CR20230256A - Compuestos farmacéuticos - Google Patents
Compuestos farmacéuticosInfo
- Publication number
- CR20230256A CR20230256A CR20230256A CR20230256A CR20230256A CR 20230256 A CR20230256 A CR 20230256A CR 20230256 A CR20230256 A CR 20230256A CR 20230256 A CR20230256 A CR 20230256A CR 20230256 A CR20230256 A CR 20230256A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- pharmaceutical compounds
- muscarinic
- agonists
- receptors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000017924 CHRM4 Human genes 0.000 abstract 2
- 102000007207 Muscarinic M1 Receptor Human genes 0.000 abstract 2
- 108010008406 Muscarinic M1 Receptor Proteins 0.000 abstract 2
- 101100107916 Xenopus laevis chrm4 gene Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Esta invención se refiere a compuestos que son agonistas del receptor muscarínico M<sub>1</sub> y M<sub>4</sub> y que son útiles en el tratamiento de enfermedades mediadas por los receptores muscarínicos M<sub>1 </sub>y/o M<sub>4</sub>. También se proporcionan composiciones farmacéuticas que contienen los compuestos y los usos terapéuticos de los compuestos. Los compuestos proporcionados son de fórmula (1): y sus sales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2020191.9A GB202020191D0 (en) | 2020-12-18 | 2020-12-18 | Pharmaceutical compounds |
PCT/GB2021/053372 WO2022129951A1 (en) | 2020-12-18 | 2021-12-20 | Pharmaceutical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20230256A true CR20230256A (es) | 2023-09-29 |
Family
ID=74221349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20230256A CR20230256A (es) | 2020-12-18 | 2021-12-20 | Compuestos farmacéuticos |
Country Status (17)
Country | Link |
---|---|
US (1) | US11999745B2 (es) |
EP (1) | EP4263536A1 (es) |
JP (1) | JP2024504252A (es) |
KR (1) | KR20230121830A (es) |
CN (1) | CN116848109A (es) |
AU (1) | AU2021404194A1 (es) |
CA (1) | CA3202054A1 (es) |
CL (1) | CL2023001755A1 (es) |
CO (1) | CO2023007838A2 (es) |
CR (1) | CR20230256A (es) |
DO (1) | DOP2023000125A (es) |
EC (1) | ECSP23044370A (es) |
GB (1) | GB202020191D0 (es) |
IL (1) | IL303484A (es) |
MX (1) | MX2023007140A (es) |
PE (1) | PE20240646A1 (es) |
WO (1) | WO2022129951A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112014012056B1 (pt) | 2011-11-18 | 2021-12-14 | Heptares Therapeutics Limited | Compostos agonistas do receptor m1 muscarínico, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para tratar um distúrbio cognitivo ou psicótico ou para tratamento ou diminuição da severidade da dor aguda, crônica, neuropática ou inflamatória |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
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BR112014012056B1 (pt) | 2011-11-18 | 2021-12-14 | Heptares Therapeutics Limited | Compostos agonistas do receptor m1 muscarínico, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para tratar um distúrbio cognitivo ou psicótico ou para tratamento ou diminuição da severidade da dor aguda, crônica, neuropática ou inflamatória |
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WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
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GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
SI3265459T1 (sl) | 2015-02-13 | 2019-09-30 | Suven Life Sciences Limited, | Amidne spojine kot 5-HT4 receptor agonisti |
GB201504675D0 (en) | 2015-03-19 | 2015-05-06 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201513740D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonist |
GB201513742D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
US10259787B2 (en) | 2016-10-14 | 2019-04-16 | Heptares Therapeutics Limited | Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists |
GB201709652D0 (en) * | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
TW201922758A (zh) | 2017-10-24 | 2019-06-16 | 美商歐樂根公司 | 烯胺及烯胺的非鏡像選擇性還原 |
GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201810245D0 (en) * | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB202103211D0 (en) | 2021-03-08 | 2021-04-21 | Heptares Therapeutics Ltd | Pharmaceutical compounds for use in therapy |
-
2020
- 2020-12-18 GB GBGB2020191.9A patent/GB202020191D0/en not_active Ceased
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2021
- 2021-12-20 IL IL303484A patent/IL303484A/en unknown
- 2021-12-20 CA CA3202054A patent/CA3202054A1/en active Pending
- 2021-12-20 JP JP2023536899A patent/JP2024504252A/ja active Pending
- 2021-12-20 KR KR1020237023911A patent/KR20230121830A/ko unknown
- 2021-12-20 AU AU2021404194A patent/AU2021404194A1/en active Pending
- 2021-12-20 CR CR20230256A patent/CR20230256A/es unknown
- 2021-12-20 CN CN202180093050.7A patent/CN116848109A/zh active Pending
- 2021-12-20 EP EP21836606.0A patent/EP4263536A1/en active Pending
- 2021-12-20 PE PE2023001903A patent/PE20240646A1/es unknown
- 2021-12-20 WO PCT/GB2021/053372 patent/WO2022129951A1/en active Application Filing
- 2021-12-20 MX MX2023007140A patent/MX2023007140A/es unknown
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2022
- 2022-07-27 US US17/874,564 patent/US11999745B2/en active Active
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2023
- 2023-06-15 CO CONC2023/0007838A patent/CO2023007838A2/es unknown
- 2023-06-15 EC ECSENADI202344370A patent/ECSP23044370A/es unknown
- 2023-06-15 CL CL2023001755A patent/CL2023001755A1/es unknown
- 2023-06-15 DO DO2023000125A patent/DOP2023000125A/es unknown
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CL2023001755A1 (es) | 2024-01-05 |
ECSP23044370A (es) | 2023-08-31 |
US11999745B2 (en) | 2024-06-04 |
AU2021404194A1 (en) | 2023-08-03 |
EP4263536A1 (en) | 2023-10-25 |
DOP2023000125A (es) | 2023-08-31 |
JP2024504252A (ja) | 2024-01-31 |
MX2023007140A (es) | 2023-08-25 |
KR20230121830A (ko) | 2023-08-21 |
CO2023007838A2 (es) | 2023-10-30 |
CN116848109A (zh) | 2023-10-03 |
US20220380379A1 (en) | 2022-12-01 |
CA3202054A1 (en) | 2022-06-23 |
IL303484A (en) | 2023-08-01 |
WO2022129951A1 (en) | 2022-06-23 |
GB202020191D0 (en) | 2021-02-03 |
PE20240646A1 (es) | 2024-04-04 |
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