CN115605459A - 用于标记肿瘤组织的新型荧光化合物 - Google Patents

用于标记肿瘤组织的新型荧光化合物 Download PDF

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Publication number
CN115605459A
CN115605459A CN202180035401.9A CN202180035401A CN115605459A CN 115605459 A CN115605459 A CN 115605459A CN 202180035401 A CN202180035401 A CN 202180035401A CN 115605459 A CN115605459 A CN 115605459A
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chemical formula
compounds
tumor tissue
compound
tumor
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Chinese (zh)
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J·特兰-古永
V·古永
F·舍宁斯基
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202180035401.9A 2020-05-15 2021-05-12 用于标记肿瘤组织的新型荧光化合物 Pending CN115605459A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511568024.1A CN121471129A (zh) 2020-05-15 2021-05-12 用于标记肿瘤组织的新型荧光化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FRFR2004868 2020-05-15
FR2004868A FR3110165B1 (fr) 2020-05-15 2020-05-15 Nouveaux composés fluorescents pour le marquage de tissu tumoral
PCT/FR2021/050832 WO2021229188A1 (fr) 2020-05-15 2021-05-12 Nouveaux composés fluorescents pour le marquage de tissu tumoral

Related Child Applications (1)

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CN202511568024.1A Division CN121471129A (zh) 2020-05-15 2021-05-12 用于标记肿瘤组织的新型荧光化合物

Publications (1)

Publication Number Publication Date
CN115605459A true CN115605459A (zh) 2023-01-13

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CN202180035401.9A Pending CN115605459A (zh) 2020-05-15 2021-05-12 用于标记肿瘤组织的新型荧光化合物
CN202511568024.1A Pending CN121471129A (zh) 2020-05-15 2021-05-12 用于标记肿瘤组织的新型荧光化合物

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US (1) US20230203014A1 (https=)
EP (1) EP4149925A1 (https=)
JP (2) JP2023525601A (https=)
KR (1) KR20230010713A (https=)
CN (2) CN115605459A (https=)
BR (1) BR112022023154A2 (https=)
CA (1) CA3178232A1 (https=)
FR (1) FR3110165B1 (https=)
WO (1) WO2021229188A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116947829A (zh) * 2023-07-05 2023-10-27 上海师范大学 一种基于新吲哚菁绿ir820的荧光化合物及其制备和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023150222A1 (en) * 2022-02-02 2023-08-10 Vergent Bioscience, Inc. Methods for localization of cancerous tissue using fluorescent molecular imaging agent for diagnosis or treatment
CN114751907A (zh) * 2022-03-17 2022-07-15 南京诺源医疗器械有限公司 一种主动靶向叶酸受体近红外荧光分子及其制备方法和用途

Citations (5)

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Publication number Priority date Publication date Assignee Title
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
CN102268191A (zh) * 2010-06-06 2011-12-07 史春梦 七甲川吲哚花菁染料及其合成方法和应用
WO2014101339A1 (zh) * 2012-12-28 2014-07-03 浙江海正药业股份有限公司 菁染料化合物及其制备方法、用于光动力学疗法的双重功能剂及其制备方法
CN105693590A (zh) * 2016-01-15 2016-06-22 复旦大学 一种pH控制识别肿瘤细胞的光热试剂及其制备方法和应用
WO2019145532A1 (en) * 2018-01-26 2019-08-01 Universite De Strasbourg Fluorescent polymeric coating film for medical devices

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07287346A (ja) * 1994-04-08 1995-10-31 E I Du Pont De Nemours & Co 近赤外ハレーション防止用の新規なエーテル色素を有する写真エレメント
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
KR101980292B1 (ko) * 2017-08-03 2019-05-20 (주)바이오액츠 형광 화합물 및 이의 제조방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
CN102268191A (zh) * 2010-06-06 2011-12-07 史春梦 七甲川吲哚花菁染料及其合成方法和应用
WO2014101339A1 (zh) * 2012-12-28 2014-07-03 浙江海正药业股份有限公司 菁染料化合物及其制备方法、用于光动力学疗法的双重功能剂及其制备方法
CN105693590A (zh) * 2016-01-15 2016-06-22 复旦大学 一种pH控制识别肿瘤细胞的光热试剂及其制备方法和应用
WO2019145532A1 (en) * 2018-01-26 2019-08-01 Universite De Strasbourg Fluorescent polymeric coating film for medical devices

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUIYUAN ZHANG等: "A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine-IR820 Prodrug Encapsulated ZIF-8 toward Chemo-Photothermal Therapy", ADV. FUNCT. MATER., vol. 28, 1 July 2018 (2018-07-01), pages 1802830 *
LUCJAN STREKOWSKI等: "Water-Soluble pH-Sensitive 2, 6-Bis(substituted ethylidene)-cyclohexanone/Hydroxy Cyanine Dyes that Absorb in the Visible/Near-Infrared Regions", J. HETEROCYCLIC CHEM., vol. 41, 31 December 2004 (2004-12-31), pages 227 - 232 *
MICHAEL P. A. WILLIAMS等: "Synthesis, Photophysical, Electrochemical, Tumor-Imaging, and Phototherapeutic Properties of Purpurinimide-N-substituted Cyanine Dyes Joined with Variable Lengths of Linkers", BIOCONJUGATE CHEM., vol. 22, 11 October 2011 (2011-10-11), pages 2283 - 2295, XP055271457, DOI: 10.1021/bc200345p *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116947829A (zh) * 2023-07-05 2023-10-27 上海师范大学 一种基于新吲哚菁绿ir820的荧光化合物及其制备和应用
CN116947829B (zh) * 2023-07-05 2025-09-23 上海内瑟汐医疗科技有限公司 一种基于新吲哚菁绿ir820的荧光化合物及其制备和应用

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Publication number Publication date
BR112022023154A2 (pt) 2023-02-07
FR3110165A1 (fr) 2021-11-19
US20230203014A1 (en) 2023-06-29
JP2023525601A (ja) 2023-06-16
JP2026042845A (ja) 2026-03-11
FR3110165B1 (fr) 2022-10-28
CA3178232A1 (fr) 2021-11-18
WO2021229188A1 (fr) 2021-11-18
EP4149925A1 (fr) 2023-03-22
KR20230010713A (ko) 2023-01-19
CN121471129A (zh) 2026-02-06

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