CN1163490C - 制备环状硫代酰胺化合物的方法 - Google Patents

制备环状硫代酰胺化合物的方法 Download PDF

Info

Publication number
CN1163490C
CN1163490C CNB001048325A CN00104832A CN1163490C CN 1163490 C CN1163490 C CN 1163490C CN B001048325 A CNB001048325 A CN B001048325A CN 00104832 A CN00104832 A CN 00104832A CN 1163490 C CN1163490 C CN 1163490C
Authority
CN
China
Prior art keywords
compound
formula
acid
preparation
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB001048325A
Other languages
English (en)
Chinese (zh)
Other versions
CN1273244A (zh
Inventor
G��J�����ֿ�
G·J·卡林科
J·W·拉格根
ϣ
P·D·希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1273244A publication Critical patent/CN1273244A/zh
Application granted granted Critical
Publication of CN1163490C publication Critical patent/CN1163490C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CNB001048325A 1999-03-30 2000-03-30 制备环状硫代酰胺化合物的方法 Expired - Fee Related CN1163490C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12683199P 1999-03-30 1999-03-30
US60/126,831 1999-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100014528A Division CN1290829C (zh) 1999-03-30 2000-03-30 制备环状硫代酰胺化合物的方法

Publications (2)

Publication Number Publication Date
CN1273244A CN1273244A (zh) 2000-11-15
CN1163490C true CN1163490C (zh) 2004-08-25

Family

ID=22426907

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB001048325A Expired - Fee Related CN1163490C (zh) 1999-03-30 2000-03-30 制备环状硫代酰胺化合物的方法
CNB2004100014528A Expired - Fee Related CN1290829C (zh) 1999-03-30 2000-03-30 制备环状硫代酰胺化合物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2004100014528A Expired - Fee Related CN1290829C (zh) 1999-03-30 2000-03-30 制备环状硫代酰胺化合物的方法

Country Status (25)

Country Link
US (1) US6388127B1 (enExample)
EP (1) EP1041070B1 (enExample)
JP (1) JP3566175B2 (enExample)
KR (1) KR100386524B1 (enExample)
CN (2) CN1163490C (enExample)
AR (1) AR029744A1 (enExample)
AT (1) ATE277025T1 (enExample)
AU (1) AU777097B2 (enExample)
BR (1) BR0001492A (enExample)
CA (1) CA2302727C (enExample)
CZ (1) CZ298140B6 (enExample)
DE (1) DE60013942T2 (enExample)
DK (1) DK1041070T3 (enExample)
ES (1) ES2226715T3 (enExample)
HU (1) HUP0001327A3 (enExample)
ID (1) ID25428A (enExample)
IL (1) IL135243A (enExample)
IN (1) IN188844B (enExample)
PL (1) PL196446B1 (enExample)
PT (1) PT1041070E (enExample)
RU (1) RU2219173C2 (enExample)
TR (1) TR200000834A2 (enExample)
TW (1) TW460472B (enExample)
YU (1) YU15500A (enExample)
ZA (1) ZA200001536B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60013942T2 (de) * 1999-03-30 2006-02-23 Pfizer Products Inc., Groton Verfahren zur Herstellung von cyclischen Thioamiden
US9557336B2 (en) 2012-09-07 2017-01-31 University Of Rochester Methods and compositions for site-specific labeling of peptides and proteins
US9999921B2 (en) 2015-06-15 2018-06-19 Gm Global Technology Operatioins Llc Method of making aluminum or magnesium based composite engine blocks or other parts with in-situ formed reinforced phases through squeeze casting or semi-solid metal forming and post heat treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755278A (en) * 1956-07-17 Thiamori
GB8412862D0 (en) * 1984-05-19 1984-06-27 Beecham Group Plc Compounds
EP0233287B1 (en) * 1984-10-04 1991-01-30 Zenyaku Kogyo Kabushikikaisha 1,4-thiazine derivatives, process for their preparation, and cardiotonics containing the same
IL106142A (en) * 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
WO1994003652A1 (fr) 1992-07-31 1994-02-17 Yokota Corporation Co., Ltd. Procede permettant de fabriquer des metaux de haute purete a partir de ferrailles de metaux usines
GB9225377D0 (en) * 1992-12-04 1993-01-27 Ici Plc Herbicides
TW280812B (enExample) * 1993-07-02 1996-07-11 Bayer Ag
FR2715933B1 (fr) * 1994-02-07 1996-04-12 Oreal Nouveaux N-(hydroxyalkyl) carbamates d'alkyle et leurs applications en cosmétique, plus particulièrement dans des compositions capillaires.
US5663409A (en) * 1995-06-07 1997-09-02 Novus International, Inc. Process for the preparation of 3-(methylthio) propanal and 2-hydroxy-4-(methylthio) butanenitrile
UA56185C2 (uk) * 1996-09-30 2003-05-15 Пфайзер Інк. Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування
DE60013942T2 (de) * 1999-03-30 2006-02-23 Pfizer Products Inc., Groton Verfahren zur Herstellung von cyclischen Thioamiden

Also Published As

Publication number Publication date
AU777097B2 (en) 2004-09-30
EP1041070A1 (en) 2000-10-04
HUP0001327A3 (en) 2003-06-30
CA2302727C (en) 2004-02-24
KR20010014647A (ko) 2001-02-26
CN1273244A (zh) 2000-11-15
ID25428A (id) 2000-10-05
PT1041070E (pt) 2004-12-31
CA2302727A1 (en) 2000-09-30
HUP0001327A2 (hu) 2001-04-28
JP2000309581A (ja) 2000-11-07
EP1041070B1 (en) 2004-09-22
CZ20001142A3 (cs) 2000-12-13
HK1032053A1 (en) 2001-07-06
ES2226715T3 (es) 2005-04-01
PL339287A1 (en) 2000-10-09
ZA200001536B (en) 2001-09-27
IN188844B (enExample) 2002-11-09
HK1064364A1 (en) 2005-01-28
CN1290829C (zh) 2006-12-20
TR200000834A2 (tr) 2000-11-21
US6388127B1 (en) 2002-05-14
AU2263500A (en) 2000-10-05
DE60013942T2 (de) 2006-02-23
BR0001492A (pt) 2000-10-17
CZ298140B6 (cs) 2007-07-04
DE60013942D1 (de) 2004-10-28
IL135243A0 (en) 2001-05-20
IL135243A (en) 2005-09-25
PL196446B1 (pl) 2008-01-31
CN1519230A (zh) 2004-08-11
DK1041070T3 (da) 2005-01-24
ATE277025T1 (de) 2004-10-15
TW460472B (en) 2001-10-21
JP3566175B2 (ja) 2004-09-15
AR029744A1 (es) 2003-07-16
RU2219173C2 (ru) 2003-12-20
KR100386524B1 (ko) 2003-06-02
HU0001327D0 (en) 2000-06-28
YU15500A (sh) 2002-03-18

Similar Documents

Publication Publication Date Title
JP7252908B2 (ja) Ｓ１ｐ１活性を調節するための化合物およびその使用法
JP3933889B2 (ja) 新規ジフェニル尿素化合物、その製法、及びそれを含む医薬組成物
KR20070097590A (ko) 치환된 아릴아민 화합물 및 5―ｈｔ6 조절제로서의 이의용도
EP1438973A1 (en) Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
JPH11322711A (ja) 複素環式カルボキサミド
CN1056693A (zh) 药物化合物
JPH11506472A (ja) ５―ｈｔ１ａおよび／または５―ｈｔ１ｄ受容体の選択的（アンタ）アゴニストとしてのベンジル（イデン）―ラクタム誘導体、その調製法及びその使用法
CN1260797A (zh) 3－取代的3,4－二氢噻吩并[2,3－d]嘧啶衍生物及其制备和用途
CN1311681A (zh) 顽固性抑郁治疗的联合疗法
WO2010040274A1 (zh) 新型多巴胺d3受体配体，其制备方法及其医药用途
JP2022547079A (ja) てんかんを治療する方法を使用しててんかんを治療する方法
CN1146549C (zh) 作为治疗活性化合物的磺酰基噁唑胺
CN1768043A (zh) 作为5－ht受体拮抗剂用于治疗精神病和神经病学障碍的1,3,4－取代的吡唑
CN1050128C (zh) 5－酰胺基－1,2,4－噻二唑及其制备和药物组合物
KR20070091210A (ko) 글리신 수송 억제제
CN1202106A (zh) 选择性的β3肾上腺素能激动剂
CN1163490C (zh) 制备环状硫代酰胺化合物的方法
CN1332740A (zh) 用于抗抑郁疗法的5－ht1拮抗剂
CN1378528A (zh) 羰基氨基衍生物对抗cns障碍的应用
CN1342080A (zh) 5－ht5配体用于治疗神经变性和神经精神疾病的应用
CN1247593C (zh) 噻庚英并[3,2－b]二氢吡啶和相关组合物及方法
HK1064364B (en) Process for preparing cyclic thioamides
CN1072411A (zh) 用于治疗的新的活性化合物
TWI359137B (en) Hepatitis c virus inhibitors
HK1032053B (en) Process for preparing cyclic thioamides

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1032053

Country of ref document: HK

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee