PE20240646A1 - Compuestos farmaceuticos - Google Patents

Compuestos farmaceuticos

Info

Publication number
PE20240646A1
PE20240646A1 PE2023001903A PE2023001903A PE20240646A1 PE 20240646 A1 PE20240646 A1 PE 20240646A1 PE 2023001903 A PE2023001903 A PE 2023001903A PE 2023001903 A PE2023001903 A PE 2023001903A PE 20240646 A1 PE20240646 A1 PE 20240646A1
Authority
PE
Peru
Prior art keywords
compounds
treatment
pharmaceutical compounds
diseases mediated
muscarinic receptors
Prior art date
Application number
PE2023001903A
Other languages
English (en)
Inventor
Charlotte Fieldhouse
Miles Stuart Congreve
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Publication of PE20240646A1 publication Critical patent/PE20240646A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion se refiere a compuestos que son agonistas del receptor muscarinico M1 y M4 y que son utiles en el tratamiento de enfermedades mediadas por los receptores muscarinicos M1 y/o M4. Los compuestos proporcionados son de formula (1) y sus sales. Tambien se proporcionan composiciones farmaceuticas que contienen los compuestos y los usos terapeuticos de los compuestos en el tratamiento de la enfermedad de Alzheimer, esquizofrenia, trastornos cognitivos y otras enfermedades mediadas por los receptores muscarinicos M1/M4, incluyendo, pero no limitado al tratamiento o alivio del dolor.
PE2023001903A 2020-12-18 2021-12-20 Compuestos farmaceuticos PE20240646A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2020191.9A GB202020191D0 (en) 2020-12-18 2020-12-18 Pharmaceutical compounds
PCT/GB2021/053372 WO2022129951A1 (en) 2020-12-18 2021-12-20 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
PE20240646A1 true PE20240646A1 (es) 2024-04-04

Family

ID=74221349

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2023001903A PE20240646A1 (es) 2020-12-18 2021-12-20 Compuestos farmaceuticos

Country Status (17)

Country Link
US (1) US11999745B2 (es)
EP (1) EP4263536A1 (es)
JP (1) JP2024504252A (es)
KR (1) KR20230121830A (es)
CN (1) CN116848109A (es)
AU (1) AU2021404194A1 (es)
CA (1) CA3202054A1 (es)
CL (1) CL2023001755A1 (es)
CO (1) CO2023007838A2 (es)
CR (1) CR20230256A (es)
DO (1) DOP2023000125A (es)
EC (1) ECSP23044370A (es)
GB (1) GB202020191D0 (es)
IL (1) IL303484A (es)
MX (1) MX2023007140A (es)
PE (1) PE20240646A1 (es)
WO (1) WO2022129951A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9187451B2 (en) 2011-11-18 2015-11-17 Heptares Therapeutics Limited Muscarinic M1 receptor agonists
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

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Also Published As

Publication number Publication date
ECSP23044370A (es) 2023-08-31
GB202020191D0 (en) 2021-02-03
WO2022129951A1 (en) 2022-06-23
JP2024504252A (ja) 2024-01-31
CR20230256A (es) 2023-09-29
MX2023007140A (es) 2023-08-25
AU2021404194A9 (en) 2024-10-17
IL303484A (en) 2023-08-01
AU2021404194A1 (en) 2023-08-03
CO2023007838A2 (es) 2023-10-30
EP4263536A1 (en) 2023-10-25
CA3202054A1 (en) 2022-06-23
CL2023001755A1 (es) 2024-01-05
KR20230121830A (ko) 2023-08-21
US11999745B2 (en) 2024-06-04
US20220380379A1 (en) 2022-12-01
CN116848109A (zh) 2023-10-03
DOP2023000125A (es) 2023-08-31

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