UY26728A1 - Derivados de la benzocicloalquilenilamina como antagonistas de los receptores muscarínicos - Google Patents

Derivados de la benzocicloalquilenilamina como antagonistas de los receptores muscarínicos

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Publication number
UY26728A1
UY26728A1 UY26728A UY26728A UY26728A1 UY 26728 A1 UY26728 A1 UY 26728A1 UY 26728 A UY26728 A UY 26728A UY 26728 A UY26728 A UY 26728A UY 26728 A1 UY26728 A1 UY 26728A1
Authority
UY
Uruguay
Prior art keywords
antagonists
benzocicloalquilenilamina
derivatives
muscarinic receptors
compounds
Prior art date
Application number
UY26728A
Other languages
English (en)
Inventor
Ann Marie Madera
Robert James Weikert
Russel Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY26728A1 publication Critical patent/UY26728A1/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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Abstract

La presente invención se refiere a compuestos que son en general antagonistas de receptores muscarínicos M2/M3 y que pueden representarse por la fórmula I en la que X , Y y Z son -O-, -S- o >N-R4 y los demás sustituyentes tienen los significados definidos en la especificación; o "profármacos", isómeros individuales, mezclas racémicas o no racémicas de isómeros, y sales farmaceúticamente aceptables o solvatos de los mismos. La invención se refiere además a composiciones farmacéuticas que contienen tales compuestos, a un proceso para su obtención y a su utilización para tratamiento de enfermedades asociadas con trastornos del músculo liso.
UY26728A 2000-05-25 2001-05-24 Derivados de la benzocicloalquilenilamina como antagonistas de los receptores muscarínicos UY26728A1 (es)

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US20748300P 2000-05-25 2000-05-25
US26761701P 2001-02-09 2001-02-09

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US6640155B2 (en) 2000-08-22 2003-10-28 Lam Research Corporation Chemical mechanical polishing apparatus and methods with central control of polishing pressure applied by polishing head
EP1453805B1 (en) * 2001-12-03 2010-12-22 F. Hoffmann-La Roche AG 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
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