CN115350233B - Oral liquid for protecting livers of livestock and poultry and preparation method thereof - Google Patents
Oral liquid for protecting livers of livestock and poultry and preparation method thereof Download PDFInfo
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention provides a traditional Chinese medicine composition for protecting livers of livestock and poultry, which is characterized by comprising the following raw materials in parts by weight: 20-40 parts of broussonetia papyrifera, 10-30 parts of drunk spruce, 10-30 parts of nutgrass galingale rhizome, 5-15 parts of Chinese mahonia leaves and 5-15 parts of sweet potato roots. The traditional Chinese medicine composition has the effects of detoxifying, expelling toxin, resolving hard mass, removing blood stasis, promoting liver cell regeneration and promoting liver function recovery to be a treatment rule, is reasonable in formula, has obvious effects of nourishing and protecting the liver, decomposing toxin in bodies, recovering liver function and improving production performance, and is effective in treating livestock and poultry liver poisoning.
Description
Technical Field
The invention relates to the field of traditional Chinese veterinary medicines, in particular to an oral liquid for protecting livers of livestock and poultry and a preparation method thereof.
Background
Along with the continuous improvement of the living standard of people, people pay more attention to the health problem of foods, especially livestock and poultry meat. The growth health of animals is ensured, and the quality of life of human beings can be improved, but in the breeding process, the liver injury of livestock and poultry can be caused by a large amount of antibiotics, drug toxic and side effects, edible mildewed feed, water pollution, poor breeding environment, some bacterial diseases, viral diseases, parasitic diseases and the like occurring in the growth process of livestock and poultry.
Liver is one of the very important viscera of animals, and liver belongs to wood in five elements, is yang in yin, is in spring qi, merges tendons in vivo, opens into eyes, is in the paws, and is in the fluid, tears. The physiological function of the liver is mainly dredging and discharging, i.e. dredging and discharging. Liver governs smoothing flow of qi, and means that liver has the characteristics of dredging, soothing, regulating and raising hair, and can smooth qi movement of the whole body. Its role is mainly represented in the following three aspects. 1) Regulating qi movement: the qi movement means the lifting, entering and exiting movement of the qi. 2) Regulating emotion: emotion, namely emotion and emotion, means the regulating action of liver on qi movement through its function of dredging and discharging. 3) Assist digestion: the liver's function of smoothing flow of qi and promoting digestion is mainly achieved by coordinating the ascending and descending of the spleen and stomach and regulating the secretion and excretion of bile. In addition, the liver governs smoothing flow of qi and regulating qi movement, and is also beneficial to the dredging of triple energizer channels and coordination of water metabolism. The liver has the functions of storing blood and regulating blood flow, so that it is suitable for different physiological conditions. Liver is also a detoxified organ, and liver injury can have a great influence on the organism. When the liver of the organism is damaged, thereby leading to liver dysfunction, the growth of the organism is blocked, the immunity is reduced, the digestive metabolism of the organism is disturbed, the growth and development of the livestock are affected slightly, and the death and panning rate of the livestock is increased heavily. Liver damage of livestock and poultry affects healthy growth of animals, and the problem also affects healthy development of the breeding industry seriously.
The sick chickens are characterized by low spirit, slow growth and development of individual chickens, little exercise amount and slow movement in clinical symptoms, and most of chicken manure is yellow and white and more manure, which can indicate that most of the sick chickens are mainly due to damp-heat and liver depression during the disease period. When the chicken is taken by a user, the liver is discolored and enlarged, and has hard quality and bleeding, and the reasons are that damp-heat epidemic toxin attacks nutrient blood, nutrient qi is not sufficient, the disease is blocked in the liver for a long time, qi movement is blocked, blood stasis is remained, and phlegm turbidity blocks collaterals. In terms of treatment, the prescription for clearing heat and detoxicating, soothing liver and nourishing liver can achieve better curative effect according to the diagnosis and treatment of etiology.
At present, in the process of breeding livestock and poultry, after the livestock and poultry show clinical symptoms, most of the livestock and poultry are treated by using antibiotic medicaments, and the effect is not ideal due to the fact that the medicament residue and the medicament resistance of the antibiotics and the long-term massive use can influence the normal microbial colony of the intestinal canal of the organism and have certain toxic and side effects on other tissues and organs. Along with the increasing emphasis of healthy green foods and the strict restriction of antibiotics in various countries, medicinal plants are imperative to replace antibiotics for preventing and treating liver injury. Therefore, the development of the safe and effective liver-protecting medicine without medicine residues, medicine resistance and toxic and side effects has very important significance.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an oral liquid for protecting livers of livestock and poultry, which has no drug residues, drug resistance and toxic and side effects, and is safe and effective, and a preparation method thereof.
In order to achieve the above purpose, the invention provides a traditional Chinese medicine composition for protecting livers of livestock and poultry, which is characterized by comprising the following raw materials in parts by weight: 20-40 parts of broussonetia papyrifera, 10-30 parts of drunk spruce, 10-30 parts of nutgrass galingale rhizome, 5-15 parts of Chinese mahonia leaves and 5-15 parts of sweet potato roots.
The traditional Chinese medicine composition disclosed by the invention has the effects of clearing heat and detoxicating, soothing liver and nourishing liver, promoting regeneration of liver cells and promoting recovery of liver functions.
The pharmacological actions of the traditional Chinese medicine components are as follows:
broussonetia papyrifera (L.) Makino is red: cool, sour, enter lung and liver meridians; has effects of clearing lung heat and removing liver fire. The whole herb is used as medicine, has the effects of clearing liver and improving vision, and can be used for treating tinnitus, eye fog and other symptoms or removing liver fire.
Intoxicated spruce vine: pungent and flat taste; enter liver and kidney meridians; has effects of dispersing and eliminating dampness, and removing dirt and treating malaria. Is mainly used for treating fetal toxin sore and rash; malaria.
And (3) rhizoma cyperi: taste, xin Wei bitter and sweet, and level; enter liver, triple energizer meridian; has effects of activating qi-flowing, resolving stagnation, regulating menstruation and relieving pain; can be used for treating stagnation of liver qi, chest pain, hypochondrium pain, abdominal distention, dyspepsia, chest distress, and cold hernia abdominal pain.
Folium Mahoniae: bitter and cool; enter liver and kidney meridians; clearing deficiency heat, tonifying liver and kidney, and dispelling wind-dampness; cough, hemoptysis and dizziness due to yin deficiency and fatigue heat.
Root of sweet Pachyrhizus: bitter and astringent, cool; has effects of clearing heat and promoting diuresis; is mainly used for treating diarrhea, dysentery, jaundice, scrofula.
Further, the traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising the following raw materials in parts by weight: 25-35 parts of broussonetia papyrifera, 15-25 parts of drunk spruce stems, 15-25 parts of nutgrass galingale rhizome, 8-12 parts of Chinese mahonia leaves and 8-12 parts of sweet potato roots.
Further, the traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising the following raw materials in parts by weight: 30 parts of broussonetia papyrifera, 20 parts of buddleia, 20 parts of nutgrass galingale rhizome, 10 parts of Chinese mahonia leaf and 10 parts of sweet potato root.
In another aspect, the invention provides a preparation method of a traditional Chinese medicine composition for protecting livers of livestock and poultry, the method comprises the following steps:
s1: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-40 parts of broussonetia papyrifera, 10-30 parts of drunk spruce, 10-30 parts of nutgrass galingale rhizome, 5-15 parts of Chinese mahonia leaves and 5-15 parts of sweet potato roots;
s2: decocting with water twice, each time with water 10-12 times of the total weight of all the medicinal materials, soaking for 2 hr in advance, each time for 2-3 hr, filtering to obtain filtrate, and mixing the filtrates;
s3: concentrating the filtrate into clear paste with the relative density of 1.10-1.20;
s4: cooling the liquid medicine, slowly adding 70% ethanol with the amount of 2 times of the weight of the liquid medicine, stirring uniformly, hermetically refrigerating for 24-48 h, filtering, and recovering ethanol from the filtrate to obtain refined liquid.
In a third aspect, the invention also provides an application of the traditional Chinese medicine composition for protecting livers of livestock and poultry, which is used for treating liver injury diseases of livestock and poultry, wherein the liver injury diseases comprise acute and chronic hepatitis, drug hepatitis, viral hepatitis and the like, and liver injury caused by feed mildew, disease infection, water quality pollution, drug accumulation poisoning and other factors.
The traditional Chinese medicine composition for protecting livers of livestock and poultry can be further prepared into pharmaceutical preparations, including granules, oral liquid, powder, tablets and the like.
The refined liquid can be further dissolved with water to obtain the traditional Chinese medicine oral liquid, and when the oral liquid is used for preventing and treating livestock and poultry with liver damage, the oral liquid can be freely drunk for patients, for example, 1000 jin of water is added per 500mL of oral liquid, and the oral liquid can be freely drunk.
The traditional Chinese medicine composition has the beneficial effects that:
the traditional Chinese medicine composition has the effects of clearing heat and detoxicating, soothing liver and nourishing liver, promoting liver cell regeneration and promoting liver function recovery as a treatment rule, has reasonable formula, has obvious effects of nourishing and protecting liver, decomposing toxin in vivo, recovering liver function and improving production performance, effectively treats livestock and poultry liver poisoning, has the cure rate of more than 90 percent and is not easy to relapse;
the traditional Chinese medicine composition is convenient to use, harmless to human and livestock, high in cure rate, free of medicine residues and free of toxic and side effects;
the traditional Chinese medicine composition is prepared from pure traditional Chinese medicines with abundant resources and excellent quality in northwest areas, has wide sources and low cost, extracts active ingredients to a greater extent by utilizing a water extraction and alcohol precipitation method, improves the extraction rate of medicinal materials, reduces the dosage of animals, reduces the cost, increases the efficiency, has high economic benefit and is suitable for large-scale production and application.
The invention belongs to a pure traditional Chinese medicine preparation, has no medicine residue and no medicine resistance, and is a green, environment-friendly, safe and effective traditional Chinese medicine preparation.
Drawings
FIG. 1 is a liver picture of a normal rat in a blank group in test example 1 of the present invention;
FIG. 2 is a photograph of the liver of a rat after toxicity-counteracting and modeling in test example 1 of the present invention;
FIG. 3 liver pictures of drug rats used in the test group of test example 1 of the present invention;
FIG. 4 is a liver picture of a normal healthy broiler of the test group of inventive test example 2;
FIG. 5 is a photograph of the liver of a test group of sick broiler chickens in test example 2 of the present invention;
FIG. 6 liver pictures of the drug broiler used in the test group of inventive test example 2.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the present invention will be further described in detail by means of specific embodiments, with the understanding that the described embodiments are only for explaining the present invention and not limiting the present invention.
Example 1 preparation of oral liquid
30 parts of broussonetia papyrifera, 20 parts of buddleia, 20 parts of nutgrass galingale rhizome, 10 parts of Chinese mahonia leaf and 10 parts of sweet potato root.
The oral liquid for protecting livers of livestock and poultry is prepared according to the following steps:
the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 30 parts of broussonetia papyrifera, 20 parts of buddleia, 20 parts of nutgrass galingale rhizome, 10 parts of Chinese mahonia leaf and 10 parts of sweet potato root; decocting with water twice, wherein the water consumption is 10 times of the total weight of all the medicinal materials, firstly soaking for 2 hours in advance, filtering to obtain filtrate, combining the two decocted filtrate, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20; cooling the liquid medicine, slowly adding 70% ethanol with the amount of 2 times of the weight of the liquid medicine, stirring uniformly, hermetically refrigerating for 24 hours, filtering, and recovering ethanol from the filtrate to obtain refined liquid; then adding water for dissolution, heating to be completely dissolved, standing and refrigerating for 12 hours, filtering, adding water to a specified amount, packaging, and sterilizing to obtain the oral liquid.
The obtained livestock and poultry liver-protecting oral liquid is used for preventing and treating livestock and poultry animals with liver damage, and the specific dosage is as follows: every 500mL of the oral liquid can be drunk freely after 1000 jin of water.
Example 2
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of broussonetia papyrifera, 10 parts of buddleia, 10 parts of nutgrass galingale rhizome, 5 parts of Chinese mahonia leaf and 5 parts of sweet potato root.
The preparation method is described in example 1.
Example 3
This example differs from example 1 in the raw materials (in parts by weight): 40 parts of broussonetia papyrifera, 30 parts of buddleia, 30 parts of nutgrass galingale rhizome, 15 parts of Chinese mahonia leaf and 15 parts of sweet potato root.
The preparation method is described in example 1.
Example 4
This example differs from example 1 in the raw materials (in parts by weight): 25 parts of broussonetia papyrifera, 15 parts of buddleia, 15 parts of nutgrass galingale rhizome, 8 parts of Chinese mahonia leaf and 8 parts of sweet potato root.
The preparation method is described in example 1.
Example 5
This example differs from example 1 in the raw materials (in parts by weight): 35 parts of broussonetia papyrifera, 25 parts of buddleia, 25 parts of nutgrass galingale rhizome, 12 parts of Chinese mahonia leaf and 12 parts of sweet potato root.
The preparation method is described in example 1.
Comparative example 1
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of broussonetia papyrifera, 20 parts of buddleia, 20 parts of nutgrass galingale rhizome and 10 parts of Chinese mahonia leaf.
The preparation method is described in example 1.
Comparative example 2
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of broussonetia papyrifera, 20 parts of buddleia, 10 parts of folium mahoniae and 10 parts of radix Pachyrhizi Erosi root.
The preparation method is described in example 1.
Comparative example 3
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of broussonetia papyrifera, 20 parts of buddleia, 10 parts of liquorice, 10 parts of mahonia leaves and 10 parts of sweet potato roots.
The preparation method is described in example 1.
Comparative example 4
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of coptis chinensis, 20 parts of buddleia, 20 parts of nutgrass galingale rhizome, 10 parts of Chinese mahonia leaves and 10 parts of sweet potato root.
The preparation method is described in example 1.
Test example 1
The Chinese medicinal preparation has the effect of protecting liver injury
Test animals: healthy SD rats (purchased from Beijing Veitz laboratory animal technologies Co., ltd.) were randomly grouped into 10 groups and were adapted for one week prior to molding.
And (3) molding reagent: carbon tetrachloride (analytical purity, manufacturer; beijing chemical reagent plant); edible oil (Lu Hua peanut oil).
The molding method comprises the following steps: the peanut oil is used for preparing 40% carbon tetrachloride into a solution, and the rest groups except for a blank group are subcutaneously injected with 40% carbon tetrachloride solution according to the initial dose of 5mL/kg and the rest doses of 3mL/kg, and the blank group rats are subcutaneously injected with an equal amount of physiological saline.
In the practical test, the taking part of each rat is the outer muscle of the left thigh and the right thigh alternately in the first 3 weeks, and the injection is changed into the back subcutaneous injection in the 4 th week, so that the injection of the alternate part is used for preventing the local severe ulcer possibly occurring in the single injection, and the operation is not easy. 2 times per week for 6 weeks. The rats in the test group are given the traditional Chinese medicine oral liquid medicine prepared in the stomach-lavage example 1; the rats in the control group 1-4 are respectively given with the traditional Chinese medicine oral liquid medicines prepared in the comparative gastric lavage examples 1-4; rats in the blank group and model group were given an equivalent amount of physiological saline for lavage. During this period, animals were observed for activity, mental status and death, and rats were weighed weekly. 24 hours after the last administration, the grains are broken, weighed, the heart is sampled, and ALT, AST, ALP is measured to anatomically examine the pathological changes of the liver of the rat.
The results of testing the serum ALT, AST, ALP of each group of rats are shown in table 1;
table 1 effects of each group on liver fibrosis rat serum ALT, AST, ALP were tested
| Group of | ALT(U/L) | AST(U/L) | ALP(U/L) |
| Blank group | 54.83±3.21a | 178.51±5.36a | 194.24±2.56a |
| Model group | 223.53±5.40b | 363.57±8.41b | 290.00±3.31b |
| Test group | 97.73±4.12a | 200.37±6.78a | 224.37±2.97a |
| Control group 1 | 158.90±5.11ab | 321.87±6.85b | 233.59±4.73 |
| Control group 2 | 204.01±8.53b | 307.36±9.44b | 263.05±5.81b |
| Control group 3 | 167.14±6.19ab | 235.56±8.28a | 236.21±5.23 |
| Control group 4 | 176.74±7.27b | 283.59±6.63b | 241.64±6.05 |
Injecting; the marked difference (P < 0.05) from the model group is marked as a; the significant difference (P < 0.05) from the blank group is labeled b.
The test results show that the traditional Chinese medicine oral liquid prepared by the invention has the effect of protecting liver function injury to a certain extent.
Test example 2
Verification of the Chinese medicinal preparation in broiler chicken breeding
3000 Ross 308 broilers with two weeks of age are selected and randomly divided into 6 groups, and 500 broilers in each group are respectively a blank group, a test group and a control group, and 1-4. Before the beginning of the test, the broiler chicken shows symptoms of impaired liver functions such as mental depression, no vitality, inappetence, reduced feed intake, diarrhea, emaciation, and willing to stand on lying down. The blank group did not use any drug; test group feeding the oral liquid of the invention prepared in example 1, and control groups 1-4 respectively feeding the oral liquid prepared in comparative examples 1-4, wherein the dosage of the oral liquid is 500mL, the oral liquid is 1000 jin, the oral liquid is free to drink, the oral liquid is continuously fed for 7 days, and then the oral liquid is continuously cultivated for 7 days, and the change of chicken flock, the change of health state, the death number, the cutting inspection of dead chickens and the like are observed every day.
The curative effect judgment criteria are as follows:
the method is effective: the spirit and appetite of the sick chickens are recovered to be normal, the feed intake is increased, the weight is recovered, and the diarrhea frequency is reduced;
and (3) curing: the spirit and appetite of the sick chickens are recovered to be normal, the feed intake is normal, the weight is increased, and the diarrhea is avoided;
invalidation: the sick chickens are listlessness, inappetence, reduced feed intake, continuous emaciation, serious diarrhea, incapacity of moving or dying.
Table 2 influence of various groups of Chinese medicinal preparations on broiler chicken raising
As shown in Table 2, the mortality rate of the broiler chickens can reach 7.0% when no medicine is used, and the mortality rate of the broiler chickens is obviously reduced after the medicines are used in the test group and the control group 1-4, and the broiler chickens have a better curative effect on the sick chickens in the feeding process. The cure rate of the test group can reach more than 90%, the cure rate of the control group 1-4 is about 80%, the cure rate of the test group is obviously higher than that of the control group 1-4, the effective number of the test group is obviously higher than that of the control group 1-4, and the death rate of the test group is obviously lower than that of the control group 1-4. The results show that the traditional Chinese medicine oral liquid can obviously relieve liver injury diseases of sick chickens, improve mental conditions, restore appetite, increase weight of broiler chickens, improve diarrhea symptoms of the broiler chickens, reduce death rate and have more remarkable treatment effect. The medicines in the formula are reasonably compatible, the efficacy of each medicine is fully exerted, the synergistic effect of the medicines is enhanced, and the traditional Chinese medicine oral liquid can play a good role in protecting the liver of broiler chickens in cultivation.
Claims (4)
1. The traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising, by weight, 20-40 parts of broussonetia papyrifera, 10-30 parts of buddleia, 10-30 parts of nutgrass galingale rhizome, 5-15 parts of Chinese mahonia leaf and 5-15 parts of sweet potato root.
2. The traditional Chinese medicine composition for protecting livers of livestock and poultry according to claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 25-35 parts of broussonetia papyrifera, 15-25 parts of buddleia, 15-25 parts of nutgrass galingale rhizome, 8-12 parts of mahonia leaves and 8-12 parts of sweet potato roots.
3. The method for preparing the traditional Chinese medicine composition for protecting livers of livestock and poultry according to claim 1, which comprises the following steps:
s1: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-40 parts of broussonetia papyrifera, 10-30 parts of drunk spruce, 10-30 parts of nutgrass galingale rhizome, 5-15 parts of Chinese mahonia leaves and 5-15 parts of sweet potato roots;
s2: decocting with water twice, wherein the water consumption is 10-12 times of the total weight of all the medicinal materials, firstly soaking for 2 hours in advance, filtering each time for 2-3 hours to obtain filtrate, and combining the filtrates obtained by the two decoction;
s3: concentrating the filtrate into clear paste with the relative density of 1.10-1.20;
s4: cooling the liquid medicine, slowly adding 70% ethanol with the amount of 2 times of the weight of the liquid medicine, stirring uniformly, hermetically refrigerating for 24-48 h, filtering, and recovering ethanol from the filtrate to obtain refined liquid.
4. The use of the liver-protecting Chinese medicinal composition for livestock and poultry according to claim 1 in preparing medicaments for treating liver injury diseases of livestock and poultry, wherein the liver injury diseases comprise acute and chronic hepatitis.
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| CN105106533A (en) * | 2015-10-11 | 2015-12-02 | 王莹莹 | Traditional Chinese medicine composition for treating gestational gallstones |
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| CN106309825A (en) * | 2015-06-16 | 2017-01-11 | 于敏 | Pharmaceutical composition conducive to reducing liver injury and preparation method thereof |
| CN105106533A (en) * | 2015-10-11 | 2015-12-02 | 王莹莹 | Traditional Chinese medicine composition for treating gestational gallstones |
| CN113925894A (en) * | 2021-10-28 | 2022-01-14 | 北京生泰尔科技股份有限公司 | Antibacterial and anti-inflammatory Chinese herbal medicine extract feed additive and application thereof |
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