CN115350233A - Oral liquid for protecting livers of livestock and poultry and preparation method thereof - Google Patents
Oral liquid for protecting livers of livestock and poultry and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for protecting livers of livestock and poultry, which is characterized by comprising the following raw material medicines in parts by weight: 20 to 40 portions of paper mulberry fruit, 10 to 30 portions of kadsura heterostemon, 10 to 30 portions of nutgrass galingale rhizome, 5 to 15 portions of leatherleaf mahonia leaf and 5 to 15 portions of pachyrhizus root. The traditional Chinese medicine composition takes detoxification, toxin expelling, stagnation elimination, blood stasis removing, hepatocyte regeneration promoting and liver function recovery promoting as treatment rules, has reasonable formula, has obvious effects of nourishing and protecting the liver, decomposing toxin in the body, recovering the liver function and improving the production performance, and effectively treats the liver poisoning of livestock and poultry.
Description
Technical Field
The invention relates to the field of traditional Chinese veterinary medicines, and in particular relates to an oral liquid for protecting livers of livestock and poultry and a preparation method thereof.
Background
With the continuous improvement of living standard of people, people pay more attention to the health problem of food, especially livestock and poultry meat. The growth health of animals is ensured, the life quality of human beings can be improved, but in the culture process, the liver damage of livestock and poultry can be caused by a large amount of antibiotics, drug toxic and side effects, the eating of mildewed feed, water pollution, poor breeding environment, bacterial diseases, viral diseases, parasitic diseases and the like in the growth process of livestock and poultry.
The liver is one of the very important viscera of animals, belongs to wood in five elements, is yang in yin, is communicated with spring qi, is in body muscles and tendons, is open to eyes, blooms in claws, and is tear in fluid. The physiological function of the liver is to dredge the flow of qi, i.e., to dredge the smooth flow of qi. The liver governs smoothing flow of qi, meaning that the liver has the characteristics of dredging, smoothing, regulating and ascending, and can regulate qi movement of the whole body. The function is mainly shown in the following three aspects. 1) Regulating qi activity: qi movement means the ascending, descending, exiting and entering of qi. 2) Adjusting emotion: emotional feeling, feeling and emotion, refers to the regulation of qi movement by the liver through its function of smoothing flow of qi. 3) Assisting digestion: the function of the liver in smoothing flow of qi and promoting digestion is mainly achieved by coordinating the ascending and descending of the spleen and stomach and regulating the secretion and excretion of bile. In addition, the liver governs smoothing flow of qi and regulates qi movement, and is also beneficial to the smoothing of triple energizer water passage and coordination of water metabolism. The physiological function of the liver is to store blood, which means that the liver has the functions of storing blood and regulating blood flow to meet the needs of the body in different physiological states. The liver is also a detoxifying organ, and liver damage can have great influence on the body. When the liver of the body is damaged, the liver function is abnormal, the growth of the body is hindered, the immunity is reduced, the digestive and metabolic function of the body is disordered, the growth and development of the livestock are influenced slightly, and the death and culling rate of the livestock is increased seriously. Liver damage of livestock and poultry affects the healthy growth of animals, and the problem also seriously affects the healthy development of the breeding industry.
The clinical symptoms of the sick chicken are cachexia, slow growth and development of chicken heads, little and slow exercise amount, and most of chicken manure is yellowish white and more loose manure, which indicates that the majority of the sick chicken during the disease period is mainly damp-heat liver depression. The dead chicken is necropsied, and the liver shows the phenomena of fading, swelling, hard texture and bleeding due to the fact that heat and dampness epidemic toxin attacks nutrient blood, nutrient-qi disharmony, qi and blood are not sufficient, the disease is blocked in the liver for a long time, qi movement is blocked, blood stasis is left in the blood stasis, and phlegm blocks collaterals. In treatment, treatment is carried out according to the etiology by differentiation of symptoms and signs, and a prescription for clearing heat, removing toxicity, soothing liver and nourishing liver can obtain better curative effect.
At present, in the process of breeding livestock and poultry, generally after the livestock and poultry show clinical symptoms, most of the livestock and poultry are treated by using antibiotic drugs, and due to drug residues and drug resistance of the antibiotics, and long-term use of a large amount of the antibiotics can influence normal microbial colonies in intestinal tracts of organisms, and certain toxic and side effects can be caused on other tissues and organs, so that the effect is not ideal. With people focusing on healthy green food more and strict restrictions on the use of antibiotics in various countries, it is imperative that medicinal plants replace antibiotics to prevent and treat liver injury. Therefore, the development of a liver protection medicine which has no medicine residue, no drug resistance, no toxic or side effect, safety and effectiveness has very important significance.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the safe and effective oral liquid for protecting the liver of livestock and poultry without medicine residues, drug resistance and toxic and side effects and the preparation method thereof.
In order to achieve the above purpose, the invention provides a traditional Chinese medicine composition for protecting livers of livestock and poultry, which is characterized in that the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20 to 40 portions of paper mulberry fruit, 10 to 30 portions of kadsura heterostemon, 10 to 30 portions of nutgrass galingale rhizome, 5 to 15 portions of leatherleaf mahonia leaf and 5 to 15 portions of pachyrhizus root.
The traditional Chinese medicine composition provided by the invention has the treatment principle of clearing away heat and toxic materials, soothing the liver, nourishing the liver, promoting the regeneration of liver cells and promoting the recovery of liver function.
The pharmacological actions of the traditional Chinese medicine components are as follows:
herba Sarcopyramis Nebrosi: cool in nature, sour in taste, entering lung and liver meridians; has the effects of clearing away lung heat and removing liver fire. The whole herb is used as a medicine, has the effects of clearing liver and improving vision, and is used for treating tinnitus, eye fog and other diseases or dispelling liver fire.
Drupellow: pungent and mild in nature and flavor; entering liver and kidney meridians; has the effects of dispersing obstruction and eliminating dampness, removing dirt and treating malaria. Mainly treats carbuncle, sore and rash; malaria.
Rhizoma cyperi: nature and taste, xin Weigu sweet, neutral; entering liver and triple energizer meridian; has the effects of promoting qi circulation, resolving stagnation, regulating menstruation and relieving pain; can be used for treating stagnation of qi due to depression of the liver, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, fullness and stuffiness in chest and stomach, and cold hernia with abdominal pain.
Leaf of leatherleaf mahonia: taste, bitter and cool; entering liver and kidney meridians; clearing away deficiency heat, benefiting liver and kidney, and dispelling pathogenic wind and dampness; it is mainly indicated for yin deficiency with internal heat, cough with hemoptysis, dizziness.
Sweet potato root: the nature and taste are bitter and astringent, and the tea is cool; has the effects of clearing heat and promoting diuresis; it is used for treating diarrhea, dysentery, jaundice, and scrofula.
Further, the traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising the following raw material medicines in parts by weight: 25 to 35 portions of paper mulberry fruit, 15 to 25 portions of drupellow, 15 to 25 portions of nutgrass galingale rhizome, 8 to 12 portions of leatherleaf mahonia leaf and 8 to 12 portions of pachyrhizus root.
Furthermore, the traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising the following raw material medicines in parts by weight: 30 parts of paper mulberry fruit, 20 parts of kadsura heterostemma, 20 parts of rhizoma cyperi, 10 parts of mahonia leaf and 10 parts of radix trichosanthis.
On the other hand, the invention provides a preparation method of a traditional Chinese medicine composition for protecting livers of livestock and poultry, which comprises the following steps:
s1: taking the following traditional Chinese medicine raw materials in parts by weight: 20 to 40 portions of paper mulberry fruit, 10 to 30 portions of kadsura heteroclita, 10 to 30 portions of nutgrass galingale rhizome, 5 to 15 portions of leatherleaf mahonia leaf and 5 to 15 portions of pachyrhizus root;
s2: decocting with water twice, wherein the water consumption of each time is 10-12 times of the total weight of all the medicinal materials, soaking for 2 hours in advance by decocting with water for the first time, filtering to obtain filtrate, and combining the filtrates obtained by decocting for two times;
s3: concentrating the filtrate into clear paste with the relative density of 1.10-1.20;
s4: after the liquid medicine is cooled, slowly adding 70% by weight of ethanol, the amount of which is 2 times of the weight of the liquid medicine, uniformly stirring, carrying out closed refrigeration for 24-48 h, filtering, and recovering ethanol from the filtrate to obtain refined liquid.
In a third aspect, the invention also provides an application of the traditional Chinese medicine composition for protecting livers of livestock and poultry, which is used for treating liver injury diseases of livestock and poultry, wherein the liver injury diseases comprise acute and chronic hepatitis, drug-induced hepatitis, viral hepatitis and the like, and liver injury caused by factors such as feed mildew, disease infection, water pollution, drug accumulation poisoning and the like.
The traditional Chinese medicine composition for protecting livers of livestock and poultry can be further prepared into pharmaceutical preparations, including granules, oral liquid, powder, tablets and the like.
The traditional Chinese medicine oral liquid can be obtained by further dissolving refined liquid with water, and when the oral liquid is used for preventing and treating livestock and poultry with damaged liver, the oral liquid can be freely drunk by sick poultry, for example, 1000 jin of water is drunk by every 500mL of the oral liquid.
The traditional Chinese medicine composition has the following beneficial effects:
the traditional Chinese medicine composition takes the effects of clearing heat, removing toxicity, soothing liver, nourishing liver, promoting hepatocyte regeneration and promoting liver function recovery as a treatment rule, has reasonable formula, has the obvious effects of nourishing and protecting liver, decomposing toxin in vivo, recovering liver function and improving production performance, effectively treats livestock and poultry hepatotoxicity, has the cure rate of more than 90 percent and is not easy to relapse;
the traditional Chinese medicine composition is convenient to use, harmless to human and livestock, high in cure rate, free of medicine residue and toxic and side effects;
the traditional Chinese medicine composition is prepared from pure traditional Chinese medicines with abundant resources and excellent quality in northwest region, has wide sources and low cost, extracts effective components to a greater extent by a water extraction and alcohol precipitation method, improves the extraction rate of medicinal materials, reduces the dosage of animals, reduces cost and improves efficiency, has high economic benefit, and is suitable for large-scale production and application.
The invention belongs to a pure Chinese medicinal preparation, has no medicinal residue and no drug resistance, and is a green, environment-friendly, safe and effective Chinese medicinal preparation.
Drawings
FIG. 1 is a photograph of liver of a blank group of normal rats in test example 1 of the present invention;
FIG. 2 is a photograph of the liver of a rat subjected to challenge and modeling in the model group of Experimental example 1 of the present invention;
FIG. 3 is a photograph of liver of rats using the drugs in the test group of test example 1 of the present invention;
FIG. 4 is a liver picture of a normal and healthy broiler chicken in the test group in test example 2 of the present invention;
FIG. 5 is a liver image of a disease-affected broiler chicken tested in test example 2 of the present invention;
FIG. 6 is a picture of liver of broiler chicken using the drug of the test group in test example 2 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the present invention is further described in detail by the following specific embodiments, and it should be understood that the described embodiments are only used for explaining the present invention and do not limit the present invention.
EXAMPLE 1 preparation of oral liquid
30 parts of paper mulberry fruit, 20 parts of kadsura heteroclita, 20 parts of rhizoma cyperi, 10 parts of mahonia leaf and 10 parts of radix trichosanthis.
The oral liquid for protecting livers of livestock and poultry is prepared according to the following steps:
taking the following traditional Chinese medicine raw materials in parts by weight: 30 parts of Sarcopyramis nepalensis, 20 parts of kadsura Heterophylla, 20 parts of rhizoma cyperi, 10 parts of leatherleaf mahonia, and 10 parts of radix trichosanthis; decocting with water twice, wherein the water consumption is 10 times of the total weight of all the medicinal materials each time, soaking for 2 hours in advance by decocting with water for the first time, filtering to obtain filtrate, combining the filtrates obtained by decocting for two times, and concentrating the filtrate into clear paste with the relative density of 1.10-1.20; cooling the liquid medicine, slowly adding 70% ethanol in an amount of 2 times the weight of the liquid medicine, stirring, hermetically refrigerating for 24h, filtering, and recovering ethanol from the filtrate to obtain refined solution; and then adding water to dissolve, heating until the mixture is completely dissolved, standing and refrigerating for 12h, filtering, adding water to a specified amount, subpackaging and sterilizing to obtain the oral liquid.
The obtained livestock and poultry liver protection oral liquid is used for preventing and treating livestock and poultry with damaged liver, and the specific dosage is as follows: every 500mL of oral liquid can be drunk freely with 1000 jin of water.
Example 2
The difference between the present example and example 1 is in the raw materials (in parts by weight): 20 parts of Sarcopyramis nepalensis, 10 parts of kadsura Heterophylla, 10 parts of rhizoma cyperi, 5 parts of leatherleaf mahonia, and 5 parts of radix trichosanthis.
The preparation process is referred to example 1.
Example 3
The difference between the present example and example 1 is in the raw materials (in parts by weight): 40 parts of paper mulberry fruit, 30 parts of kadsura heteroclita, 30 parts of rhizoma cyperi, 15 parts of mahonia leaf and 15 parts of radix trichosanthis.
The preparation method refers to example 1.
Example 4
The difference between the present example and example 1 is in the raw materials (in parts by weight): 25 parts of paper mulberry fruit, 15 parts of kadsura heterostemma, 15 parts of rhizoma cyperi, 8 parts of mahonia leaf and 8 parts of radix trichosanthis.
The preparation process is referred to example 1.
Example 5
The difference between the present example and example 1 is in the raw materials (in parts by weight): 35 parts of Sarcopyramis nepalensis, 25 parts of kaihou, 25 parts of rhizoma cyperi, 12 parts of mahonia leaves and 12 parts of radix trichosanthis.
The preparation method refers to example 1.
Comparative example 1
The difference between the present example and example 1 is in the raw materials (in parts by weight): 20 parts of paper mulberry fruit, 20 parts of kadsura heteroclita, 20 parts of rhizoma cyperi and 10 parts of mahonia leaf.
The preparation process is referred to example 1.
Comparative example 2
The difference between the present example and example 1 is in the raw materials (in parts by weight): 20 parts of Sarcopyramis nepalensis, 20 parts of drupelgia chinensis, 10 parts of leatherleaf mahonia and 10 parts of radix Pachyrhizi Erosi.
The preparation process is referred to example 1.
Comparative example 3
The difference between the embodiment and the embodiment 1 is that the raw materials (in parts by weight): 20 parts of Sarcopyramis nepalensis, 20 parts of kadsura Heterophylla, 10 parts of liquorice, 10 parts of mahonia leaf and 10 parts of radix Pachyrhizi Erosi.
The preparation process is referred to example 1.
Comparative example 4
The difference between the present example and example 1 is in the raw materials (in parts by weight): 20 parts of coptis chinensis, 20 parts of kadsura heterostemma, 20 parts of rhizoma cyperi, 10 parts of Chinese mahonia leaves and 10 parts of radix trichosanthis.
The preparation process is referred to example 1.
Test example 1
The traditional Chinese medicine preparation of the invention has the protection effect on liver injury
Test animals: healthy SD rats (purchased from Beijing Wintolidhua laboratory animals technology Co., ltd.) were randomly grouped into 10 rats each, and were acclimatized for one week before molding.
Molding reagent: carbon tetrachloride (analytical pure, manufacturer; beijing chemical reagent works); edible oil (Lu Hua edible peanut oil).
The molding method comprises the following steps: the carbon tetrachloride is prepared into 40% solution by peanut oil, the other groups except the blank group are injected with 40% carbon tetrachloride solution subcutaneously according to the first dose of 5mL/kg and the other dose of 3mL/kg, and the rats in the blank group are injected with the same amount of physiological saline subcutaneously.
In practical experiments of the research, the left and right thigh muscle is alternately injected into the collected parts in the first 3 weeks of each rat, and the subcutaneous injection is changed into the subcutaneous injection in the back from the 4 th week, so that the injection in the alternative parts is used for preventing the local severe ulceration of a single injection, and the operation is not easy. 2 times a week for 6 weeks. The rats in the experimental group were administered the Chinese medicinal oral liquid preparation prepared in gavage example 1; the rats of the control groups 1 to 4 are respectively given the traditional Chinese medicine oral liquid medicines prepared in the gavage comparative examples 1 to 4; rats in the blank and model groups were given gavage equivalent amounts of physiological saline. During this period, animals were observed for activity, mental status and death, and the rats were weighed weekly. 24h after the last administration, the grains are cut off, weighed, the heart is sampled, ALT, AST and ALP are measured, and the liver pathological changes of the rats are examined in a dissecting way.
The measurement results of ALT, AST and ALP of serum of rats in each group are shown in Table 1;
TABLE 1 test of the Effect of groups on liver fibrosis rat serum ALT, AST and ALP
| Group of | ALT(U/L) | AST(U/L) | ALP(U/L) |
| Blank group | 54.83±3.21a | 178.51±5.36a | 194.24±2.56a |
| Model set | 223.53±5.40b | 363.57±8.41b | 290.00±3.31b |
| Test group | 97.73±4.12a | 200.37±6.78a | 224.37±2.97a |
| Control group 1 | 158.90±5.11ab | 321.87±6.85b | 233.59±4.73 |
| Control group 2 | 204.01±8.53b | 307.36±9.44b | 263.05±5.81b |
| Control group 3 | 167.14±6.19ab | 235.56±8.28a | 236.21±5.23 |
| Control group 4 | 176.74±7.27b | 283.59±6.63b | 241.64±6.05 |
Injecting; marked with a significant difference (P < 0.05) compared with the model group; there was a significant difference (P < 0.05) from the blank group, labeled b.
The test results show that the traditional Chinese medicine oral liquid prepared by the invention has the effect of protecting liver function damage to a certain extent.
Test example 2
Verification of traditional Chinese medicine preparation on broiler chicken breeding
3000 Ross 308 broilers of two weeks old are selected and randomly divided into 6 groups of 500, wherein each group comprises a blank group, a test group and a control group of 1-4. Before the test begins, the broiler chickens have clinical manifestations of impaired liver functions such as mental depression, lack of vitality, inappetence, decreased feed intake, diarrhea, emaciation, lying and unwilling to stand and the like. The blank group did not contain any drug; the oral liquid prepared in the example 1 is fed to a test group, the oral liquid prepared in the comparative examples 1-4 is respectively fed to control groups 1-4, the dosage of the oral liquid is 500mL, 1000 jin of water is added into the oral liquid, the oral liquid is freely drunk and continuously administrated for 7 days, then the breeding is continued for 7 days, and the change of chicken flocks, the change of health status, the number of dead chickens, the autopsy of dead chickens and the like are observed every day.
The criteria for determining the efficacy are as follows:
the method has the following advantages: the sick chicken recovers the normal spirit and appetite, the feed intake is increased, the weight is recovered, and the diarrhea frequency is reduced;
and (3) curing: the sick chicken recovers the normal spirit and appetite, the feed intake is normal, the weight is increased, and no diarrhea exists;
and (4) invalidation: the sick chicken is listened, inappetence, decreased feed intake, emaciation, diarrhea, and mobility or death.
Table 2 Effect of Chinese medicinal preparations on broiler breeding
As can be seen from Table 2, the mortality rate of broiler chickens in the breeding process can reach 7.0% when the medicines are not used, and the mortality rate of broiler chickens in the test group and the control groups 1-4 is obviously reduced after the medicines are used, so that the broiler chickens have a good cure effect on sick chickens in the breeding process. The cure rate of the test group can reach more than 90%, the cure rate of the control groups 1-4 is about 80%, the cure rate of the test group is obviously higher than that of the control groups 1-4, the effective number of the test group is obviously higher than that of the control groups 1-4, and the death rate of the test group is also obviously lower than that of the control groups 1-4. The results show that the traditional Chinese medicine oral liquid can obviously relieve liver injury of sick chickens, improve mental status, recover appetite, increase weight of the chickens, improve diarrhea symptoms of the chickens, reduce death rate and has more obvious treatment effect. The traditional Chinese medicine oral liquid disclosed by the invention has the advantages that the medicines in the formula are reasonably compatible, the effects of all medicinal materials are fully exerted, the medicinal effects are synergistically enhanced, and the traditional Chinese medicine oral liquid disclosed by the invention can play a good protection role on the liver of broiler chickens in breeding.
Claims (6)
1. The traditional Chinese medicine composition for protecting livers of livestock and poultry is characterized by comprising the following raw material medicines in parts by weight: 20 to 40 portions of paper mulberry fruit, 10 to 30 portions of kadsura heterostemon, 10 to 30 portions of nutgrass galingale rhizome, 5 to 15 portions of leatherleaf mahonia leaf and 5 to 15 portions of pachyrhizus root.
2. The traditional Chinese medicine composition for protecting livers of livestock and poultry according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 25 to 35 portions of Sarcopyramis nepalensis, 15 to 25 portions of drupelgia chinensis, 15 to 25 portions of rhizoma cyperi, 8 to 12 portions of Chinese mahonia leaves and 8 to 12 portions of radix trichosanthis.
3. The liver-protecting traditional Chinese medicine composition for livestock and poultry according to claim 1, characterized in that the raw material drugs of the traditional Chinese medicine composition comprise, by weight, 20-40 parts of Sarcopyramis nepalensis, 10-30 parts of kadsura heterostemma, 10-30 parts of rhizoma cyperi, 5-15 parts of folium Mahoniae and 5-15 parts of radix trichosanthis.
4. The method for preparing the traditional Chinese medicine composition for protecting livers of livestock and poultry according to claim 1, comprising the following steps:
s1: taking the following traditional Chinese medicine raw materials in parts by weight: 20 to 40 portions of paper mulberry fruit, 10 to 30 portions of kadsura heteroclita, 10 to 30 portions of nutgrass galingale rhizome, 5 to 15 portions of leatherleaf mahonia leaf and 5 to 15 portions of pachyrhizus root;
s2: decocting with water twice, wherein the water consumption of each time is 10-12 times of the total weight of all the medicinal materials, soaking for 2 hours in advance by decocting with water for the first time, filtering to obtain filtrate, and combining the filtrates obtained by decocting for two times;
s3: concentrating the filtrate into clear paste with the relative density of 1.10-1.20;
s4: after the liquid medicine is cooled, slowly adding 70% of ethanol in a mass part which is 2 times of the weight of the liquid medicine, uniformly stirring, carrying out closed refrigeration for 24-48 h, filtering, and recovering ethanol from the filtrate to obtain refined liquid.
5. The use of the liver protecting Chinese medicinal composition for livestock and poultry according to claim 1 for preparing a medicament for treating liver injury diseases of livestock and poultry, wherein the liver injury diseases comprise acute and chronic hepatitis.
6. The pharmaceutical preparation comprising the traditional Chinese medicine composition for protecting livers of livestock and poultry according to claim 1 comprises granules, oral liquid, powder and tablets.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106533A (en) * | 2015-10-11 | 2015-12-02 | 王莹莹 | Traditional Chinese medicine composition for treating gestational gallstones |
| CN106309825A (en) * | 2015-06-16 | 2017-01-11 | 于敏 | Pharmaceutical composition conducive to reducing liver injury and preparation method thereof |
| CN113925894A (en) * | 2021-10-28 | 2022-01-14 | 北京生泰尔科技股份有限公司 | Antibacterial and anti-inflammatory Chinese herbal medicine extract feed additive and application thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309825A (en) * | 2015-06-16 | 2017-01-11 | 于敏 | Pharmaceutical composition conducive to reducing liver injury and preparation method thereof |
| CN105106533A (en) * | 2015-10-11 | 2015-12-02 | 王莹莹 | Traditional Chinese medicine composition for treating gestational gallstones |
| CN113925894A (en) * | 2021-10-28 | 2022-01-14 | 北京生泰尔科技股份有限公司 | Antibacterial and anti-inflammatory Chinese herbal medicine extract feed additive and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 无: "地黄合剂对免疫抑制小鼠T细胞亚群及白细胞介素Ⅱ的调节作用", 江西中医药, vol. 25, no. 02, pages 63 * |
| 邓红;: "保肝中药面面观", 食品与健康, no. 09, pages 816 * |
| 郭晔, 等: "黄芪多糖粉对犬瘟热和细小病毒抗体效价影响的研究", 兽医导刊, no. 15, pages 72 - 73 * |
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