JP2023525601A - 腫瘍組織を標識するための新規蛍光化合物 - Google Patents

腫瘍組織を標識するための新規蛍光化合物 Download PDF

Info

Publication number
JP2023525601A
JP2023525601A JP2023514171A JP2023514171A JP2023525601A JP 2023525601 A JP2023525601 A JP 2023525601A JP 2023514171 A JP2023514171 A JP 2023514171A JP 2023514171 A JP2023514171 A JP 2023514171A JP 2023525601 A JP2023525601 A JP 2023525601A
Authority
JP
Japan
Prior art keywords
compound
compounds
tumor
tumor tissue
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023514171A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023525601A5 (https=
Inventor
ジョアン・トラン－ギヨン
ヴァンサン・ギヨン
フランソワ・シェルニンスキー
Original Assignee
プロイメージング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by プロイメージング filed Critical プロイメージング
Publication of JP2023525601A publication Critical patent/JP2023525601A/ja
Publication of JP2023525601A5 publication Critical patent/JP2023525601A5/ja
Priority to JP2025284837A priority Critical patent/JP2026042845A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2023514171A 2020-05-15 2021-05-12 腫瘍組織を標識するための新規蛍光化合物 Pending JP2023525601A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025284837A JP2026042845A (ja) 2020-05-15 2025-12-26 腫瘍組織を標識するための新規蛍光化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR2004868 2020-05-15
FR2004868A FR3110165B1 (fr) 2020-05-15 2020-05-15 Nouveaux composés fluorescents pour le marquage de tissu tumoral
PCT/FR2021/050832 WO2021229188A1 (fr) 2020-05-15 2021-05-12 Nouveaux composés fluorescents pour le marquage de tissu tumoral

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025284837A Division JP2026042845A (ja) 2020-05-15 2025-12-26 腫瘍組織を標識するための新規蛍光化合物

Publications (2)

Publication Number Publication Date
JP2023525601A true JP2023525601A (ja) 2023-06-16
JP2023525601A5 JP2023525601A5 (https=) 2024-02-26

Family

ID=72644317

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2023514171A Pending JP2023525601A (ja) 2020-05-15 2021-05-12 腫瘍組織を標識するための新規蛍光化合物
JP2025284837A Pending JP2026042845A (ja) 2020-05-15 2025-12-26 腫瘍組織を標識するための新規蛍光化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025284837A Pending JP2026042845A (ja) 2020-05-15 2025-12-26 腫瘍組織を標識するための新規蛍光化合物

Country Status (9)

Country Link
US (1) US20230203014A1 (https=)
EP (1) EP4149925A1 (https=)
JP (2) JP2023525601A (https=)
KR (1) KR20230010713A (https=)
CN (2) CN115605459A (https=)
BR (1) BR112022023154A2 (https=)
CA (1) CA3178232A1 (https=)
FR (1) FR3110165B1 (https=)
WO (1) WO2021229188A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023150222A1 (en) * 2022-02-02 2023-08-10 Vergent Bioscience, Inc. Methods for localization of cancerous tissue using fluorescent molecular imaging agent for diagnosis or treatment
CN114751907A (zh) * 2022-03-17 2022-07-15 南京诺源医疗器械有限公司 一种主动靶向叶酸受体近红外荧光分子及其制备方法和用途
CN116947829B (zh) * 2023-07-05 2025-09-23 上海内瑟汐医疗科技有限公司 一种基于新吲哚菁绿ir820的荧光化合物及其制备和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
JPH07287346A (ja) * 1994-04-08 1995-10-31 E I Du Pont De Nemours & Co 近赤外ハレーション防止用の新規なエーテル色素を有する写真エレメント
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
EP2940021A1 (en) * 2012-12-28 2015-11-04 Zhejiang Hisun Pharmaceutical Co. Ltd. Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor
KR20190014625A (ko) * 2017-08-03 2019-02-13 (주)바이오액츠 형광 화합물 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102268191B (zh) * 2010-06-06 2013-08-14 史春梦 七甲川吲哚花菁染料及其合成方法和应用
CN105693590B (zh) * 2016-01-15 2019-01-15 复旦大学 一种pH控制识别肿瘤细胞的光热试剂及其制备方法和应用
EP3517146A1 (en) * 2018-01-26 2019-07-31 Université de Strasbourg Fluorescent polymeric coating film for medical devices

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
JPH07287346A (ja) * 1994-04-08 1995-10-31 E I Du Pont De Nemours & Co 近赤外ハレーション防止用の新規なエーテル色素を有する写真エレメント
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
EP2940021A1 (en) * 2012-12-28 2015-11-04 Zhejiang Hisun Pharmaceutical Co. Ltd. Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor
KR20190014625A (ko) * 2017-08-03 2019-02-13 (주)바이오액츠 형광 화합물 및 이의 제조방법

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADV. FUNCT. MATER., vol. Vol. 28, 1802830, JPN6025001304, 2018, pages 1 - 10, ISSN: 0005817890 *
BIOCONJUGATE CHEM., vol. 22, JPN6025001305, 2011, pages 2283 - 2295, ISSN: 0005817889 *
J. MATER. CHEM. B, vol. 5, JPN6025001300, 2017, pages 5027 - 5036, ISSN: 0005817894 *
NANOSCALE, vol. 7, JPN6025001303, 2015, pages 16330 - 16336, ISSN: 0005817891 *
SOFT MATTER., vol. 14, JPN6025001301, 2018, pages 4495 - 4504, ISSN: 0005817893 *
THERANOSTICS, vol. Vol. 3, Issue 9, JPN6025001302, 2013, pages 703 - 718, ISSN: 0005817892 *

Also Published As

Publication number Publication date
BR112022023154A2 (pt) 2023-02-07
FR3110165A1 (fr) 2021-11-19
US20230203014A1 (en) 2023-06-29
JP2026042845A (ja) 2026-03-11
FR3110165B1 (fr) 2022-10-28
CA3178232A1 (fr) 2021-11-18
WO2021229188A1 (fr) 2021-11-18
EP4149925A1 (fr) 2023-03-22
CN115605459A (zh) 2023-01-13
KR20230010713A (ko) 2023-01-19
CN121471129A (zh) 2026-02-06

Similar Documents

Publication Publication Date Title
EP1480683B1 (en) Near infrared fluorescent contrast agent and method for fluorescence imaging
JP2026042845A (ja) 腫瘍組織を標識するための新規蛍光化合物
AU2010210547B2 (en) Charge-balanced imaging agents
CN105339436B (zh) 4,4-二取代环己基桥连七甲川花菁染料及其应用
JP7308366B2 (ja) アクティブターゲティング型葉酸受容体近赤外蛍光分子及びその調製方法
JP2016193907A (ja) 蛍光リン脂質エーテル化合物、組成物、及びその使用
CN101296927A (zh) 生物相容的含n,n-二取代磺酰胺的荧光染料标记
CN116034139A (zh) 制备和合成荧光染料化合物的方法及其用途
US8916137B2 (en) Monofunctional carbocyanine dyes for in vivo and in vitro imaging
WO2026081650A1 (zh) 一种靶向近红外荧光化合物及其制备方法和应用
JP2012509300A (ja) 色素コンジュゲートイメージング剤
JP2010203966A (ja) 低酸素領域イメージング用近赤外蛍光プローブ
RU2847417C1 (ru) Новые флуоресцентные соединения для введения метки в опухолевую ткань
KR102034113B1 (ko) 종양특이성을 증가시킨 신장배출형 형광 조영제 및 이를 이용한 영상화 방법
CN115337409B (zh) 白蛋白结合型近红外荧光探针-脂肪酸共轭物及其制备方法和应用
WO2022202863A1 (ja) がん造影用組成物
CN119798132A (zh) 一种靶向psma的荧光二聚体探针及其药用盐和应用
HK40096921A (zh) 癌造影用组合物
JP2005145819A (ja) 蛍光造影剤および体外蛍光造影方法
JP2005170812A (ja) 蛍光造影剤及び蛍光造影方法
KR20190136341A (ko) 신호 대 배경비 향상을 위한 전하 균형 형광 조영제 및 이를 이용한 영상화 방법
CN107739528A (zh) 一种五肽改性菁染料化合物及其制备方法和应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240214

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250121

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250415

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250722

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20251226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20260317

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260331

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20260414