CN116848109B - 药物化合物 - Google Patents

药物化合物

Info

Publication number
CN116848109B
CN116848109B CN202180093050.7A CN202180093050A CN116848109B CN 116848109 B CN116848109 B CN 116848109B CN 202180093050 A CN202180093050 A CN 202180093050A CN 116848109 B CN116848109 B CN 116848109B
Authority
CN
China
Prior art keywords
compound
acid
salt
compounds
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180093050.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN116848109A (zh
Inventor
夏洛特·菲尔德豪斯
迈尔斯·斯图尔特·康格里夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nichela Pharmaceuticals Uk Ltd
Nxera Pharma UK Ltd
Original Assignee
Nichela Pharmaceuticals Uk Ltd
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nichela Pharmaceuticals Uk Ltd, Heptares Therapeutics Ltd filed Critical Nichela Pharmaceuticals Uk Ltd
Publication of CN116848109A publication Critical patent/CN116848109A/zh
Application granted granted Critical
Publication of CN116848109B publication Critical patent/CN116848109B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180093050.7A 2020-12-18 2021-12-20 药物化合物 Active CN116848109B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2020191.9 2020-12-18
GBGB2020191.9A GB202020191D0 (en) 2020-12-18 2020-12-18 Pharmaceutical compounds
PCT/GB2021/053372 WO2022129951A1 (en) 2020-12-18 2021-12-20 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
CN116848109A CN116848109A (zh) 2023-10-03
CN116848109B true CN116848109B (zh) 2026-02-10

Family

ID=74221349

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180093050.7A Active CN116848109B (zh) 2020-12-18 2021-12-20 药物化合物

Country Status (18)

Country Link
US (1) US11999745B2 (https=)
EP (1) EP4263536A1 (https=)
JP (1) JP7730369B2 (https=)
KR (1) KR20230121830A (https=)
CN (1) CN116848109B (https=)
AU (1) AU2021404194A1 (https=)
CA (1) CA3202054A1 (https=)
CL (1) CL2023001755A1 (https=)
CO (1) CO2023007838A2 (https=)
CR (1) CR20230256A (https=)
DO (1) DOP2023000125A (https=)
EC (1) ECSP23044370A (https=)
GB (1) GB202020191D0 (https=)
IL (1) IL303484A (https=)
JO (1) JOP20230128A1 (https=)
MX (1) MX2023007140A (https=)
PE (1) PE20240646A1 (https=)
WO (1) WO2022129951A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2780015B1 (en) 2011-11-18 2017-01-04 Heptares Therapeutics Limited Muscarinic m1 receptor agonists
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019243850A1 (en) * 2018-06-22 2019-12-26 Heptares Therapeutics Limited Oxadiazoles as agonists of the muscarinic m1 and/or m4 receptor

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Patent Citations (1)

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JP2024504252A (ja) 2024-01-31
AU2021404194A1 (en) 2023-08-03
AU2021404194A9 (en) 2024-10-17
PE20240646A1 (es) 2024-04-04
WO2022129951A1 (en) 2022-06-23
US11999745B2 (en) 2024-06-04
JP7730369B2 (ja) 2025-08-27
MX2023007140A (es) 2023-08-25
US20220380379A1 (en) 2022-12-01
IL303484A (en) 2023-08-01
CL2023001755A1 (es) 2024-01-05
CR20230256A (es) 2023-09-29
DOP2023000125A (es) 2023-08-31
KR20230121830A (ko) 2023-08-21
ECSP23044370A (es) 2023-08-31
EP4263536A1 (en) 2023-10-25
CA3202054A1 (en) 2022-06-23
GB202020191D0 (en) 2021-02-03
CO2023007838A2 (es) 2023-10-30
CN116848109A (zh) 2023-10-03
JOP20230128A1 (ar) 2023-06-06

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