CN116096393A - 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用 - Google Patents

人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用 Download PDF

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Publication number
CN116096393A
CN116096393A CN202180056132.4A CN202180056132A CN116096393A CN 116096393 A CN116096393 A CN 116096393A CN 202180056132 A CN202180056132 A CN 202180056132A CN 116096393 A CN116096393 A CN 116096393A
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China
Prior art keywords
radix
fructus
ginsenoside
rhizoma
composition
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CN202180056132.4A
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Inventor
王硕
富力
柳洋
鲁明明
林荣鑫
付文斐
冯雪
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Dalian Fu Sheng Natural Pharmaceutical Development Co ltd
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Dalian Fu Sheng Natural Pharmaceutical Development Co ltd
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Abstract

一种人参皂苷Rg3与人参皂苷Rg5的组合物及其制备方法，以及在制备提高免疫、抗肿瘤、抗肿瘤靶向药物的耐药性、减轻放化疗毒副反应或抗疲劳的药品、食品和保健品中的应用。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN202180056132.4A 2020-08-25 2021-08-20 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用 Pending CN116096393A (zh)

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CN202010861400.7A CN112245443A (zh) 2020-08-25 2020-08-25 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用
PCT/CN2021/113658 WO2022042428A1 (zh) 2020-08-25 2021-08-20 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112245443A (zh) * 2020-08-25 2021-01-22 富力 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用
CN112315989B (zh) * 2020-09-29 2022-11-22 吉林瑞诺科技有限公司 一种富集稀有人参皂苷的西洋参产品
CN112315967B (zh) * 2020-09-29 2022-12-13 吉林瑞诺科技有限公司 一种三七产品
CN112121071B (zh) * 2020-09-29 2022-11-22 吉林瑞诺科技有限公司 一种以人参为原料制备的产品
CN112294830B (zh) * 2020-09-29 2022-11-22 吉林瑞诺科技有限公司 一种富集稀有人参皂苷的西洋参叶产品
CN112315968B (zh) * 2020-09-29 2022-11-22 吉林瑞诺科技有限公司 一种富含稀有人参皂苷的人参叶产品
CN112656828B (zh) * 2020-09-29 2023-09-19 吉林瑞诺科技有限公司 一种三七叶产品
CN116120389B (zh) * 2023-03-29 2023-07-18 中国农业科学院特产研究所 人参皂苷Rg5及制备和在制备过敏性鼻炎药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1883492A (zh) * 2006-05-22 2006-12-27 富力 20(R)－人参皂苷Rg3药用组合物水溶液及制备方法
CN106109482A (zh) * 2016-07-29 2016-11-16 陕西巨子生物技术有限公司 一种具有抗肿瘤活性的二醇组稀有人参皂苷组合物
CN106727630A (zh) * 2016-12-04 2017-05-31 西北大学 人参皂苷Rg5在制备抗肿瘤药物中的应用
CN109316517A (zh) * 2018-09-27 2019-02-12 辽宁熙峰药业集团有限公司 一种鲜人参膏的制备方法及应用
CN112245443A (zh) * 2020-08-25 2021-01-22 富力 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101352465B (zh) * 2008-09-12 2011-08-03 中国科学院长春应用化学研究所 一种人参保健品冲剂的制备方法
KR101260047B1 (ko) * 2012-05-25 2013-05-06 한국과학기술연구원 마이크로웨이브 조사에 의해 진세노사이드 알지3, 알지5 및 알케이1의 함량비율이 증가된 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물
CN106063788B (zh) * 2015-04-23 2020-02-11 富力 连翘苷、连翘苷衍生物、连翘苷与连翘脂素组合物在制备缓解或/和治疗呕吐药物中的应用
CN106924277A (zh) * 2017-05-18 2017-07-07 华瑞（福建）生物科技有限公司 人参皂苷Rg5在制备抗抑郁药物中的应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1883492A (zh) * 2006-05-22 2006-12-27 富力 20(R)－人参皂苷Rg3药用组合物水溶液及制备方法
CN106109482A (zh) * 2016-07-29 2016-11-16 陕西巨子生物技术有限公司 一种具有抗肿瘤活性的二醇组稀有人参皂苷组合物
CN106727630A (zh) * 2016-12-04 2017-05-31 西北大学 人参皂苷Rg5在制备抗肿瘤药物中的应用
CN109316517A (zh) * 2018-09-27 2019-02-12 辽宁熙峰药业集团有限公司 一种鲜人参膏的制备方法及应用
CN112245443A (zh) * 2020-08-25 2021-01-22 富力 人参皂苷Rg3与Rg5的组合物及其抗肿瘤等药用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
苏晓梅;张丹参;: "人参皂苷-Rg3的药理作用研究进展", 神经药理学报, no. 01, pages 38 *
郑飞;王微;于珊珊;戴雨霖;刘尚;文连奎;越皓;: "高效液相色谱-飞行时间质谱联用法分析人参及人参皂苷与山楂配伍过程中的水解行为", 应用化学, no. 06, pages 724 *

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