CN1342080A - 5-ht5配体用于治疗神经变性和神经精神疾病的应用 - Google Patents
5-ht5配体用于治疗神经变性和神经精神疾病的应用 Download PDFInfo
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Abstract
Description
化合物 | Ki[M] |
R(+)-8-OH-DPAT | 1.25·10-7 |
5-CT | 1.44·10-9 |
化合物A | 6.61·10-7 |
化合物B | 1.24·10-7 |
化合物C | 2.37·10-7 |
活性化合物 | 剂量,静注(mg/kg+mg/kg/h) | 梗塞体积,%对照[平均值±SD,(n)] | P,司徒登t试验,双侧 | |
安慰剂 | 活性物质 | |||
R(+)-8-OH-DPAT | 2+1 | 100±11(12) | 72±32(12) | 0.0086 |
化合物A | 4+2 | 100±25(12) | 62±18(10) | 0.0013 |
化合物B | 2+1 | 100±20(12) | 66±19(9) | 0.0015 |
化合物C | 1+0.5 | 100 | 67 | <0.05 |
活性化合物 | 剂量(mg/kg,腹膜内) | 商Mw±sm(n) | P,司徒登t试验,双侧 | |
安慰剂 | 活性物质 | |||
化合物C[15+120分钟后] | 20+20 | 0.33±0.05(10) | 0.56±0.05(10) | <0.05 |
化合物B[15+120分钟后] | 20+20 | 0.44±0.03(17) | 0.64±0.03(12) | <0.05 |
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19900673.3 | 1999-01-11 | ||
DE19900673A DE19900673A1 (de) | 1999-01-11 | 1999-01-11 | Verwendung von Bindungspartnern für 5-HT5-Rezeptoren zur Behandlung neurodegenerativer und neuropsychiatrischer Störungen |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200810001649XA Division CN101239062A (zh) | 1999-01-11 | 2000-01-11 | 5-ht5配体用于治疗神经变性和神经精神疾病的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1342080A true CN1342080A (zh) | 2002-03-27 |
CN100370989C CN100370989C (zh) | 2008-02-27 |
Family
ID=7893918
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008045445A Expired - Fee Related CN100370989C (zh) | 1999-01-11 | 2000-01-11 | 5-ht5配体在制备治疗神经变性疾病的药物中的应用 |
CNA200810001649XA Pending CN101239062A (zh) | 1999-01-11 | 2000-01-11 | 5-ht5配体用于治疗神经变性和神经精神疾病的应用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200810001649XA Pending CN101239062A (zh) | 1999-01-11 | 2000-01-11 | 5-ht5配体用于治疗神经变性和神经精神疾病的应用 |
Country Status (9)
Country | Link |
---|---|
US (3) | US6750221B1 (zh) |
EP (2) | EP1143975A1 (zh) |
JP (1) | JP2002534466A (zh) |
CN (2) | CN100370989C (zh) |
AU (1) | AU2663300A (zh) |
CA (2) | CA2359357C (zh) |
DE (1) | DE19900673A1 (zh) |
MX (1) | MXPA01006987A (zh) |
WO (1) | WO2000041696A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA77650C2 (en) * | 1999-12-06 | 2007-01-15 | Lundbeck & Co As H | Use of serotonin reuptake inhibitor in combination with deramcyclane |
DE10031389A1 (de) * | 2000-07-03 | 2002-01-17 | Knoll Ag | Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
DE10259382A1 (de) * | 2002-12-18 | 2004-07-01 | Abbott Gmbh & Co. Kg | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-4-on-Derivate, ihre Herstellung und Verwendung |
DE102004008141A1 (de) | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
EP1917251B1 (de) * | 2005-08-21 | 2013-04-03 | Abbott GmbH & Co. KG | 5-ring-heteroaromaten-verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
WO2007022964A2 (de) * | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
US8637263B1 (en) * | 2010-10-14 | 2014-01-28 | Epiomed Therapeutics, Inc. | Assay for determination of compounds having anti-emetic activity |
KR20220015413A (ko) * | 2019-05-29 | 2022-02-08 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 간질을 치료하기 위한 방법 및 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5001130A (en) | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
FR2693200B1 (fr) * | 1992-07-01 | 1994-08-19 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations. |
DE19636769A1 (de) * | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
DE19724979A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-substituierte Pyrido [3,4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
DE19900545A1 (de) | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Pyrimidinderivaten zur Prophylaxe und Therapie der zerebralen Ischämie |
JP5962707B2 (ja) * | 2013-07-31 | 2016-08-03 | 三菱マテリアル株式会社 | 電子・電気機器用銅合金、電子・電気機器用銅合金塑性加工材、電子・電気機器用銅合金塑性加工材の製造方法、電子・電気機器用部品及び端子 |
-
1999
- 1999-01-11 DE DE19900673A patent/DE19900673A1/de not_active Withdrawn
-
2000
- 2000-01-11 US US09/889,157 patent/US6750221B1/en not_active Expired - Fee Related
- 2000-01-11 WO PCT/EP2000/000143 patent/WO2000041696A1/de active Application Filing
- 2000-01-11 CA CA002359357A patent/CA2359357C/en not_active Expired - Fee Related
- 2000-01-11 AU AU26633/00A patent/AU2663300A/en not_active Abandoned
- 2000-01-11 CA CA2640591A patent/CA2640591C/en not_active Expired - Fee Related
- 2000-01-11 EP EP00904894A patent/EP1143975A1/de not_active Withdrawn
- 2000-01-11 MX MXPA01006987A patent/MXPA01006987A/es not_active IP Right Cessation
- 2000-01-11 JP JP2000593307A patent/JP2002534466A/ja not_active Ceased
- 2000-01-11 EP EP10178088A patent/EP2266570A1/de not_active Withdrawn
- 2000-01-11 CN CNB008045445A patent/CN100370989C/zh not_active Expired - Fee Related
- 2000-01-11 CN CNA200810001649XA patent/CN101239062A/zh active Pending
-
2004
- 2004-05-03 US US10/836,349 patent/US20040202656A1/en not_active Abandoned
-
2011
- 2011-11-15 US US13/296,433 patent/US20120196301A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000041696A1 (de) | 2000-07-20 |
EP1143975A1 (de) | 2001-10-17 |
CN100370989C (zh) | 2008-02-27 |
CA2359357C (en) | 2008-09-09 |
JP2002534466A (ja) | 2002-10-15 |
EP2266570A1 (de) | 2010-12-29 |
US20040202656A1 (en) | 2004-10-14 |
MXPA01006987A (es) | 2002-09-18 |
CA2640591A1 (en) | 2000-07-20 |
US20120196301A1 (en) | 2012-08-02 |
CN101239062A (zh) | 2008-08-13 |
CA2359357A1 (en) | 2000-07-20 |
DE19900673A1 (de) | 2000-07-13 |
CA2640591C (en) | 2011-01-04 |
AU2663300A (en) | 2000-08-01 |
US6750221B1 (en) | 2004-06-15 |
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