CN1159316C - 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 - Google Patents

异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 Download PDF

Info

Publication number
CN1159316C
CN1159316C CNB021070547A CN02107054A CN1159316C CN 1159316 C CN1159316 C CN 1159316C CN B021070547 A CNB021070547 A CN B021070547A CN 02107054 A CN02107054 A CN 02107054A CN 1159316 C CN1159316 C CN 1159316C
Authority
CN
China
Prior art keywords
formula
compound
hydroxyl
branched
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB021070547A
Other languages
English (en)
Chinese (zh)
Other versions
CN1375494A (zh
Inventor
M
M·威尔兹比克
M-F·博萨德
A·罗斯奥
J-A·布廷
P·德拉格兰杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of CN1375494A publication Critical patent/CN1375494A/zh
Application granted granted Critical
Publication of CN1159316C publication Critical patent/CN1159316C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB021070547A 2001-03-12 2002-03-12 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 Expired - Fee Related CN1159316C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0103293 2001-03-12
FR0103293A FR2821843B1 (fr) 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CN1375494A CN1375494A (zh) 2002-10-23
CN1159316C true CN1159316C (zh) 2004-07-28

Family

ID=8860976

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB021070547A Expired - Fee Related CN1159316C (zh) 2001-03-12 2002-03-12 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物

Country Status (24)

Country Link
US (1) US6465660B1 (enExample)
EP (1) EP1241169B1 (enExample)
JP (1) JP3842151B2 (enExample)
KR (1) KR100450313B1 (enExample)
CN (1) CN1159316C (enExample)
AR (1) AR034583A1 (enExample)
AT (1) ATE248171T1 (enExample)
AU (1) AU779702B2 (enExample)
BR (1) BR0200721A (enExample)
CA (1) CA2376876C (enExample)
DE (1) DE60200023T2 (enExample)
DK (1) DK1241169T3 (enExample)
EA (1) EA004035B1 (enExample)
ES (1) ES2206438T3 (enExample)
FR (1) FR2821843B1 (enExample)
HK (1) HK1049000B (enExample)
HU (1) HUP0200913A3 (enExample)
MX (1) MXPA02002601A (enExample)
NO (1) NO20021198L (enExample)
NZ (1) NZ517742A (enExample)
PL (1) PL352750A1 (enExample)
PT (1) PT1241169E (enExample)
SI (1) SI1241169T1 (enExample)
ZA (1) ZA200202030B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1537113B9 (en) * 2002-06-21 2010-05-26 Suven Life Sciences Limited Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
CA2490002C (en) * 2002-06-21 2009-07-07 Suven Life Sciences Limited Novel tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
ES2425143T3 (es) * 2002-11-28 2013-10-11 Suven Life Sciences Limited N-Arilsulfonil-3-aminoalcoxiindoles
KR100739987B1 (ko) * 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
RU2387655C2 (ru) * 2004-08-09 2010-04-27 Бристол-Маерс Сквибб Компани Ингибиторы репликации вируса гепатита с
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
JP2025530666A (ja) 2022-09-02 2025-09-17 デックスコム・インコーポレーテッド 連続分析物センサデバイス及び方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5377098A (en) * 1976-12-16 1978-07-08 Sumitomo Chem Co Ltd Preparation of indoloisoquinoline derivative
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US5441955A (en) * 1993-11-19 1995-08-15 Pathogenesis Corporation Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
FR2743365A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant
US20020040018A1 (en) * 2000-06-23 2002-04-04 Jones Robert M. Subtype selective melatonergics

Also Published As

Publication number Publication date
EA004035B1 (ru) 2003-12-25
NO20021198L (no) 2002-09-13
DE60200023T2 (de) 2004-06-03
MXPA02002601A (es) 2004-11-12
EP1241169B1 (fr) 2003-08-27
NO20021198D0 (no) 2002-03-11
JP2002265469A (ja) 2002-09-18
CA2376876C (fr) 2006-07-11
AR034583A1 (es) 2004-03-03
HK1049000A1 (en) 2003-04-25
HUP0200913A3 (en) 2004-11-29
US6465660B1 (en) 2002-10-15
HUP0200913A2 (hu) 2002-11-28
HK1049000B (zh) 2005-01-07
DE60200023D1 (de) 2003-10-02
ES2206438T3 (es) 2004-05-16
PL352750A1 (en) 2002-09-23
FR2821843B1 (fr) 2003-05-09
FR2821843A1 (fr) 2002-09-13
CN1375494A (zh) 2002-10-23
HU0200913D0 (enExample) 2002-05-29
AU2324202A (en) 2002-09-19
AU779702B2 (en) 2005-02-10
EP1241169A1 (fr) 2002-09-18
PT1241169E (pt) 2003-11-28
SI1241169T1 (en) 2003-12-31
ATE248171T1 (de) 2003-09-15
ZA200202030B (en) 2002-10-03
KR20020072782A (ko) 2002-09-18
CA2376876A1 (fr) 2002-09-12
KR100450313B1 (ko) 2004-09-30
JP3842151B2 (ja) 2006-11-08
BR0200721A (pt) 2002-12-03
EA200200241A1 (ru) 2002-10-31
DK1241169T3 (da) 2003-11-24
NZ517742A (en) 2003-02-28

Similar Documents

Publication Publication Date Title
CN1680284A (zh) 阿戈美拉汀的新合成方法、新晶型及其药物组合物
CN1097054C (zh) 三环类吡唑衍生物及其组合物
CN1368960A (zh) 吲哚衍生物、制备它们的方法、含有它们的药用组合物和它们的医疗应用
CN1039491C (zh) 四氢咔唑化合物及其制备方法和应用
CN85101761A (zh) 新型色胺衍生物的制备方法和应用
CN1061653C (zh) 苯并呋喃化合物,其制备方法及其药物组合物
CN1159316C (zh) 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物
CN1145896A (zh) 新的烷氧芳基化合物,其制备方法和含有它们的药用组合物
CN1130184A (zh) 新三环酰胺化合物,其制法和含它们的药物组合物
CN1507437A (zh) 具有5-羟色胺5-ht1a活性的支链金刚烷基及降金刚烷基芳基-与芳烷基-哌嗪
CN88102422A (zh) 苯并氮杂草衍生物
CN1307567A (zh) 1,5-苯并二氮杂䓬类衍生物
CN1293195A (zh) 新的多环氮杂吲哚化合物,其制备方法及包含它们的药物组合物
HK1049160A1 (en) 1-Amino-alkylcyclohexane compound nmda receptor antagonist
CN1144800C (zh) 作为5-羟色胺能药物的吲哚基衍生物
CN1185214C (zh) 新的茚并吲哚酮化合物,其制备方法和含有这种化合物的药物组合物
CN1250771A (zh) 具有亚环烷基链的新环状化合物,其制备方法和含有它们的药物组合物
CN1337956A (zh) 新的吗啉代苯甲酰胺盐
CN1178529A (zh) 用作速激肽受体拮抗剂的杂环取代的哌嗪酮衍生物
CN1304409A (zh) 用于治疗抑郁症的吲哚-3-基-环己胺衍生物(5-ht1受体拮抗剂)
CN1050358C (zh) 新四环哌嗪和1,4-噁嗪化合物,其制备和药物组合物
CN1077890C (zh) 作为多巴胺d2激动剂的4-氨基乙氧基-吲哚衍生物
CN1152861C (zh) 用作雌激素药物的n-取代的二氢吲哚类化合物
CN1067887A (zh) 2-氨基嘧啶-4-甲酰胺衍生物及其制法和医疗应用
CN1308069A (zh) 取代的(二氢)苯并噁嗪和(二氢)苯并噻嗪化合物,其制法和药物组合物

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1049000

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040728

Termination date: 20100312