FR2821843B1 - Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2821843B1
FR2821843B1 FR0103293A FR0103293A FR2821843B1 FR 2821843 B1 FR2821843 B1 FR 2821843B1 FR 0103293 A FR0103293 A FR 0103293A FR 0103293 A FR0103293 A FR 0103293A FR 2821843 B1 FR2821843 B1 FR 2821843B1
Authority
FR
France
Prior art keywords
isoindoloindolone
derivatives
novel
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0103293A
Other languages
English (en)
French (fr)
Other versions
FR2821843A1 (fr
Inventor
Michel Wierzbicki
Marie Francoise Boussard
Anne Rousseau
Jean Albert Boutin
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to FR0103293A priority Critical patent/FR2821843B1/fr
Priority to US10/083,074 priority patent/US6465660B1/en
Priority to KR10-2002-0012699A priority patent/KR100450313B1/ko
Priority to BR0200721-5A priority patent/BR0200721A/pt
Priority to DK02290598T priority patent/DK1241169T3/da
Priority to CA002376876A priority patent/CA2376876C/fr
Priority to AT02290598T priority patent/ATE248171T1/de
Priority to ARP020100863A priority patent/AR034583A1/es
Priority to DE60200023T priority patent/DE60200023T2/de
Priority to EP02290598A priority patent/EP1241169B1/fr
Priority to PT02290598T priority patent/PT1241169E/pt
Priority to HU0200913A priority patent/HUP0200913A3/hu
Priority to NO20021198A priority patent/NO20021198L/no
Priority to MXPA02002601A priority patent/MXPA02002601A/es
Priority to JP2002065233A priority patent/JP3842151B2/ja
Priority to SI200230002T priority patent/SI1241169T1/xx
Priority to NZ517742A priority patent/NZ517742A/xx
Priority to ES02290598T priority patent/ES2206438T3/es
Priority to EA200200241A priority patent/EA004035B1/ru
Priority to CNB021070547A priority patent/CN1159316C/zh
Priority to ZA200202030A priority patent/ZA200202030B/xx
Priority to AU23242/02A priority patent/AU779702B2/en
Priority to PL02352750A priority patent/PL352750A1/xx
Publication of FR2821843A1 publication Critical patent/FR2821843A1/fr
Priority to HK03101182.3A priority patent/HK1049000B/zh
Application granted granted Critical
Publication of FR2821843B1 publication Critical patent/FR2821843B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR0103293A 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2821843B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR0103293A FR2821843B1 (fr) 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10/083,074 US6465660B1 (en) 2001-03-12 2002-02-26 Isoindoloindolone compounds
KR10-2002-0012699A KR100450313B1 (ko) 2001-03-12 2002-03-09 이소인돌로인돌론 화합물, 이들의 제조 방법, 및 이들을함유하는 약제 조성물
NZ517742A NZ517742A (en) 2001-03-12 2002-03-11 Isoindoloindolone compounds useful for treating disorders of the melatonin system
CA002376876A CA2376876C (fr) 2001-03-12 2002-03-11 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AT02290598T ATE248171T1 (de) 2001-03-12 2002-03-11 Isoindoloindolon-derivate, verfahren zu ihrer herstellung und die enthaltende pharmazeutische zusammensetzungen
ARP020100863A AR034583A1 (es) 2001-03-12 2002-03-11 Compuestos de isoindoloindolona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
DE60200023T DE60200023T2 (de) 2001-03-12 2002-03-11 Isoindoloindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltende pharmazeutische Zusammensetzungen
EP02290598A EP1241169B1 (fr) 2001-03-12 2002-03-11 Dérivés d'isoindoloindolone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
PT02290598T PT1241169E (pt) 2001-03-12 2002-03-11 Derivados de isoindoloindolona processo para a sua preparacao e as composicoes farmaceuticas que os contem
HU0200913A HUP0200913A3 (en) 2001-03-12 2002-03-11 Isoindoindololone derivatives process for their preparation and pharmaceutical compositions containing them
NO20021198A NO20021198L (no) 2001-03-12 2002-03-11 Nye isoindoloindolonforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
BR0200721-5A BR0200721A (pt) 2001-03-12 2002-03-11 Compostos de isoindoloindolona, processo para a fabricação dos mesmos e composições farmacêuticas que contêm os mesmos
JP2002065233A JP3842151B2 (ja) 2001-03-12 2002-03-11 新規イソインドロインドロン化合物、それらの製造方法およびそれらを含む医薬組成物
SI200230002T SI1241169T1 (en) 2001-03-12 2002-03-11 Isoindoloindolone derivatives, process for their preparation and pharmaceutical compositions containing them
DK02290598T DK1241169T3 (da) 2001-03-12 2002-03-11 Isoindoloindolonforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
ES02290598T ES2206438T3 (es) 2001-03-12 2002-03-11 Derivados de isoindolo-indolona, su procedimiento de preparaacion y las composiciones farmaceuticas que los contienen.
EA200200241A EA004035B1 (ru) 2001-03-12 2002-03-11 Производные изоиндолоиндолона, способ их получения и содержащие их фармацевтические композиции
MXPA02002601A MXPA02002601A (es) 2001-03-12 2002-03-11 Compuestos nuevos de isoindoloindolona, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
CNB021070547A CN1159316C (zh) 2001-03-12 2002-03-12 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物
ZA200202030A ZA200202030B (en) 2001-03-12 2002-03-12 Isoindoloindolone compounds, a process for their preparation and pharmaceutical compositions containing them.
AU23242/02A AU779702B2 (en) 2001-03-12 2002-03-12 New isoindoloindolone compounds, a process for their preparation and pharmaceutical compositions containing them
PL02352750A PL352750A1 (en) 2001-03-12 2002-03-12 Novel isoindoloindolone compounds, method of obtaining them and pharamcological composition containing such compounds
HK03101182.3A HK1049000B (zh) 2001-03-12 2003-02-18 異吲並吲酮化合物、它們的製備方法和含有它們的藥物組合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0103293A FR2821843B1 (fr) 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2821843A1 FR2821843A1 (fr) 2002-09-13
FR2821843B1 true FR2821843B1 (fr) 2003-05-09

Family

ID=8860976

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0103293A Expired - Fee Related FR2821843B1 (fr) 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (24)

Country Link
US (1) US6465660B1 (enExample)
EP (1) EP1241169B1 (enExample)
JP (1) JP3842151B2 (enExample)
KR (1) KR100450313B1 (enExample)
CN (1) CN1159316C (enExample)
AR (1) AR034583A1 (enExample)
AT (1) ATE248171T1 (enExample)
AU (1) AU779702B2 (enExample)
BR (1) BR0200721A (enExample)
CA (1) CA2376876C (enExample)
DE (1) DE60200023T2 (enExample)
DK (1) DK1241169T3 (enExample)
EA (1) EA004035B1 (enExample)
ES (1) ES2206438T3 (enExample)
FR (1) FR2821843B1 (enExample)
HK (1) HK1049000B (enExample)
HU (1) HUP0200913A3 (enExample)
MX (1) MXPA02002601A (enExample)
NO (1) NO20021198L (enExample)
NZ (1) NZ517742A (enExample)
PL (1) PL352750A1 (enExample)
PT (1) PT1241169E (enExample)
SI (1) SI1241169T1 (enExample)
ZA (1) ZA200202030B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE60329607D1 (de) * 2002-06-21 2009-11-19 Suven Life Sciences Ltd Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
ES2276109T3 (es) * 2002-06-21 2007-06-16 Suven Life Sciences Limited Nuevos indoles arilcarbonilicos tetraciclicos que tienen afinidad por el receptor de serotonina, utiles como agentes terapeuticos, proceso para su preparacion y mezclas farmaceuticas que los contienen.
MXPA05005700A (es) * 2002-11-28 2005-08-16 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxiindoles.
EA009367B1 (ru) * 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА
RU2387655C2 (ru) * 2004-08-09 2010-04-27 Бристол-Маерс Сквибб Компани Ингибиторы репликации вируса гепатита с
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
CN119730789A (zh) 2022-09-02 2025-03-28 德克斯康公司 连续分析物传感器设备和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5377098A (en) * 1976-12-16 1978-07-08 Sumitomo Chem Co Ltd Preparation of indoloisoquinoline derivative
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US5441955A (en) * 1993-11-19 1995-08-15 Pathogenesis Corporation Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
FR2743365A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant
AU2001268677A1 (en) * 2000-06-23 2002-01-08 Cognetix, Inc. Subtype selective melatonergics

Also Published As

Publication number Publication date
NO20021198D0 (no) 2002-03-11
ATE248171T1 (de) 2003-09-15
US6465660B1 (en) 2002-10-15
JP3842151B2 (ja) 2006-11-08
HK1049000B (zh) 2005-01-07
CN1375494A (zh) 2002-10-23
ES2206438T3 (es) 2004-05-16
CA2376876C (fr) 2006-07-11
EA200200241A1 (ru) 2002-10-31
KR100450313B1 (ko) 2004-09-30
KR20020072782A (ko) 2002-09-18
DK1241169T3 (da) 2003-11-24
FR2821843A1 (fr) 2002-09-13
HUP0200913A2 (hu) 2002-11-28
ZA200202030B (en) 2002-10-03
CA2376876A1 (fr) 2002-09-12
AU779702B2 (en) 2005-02-10
NZ517742A (en) 2003-02-28
CN1159316C (zh) 2004-07-28
DE60200023T2 (de) 2004-06-03
PT1241169E (pt) 2003-11-28
MXPA02002601A (es) 2004-11-12
AR034583A1 (es) 2004-03-03
DE60200023D1 (de) 2003-10-02
EA004035B1 (ru) 2003-12-25
AU2324202A (en) 2002-09-19
PL352750A1 (en) 2002-09-23
JP2002265469A (ja) 2002-09-18
SI1241169T1 (en) 2003-12-31
BR0200721A (pt) 2002-12-03
NO20021198L (no) 2002-09-13
HU0200913D0 (enExample) 2002-05-29
HUP0200913A3 (en) 2004-11-29
EP1241169A1 (fr) 2002-09-18
EP1241169B1 (fr) 2003-08-27
HK1049000A1 (en) 2003-04-25

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Effective date: 20051130