PT1919475E - Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 - Google Patents

Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 Download PDF

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Publication number
PT1919475E
PT1919475E PT06818244T PT06818244T PT1919475E PT 1919475 E PT1919475 E PT 1919475E PT 06818244 T PT06818244 T PT 06818244T PT 06818244 T PT06818244 T PT 06818244T PT 1919475 E PT1919475 E PT 1919475E
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PT
Portugal
Prior art keywords
carbolin
tetrahydro
sulfonamide derivatives
ligands
beta
Prior art date
Application number
PT06818244T
Other languages
English (en)
Inventor
Jose Luis Diaz-Fernandez
Ramon Merce-Vidal
Joerg Holenz
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of PT1919475E publication Critical patent/PT1919475E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT06818244T 2005-07-28 2006-07-26 Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 PT1919475E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05380174A EP1747779A1 (en) 2005-07-28 2005-07-28 Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands

Publications (1)

Publication Number Publication Date
PT1919475E true PT1919475E (pt) 2009-05-05

Family

ID=35559403

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06818244T PT1919475E (pt) 2005-07-28 2006-07-26 Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6

Country Status (11)

Country Link
US (1) US8263609B2 (pt)
EP (2) EP1747779A1 (pt)
JP (1) JP2009502840A (pt)
CN (1) CN101272785A (pt)
AT (1) ATE424822T1 (pt)
CA (1) CA2616729A1 (pt)
DE (1) DE602006005685D1 (pt)
ES (1) ES2321879T3 (pt)
HK (1) HK1120725A1 (pt)
PT (1) PT1919475E (pt)
WO (1) WO2007028460A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP2020230B1 (en) * 2007-08-01 2011-01-19 Laboratorios del Dr. Esteve S.A. Combination of at least two 5-HT6-Ligands
EP2194980A4 (en) * 2007-09-20 2012-01-18 D2E Llc PYRIDO FLUORINE DERIVATIVES [4,3-B] HYDROGENATED INDOLES HAVING NEUROPROTECTIVE AND COGNITIVE PROPERTIES, PREPARATION METHOD AND USE
EP2053052A1 (en) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
BRPI0906244A2 (pt) * 2008-03-24 2015-06-30 Medivation Technologies Inc Composto, composição farmacêutica, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissores ou um distúrbio neuronal em um indivíduo, uso de um composto e kit
JP5529843B2 (ja) * 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
PT2271613E (pt) * 2008-03-27 2014-07-16 Gruenenthal Gmbh Hidroximetilciclo-hexilamina
RU2515895C2 (ru) * 2008-03-27 2014-05-20 Грюненталь Гмбх Производные спиро(5.5)ундекана
US20090247530A1 (en) 2008-03-27 2009-10-01 Grunenthal Gmbh Substituted 4-aminocyclohexane derivatives
PE20091650A1 (es) * 2008-03-27 2009-11-07 Gruenenthal Chemie Derivados de ciclohexano espirociclicos sustituidos
EP2116546A1 (en) 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-phenyl-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide derivatives as 5-HT6 ligands
EP2116547A1 (en) 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands
CN102227431A (zh) 2008-09-29 2011-10-26 雅培制药有限公司 吲哚和二氢吲哚衍生物及其应用方法
US9625475B2 (en) 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
CN104557664B (zh) * 2013-10-19 2020-01-21 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
CN107686511A (zh) * 2016-08-05 2018-02-13 首都医科大学 甲基四氢‑β‑咔啉‑3‑甲酰YIGS肽,其合成,抗血栓作用和应用
CN107686510A (zh) * 2016-08-05 2018-02-13 首都医科大学 甲基四氢‑β‑咔啉‑3‑甲酰RGD肽,其合成,抗血栓作用和应用
WO2022047583A1 (en) * 2020-09-02 2022-03-10 Magicmed Industries Inc. Nitrated psilocybin derivatives and use thereof for modulating 5-ht2a receptor and for treating a psychiatric disorder

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US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
AU6298196A (en) 1995-06-23 1997-01-22 Novo Nordisk A/S Tetrahydro-betacarboline derivatives and their preparation and use
PL195682B1 (pl) 1997-12-24 2007-10-31 Sanofi Aventis Deutschland Pochodne indolu, sposób ich wytwarzania, środek farmaceutyczny oraz zastosowanie pochodnych indolu
EP1319004A2 (en) * 2000-09-20 2003-06-18 PHARMACIA & UPJOHN COMPANY Substituted azepino[4,5-b]indole derivatives
WO2002064591A2 (en) 2001-02-12 2002-08-22 Lilly Icos Llc Carboline derivatives
JP4220779B2 (ja) 2001-02-12 2009-02-04 リリー アイコス リミテッド ライアビリティ カンパニー 化学化合物
ATE348101T1 (de) 2001-04-25 2007-01-15 Lilly Icos Llc Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion
US20030095958A1 (en) * 2001-04-27 2003-05-22 Bhisetti Govinda R. Inhibitors of bace
JP2004536816A (ja) 2001-06-05 2004-12-09 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅ５阻害剤としてのカルボリン誘導体
WO2003030901A1 (en) * 2001-10-09 2003-04-17 Pharmacia & Upjohn Company Arylsulphonyl-substituted tetrahydro- and hexahydro-carbazoles as 5-ht-6 receptor ligands
TW200524864A (en) * 2003-11-10 2005-08-01 Wyeth Corp Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands
ES2363348T3 (es) * 2004-10-14 2011-08-01 ABBOTT GMBH & CO. KG Compuestos aromáticos bicíclicos sustituidos con aminometilo adecuados para tratar trastornos que responden a la modulación del receptor d3 de dopamina.

Also Published As

Publication number Publication date
EP1919475B1 (en) 2009-03-11
CA2616729A1 (en) 2007-03-15
JP2009502840A (ja) 2009-01-29
ES2321879T3 (es) 2009-06-12
DE602006005685D1 (de) 2009-04-23
US8263609B2 (en) 2012-09-11
US20080280942A1 (en) 2008-11-13
EP1919475A1 (en) 2008-05-14
WO2007028460A1 (en) 2007-03-15
HK1120725A1 (en) 2009-04-09
EP1747779A1 (en) 2007-01-31
ATE424822T1 (de) 2009-03-15
CN101272785A (zh) 2008-09-24

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