-17 2014-08-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ187066A (en) * 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
DE2855226A1 (en) * 1978-12-21 1980-07-10 Hoechst Ag METHOD FOR PRODUCING BENZIMIDAZOLONE (2)
JPS57157287A (en) * 1981-03-24 1982-09-28 Matsushita Electronics Corp Large scale ic circuit for crt display
JPH0361765U (en) * 1989-10-19 1991-06-17
JP6321673B2 (en) * 2012-12-20 2018-05-09 ルゥ チーン−ビン Radiosensitizer compounds for use in combination with radiation

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624186B2 (en) * 1998-12-04 2003-09-23 Neurosearch A/S Ion channel modulating agents comprising novel benzimidazolone derivatives
US8722667B2 (en) 1999-04-30 2014-05-13 The Regents Of The University Of Michigan Compositions and methods for inhibiting the proliferation of cells
US8168626B2 (en) 1999-04-30 2012-05-01 The Regents Of The University Of Michigan Benzodiazepine compositions for treating epidermal hyperplasia and related disorders
US8809323B2 (en) 1999-04-30 2014-08-19 The Regents Of The University Of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US8415343B2 (en) 1999-04-30 2013-04-09 The Regents Of The University Of Michigan Compositions and methods for inhibiting the proliferation of cells
US7994313B2 (en) 2005-06-01 2011-08-09 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US8088759B2 (en) 2005-11-01 2012-01-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US8791104B2 (en) 2005-11-01 2014-07-29 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US8097612B2 (en) 2006-06-09 2012-01-17 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7851465B2 (en) 2007-03-09 2010-12-14 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US8242109B2 (en) 2007-03-09 2012-08-14 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US8324258B2 (en) 2007-09-14 2012-12-04 The Regents Of The University Of Michigan F1F0-ATPase inhibitors and related methods
US8461153B2 (en) 2007-11-06 2013-06-11 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8759340B2 (en) 2007-11-06 2014-06-24 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8188072B2 (en) 2007-11-06 2012-05-29 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8497307B2 (en) 2008-09-11 2013-07-30 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
US8815845B2 (en) 2009-11-17 2014-08-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Also Published As

Publication number Publication date
JPS558974B1 (en) 1980-03-07
CH559729A5 (en) 1975-03-14
FR2113192A5 (en) 1972-06-23
BR7107095D0 (en) 1973-08-16
IT995020B (en) 1975-11-10
CA940933A (en) 1974-01-29

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee