PT1919475E - Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 - Google Patents

Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 Download PDF

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Publication number
PT1919475E
PT1919475E PT06818244T PT06818244T PT1919475E PT 1919475 E PT1919475 E PT 1919475E PT 06818244 T PT06818244 T PT 06818244T PT 06818244 T PT06818244 T PT 06818244T PT 1919475 E PT1919475 E PT 1919475E
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PT
Portugal
Prior art keywords
carbolin
tetrahydro
sulfonamide derivatives
ligands
beta
Prior art date
Application number
PT06818244T
Other languages
English (en)
Inventor
Jose Luis Diaz-Fernandez
Ramon Merce-Vidal
Joerg Holenz
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of PT1919475E publication Critical patent/PT1919475E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT06818244T 2005-07-28 2006-07-26 Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6 PT1919475E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05380174A EP1747779A1 (en) 2005-07-28 2005-07-28 Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands

Publications (1)

Publication Number Publication Date
PT1919475E true PT1919475E (pt) 2009-05-05

Family

ID=35559403

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06818244T PT1919475E (pt) 2005-07-28 2006-07-26 Derivados de tetrahidro-â-carbolino-sulfonamida de como ligandos de 5-ht6

Country Status (11)

Country Link
US (1) US8263609B2 (pt)
EP (2) EP1747779A1 (pt)
JP (1) JP2009502840A (pt)
CN (1) CN101272785A (pt)
AT (1) ATE424822T1 (pt)
CA (1) CA2616729A1 (pt)
DE (1) DE602006005685D1 (pt)
ES (1) ES2321879T3 (pt)
HK (1) HK1120725A1 (pt)
PT (1) PT1919475E (pt)
WO (1) WO2007028460A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
ATE495737T1 (de) * 2007-08-01 2011-02-15 Esteve Labor Dr Kombination von mindestens zwei 5-ht6-liganden
EP2194980A4 (en) * 2007-09-20 2012-01-18 D2E Llc PYRIDO FLUORINE DERIVATIVES [4,3-B] HYDROGENATED INDOLES HAVING NEUROPROTECTIVE AND COGNITIVE PROPERTIES, PREPARATION METHOD AND USE
EP2053052A1 (en) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
CA2719412A1 (en) 2008-03-24 2009-10-01 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
PE20091822A1 (es) * 2008-03-27 2009-12-10 Gruenenthal Chemie Hidroximetilciclohexilaminas
KR20120075500A (ko) 2008-03-27 2012-07-06 그뤼넨탈 게엠베하 치환된 4-아미노사이클로헥산 유도체
CN102083790B (zh) * 2008-03-27 2014-03-05 格吕伦塔尔有限公司 螺(5.5)十一烷衍生物
PT2260042E (pt) * 2008-03-27 2011-12-06 Gruenenthal Gmbh Derivados de ciclo-hexano espirocíclicos substituídos
CA2719743A1 (en) * 2008-03-27 2009-10-01 Gruenenthal Gmbh Substituted cyclohexyldiamines
EP2116547A1 (en) 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands
EP2116546A1 (en) 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-phenyl-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide derivatives as 5-HT6 ligands
MX2011003435A (es) 2008-09-29 2011-05-02 Abbott Lab Derivados de indol y de ondolina y metodos de uso de los mismos.
US9625475B2 (en) 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
JP6107650B2 (ja) 2011-03-18 2017-04-05 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
CN104557664B (zh) * 2013-10-19 2020-01-21 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
CN107686511A (zh) * 2016-08-05 2018-02-13 首都医科大学 甲基四氢‑β‑咔啉‑3‑甲酰YIGS肽,其合成,抗血栓作用和应用
CN107686510A (zh) * 2016-08-05 2018-02-13 首都医科大学 甲基四氢‑β‑咔啉‑3‑甲酰RGD肽,其合成,抗血栓作用和应用
EP4208446A4 (en) * 2020-09-02 2024-10-30 Enveric Biosciences Canada Inc NITRATED PSILOCYBIN DERIVATIVES AND USE THEREOF FOR MODULATION OF THE 5-HT2A RECEPTOR AND FOR TREATMENT OF A PSYCHIATRIC ILLNESS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
AU6298196A (en) 1995-06-23 1997-01-22 Novo Nordisk A/S Tetrahydro-betacarboline derivatives and their preparation and use
PT1042287E (pt) 1997-12-24 2005-08-31 Aventis Pharma Gmbh Derivados de indole como inibidores do factor xa
AR034264A1 (es) * 2000-09-20 2004-02-18 Upjohn Co Derivados azepino(4,5-b)indol sustituidos y composiciones farmaceuticas
EP1360185B1 (en) 2001-02-12 2005-08-24 Lilly Icos LLC Carboline derivatives
MXPA03007142A (es) 2001-02-12 2004-05-24 Lilly Icos Llc Derivados de carbolina.
WO2002088123A1 (en) 2001-04-25 2002-11-07 Lilly Icos Llc Chemical compounds
EP1389194A2 (en) * 2001-04-27 2004-02-18 Vertex Pharmaceuticals Incorporated Inhibitors of bace
CA2445460A1 (en) 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
EP1434578A1 (en) * 2001-10-09 2004-07-07 PHARMACIA & UPJOHN COMPANY Arylsulphonyl-substituted tetrahydro- and hexahydro-carbazoles as 5-ht-6 receptor ligands
TW200524864A (en) * 2003-11-10 2005-08-01 Wyeth Corp Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands
MX2007004354A (es) * 2004-10-14 2007-07-17 Abbot Gmbh & Co Kg Compuestos aromaticos biciclicos sustituidos con aminometilo adecuados para tratar trastornos que responden a la modulacion del receptor de dopamina d3.

Also Published As

Publication number Publication date
WO2007028460A1 (en) 2007-03-15
EP1919475B1 (en) 2009-03-11
US20080280942A1 (en) 2008-11-13
JP2009502840A (ja) 2009-01-29
CA2616729A1 (en) 2007-03-15
DE602006005685D1 (de) 2009-04-23
ES2321879T3 (es) 2009-06-12
CN101272785A (zh) 2008-09-24
US8263609B2 (en) 2012-09-11
EP1919475A1 (en) 2008-05-14
EP1747779A1 (en) 2007-01-31
ATE424822T1 (de) 2009-03-15
HK1120725A1 (en) 2009-04-09

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